Identification of Potential Inhibitors Targeting Non-Structural Proteins NS3 and NS5 of Dengue Virus Using Docking and Deep Learning Approaches by Alomgir Hossain, Faria Tasnin Joti, Md. Shohag Hossain, Abdullah Al-Noman, Chomong Thowing, Mehjabin Mursona, Md. Robiul Islam, Md. Ekhtiar Rahman, Mohammad Nurul Matin, Md Azizul Haque

“…Our identified new drug candidates might help for developing effective antiviral inhibitors against the DENV. …”
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5G Networks Security Mitigation Model: An ANN-ISM Hybrid Approach by Rafiq Ahmad Khan, Habib Ullah Khan, Hathal Salamah Alwageed, Hussein Al Hashimi, Ismail Keshta

“…The main goal of this study is to develop a 5G network security mitigation model (5GN-SMM) that leverages the predictive capabilities of ANN and the analysis of ISM to identify and mitigate security threats by providing practices in 5G networks. …”
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COMPLEX EVALUATION OF THE SIGNIFICANCE OF POPULATIONAL GENETIC MARKERS ASSOCIATED WITH MYOCARDIAL INFARCTION AND RISK FACTORS by V. N. Maksimov, P. S. Orlov, А. A. Ivanova, N. G. Lozhkina, А. D. Kuimov, S. V. Savchenko, V. P. Novoselov, М. I. Voevoda, S. К. Malyutina

“…Genes polymorphism was tested with PCR real-time according to the protocol by equipment developer (TaqMan, Applied Biosystems, USA), device ABI 7900HT. …”
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Machine learning-based ultrasound radiomics for predicting risk of recurrence in breast cancer by Wei Fan, Hao Cui, Xiaoxue Liu, Xudong Zhang, Xinran Fang, Junjia Wang, Zihao Qin, Xiuhua Yang, Jiawei Tian, Lei Zhang

“…PurposeTo develop a radiomics model based on ultrasound images for predicting risk of recurrence in breast cancer patients.MethodsIn this retrospective study, 420 patients with pathologically confirmed breast cancer were included, randomly divided into training (70%) and test (30%) sets, with an independent external validation cohort of 90 patients. …”
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Bicuspid aortic valve repair using geometric ring annuloplasty: A first-in-humans pilot trialCentral MessagePerspective by J. Scott Rankin, MD, Domenico Mazzitelli, MD, Theodor J.M. Fischlein, MD, Yeong-Hoon Choi, MD, Diana Aicher, MD, Lawrence M. Wei, MD, Vinay Badhwar, MD

“…A geometric annuloplasty ring has been developed, and 2-year regulatory outcomes of a first-in-humans pilot trial are reported. …”
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Novel HSA-PMEMA Nanomicelles Prepared via Site-Specific In Situ Polymerization-Induced Self-Assembly for Improved Intracellular Delivery of Paclitaxel by Yang Chen, Shuang Liang, Binglin Chen, Fei Jiao, Xuliang Deng, Xinyu Liu

“…Tremendous potential lies in these micelles for developing safer and more efficient next-generation PTX formulations for tumor treatment.…”
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Six decades of global coral bleaching monitoring: a review of methods and call for enhanced standardization and coordination by Andrea Rivera-Sosa, Aarón Israel Muñiz-Castillo, Ben Charo, Gregory P. Asner, Chris M. Roelfsema, Simon D. Donner, Brianna D. Bambic, Ana Gabriela Bonelli, Ana Gabriela Bonelli, Morgan Pomeroy, Morgan Pomeroy, Derek Manzello, Paulina Martin, Helen E. Fox

“…These issues hinder comparative analyses and contribute to discrepancies in global bleaching impact assessments. We developed a typology of twenty-nine coral bleaching methods used across various scales, encompassing remote sensing tools, underwater surveys, and specimen collection. …”
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Testing of Retail Cheese, Butter, Ice Cream, and Other Dairy Products for Highly Pathogenic Avian Influenza in the US by David L. Suarez, Iryna V. Goraichuk, Lindsay Killmaster, Erica Spackman, Nicole J. Clausen, Tristan J. Colonius, Cynthia L. Leonard, Monica L. Metz

“…Revised protocols were developed to extract RNA from solid dairy products including cheese and butter. …”
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Differences between suspected keratoconus and subclinical keratoconus via multiparameter analysis in Chinese populations by Yusu Peng, Qingqing Feng, Ting Shao, Jiafan Zhang, Sai Liu, Huifeng Wang, Hua Li, Keli Long

“…To improve the safety of the surgery, we aim to distinguish between suspected KC and subclinical KC, while also developing a predictive model for KC. This cross-sectional study investigated 116 eyes with suspected KC (I-S Value > 1.4 D and ≤ 1.9 D) and 28 eyes with subclinical KC. …”
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Comparing AI/ML approaches and classical regression for predictive modeling using large population health databases: Applications to COVID-19 case prediction by Lise M. Bjerre, Cayden Peixoto, Rawan Alkurd, Robert Talarico, Rami Abielmona

“…Using demographic, socio-economic and health data (including COVID-19 PCR test results and available, symptom data), we developed predictive models for the purpose of COVID-19 case identification using the following approaches: classical multivariate logistic regression (LR); deep neural network (DNN); random forest (RF); and gradient boosting trees (GBT). …”
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Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations by Cheng Zhang, Yina Li, Fangyang Li, Wanyun Dang, Zhuo Shi, Chunqi Yang, Chengrong Xiao, Xianglin Tang, Yuguang Wang, Yuguang Wang, Yuguang Wang, Yue Gao, Yue Gao, Yue Gao, Yue Gao

“…An innovative similarity model was developed to identify toxic components within the TCM formulations. …”
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Computational identification of promising genetic markers associated with molecular mechanisms of reduced rice resistance to <i>Rhizoctonia solani</i> under excess nitrogen fertili... by E. A. Antropova, A. R. Volyanskaya, A. V. Adamovskaya, P. S. Demenkov, I. V. Yatsyk, T. V. Ivanisenko, Y. L. Orlov, Ch. Haoyu, M. Chen, V. A. Ivanisenko

“…This study opens prospects for developing innovative strategies in rice breeding aimed at optimizing the balance between yield and disease resistance in modern agrotechnical conditions.…”
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Optimization of IMU-based bending strain solving algorithm and full-scale experimental validation by Tong SHI, Xiaoben LIU, Lin ZHANG, Jun WANG, Rui LI, Ting Xie, Qingshan FENG, Qiyu HUANG

“…Methods A simulation model was developed for IMU in-line detectors based on their actual size, without abnormal vibrations and other interferences. …”
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Ecological impacts of single-axis photovoltaic solar energy with periodic mowing on microclimate and vegetation by Yudi Li, Yudi Li, Alona Armstrong, Alona Armstrong, Christopher Simmons, Noah Z. Krasner, Noah Z. Krasner, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez

“…In the state of California’s Great Central Valley (United States), we developed a novel experimental framework to characterize five distinct “micro-patches” that capture the full spectrum of microclimate and vegetation zones modulated by the tracking PV system and O&amp;M. …”
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Do shoulder kinematics change after reverse total shoulder arthroplasty? by Itaru Kawashima, MD, PhD, Eric R. Wagner, MD, MS, Joseph J. King, MD, Zaamin B. Hussain, MD, EdM, Sameer R. Khawaja, BS, Jaden C. Hadrick, BS, Krishna N. Chopra, MA, Michael B. Gottschalk, MD, Scott A. Banks, PhD, Thomas W. Wright, MD

“…However, it remains unclear whether the kinematic changes observed in shoulders following rTSA were present preoperatively or developed as a result of the surgery. Furthermore, the impact of preoperative scapulohumeral rhythm (SHR) on the postoperative SHR after rTSA is also poorly understood. …”
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Revealing the heterogeneity of treatment resistance in less‐defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy by Wei Hua, Jie Liu, Yue Li, Hua Yin, Hao‐Rui Shen, Jia‐Zhu Wu, Yi‐Lin Kong, Bi‐Hui Pan, Jun‐Heng Liang, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu

“…This tool facilitates the forecasting of outcomes for these patients, enhancing the precision of their clinical management. Key points Developing the Programmed Cell Death Index (PCDI) utilizing multiple machine learning algorithms for patients with less‐defined subtype diffuse large B‐cell lymphoma. …”
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Numerical Simulation of Dynamic Response of Slab-Column Structures under Fire-Explosion Coupled Effects by LIU Jingbo, YANG Qiong, WU Lei, WANG Chengquan, YU Xiongfei, FANG Mingyu, DONG Tengfang

“…In the validation stage, two distinct finite element models were developed and rigorously validated against full-scale experimental data from existing literature. …”
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Phylogenomic insights into the origin of the Norton grape by Luke Sparreo, Alicia Talavera, Ze‐Long Nie, Gabriel Johnson, Robert Literman, Sara Handy, Jun Wen

“…Norton represents a pattern consistent with other popular grape cultivars, where a cultivar was developed via hybridization, including backcrossing with wild species, creating a disease‐resistant cultivar.…”
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A Novel Inflammation-Marker-Based Prognostic Model for Advanced Pulmonary Lymphoepithelioma-Like Carcinoma by Chen X, Liu T, Mo S, Yang Y, Chen X, Hong S, Zhou T, Chen G, Zhang Y, Ma Y, Ma Y, Zhang L, Zhao Y

“…Xueyuan Chen,1,&ast; Tingting Liu,1,&ast; Silang Mo,1,&ast; Yuwen Yang,1 Xiang Chen,1 Shaodong Hong,1 Ting Zhou,1 Gang Chen,1 Yaxiong Zhang,1 Yuxiang Ma,2 Yuanzheng Ma,1 Li Zhang,1 Yuanyuan Zhao1 1Medical Oncology Department, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Clinical Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Li Zhang; Yuanyuan Zhao, Sun Yat-sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, People’s Republic of China, Email zhangli@sysucc.org.cn; zhaoyy@sysucc.org.cnPurpose: This study aimed to investigate the prognostic value of inflammation markers for advanced pulmonary lymphoepithelioma-like carcinoma (PLELC) and develop an effective prognostic model based on inflammation markers to predict the overall survival (OS) of this population.Methods: Cox regression analysis was performed on 18 clinical and inflammation features, and a nomogram was created to predict overall survival (OS). …”
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A qualitative study on the relationship between doctors and nurses offering primary health at KwaNobuhle (Uitenhage) by M.D. Qolohle, H.H. Conradie, G.A. Ogunbanjo, N.H. Malete

“…In addition, the district health system was developed with the aim of keeping people healthy by creating small management systems adapted to cater for local needs. …”
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