The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review by Yan Chen, Yan Chen, Jiaojiao Zhao, Jiaojiao Zhao, Yifei Wang, Yifei Wang, Long Ge, Long Ge, Joey Sum-wing Kwong, Junjie Lan, Rui Zhang, Huaye Zhao, Linfang Hu, Jiaxue Wang, Shuimei Sun, Songsong Tan, Xiaoqing Lin, Rui He, Wenyi Zheng, Xiaosi Li, Jiaxing Zhang

“…Furthermore, the risk of AEs and SAEs was comparable for the three triazoles, but the risk of SAEs was significantly higher for D-AmB than others.ConclusionThe efficacy and safety of triazoles are more favorable than D-AmB in the primary therapy of IA, with ISA being the optimal choice.Systematic Review RegistrationPROSPERO CRD42023407632.…”
Get full text

Identification of HLA-B*13:01 allele in leprosy patients with dapsone hypersensitivity syndrome in Ambon, Indonesia by Sri Linuwih Susetyo Wardhani Menaldi, Mufqi Handaru Priyanto, Sandra Widaty, Yunia Irawati, Yulia Ariani Aswin, Dwi Anita Suryandari, Melani Marissa, Iwan Ariawan, Emiliana Kartika, Malika Sabrina Yunifananda, Hok Bing Thio

“…Significance was set at p<0.05.ResultsA total of 8 cases and 53 controls were included. The HLA-B*13:01 was present in 100% of DHS cases and 6% of controls. …”
Get full text

Subnational introduction of the RTS,S/AS01E malaria vaccine into routine immunization: experience and lessons from the three pilot countries by Rose Jalang’o, Kwame Amponsa-Achiano, Mike Chisema, Keziah Malm, Lydiah Khalayi, Brenda Mhone, Wahjib Mohammed, Franklin Asiedu-Bekoe, Adam Haji, Josephine Njoroge, Boston Zimba, Esther Chirwa, Peter O. Tweneboah, Jackson Sillah, Mgaywa G. M. D. Magafu, Cynthia Bergstrom, Tracey Goodman, Jenny Walldorf, Kristen Kelleher, Eliane Pellaux-Furrer, Mary J. Hamel, Michael R. Adjei, Rafiq N. A. Okine

“…With the global vaccine supply boosted by the pre-qualification of a second malaria vaccine, R21/Matrix-M (R21), in October 2023, many endemic countries (20 as of April 2025) have introduced malaria vaccines into their national childhood immunization and malaria control programmes. More endemic countries are expected to introduce or scale up malaria vaccines in 2025 and beyond. …”
Get full text

IORT for early-stage, low-risk breast cancer: Outcomes from a prospective, observational study by Amalia Palacios-Eito, María del Carmen Moreno-Manzanaro, María Espinosa-Calvo, Fátima Ginés-Santiago, Juan Adrián Camús-Martínez, Ángel Calvo-Tudela, Pilar Rioja-Torres, Sara Romero-Martín, José Antonio Miñano-Herrero, Gustavo R. Sarria, Sonia García-Cabezas

“…Conclusions: Local recurrence rates were low amongst all groups. Superior control outcomes could be obtained by applying more restrictive criteria than the TARGIT A trial. …”
Get full text

Study on Performance of Coordinated Ventilation Strategies during T-Shaped Subway Station Hall Fire by Yanan Hou, Wei Ding, Zhengbo Hou, Xingcheng Li, Ling Li, Zhihao Yang, Congling Shi

“…However, for fires on the ‘T’s longitudinal side, horizontal fans are ineffective in controlling smoke flow, making the traditional fire shutter closure optimal. …”
Get full text

Microbial mineralization combined with vegetation soil stabilization in coal mining subsidence areas by Ying GAO, Tao LI, Kaidan ZHENG, Limin FAN, Ruhong BAI, Qiang SUN

“…The addition of root system with MICP solidification increased the cohesion and internal friction angle of solidified soil by 62.3% and 19.4%, respectively. The optimal parameters for joint solidification of the two are: root length of 5−10 cm, root addition ratio of 0.8%, and bacterial gum ratio of 1∶1.5 During the solidification process of MICP, the production of calcium carbonate D1>D2>D3 indicates that the more severe the coal mining disturbance, the higher the degree of MICP intervention and repair. …”
Get full text

Dynamic Femur Fracture Brace vs Hip Spica Cast for Pediatric Femoral Shaft Fractures: A Retrospective Comparative Cohort Study by Virginia F. Casey, MD, Calvin C. Chandler, MD, George D. Graham, MD, Steven L. Frick, MD

“…Level of Evidence: Level III retrospective case-control study…”
Get full text

Efficacy and safety of non-pharmacological therapies for primary insomnia: a network meta-analysis by Qin-hong Zhang, Qin-hong Zhang, Yong-jian Liu, Guanhu Yang, Guanhu Yang, Guanhu Yang, Mei-yi Zhu, Jia-hui Yang, Lun Li, Xiu-mei Yan, Qi-lin Liu, Jin-huan Yue, Xiao-ling Li, Yi-ming Li, Tian-cheng Xu, Fan Jiang

“…Future studies should use standardized measures for more specific insomnia assessment.…”
Get full text

Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study by Michael S Deiner, Russell Y Deiner, Cherie Fathy, Natalie A Deiner, Vagelis Hristidis, Stephen D McLeod, Thomas J Bukowski, Thuy Doan, Gerami D Seitzman, Thomas M Lietman, Travis C Porco

“…However, public health actions for likely outbreaks could benefit more by knowing additional epidemiological characteristics, such as outbreak type, size, and severity. …”
Get full text

Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome by Xiaoshuang Yin, Jinmei Zou, Jing Yang

“…A 1:1 propensity score matching (PSM) approach was used to control for potential confounding variables. The threshold value of ANLR influencing survival was determined using maximally selected rank statistics, which is based on the log-rank test. …”
Get full text

Dynamics of T cell subpopulation in patients with aplastic anemia during immunosuppressive therapy by A. V. Abramova, E. A. Mikhailova, I. V. Galtseva, Z. T. Fidarova, A. V. Luchkin, N. M. Kapranov, Yu. O. Davydova, S. M. Kulikov, V. V. Troitskaya, E. N. Parovichnikova

“…The number of these cells at the onset and control points significantly correlated with the response to IST. …”
Get full text

Impact of Subsequent Treatment on Clinical Outcomes in Patients with EGFR-Mutant Non-Small Cell Lung Cancer Transformed to Small-Cell Lung Cancer by Chen CY, Ko HW, Hu PW, Chang CY, Chen CY, Chang SC, Chiu YC, Wei YF

“…The overall response rate (ORR), disease control rate (DCR), and median PFS for subsequent treatments were 38.5%, 69.2%, and 6.4 months, respectively. …”
Get full text

Application of artificial intelligence in the diagnosis of malignant digestive tract tumors: focusing on opportunities and challenges in endoscopy and pathology by Yinhu Gao, Peizhen Wen, Yuan Liu, Yahuang Sun, Hui Qian, Xin Zhang, Huan Peng, Yanli Gao, Cuiyu Li, Zhangyuan Gu, Huajin Zeng, Zhijun Hong, Weijun Wang, Ronglin Yan, Zunqi Hu, Hongbing Fu

Get full text

Psychopathological Comorbidities in Children and Adolescents with Feeding and Eating Disorders: An Italian Clinical Study by Maria Califano, Jacopo Pruccoli, Oliviero Cavallino, Alessandra Lenzi, Antonia Parmeggiani

“…., attention-deficit/hyperactivity disorder (ADHD) (30.5%); (5) disruptive and impulse-control disorders (13.9%); and (6) psychotic symptoms (40.3%). …”
Get full text

Hydrogen Production, Transporting and Storage Processes—A Brief Review by José Pereira, Reinaldo Souza, Jeferson Oliveira, Ana Moita

“…It explores parameters that influence hydrogen production, highlighting the importance of adequately controlling the temperature and concentration of the electrolytic medium to optimize the chemical reactions involved and ensure more efficient production. …”
Get full text

Is Childhood IgA Nephropathy Different From Adult IgA Nephropathy? A Narrative Review by Areefa Alladin-Karan, Susan M. Samuel, Andrew W. Wade, Pietro Ravani, Silviu Grisaru, Ngan N. Lam, Kathryn A. Birnie, Robert R. Quinn

“…Children were started on immunosuppressive therapy sooner than adults. Adults were more likely to be optimized with renin-angiotensin system inhibitors (87-94% vs 49-75%). …”
Get full text

Developing an effective teaching model in order to improve the educational level of schools by Mehdi Mohammadi, fardin Abdollahy, Rafigh Hasani

“…In explaining the findings of this research, it can be said that the optimal classroom management mentioned by the interviewees includes: classroom preparation, planning, parents' participation in their children's education process, welcoming students' interaction with each other, the ability to communicate with problematic students, continuous and formative evaluation, respecting the order of the teacher while teaching, having a lesson plan, having a logical order in teaching, on time attendance control, strictness on time, removing communication barriers while teaching, providing a learning environment, and human relations governing the classroom atmosphere. …”
Get full text

Analysis of phenotypic manifestations of connective tissue dysplasia in adult patients with osteogenesis imperfecta and development of a diagnostic algorithm by D. I. Valeeva, R. I. Khusainova, L. N. Khusainova, M. M. Khafizov, A. V. Tyurin

“…In type III, spinal deformities are characteristic, chest deformities were more often observed in patients with type V OI. A clinical algorithm for determining OI types was developed to optimize diagnostics and genotyping.…”
Get full text

Axial Performances of CFRP-PVC Confined RAC Columns: Experimental and Numerical Study by Zidong Hu, Ruoyu Cao, Qiaoyun Wu, Cheng Zhao, Jie Li, Xuyong Chen

“…Axial compression tests reveal that specimens with a central CFRP strip width equal to or greater than 75 mm achieve peak loads up to 1331 kN and that, after rupture of the central strip, the remaining strips continue to carry load, producing a more gradual stress–strain decline and enhanced ductility compared to fully wrapped controls (peak load 1219 kN). …”
Get full text

Research Progress on Ambient Visual Information Analysis and Perception Measurement Methods for Motion Vision by Haipeng ZHU, Yuhang KONG, (JPN) OHNO Ryuzo

“…VR environments, combined with omnidirectional treadmills and handheld controllers, provide more accurate motion simulation by allowing users to simulate physical movements and choose walking paths freely and replicating real-world tour behaviors. …”
Get full text