Impact of early β-blocker use on the incidence of sepsis and clinical outcomes following cardiac surgery: a retrospective cohort study by Chen Yin, Chengjian Guan, Qianli Ma, Shaotong Zhang, Qian Chen, Bing Xiao

“…Sensitivity analyses using Fine-Gray competing risk models and cumulative incidence functions were performed. …”
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Effectiveness of different exercise interventions on depressive symptoms among college students: a network meta-analysis by Yang Xiao, Chaofan Shi, Xiaotian Zhang, Haitao Liu

“…Results Forty-two randomized controlled trials involving 1,169 participants were included. …”
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Comparing warming strategies to reduce hypothermia and shivering in elderly abdominal or pelvic surgery patients: a network meta-analysis by Wenyun Zheng, Bin Huang, Li Bao, Jun Wang, Jingfen Jin

“…We conducted a comprehensive literature search across PubMed, EMBASE, Cochrane library, and China Wanfang databases for randomized controlled trials (RCTs) published up to April 2024. …”
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A multilevel meta-analysis of the effects of repeated sprint training in hypoxia on athletic performance by Meng Han, Binglin Liu

“…BackgroundRepeated-sprint training in hypoxia (RSH) has emerged as a novel strategy to optimize repeated-sprint ability (RSA), aerobic capacity, and anaerobic performance in athletes. …”
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Advancement in predictive biomarkers for gestational diabetes mellitus diagnosis and related outcomes: a scoping review by Fabricio Da Silva Costa, Hasini Rathnayake, Luhao Han, Cristiane Paganoti, Brett Dyer, Avinash Kundur, Indu Singh, Olivia J Holland

“…Multivariable models combining maternal risk factors with biomarkers provided more accurate detection but required validation for use in clinical settings.Conclusion This review recommends further research integrating novel omics technology for building accurate models for predicting GDM, perinatal outcome, and the necessity of medication while considering the optimal testing time.…”
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Machine learning and microfluidic integration for oocyte quality prediction by Hassan Saffari, Davood Fathi, Peyman Palay, Hamid Gourabi, Rouhollah Fathi

“…Immature oocytes were recorded as they passed through a custom-designed microfluidic channel under controlled flow. Using image processing, two biomechanical features—Cortical Tension (CT) and Deformation Index (DI)—were extracted. …”
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Gut-brain-liver axis in growth hormone deficiency: role of microbiota-derived short-chain fatty acids in ethnic variability and therapeutic development by Dongming Meng, Wei Kong, Sai Cheng, Hua Liu, Congfu Huang

“…These approaches also aim to optimize precision therapies, such as nanoparticle-delivered SCFAs. …”
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Childhood malaria admission rates to four hospitals in Malawi between 2000 and 2010. by Emelda A Okiro, Lawrence N Kazembe, Caroline W Kabaria, Jeffrey Ligomeka, Abdisalan M Noor, Doreen Ali, Robert W Snow

“…Trends in monthly clinical malaria admissions between January 2000 and December 2010 were analysed using time-series models controlling for covariates related to climate and service use to establish whether changes in admissions can be related to expanded coverage of interventions aimed at reducing malaria infection.…”
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Rapid differentiation of patients with lung cancers from benign lung nodule based on dried serum Fourier-transform infrared spectroscopy combined with machine learning algorithms by Huanyu Li, Lixue Dai, Shaomei Guo, Hongluan Wang, Lei Lei, Jie Yu, Xiaoyun Li, Jun Wang

“…We analyzed dried serum from 58 LC patients, 37 BLN patients, and 36 healthy controls. Five machine learning models, linear discriminant analysis (LDA), support vector machine (SVM), random forest, multilayer perceptron (MLP), and LightGBM, were optimized using FTIR spectral data (1800–900 cm−1 band). …”
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Hepatitis B virus surface antigen drives T cell immunity through non-canonical antigen presentation in mice by Xiaofang Li, Wenxuan Sun, Xiaolan Xu, Qirong Jiang, Yuheng Shi, Huixi Zhang, Weien Yu, Bisheng Shi, Simin Wan, Jiangxia Liu, Wuhui Song, Jiming Zhang, Zhenghong Yuan, Jianhua Li

“…T cell immunity is crucial for controlling and clearing HBV infection. However, the intercellular processes underlying HBsAg presentation to T cells are incompletely understood. …”
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Insights from fifteen years of real-world development, testing and implementation of youth digital mental health interventions by Shane Cross, Shaminka Mangelsdorf, Lee Valentine, Shaunagh O'Sullivan, Carla McEnery, Isabelle Scott, Tamsyn Gilbertson, Shona Louis, Jon Myer, Ping Liu, Niel Mac Dhonnagáin, Tom Wren, Eleanor Carey, Daniela Cagliarini, Ross Jacobs, Roos Pot-Kolder, Imogen Bell, Jennifer Nicholas, Lucia Valmaggia, John Gleeson, Mario Alvarez-Jimenez

“…Drawing on the work of Orygen Digital, we outline the evolution of interventions including the Moderated Online Social Therapy (MOST) platform, the Mello app, and a suite of virtual reality-based therapies; all developed to meet the complex clinical, developmental, and service needs of youth aged 12 to 25.We identify ten key challenges and opportunities encountered in designing, developing and implementing these DMHIs: (1) meaningful co-design; (2) sustained user engagement; (3) personalization and transdiagnostic targeting; (4) optimizing intensities of human support; (5) leveraging peer support and social networking; (6) embedding DMHIs in clinical services; (7) blending digital and face-to-face care; (8) building data infrastructure and learning health systems; (9) developing sustainable and scalable business models; and (10) preparing DMHIs for large language models. …”
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Therapeutic Potential of Rho Kinase Inhibitors in Corneal Disease: A Systematic Review of Preclinical and Clinical Studies by Laura Andreea Ghenciu, Diana Andrei, Claudia Borza, Roxana Iacob, Emil Robert Stoicescu, Sorin Lucian Bolintineanu, Daniela Iacob, Ovidiu Alin Haţegan

“…Future work should explore novel delivery systems and larger controlled trials to optimize dosing, safety, and long-term outcomes.…”
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Implementing artificial neural networks and support vector machines to predict lost circulation by Ahmed K. Abbas, Najim A. Al-haideri, Ali A. Bashikh

“…In the first step, field dataset, including drilling operation parameters, formation type, and lithology of the rock, as well as the drilling fluid characteristics, were collected from 385 wells drilled in southern Iraq from different fields. Then, the user-controlled parameters for ANNs (e.g., training function, number of hidden layers, transferring function, and number of neurons in each hidden layer) and SVMs (e.g., regularization factor, the type of kernel function, and its specific parameters) were optimized using the most common conventional performance criteria. …”
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Role of remote ischaemic conditioning in fracture healing and orthopaedic surgery—a systematic review and narrative synthesis by Alison Buck, Tao Wang, Sheharyar S. Baig, Arshad Majid, Ali N. Ali

“…Abstract Introduction Remote ischaemic conditioning (RIC) involves the use of controlled and transient ischemia and reperfusion cycles, commonly of the upper or lower limb, to mitigate cellular damage from ischaemic events. …”
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Glutathione deficiency and heart failure: a systematic review of human and animal evidence by Ali A. Al-Mubarak, Antonio Esquivel-Gaytan, Herman H.W. Silljé, Peter van der Meer, Nils Bomer

“…Regarding the animal evidence, 74.2 % and 79.3 % of the measurements in ischemic cardiomyopathy models and models with transverse aortic constriction, showed lower glutathione concentrations as compared to sham groups, respectively. …”
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Impact of plasticity and stress history on thermal volume changes in clays by Hamed Hoseini Mighani, Saeed Tourchi, Arash Alimardani Lavasan, Fatemehsadat Hosseini, Janos Szendefy

“…The insights gained are foundational for advancing predictive models, optimizing the design of thermally loaded geo-energy systems, and addressing climate-driven challenges such as soil-atmosphere interactions and landslide susceptibility.…”
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Synergistic Effects of Natural Products and Mesenchymal Stem Cells in Osteoarthritis Treatment: A Narrative Review by Hamoud H. Alfaqeh, Ruszymah Binti Hj Idrus, Aminuddin Bin Saim, Abid Nordin

“…Future research should focus on optimizing delivery systems, conducting large-scale randomized controlled trials, and establishing personalized treatment strategies based on patient biomarkers. …”
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Key Blasting Parameters for Deep-Hole Excavation in an Underground Tunnel of Phosphorite Mine by Xiu-wei Chai, Sha-sha Shi, Yao-feng Yan, Jian-guo Li, Long Zhang

“…In this study, through theoretical analysis of tunnel blasting, the layout of cutting holes was found to be the key factor controlling the blasting performance. The deep-hole cutting effect was first investigated by analyzing the influence of the free surface of a hollow hole using the fluid-structure interaction modeling method in ANSYS/LS-DYNA. …”
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Structure-guided design of partial agonists at an opioid receptor by Balazs R. Varga, Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy H. Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina L. Nazarova, Alexa Kouvelis, Ryosuke Shinouchi, Haylee R. Hammond, Shainnel O. Eans, Violetta Weinreb, Elyssa B. Margolis, Jonathan F. Fay, Xi-Ping Huang, Amynah Pradhan, Vsevolod Katritch, Jay P. McLaughlin, Susruta Majumdar, Tao Che

“…Partial δOR agonists may offer more controlled receptor activation than full agonists, but their development has been hindered by uncertainty regarding the molecular mechanism of partial agonism. …”
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The impact of DRG payment reform on inpatient costs for different surgery types: an empirical analysis based on Chinese tertiary hospitals by Mingwei Luo, Hongying Li, Rongyue Li, Yugao Wu, Yuping Lan, Shiwei Xie

“…This study provides empirical support for the further implementation of DRG payment reform and offers policy recommendations for optimizing China’s healthcare payment system.…”
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