Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock by Xiang-Yu Liu, Xiang-Yu Liu, Yu-Shou Wu, Yu-Shou Wu, Yi-Rui Qu, Yi-Rui Qu, Hui Zhou, Hui Zhou, Tian Liu, Xiao-Wei Su, Xiao-Wei Su, Fang-Chao Hu, Fang-Chao Hu, Jin-Guang Zheng, Shao-Fang Han, Jia-Ke Chai, Yun-Fei Chi

“…The top 10 drugs by the BES were selected for experimental validation, which were tested in a rat model with 50% total body surface area full-thickness burns (n = 286, 22/group), comparing sham controls, untreated controls, WHO-ORS, and drug-adjuvanted ORS groups. …”
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Serum Concentrations of Matrix Metalloproteinase‐1 and Procollagen Type I Carboxy Terminal Propeptide Discriminate Infarct‐Like Myocarditis and Non−ST‐Segment−Elevation Myocardial... by Lucas Bacmeister, Ersin Cavus, Sebastian Bohnen, Enver Tahir, Hanna Wolf, Annette Buellesbach, Adrian Heidenreich, Virginia K. Haacke, Susanne Weber, Ingo Hilgendorf, Tanja Zeller, Francisco Ojeda, Ulf K. Radunski, Gunnar K. Lund, Gerhard Adam, Stefan Blankenberg, Dirk Westermann, Kai Muellerleile, Diana Lindner

“…Compared with healthy controls, subjects with myocarditis had higher serum concentrations of MMP‐1 and PICP, while no difference was observed in individuals with myocardial infarction. …”
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Route of Application and Dose Evaluation of Dental Pulp Stem Cells for the Treatment of Sialadenitis Caused by Sjögren’s Syndrome: A Preclinical Study by Zhihao Du, Lifang Feng, Yu Zhang, Xin Peng, Shan Zhang, Rui Zhao, Jia Lei, Xiaotong Li, Guangyan Yu, Chong Ding

“…In this study, non-obese diabetic (<i>NOD</i>) mice were used as an animal model for studying SS, to evaluate the optimal administration route and dose range of dental pulp stem cells (DPSCs) in the treatment of sialadenitis caused by SS. …”
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Programmable Bacteria with Dynamic Virulence Modulation System for Precision Antitumor Immunity by Leyang Wu, Lin Li, Liyuan Qiao, Chenyang Li, Shuhui Zhang, Xingpeng Yin, Zengzheng Du, Ying Sun, Jiahui Qiu, Xiaoyao Chang, Bohao Wang, Zichun Hua

“…Living microbes will benefit from their controllable immunogenicity within tumors for safer antitumor applications. …”
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Predictors of recurrence after conversion therapy in unresectable hepatocellular carcinoma treated with HAIC, bevacizumab, and sintilimab by Chang-Fu Liu, Xiao-Hui Zhao, Shi-Bo Zhu, Hai-Peng Yu, Wen-Ge Xing, Hui-Kai Li

“…Monitoring of these dynamic biomarkers may guide optimal surgical timing and follow-up strategies.…”
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Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…PD-L1 is a checkpoint protein that plays important roles in immune regulation and has been implicated in the initiation and progression of multiple autoimmune diseases.MethodIn a previous study, we demonstrated that intra-articular injection with adeno-associated virus (AAV) vectors encoding wild type PD-L1 improved local inflammation in the joint in the collagen-induced arthritis (CIA) mouse model of RA. To further improve efficacy, we explored AAV-mediated delivery of the soluble PD-L1 (sPD-L1) to CIA mice.ResultAfter intra-articular injection of AAV6 vectors expressing the optimal isoform of sPD-L1 (shPD-L1), more potency was observed when compared to wild type PD-L1, with a lower dose of AAV6/shPD-L1 needed for arthritis improvement. …”
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Patterns of Engagement With the mHealth Component of a Sexual and Reproductive Health Risk Reduction Intervention for Young People With Depression: Latent Trajectory Analysis by Lydia A Shrier, Carly E Milliren, Brittany Ciriello, Madison M O'Connell, Sion Kim Harris

“…MethodsWe undertook secondary analysis of data collected from June 2021 to September 2023 in a randomized controlled trial of MARSSI versus a breast health podcast. …”
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A Governance Framework for the Geospatial Information Centres (GICs) in Developing Countries إطار حوكمة مراكز المعلومات الجغرافية المكانية في البلدان النامية... by Muhammad Abdulrahman Seddeek, Hossam Sami

“…The proposed framework illustrates departments and organizational structure, “which includes departments like data analysis, networks, cybersecurity, and the collection of geospatial and statistical data," human resources represented in personnel, tasks, and responsibilities, in addition to the data governance model and the controls for classifying collected data in light of data handling policies, and finally delivery channels for hardware applications and established geospatial data. …”
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Low-dose versus high-dose intravenous nitroglycerin in the treatment of sympathetic crashing acute pulmonary oedema: a systematic review and meta-analysis focusing on efficacy, saf... by Mohammad Iqbal, Raymond Pranata, Miftah Pramudyo, Hawani Sasmaya Prameswari, William Kamarullah, Mohammad Rizki Akbar, Triwedya Indra Dewi, Syarief Hidayat

“…Heterogeneity was assessed via I-squared (I)2, with a random-effects model applied when needed.Results Four studies (one RCT, three observational) with 185 SCAPE patients met inclusion criteria. …”
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GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…Notably, while inherited genetic variations account for part of this heterogeneity, the dynamic regulatory role of modifiable epigenetic mechanisms—particularly DNA methylation in mediating platelet reactivity—remains inadequately characterized, presenting a critical knowledge gap in optimizing precision antiplatelet strategies. Methods We utilized the 850k methylation array to measure DNA methylation levels in blood samples from 47 healthy controls and 93 patients with CHD. …”
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Tailoring dual antiplatelet therapy for stroke prevention: a meta-analysis of timing, duration, regimen, and stroke subtypes by Naif M. Alhawiti, Naif M. Alhawiti, Sherouk Fouda, Naser D. Alotaibi, Naser D. Alotaibi, Naser D. Alotaibi, Hassan A. Madkhali, Fahad K. Alsharef, Jamal M. Alhawiti, Ashraf El-Metwally

“…BackgroundDual antiplatelet therapy (DAPT) is commonly used for secondary stroke prevention, but the optimal timing and duration of treatment remain uncertain. …”
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Context, implementation and mechanisms of impact of a stepped-care WHO psychological intervention for migrants with psychological distress by Beatrice Compri, Giulia Turrini, Marianna Purgato, Richard Bryant, Paula Cristobal, Josep Maria Haro, Raffael Kalisch, Vincent Lorant, David McDaid, Kerry R. McGreevy, Roberto Mediavilla, Michela Nosè, A-La Park, Papoula Petri-Romão, Aurélia Roversi, Marit Sijbrandij, Andrea Tortelli, Anke Witteveen, Corrado Barbui

“…A mixed-methods process evaluation was conducted alongside a randomized controlled trial (RCT), following the Medical Research Council (MRC) framework. …”
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DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids by Gen Yamamoto, Raquel Carvalho-Gontijo Weber, Wonseok Lee, Vivian Zhang, Haeum Jang, Sadatsugu Sakane, Xiao Liu, Hyun Young Kim, David A. Brenner, Na Li, Tatiana Kisseleva

“…Methods: We investigated whether targeting DHCR7 can ameliorate the development of MetALD and HCC using experimental models and 3D human liver spheroids. Results: Here, we demonstrate that partial genetic ablation of the Dhcr7 gene and pharmacological blockade of DHCR7 activity with the AY9944 inhibitor suppresses hepatic steatosis (↓ lipid area, n = 15; p <0.001), inflammation (↓ F4/80, n = 6; p <0.01), fibrosis (↓ Sirius red, n = 6; p <0.01), and HCC (↓ AFP/YAP, n = 6; p <0.01) in diethylnitrosamine (DEN)-challenged high-fat diet (HFD) + ethanol (EtOH)-fed mice treated with AY9944 compared with control mice. …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…The economic analysis involved a decision-analytic model from a National Health Service and Personal Social Services perspective, populated with CHOICE cohort and published data. …”
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LimeSoDa: A dataset collection for benchmarking of machine learning regressors in digital soil mapping by Jonas Schmidinger, Sebastian Vogel, Viacheslav Barkov, Anh-Duy Pham, Robin Gebbers, Hamed Tavakoli, Jose Correa, Tiago R. Tavares, Patrick Filippi, Edward J. Jones, Vojtech Lukas, Eric Boenecke, Joerg Ruehlmann, Ingmar Schroeter, Eckart Kramer, Stefan Paetzold, Masakazu Kodaira, Alexandre M.J.-C. Wadoux, Luca Bragazza, Konrad Metzger, Jingyi Huang, Domingos S.M. Valente, Jose L. Safanelli, Eduardo L. Bottega, Ricardo S.D. Dalmolin, Csilla Farkas, Alexander Steiger, Taciara Z. Horst, Leonardo Ramirez-Lopez, Thomas Scholten, Felix Stumpf, Pablo Rosso, Marcelo M. Costa, Rodrigo S. Zandonadi, Johanna Wetterlind, Martin Atzmueller

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Predicting the environmental suitability for onchocerciasis in Africa as an aid to elimination planning. by Elizabeth A Cromwell, Joshua C P Osborne, Thomas R Unnasch, Maria-Gloria Basáñez, Katherine M Gass, Kira A Barbre, Elex Hill, Kimberly B Johnson, Katie M Donkers, Shreya Shirude, Chris A Schmidt, Victor Adekanmbi, Olatunji O Adetokunboh, Mohsen Afarideh, Ehsan Ahmadpour, Muktar Beshir Ahmed, Temesgen Yihunie Akalu, Ziyad Al-Aly, Fahad Mashhour Alanezi, Turki M Alanzi, Vahid Alipour, Catalina Liliana Andrei, Fereshteh Ansari, Mustafa Geleto Ansha, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Benjamin F Arnold, Marcel Ausloos, Martin Amogre Ayanore, Atif Amin Baig, Maciej Banach, Aleksandra Barac, Till Winfried Bärnighausen, Mohsen Bayati, Krittika Bhattacharyya, Zulfiqar A Bhutta, Sadia Bibi, Ali Bijani, Somayeh Bohlouli, Mahdi Bohluli, Oliver J Brady, Nicola Luigi Bragazzi, Zahid A Butt, Felix Carvalho, Souranshu Chatterjee, Vijay Kumar Chattu, Soosanna Kumary Chattu, Natalie Maria Cormier, Saad M A Dahlawi, Giovanni Damiani, Farah Daoud, Aso Mohammad Darwesh, Ahmad Daryani, Kebede Deribe, Samath Dhamminda Dharmaratne, Daniel Diaz, Hoa Thi Do, Maysaa El Sayed Zaki, Maha El Tantawi, Demelash Abewa Elemineh, Anwar Faraj, Majid Fasihi Harandi, Yousef Fatahi, Valery L Feigin, Eduarda Fernandes, Nataliya A Foigt, Masoud Foroutan, Richard Charles Franklin, Mohammed Ibrahim Mohialdeen Gubari, Davide Guido, Yuming Guo, Arvin Haj-Mirzaian, Kanaan Hamagharib Abdullah, Samer Hamidi, Claudiu Herteliu, Hagos Degefa de Hidru, Tarig B Higazi, Naznin Hossain, Mehdi Hosseinzadeh, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D Ilic, Irena M Ilic, Usman Iqbal, Seyed Sina Naghibi Irvani, Ravi Prakash Jha, Farahnaz Joukar, Jacek Jerzy Jozwiak, Zubair Kabir, Leila R Kalankesh, Rohollah Kalhor, Behzad Karami Matin, Salah Eddin Karimi, Amir Kasaeian, Taras Kavetskyy, Gbenga A Kayode, Ali Kazemi Karyani, Abraham Getachew Kelbore, Maryam Keramati, Rovshan Khalilov, Ejaz Ahmad Khan, Md Nuruzzaman Nuruzzaman Khan, Khaled Khatab, Mona M Khater, Neda Kianipour, Kelemu Tilahun Kibret, Yun Jin Kim, Soewarta Kosen, Kris J Krohn, Dian Kusuma, Carlo La Vecchia, Van Charles Lansingh, Paul H Lee, Kate E LeGrand, Shanshan Li, Joshua Longbottom, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Afshin Maleki, Abdullah A Mamun, Ali Manafi, Navid Manafi, Mohammad Ali Mansournia, Francisco Rogerlândio Martins-Melo, Mohsen Mazidi, Colm McAlinden, Birhanu Geta Meharie, Walter Mendoza, Endalkachew Worku Mengesha, Desalegn Tadese Mengistu, Seid Tiku Mereta, Tomislav Mestrovic, Ted R Miller, Mohammad Miri, Masoud Moghadaszadeh, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Shafiu Mohammed, Salahuddin Mohammed, Masoud Moradi, Rahmatollah Moradzadeh, Paula Moraga, Jonathan F Mosser, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Gurudatta Naik, Ionut Negoi, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Trang Huyen Nguyen, Rajan Nikbakhsh, Bogdan Oancea, Tinuke O Olagunju, Andrew T Olagunju, Ahmed Omar Bali, Obinna E Onwujekwe, Adrian Pana, Hadi Pourjafar, Fakher Rahim, Mohammad Hifz Ur Rahman, Priya Rathi, Salman Rawaf, David Laith Rawaf, Reza Rawassizadeh, Serge Resnikoff, Melese Abate Reta, Aziz Rezapour, Enrico Rubagotti, Salvatore Rubino, Ehsan Sadeghi, Abedin Saghafipour, S Mohammad Sajadi, Abdallah M Samy, Rodrigo Sarmiento-Suárez, Monika Sawhney, Megan F Schipp, Amira A Shaheen, Masood Ali Shaikh, Morteza Shamsizadeh, Kiomars Sharafi, Aziz Sheikh, B Suresh Kumar Shetty, B Suresh Kumar Shetty, Jae Il Shin, K M Shivakumar, Biagio Simonetti, Jasvinder A Singh, Eirini Skiadaresi, Amin Soheili, Shahin Soltani, Emma Elizabeth Spurlock, Mu'awiyyah Babale Sufiyan, Takahiro Tabuchi, Leili Tapak, Robert L Thompson, Alan J Thomson, Eugenio Traini, Bach Xuan Tran, Irfan Ullah, Saif Ullah, Chigozie Jesse Uneke, Bhaskaran Unnikrishnan, Olalekan A Uthman, Natalie V S Vinkeles Melchers, Francesco S Violante, Haileab Fekadu Wolde, Tewodros Eshete Wonde, Tomohide Yamada, Sanni Yaya, Vahid Yazdi-Feyzabadi, Paul Yip, Naohiro Yonemoto, Hebat-Allah Salah A Yousof, Chuanhua Yu, Yong Yu, Hasan Yusefzadeh, Leila Zaki, Sojib Bin Zaman, Maryam Zamanian, Zhi-Jiang Zhang, Yunquan Zhang, Arash Ziapour, Simon I Hay, David M Pigott

“…Using boosted regression tree models with optimised hyperparameter selection, we estimated environmental suitability for onchocerciasis at the 5 × 5-km resolution across Africa. …”
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Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia by Juan Xie, Xue-Fei Liu, Tong Zhou, Long Liu, Rui-Qin Hou, Xing-Xing Yu, Ze-Ying Fan, Qian-Nan Shang, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Xiang-Yu Zhao

“…Blockade or genetic knockout of NKG2A effectively reversed NK cell exhaustion both in vitro and in an AML mouse model. Furthermore, activation of the PI3K-AKT pathway significantly enhanced cytotoxicity in exhausted NK cells. …”
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Early Ultrasound Surveillance of Newly-Created Hemodialysis Arteriovenous Fistula by James Richards, Dominic Summers, Anna Sidders, Elisa Allen, Helen Thomas, Mohammed Ayaz Hossain, Subhankar Paul, Matthew Slater, Matthew Bartlett, Regin Lagaac, Emma Laing, Valerie Hopkins, Chloe Fitzpatrick-Creamer, Cara Hudson, Joseph Parsons, Sam Turner, Andrew Tambyraja, Subash Somalanka, James Hunter, Sam Dutta, Neil Hoye, Sarah Lawman, Tracey Salter, Mohammed Aslam, Atul Bagul, Rajesh Sivaprakasam, George Smith, Zia Moinuddin, Simon Knight, Nicholas Barnett, Reza Motallebzadeh, Gavin J. Pettigrew, Anna Sidders, Cara Hudson, Claire Foley, Valerie Hopkins, Emma Laing, Chloe Fitzpatrick-Creamer, Helen Thomas, Alison Deary, Gavin J. Pettigrew, James Richards, Mohammed Hossain, Dominic Summers, Matthew Slater, Laura Scott, Regin Lagaac, Veena Surendrakumar, Tobi Ayorinde, Igor Chipurovski, Manikandan Kathirvel, Manoj Thialli, Subhankar Paul, Andrew Norton, Simon Knight, Klaus Bond, Elizabeth Hardy, Joanne Widdup, Rachael Potter, Elisabeth Pugh, Karen Parsons, Kathryn Lafferty, Madita Gavrila, Sheera Sutherland, Ria Rabara, Rajesh Sivaprakasam, Kate Crawford, Amy Bolsworth, Naavalah Ngwa-Ndifor, Laura Clementoni, Reza Motallebzadeh, Mohammad Ayaz Hossain, Matthew Bartlett, Rani Badhan, Fernando Yuenchang, Phil Gardiner, Natasha Irani, Zia Moinuddin, Helena Edlin, Anna Jerram, Jessica Lai, Joyce Banda, Janet Bendle, Sam Turner, Maria Morgan, William Owen, Sue Dawson, Simon Daniel, Karen Allsop, Andrew Tambyraja, Sarah-Jane Carmichael, Tom Eadie, Rona Lochiel, Midel Lena, Karen Gallagher, Nicholas Barnett, Soundrie Padayachee, Philip Eldridge, May Rabuya, Naomi Hare, Subash Somalanka, Jashree Patel, Abbas Ghazanfar, Judy van Selm, Caroline Bodneck, Martia Augustin, Kwame Ansu, Nalin Khosla, Kashif Burney, Karen Dear, Duminda Basnayake, Laijee Benny, James Hunter, Carl Tiivas, Samantha Hyndman, Maria Truslove, Gail Evans, Kerry Read, Sam Dutta, Andrew Beech, Sarah Brand, Tara MacCormick-Swanson, Sarah Lawman, Darren Cheal, Mel Smith, Kate Trivedi, Valentina Toska, Lorraine Shah-Goodwin, Tracey Salter, Adnan Bajwa, John Kerr, Ana Fleet, Lianne Chapman, Sarah Gee, Thanuja Weerasinghe, Lisa Kavanagh, Louise Rowe-Leete, George Smith, Paris Cai, Judith Long, Tracey Rowe, Mohammed Aslam, Jeremy Crane, Atul Bagul, Mary Quashie-Akponeware, Kate Waters, Alexandra Howson, Neil Hoye, Alycon Walker

“…Wrist and elbow AVF nonmaturation could be optimally modeled from week 4 ultrasound parameters alone, but with only moderate positive predictive values (PPVs) (wrist, 60.6% [95% confidence interval, CI: 43.9–77.3]; elbow, 66.7% [48.9–84.4]). …”
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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…Future work A randomised controlled trial with long-term follow-up is needed to determine the cost-effectiveness of direct oral penicillin challenge. …”
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Impact of COVID-19 on Corporate Cash Holdings and Speed of Adjustment by Abbas Aflatooni, Mohammad Khatiri, Farzad Eivani

“…First, the positive and statistically significant coefficient of the COVID-19 dummy variable in the static models indicated that, after controlling for the determinants of cash holdings, as well as year and industry fixed effects, firms held a higher ratio of cash to non-cash assets (4.52-percentage point) during the COVID-19 pandemic period compared to the pre-pandemic years. …”
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