An open dataset and machine learning algorithms for Niacin Skin-Flushing Response based screening of psychiatric disorders by Xuening Lyu, Rimsa Goperma, Dandan Wang, Chunling Wan, Liang Zhao

“…The SVM training incorporates 5-fold cross-validation, Synthetic Minority Over-sampling Technique (SMOTE) for managing class imbalance, and hyperparameter tuning to optimize balanced accuracy. Results The established dataset comprises 600 high-quality NSR images from 120 individuals, encompassing a diverse cohort of healthy controls and patients with various mental illnesses. …”
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Assessing the Impact of Distance Traveled and Birth Volumes of Hospital Maternity Units on Newborn Outcomes: Population-Based Cohort Study by Anna Cantarutti, Riccardo Boracchini, Roberto Bellù, Raffaella Ronco, Federico Rea, Anna Locatelli, Rinaldo Zanini, Giovanni Corrao

“…To explore the influence of HMU volumes on the primary outcome, we identified the fractional polynomial model that best described this relationship. …”
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Effect of unilateral and bilateral plyometric training on jumping, sprinting, and change of direction abilities: a meta-analysis by Zhanming Zhang, Wenhao Qu, Wuwen Peng, Jian Sun, Jiyang Yue, Lingju Guan, Min Lu, Duanying Li

“…Study eligibility criteria To be eligible for inclusion in the meta-analysis, the study had to be:(1)healthy individuals; (2)UNI and BI plyometric training ; (3)conducted on rigid surfaces; (4)the outcome indicators were jumping ability, sprinting, and change of direction ability; (5)randomized controlled trials (RCTs). Study appraisal and synthesis methods We used the random-effects model for meta-analyses. …”
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Graph Neural Network Learning on the Pediatric Structural Connectome by Anand Srinivasan, Rajikha Raja, John O. Glass, Melissa M. Hudson, Noah D. Sabin, Kevin R. Krull, Wilburn E. Reddick

“…The extension of the adult models to the pediatric dataset and training on the smaller pediatric dataset were sub-optimal in their performance. …”
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Mucoadhesive Mini-Containers with Unidirectional Drug Release Capacity for Macromolecular Therapeutics by Han CS, Choi YR, Jung WY, Kang JH, Kim DW, Park CW

“…Insulin, a model peptide drug, was successfully loaded into the CC-C mini-containers, and circular dichroism spectroscopy analysis confirmed that its secondary structure remained intact. …”
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Investigating the peri-saphenous vein graft fat attenuation index on computed tomography angiography: relationship with progression of venous coronary artery bypass graft disease a... by Liwen Han, Lahu Like, Mengzhen Wang, Mi Zhou, Zhihan Xu, Fuhua Yan, Qiang Zhao, Wenjie Yang

“…In study 2, 42 patients with graft disease progression and 84 patients as controls were propensity score-matched. Generalized linear mixed model and continuous net reclassification improvement (NRI) were used for assessing the associations with graft disease progression. …”
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Effects of vitamin E administration on serum lipid profile in diabetic patients: a grade-assessed systematic review and dose–response meta-analysis of RCTs by Mehdi Karimi, Mohammad Amin Karimi, Farzad Fayedeh, Fatemeh Ziyafati Kafi, Kimia Kazemi, Sharareh Jahangiri, Omid Asbaghi

“…Methods A search was conducted on databases from inception to June 2025 to identify relevant randomized controlled trials (RCTs). Pooled effect sizes were estimated using weighted mean differences (WMDs) with 95% confidence intervals (CIs), applying a random-effects model. …”
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Artificial intelligence based assessment of clinical reasoning documentation: an observational study of the impact of the clinical learning environment on resident documentation qu... by Verity Schaye, David J. DiTullio, Daniel J. Sartori, Kevin Hauck, Matthew Haller, Ilan Reinstein, Benedict Guzman, Jesse Burk-Rafel

“…Future work should explore residency program and systems interventions to optimize the CLE.…”
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Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data by Nitin V Kolhe, Maarten Taal, Richard Fluck

“…The increased risk of death persisted after controlling for multiple baseline factors (OR for death vs Group 1: Group 4—22.28, Group 2—9.67, Group 3—6.44). …”
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Multi-Focused Acoustic Radiation Force Impulse Modulation of Murine Hepatic Xenografts Enhances Nanoscale DOX@Lip Delivery and Therapeutic Effect by Wu S, Wang C

“…Subsequently, murine xenograft models were established and underwent MF-ARFI preconditioning before DOX@Lip injection. …”
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Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome by Xiaoshuang Yin, Jinmei Zou, Jing Yang

“…Kaplan–Meier survival analysis and multivariate Cox proportional hazards models were employed to assess the effects of ANLR on both ACM and CVM. …”
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Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies by Zan Qiu, Yifan Cheng, Haiyan Liu, Tiandong Li, Yinan Jiang, Yin Lu, Donglin Jiang, Xiaoyue Zhang, Xinwei Wang, Zirui Kang, Lei Peng, Keyan Wang, Liping Dai, Hua Ye, Peng Wang, Jianxiang Shi

“…The presence of tumor-associated autoantibodies (TAAbs) in serum was subsequently assessed using enzyme-linked immunosorbent assays (ELISA) in 300 CRC patients and 300 healthy controls. Ten machine learning algorithms were utilized to develop diagnostic models, with the optimal one selected and integrated into an R Shiny-based GUI to enhance usability and accessibility. …”
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Multiplex engineering using microRNA-mediated gene silencing in CAR T cells by Giulia Golinelli, Giulia Golinelli, John Scholler, Audrey Roussel-Gervais, Antonija Šakić, Sten Ilmjärv, Decheng Song, Khatuna Gabunia, Mei Ji, Ting J. Fan, Aasha Gupta, Mansi Deshmukh, Abdulla Berjis, Abdulla Berjis, Riccardo Cuoghi Costantini, Kimberly Apodaca, Neil C. Sheppard, Sven Kili, Massimo Dominici, Marco Alessandrini, Carl H. June, Carl H. June, Carl H. June, Bruce L. Levine

“…In vivo, S M5CAR T cells achieved tumor control with higher persistence and superior metastasis prevention. …”
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Impact of awake prone positioning duration on intubation or mortality in COVID-19 patients with acute respiratory failure: secondary analysis of a randomized clinical trial by Qin Sun, Rui Zhang, Junyi Zhang, Jianfeng Xie, Yingzi Huang, Yi Yang, Haibo Qiu, Ling Liu, Hui Chen, the Chi-ARDS Net (Chinese ARDS Research Network)

“…Methods Data from a multicenter randomized controlled trial involving nonintubated COVID-19 patients with AHRF were analyzed. …”
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Outcomes of dual mobility versus conventional total hip arthroplasty for patients with femoral neck fractures: a systematic review and meta-analysis including registry data by Michael Silveira Santiago, Fatemeh Akbarpoor, Felipe J. Aidar, José Morais Sirqueira Neto, Marcus Vinicius Vieira de Matos Pereira Silva, Sohaib Darwish, Mohammed Ayman Khokar, Zainulabideen Ahmed, Fernanda Valeriano Zamora, Reuthemann Esequias Teixeira Tenorio Albuquerque Madruga, Alfonso López Díaz-de-Durana, María Merino-Fernandez, Leonardo da Costa Lima, Erick Sobral Porto, Davi Teixeira de Souza, Rosana Cipolotti

“…Results We included three randomized controlled trials and ten cohort studies, amounting to 21,585 patients, of which 4887 received and 16,698 received c-THA. …”
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Preparation of Nitrogen-Doped Carbon-Supported Co-V Catalyst for Catalystic Depolymerization of Lignin to Produce Monophenolic Compounds by Yuqiao MA, Xingwang LIU, Yong QIAN, Xinping OUYANG

“…By regulating the mass ratio of melamine to metal salts, the structural morphology and the types and contents of Co and N in the catalyst were precisely controlled. The optimized Co1-V3/NC (30) catalyst exhibited abundant defect sites, a high specific surface area, large pore volume, and hierarchical porous structure comprising micropores, mesopores, and macropores. …”
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Influence of germination on the production of starchy and oleaginous flours: Evaluation of the drying process, thermodynamic properties and bioactive compounds by Mailson Gonçalves Gregório, Alexandre José de Melo Queiroz, Rossana Maria Feitosa de Figueirêdo, Francislaine Suelia dos Santos, Josivanda Palmeira Gomes, Juvêncio Olegário de Oliveira Neto, Michael Marcos de Aquino Gomes, Morgana Aragão Araújo, Raniza de Oliveira Carvalho, Vitória Larissa Melquíades da Silva, Henrique Valentim Moura, Nagela Maria Henrique Mascarenhas, Bruno Farias da Silva, Yaroslávia Ferreira Paiva, Emerson Zambrano Lara

“…A negative correlation was observed between tannins and carotenoids, as controlled germination and drying reduced tannins, improving nutritional quality by decreasing antinutritional factors.…”
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Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration by Yeo Gyun Yun, Soon Chul Heo, Ji-Won Jung, Donghyeon Yeo, Seong-Jin Shin, Khaliunsarnai Tsogtbaatar, Yongsung Hwang, Jung-Hwan Lee, Jun Hee Lee, Hae-Won Kim

“…These findings underscore the interplay between cell mechanophenotype, morphology, and function, providing a strategy to optimize hydrogel-based MSC therapies. In a mouse model of ischemic hindlimb injury, mechano-primed MSCs delivered via SC hydrogels significantly improved blood reperfusion, cell survival, and anti-inflammatory responses, ultimately preventing limb loss. …”
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Designing of a Novel Aerolysin-based Multiepitope Vaccine against Aeromonas hydrophila Isolated from Osphronemus goramy Using Reverse Vaccinology: an in Silico Approaches by Rozi, Wiwiek Tyasningsih, Jola Rahmahani, Eduardus Bimo Aksono, Muchammad Yunus, Mohammad Anam Al-Arif, Suryo Kuncorojati, Rahayu Kusdarwati, Putri Desi Wulan Sari, Mohammad Noor Azmai Amal, Annas Salleh, Nadeem Khanand, Suwarno

“… • Computational methods identified and optimized B-cell and T-cell epitopes, focusing on their ability to trigger immune responses without causing toxicity or allergenicity…”
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Deployment of power-to-protein technology in Ethiopia to provide drought-related emergency relief and mitigate food insecurity by M. Buchner, H. H. Nguyen, L. T. Angenent, L. T. Angenent, L. T. Angenent, L. T. Angenent, C. Zarfl, J. G. Usack, J. G. Usack, J. G. Usack, J. G. Usack

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