Sentinel Lymph Node Biopsy vs. Axillary Lymph Node Dissection for Early-Stage Breast Cancer and Sentinel Lymph Node Metastasis: An Updated Systematic Review and Meta-Analysis With... by Sanjit Kumar Agrawal, M. Mohammed Imran, Shivank Sethi, Sanjay Kumar Yadav, Pawan Agarwal, Dhananjaya Sharma

“…Design: We have performed an updated meta-analysis of randomized controlled trials (RCTs) comparing SLNB alone or with RNI vs. …”
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Life-history traits, pace of life and dispersal among and within five species of Trichogramma wasps: a comparative analysis by Guicharnaud, Chloé, Groussier, Géraldine, Beranger, Erwan, Lamy, Laurent, Vercken, Elodie, Dahirel, Maxime

“…To understand how life-history traits and effective dispersal covary, we measured these traits in controlled conditions for 28 lines from five species of Trichogramma, which are small endoparasitoid wasps frequently used as a biological model in experimental evolution but also in biocontrol against Lepidoptera pests. …”
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Implementing Blockchain Technology for Secure Data Transactions in Cloud Computing Environments Challenges and Solutions by Dandu Varalakshmi, N Shirisha, K Suresh, Saidhbi Shaik, V Venkatesh, C F Theresa Cenate

“…In this paper, we design an optimized, cloud-based blockchain-enabled security framework for real-world scalability, performance, and regulatory constraints. …”
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Evaluating medical service performance of hospitals in Sichuan Province, China: exploratory factor analysis and hierarchical clustering analysis based on diagnosis-related groups by Xuedong Liu, Xuedong Liu, Jian Cao, Ruyu Ge, Ou Jiang

“…A comprehensive evaluation model was developed using exploratory factor analysis (EFA) based on diagnosis-related groups (DGRS) indicators to assess medical service performance. …”
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Effects of stroboscopic visual training on reaction time and movement accuracy in collegiate athletes: a systematic review and meta-analysis by Yuanyuan Luo, Yingying Cao, Xinliang Pan, Shuairan Li, Denise Koh, Yan Shi

“…The risk of bias in the included studies was assessed using the Cochrane Risk of Bias tool. A random-effects model was applied for the meta-analysis, with separate analyses conducted for time-based and accuracy-based performance measures. …”
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Effectiveness and Safety of Acupuncture for Nausea and Vomiting in Cancer Patients: A Systematic Review and Meta-Analysis by Sung-A Kim, Sujung Yeo, Sabina Lim

“…Despite the widespread use of pharmacological antiemetics, these medications are often insufficient for controlling nausea and may cause medication interactions and side effects. …”
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Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia by Maksim Mamonkin, Malcolm K Brenner, Norihiro Watanabe, Pinar Ataca Atilla, Mary K McKenna, Haruko Tashiro, Madhuwanti Srinivasan, Feiyan Mo, Brian Wesley Simons, Alexandra McLean Stevens, Michele S Redell, Helen E Heslop, Erden Atilla

“…Background C-type lectin-like molecule 1 (CLL-1) is highly expressed in acute myeloid leukemia (AML) but is absent in primitive hematopoietic progenitors, making it an attractive target for a chimeric antigen receptor (CAR) T-cell therapy. Here, we optimized our CLL-1 CAR for anti-leukemic activity in mouse xenograft models of aggressive AML.Methods First, we optimized the CLL-1 CAR using different spacer, transmembrane and costimulatory sequences. …”
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A China-Based exploration of surgical timing for polytrauma with a focus on fracture reconstruction by Chenning Ding, Mingwang Jia, Xing Han, Jiahui Zhang, Xin Zhao, Xiguang Sang

“…Postoperative infection rates, including wound infections, other complication incidences, hospital stay duration, treatment costs, and long-term outcomes will be observed and compared to identify the optimal timing for surgical intervention. This study also aims to develop effective polytrauma management models. …”
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Biochar Co-Applied with Lime Enhances Soil Phosphorus Availability via Microbial and Enzymatic Modulation of Paddy Soil by Yang Zhang, Caidi Yang, Jun Wang, Shenggao Lu

“…A correlation analysis and partial least squares path modeling (PLS-PM) indicated that Olsen-P, Bray-1 P, and inorganic P were significantly positively correlated with the activities of ALP, PD, IPP, and the <i>phoD</i> gene. …”
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Relationship between timing of achieving energy sufficiency and clinical outcomes in critically ill patients by Xiangfeng Yue, Xiaoxi Zhu, Xiaoxi Zhu, Yongchun Li, Yongchun Li, Xuemin Huang, Quanjun Lyu

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The impact of same‐day and rapid ART initiation under the Universal Health Coverage programme on HIV outcomes in Thailand: a retrospective real‐life cohort study by Sirinya Teeraananchai, David C. Boettiger, Cheewanan Lertpiriyasuwat, Rattaphon Triamwichanon, Patchara Benjarattanaporn, Nittaya Phanuphak

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Adjusting Aspergillus niger pellet diameter, population heterogeneity, and core architecture during shake flask cultivation by K. Engelbert, C. Deffur, T. C. Cairns, F. Zhang, T. Kheirkhah, H. Winter, S. Junne, P. Neubauer, H. Briesen, V. Meyer

“…Results In this study, we have developed shake flask cultivation conditions which enable reproducible macromorphological control of the multipurpose cell factory Aspergillus niger. …”
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Characterization of the novel cross-genus phage vB_SmaS_QH3 and evaluation of its antibacterial efficacy against Stenotrophomonas maltophilia by Peng Cheng, Peng Cheng, Zian Li, Lanmin Liu, Ruizhe Li, Jianwu Zhou, Xiaoqin Luo, Xiaoqin Luo, Xiaoming Mu, Jingwei Sun, Jideng Ma, Jideng Ma, Xiangren A

“…This study aims to characterize the biological properties of the novel lytic phage vB_SmaS_QH3 and comprehensively evaluate its efficacy in preventing and controlling clinically multidrug resistance Stenotrophomonas maltophilia infections using both in vivo and in vitro models.MethodsThe phage was isolated from hospital sewage using the multidrug resistant S. maltophilia no. 3738 as the host. …”
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Adjuvant endocrine treatment strategies for non-metastatic breast cancer: a network meta-analysisResearch in context by Andri Papakonstantinou, Guillermo Villacampa, Victor Navarro, Mafalda Oliveira, Antonios Valachis, Tomas Pascual, Alexios Matikas

“…We aimed to investigate the optimal endocrine therapy strategy. Methods: A systematic literature search was performed and last updated in August 2024 to identify randomized controlled trials (RCT) evaluating endocrine treatment strategies for hormone receptor positive breast cancer. …”
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Oral Metronomic Delivery of Atorvastatin and Docetaxel via Transporter-Targeted Nanoemulsions Enhances Antitumor Efficacy and Immune Modulation in Colon Cancer by Laxman Subedi, Arjun Dhwoj Bamjan, Susmita Phuyal, Bikram Khadka, Mansingh Chaudhary, Ki-Taek Kim, Ki Hyun Kim, Jung-Hyun Shim, Seung-Sik Cho, Ji Eun Yu, Jin Woo Park

“…Pharmacokinetics, tumor suppression, and immune cell infiltration were assessed in vivo using rat and CT26.CL25 mouse models. <b>Results</b>: AT/DT-NE#E showed enhanced permeability of AT and DT by 45.7- and 43.1-fold, respectively, across intestinal cell models and improved oral bioavailability by 118% and 376% compared to free drugs. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…This study elucidates the structural basis of antibody-VB12 interactions, offering critical insights for optimizing mAb quality control.…”
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Association between ambient temperature and non-accidental mortality in Guiyang, China: A time-series analysis (2013-2023). by Xuanhao Chen, Minmin Su, Minlan Yuan, Zihai Jian, Dan Yang, Hua Guo, Jianhua Zhang

“…A quasi-Poisson regression with a distributed lag non-linear model (DLNM), incorporating a 21-day lag and controlling for trends, air pollutants, and the day of the week, was applied to estimate the cumulative relative risks of non-accidental mortality due to non-optimal and extreme temperatures. …”
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Prognostic stratification through smoking status and cumulative smoking dose in advanced non-small cell lung cancer immunotherapy: a dose-dependent real-world analysis by Lan Yang, Lan Yang, Haoyu Wang, Haoyu Wang, Panwen Tian, Panwen Tian, Panwen Tian, Weimin Li, Weimin Li

“…Multivariate logistic regression and Cox proportional hazards models were used to analyze ORR and PFS, respectively.ResultsAmong the 1,192 patients, 377 were never smokers, 499 were current smokers, and 316 were former smokers. …”
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Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus by Yicheng Zhao, Jingyi Si, Shisong Jing, Bingmei Wang, Yueshan Xu, Jiyu Guan, Quan Liu, Jianlei Shen, Min Lv, Li Wang, Changfeng Zhu

“…Here, we introduce a self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA) platform that achieves targeted drug delivery through controlled aggregation and sustained release, effectively restoring MRSA susceptibility to β‐lactam antibiotics. …”
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Efficacy and Safety of Various Intravenous Thrombolytics for Acute Ischemic Stroke (AIS) at Various Dosages: A Systematic Review and Network Meta-Analysis by Yibin Hu, Shengxian Wu, Haixuan Zhang, Kangfeng Wang, Lijuan Zhang, Yizheng Ma, He Li

“…From current randomized clinical trials, the optimal type and dosage of thrombolytics for patients with AIS are unclear. …”
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