Pharmacogenomic insights into amlodipine response: the role of CACNA1D, CACNA1C, and TRIB3 variants in hypertensive patients. by Wahby M Babaresh, Zakiullah, Sohaib Ahmad Sohail, Alija Baig, Malik Faisal, Aiman Begum, Haseenullah Shah, Zia Ul Hassan, Kiran Ijaz, Syed Muhammad Mukarram Shah, Aftab Ullah

“…Conversely, the CACNA1C rs2239050 GG genotype (n = 67) was linked to improved SBP and DBP control compared to the CC genotype (n = 25). Combined genotype models (CACNA1D-CACNA1C and CACNA1D-CACNA1C-TRIB3) showed strong unadjusted associations but lost significance after adjustment. …”
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Determining seropositivity-A review of approaches to define population seroprevalence when using multiplex bead assays to assess burden of tropical diseases. by YuYen Chan, Kimberly Fornace, Lindsey Wu, Benjamin F Arnold, Jeffrey W Priest, Diana L Martin, Michelle A Chang, Jackie Cook, Gillian Stresman, Chris Drakeley

“…The most frequently applied approaches to determine seropositivity included the use of presumed unexposed populations, mixture models, receiver operating curves (ROC), and international standards. …”
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Comprehensive Approaches to Pain Management in Postoperative Spinal Surgery Patients: Advanced Strategies and Future Directions by Dhruba Podder, Olivia Stala, Rahim Hirani, Adam M. Karp, Mill Etienne

“…Effective postoperative pain management remains a major clinical challenge in spinal surgery, with poorly controlled pain affecting up to 50% of patients and contributing to delayed mobilization, prolonged hospitalization, and risk of chronic postsurgical pain. …”
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Development of a 1.0 KVA Fuelless Generator by Blessing Ngozi Goodluck Aliemeke, Munirat Abdullawal Momoh, Mercy Onoshioze Asekhome, Christian Azuka Anani, Afoke Chief Vincent

“…Integration of power factor correction capacitors and advanced control algorithms contributed to achieving a power factor close to unity, optimizing energy utilization. …”
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A Multi-Stakeholder Information System for Traffic Restriction Management by Maria Inês Malafaia, Joel Ribeiro, Tânia Fontes

“…With the anticipated surge in e-commerce logistics, the need for effective urban mobility control measures has become urgent, focusing on traffic restrictions and efficient enforcement tools. …”
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Nexus between entrepreneurship and poverty reduction: regression analysis of causality by G.R. Dauliyeva, Zh.B. Ranov, A.G. Sagynbay, S.T. Makhsutova

“…The study applies linear, logarithmic, and semi-logarithmic regression models, addressing potential issues of multicollinearity and autocorrelation. …”
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Comparison of ECG Between Gameplay and Seated Rest: Machine Learning-Based Classification by Emi Yuda, Hiroyuki Edamatsu, Yutaka Yoshida, Takahiro Ueno

“…Among all models, OCS with k = 3 achieved the highest classification accuracy for both 5 min and 10 min data. …”
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High-Q litz wire NQR sensor for medical applications by R. R. Khusnutdinov, G. V. Mozzhukhin, N. R. Khusnutdinova, B. M. Salakhutdinov

“…METHODS. Methods for optimizing the design of sensors for NQR/NMR spectrometers are considered. …”
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Design and analysis of intelligent service chain system for network security resource pool by Zenan WANG, Jiahao LI, Chaohong TAN, Dechang PI

“…The traditional network security architecture ensures network security by directing traffic through hardware based network security function devices.Since the architecture consists of fixed hardware devices, it leads to a single form of network security area deployment and poor scalability.Besides, the architecture cannot be flexibly adjusted when facing network security events, making it difficult to meet the security needs of future networks.The intelligent service chain system for network security resource pool was based on software-defined network and network function virtualization technologies, which can effectively solve the above problems.Network security functions of virtual form were added based on network function virtualization technology, combined with the existing hardware network elements to build a network security resource pool.In addition, the switching equipment connected to the network security elements can be flexibly controlled based on software-defined network technology.Then a dynamically adjustable network security service chain was built.Network security events were detected based on security log detection and a expert library consisting of security rules.This enabled dynamic and intelligent regulation of the service chain by means of centralized control in the face of network security events.The deployment process of the service chain was mathematically modeled and a heuristic algorithm was designed to realize the optimal deployment of the service chain.By building a prototype system and conducting experiments, the results show that the designed system can detect security events in seconds and automatically adjust the security service chain in minutes when facing security events, and the designed heuristic algorithm can reduce the occupation of virtual resources by 65%.The proposed system is expected to be applied to the network security area at the exit of the campus and data center network, simplifying the operation and maintenance of this area and improving the deployment flexibility of this area.…”
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The temporal and spatial evolution law of seepage parameters in the filter based on the CFD-DEM coupled flow-solid approach by Song Jingyu, Dang Faning, Gao Jun, Zhu Wuwei, Yao Yi

“…Abstract Filters are critical components of hydraulic structures such as earth-rock dams and tailings dams, functioning to prevent soil particle loss and control phreatic levels. Clogging failure in filters can severely compromise the seepage stability of dam slopes. …”
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Propofol-Fentanyl versus propofol-ketamine sedation in gastrointestinal endoscopy: A systematic review and meta-analysis by Elliott N. Rees, Lucy MS Hoade, Luke Mattey

“…Background: The optimal procedural sedation and analgesic regime for gastrointestinal endoscopy is uncertain. …”
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Evaluation of the Ellman’s Reagent Protocol for Free Sulfhydryls Under Protein Denaturing Conditions by Sophia R. Ginet, Frank Gonzalez, Maxine L. Marano, Megha D. Salecha, Joseph E. Reiner, Gregory A. Caputo

“…The assay was then applied to a variety of models and biomarker peptides and exhibits the expected linear response. …”
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Bridging Biomimetics and Additive Manufacturing for Dynamic Design Solutions by Silvia Titotto

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Neutron Cross-Section Uncertainty and Reactivity Analysis in MOX and Metal Fuels for Sodium-Cooled Fast Reactor by Oyeon Kum

“…These results underscore the importance of accurate nuclear data libraries to minimize uncertainties in criticality evaluations, and they provide a foundation for optimizing fuel compositions and refining reactor control strategies. …”
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Transethosome-mediated curcumin delivery promotes superior wound healing with reduced toxicity by Meriem Rezigue, Alaa A. A. Aljabali, Walhan Alshaer

“…Skin deposition of curcumin was significantly higher than that in the control (p < 0.05) across all layers, with minimal systemic absorption. …”
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The mechanism and heterogeneity of environmental regulations’ impact on the technological progress of dairy farming by Hao LIU, Hua PENG, Li-wang LI, Xiao-xia DONG

“…The U-type influence means moving from pollution control's high cost and low technology progress to the high profit and high innovation input generated by optimizing the breeding structure. …”
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How gamification influences e-commerce behavior in hardcore vs. casual gamers? by Junialdi Dwijaputra, Diana Purwitasari, Ellya Zulaikha

“…Grounded in the Theory of Planned Behavior (TPB), this study examines how attitudes, subjective norms, and perceived behavioral control influence user behavior in gamified e-commerce environments. …”
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Advances and controversies in emerging techniques of surgery on breast cancer by ZHANG Yujia, MA Li

“…Enhancing the accessibility of risk assessment methods and establishing precise and effective risk prediction models have emerged as important issues. Above all, the development of breast surgery shows a refinement of risk management and damage control, striving to achieve a safe “de-escalation” in surgical modalities based on individualized treatment. …”
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Methodological approaches to the integration of web resources in teaching German to primary school students by Sofya V. Getmanskaya, Rimma A. Safina

“…The results of the study make it possible to optimize the learning process and improve the training of primary school students in German. …”
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An experimental study of U-net variants on liver segmentation from CT scans by Halder Akash, Sau Arup, Majumder Surya, Kaplun Dmitrii, Sarkar Ram

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