IGF-1 regulates LARP6-mediated collagen metabolism in vaginal fibroblasts of POP patients via the PI3K/AKT pathway by Lingfan Kong, Lingyun Wei, Lin Wang, Mengyu Geng, Wenzhen Wang, Xiaochun Liu

“…This study included a population of 15 women suffering from POP as a case group and a control group of 15 women who underwent total hysterectomy for benign gynecological diseases. …”
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Efficacy and safety of non-pharmacological therapies for primary insomnia: a network meta-analysis by Qin-hong Zhang, Qin-hong Zhang, Yong-jian Liu, Guanhu Yang, Guanhu Yang, Guanhu Yang, Mei-yi Zhu, Jia-hui Yang, Lun Li, Xiu-mei Yan, Qi-lin Liu, Jin-huan Yue, Xiao-ling Li, Yi-ming Li, Tian-cheng Xu, Fan Jiang

“…Data synthesis was performed using STATA 17 software with a random-effects model, and evidence quality was appraised using the GRADE framework.ResultsPooled analyses revealed that all seven non-pharmacological therapies significantly improved PI outcomes compared to controls. …”
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C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis by Renan Pereira de Lima, Ang Li, Ankit Gilani, Alfonso Rubio-Navarro, Charles D. Warren, Isabella Y. Kong, Jacob B. Geri, James C. Lo

“…We assessed glucose homeostasis, focusing on β cell function and mass under metabolic stress conditions, to interrogate the effects of C3aR1 on β cells in a mouse model of T2D. We performed proteomic analyses on islets from control and β cell-specific C3aR1 knockout mice. …”
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HilD-regulated chemotaxis proteins contribute to Salmonella Typhimurium colonization in the gut by Kendal G. Cooper, Laszlo Kari, Audrey Chong, Naman Tandon, Kathleen Doran, Lidiane Gomes Da Silva, Diane C. Cockrell, Arden Baylink, Olivia Steele-Mortimer

“…Chemotaxis is the process by which bacteria control movement toward attractants and away from repellents. …”
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Enzyme-linked immunosorbent assay to determine the potency of a rotavirus vaccine based on virus-like particles: analytical procedure development and validation by I. E. Filatov, M. M. Silaenkova, V. V. Tsibezov, M. V. Balandina, S. N. Norkina, O. E. Latyshev, O. V. Eliseeva, S. A. Cherepushkin, T. V. Grebennikova

“…Guinea pigs were selected as a relevant model for validating the ELISA-based potency assessment procedure. …”
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“Agent – Environment” Evolution Mechanism of Greenbelt from the Perspective of Complex Adaptive System: A Case Study of Beijing’s Greenbelts by Song LIU, Peiyu SHEN, Dizi LIU, Zhaocheng BAI

“…ObjectiveSince the first successful practice in London in the 1930s, greenbelt has become an important land control and land use planning idea. Greenbelts help solve problems related to urban sprawl and provide multiple ecological, social and economic functions that have profound impact on sustainable regional development. …”
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Maternal plasma cell-free RNA as a predictive test for fetal lung maturation by Sean W. D. Carter, Kay Yi Michelle Seah, Si En Poh, Winston Koh, Haruo Usuda, Erin L. Johnson, Yusaku Kumagai, Tsukasa Takahashi, Lara J. Monteiro, Reyna Peñailillo, Gino Nardocci, Hannah R. S. Watson, Masatoshi Saito, Mahesh A. Choolani, Sebastián E. Illanes, Matthew W. Kemp

“…Methods Discovery studies utilized a preterm sheep model of pregnancy. Date mated ewes received saline (control n = 6), or antenatal steroids (dexamethasone n = 12) (betamethasone n = 11) prior to delivery and ventilation. …”
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Four New Patient-Reported Outcome Measures Examining Health-Seeking Behavior in Persons With Type 2 Diabetes Mellitus (REDD-CAT): Instrument Development Study by Suzanne E Mitchell, Michael A Kallen, Jonathan P Troost, Barbara A De La Cruz, Alexa Bragg, Jessica Martin-Howard, Ioana Moldovan, Jennifer A Miner, Brian W Jack, Noelle E Carlozzi

“… BackgroundThe management of type 2 diabetes mellitus (T2DM) includes mastery of complex care activities, self-management skills, and routine health care encounters to optimize glucose control and achieve good health. Given the lifelong course of T2DM, patients are faced with navigating complex medical and disease-specific information. …”
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Comparative efficacy and safety of different recommended doses of telitacicept in patients with systemic lupus erythematosus in China: a systematic review and meta-analysis by Shenglan Gao, Shenglan Gao, Chunlong Yang, Bitang Huang, Lawei Yang, Lu Lu, Huiting Yang, Ting Li, Qingjun Pan, Qingjun Pan, Qingjun Pan

“…The analysis included three randomized controlled trials (RCT) with 606 participants. We used fixed-effects models for meta-analyses and the risk ratios (RRs) and corresponding 95% confidence intervals (CIs) to evaluate the effectiveness and safety. …”
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Three-Dimensional Finite Element Numerical Simulation and Analysis of Solid-State Processing of Metal Material by Guang Su, Aimin Zhang

“…The results show that the 3D finite element numerical method can not only simulate various processes of flow field, temperature field, stress field, and microstructure in solid-state processing but also can provide a reliable basis for effectively obtaining a reasonable description and finding a more optimized design plan for metal material processing in a short time, which plays an important role in understanding and analyzing solid metal forming process, controlling and optimizing process parameters, guiding and mastering rheological casting, and secondary heating and rotary piercing of metal materials.…”
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Machine Learning-Based Prediction of Summer Extended-Range Precipitation and Possible Contribution of Soil Moisture over China by Yuchen YE, Haishan CHEN, Siguang ZHU, Yinshuo DONG

“…Low accuracy of extended forecast remains an important scientific problem in the current stage， and qualified extended forecast is of great significance for disaster prevention and mitigation.In this study， the machine learning method was used to forecast the summer precipitation during the extension period （5~30 days） in China， and explore the possible contribution of soil moisture to extended forecast of precipitation.Based on the results， machine learning methods remarkably outweigh traditional linear models in terms of forecast accuracy， with Catboost， Lightgbm and Adaboost being the optimal machine learning methods.According to further analysis， the abnormal evaporation and sensible heat anomaly caused by the surface soil moisture anomaly in the Yangtze River Basin can lead to the atmospheric circulation and vertical movement anomaly， which eventually affects summer precipitation.The set of three optimal machine learning methods was applied to calculate the contribution rate of each forecasting factor in the model.It was found that the local soil moisture dominated the extended precipitation in the Yangtze River Basin from the 5th day to the 10th day， while the local soil moisture played a dominant role on previous precipitation from the 10th day to the 15th day， and the extended precipitation in the Yangtze River Basin during the period of Day 20~30 was basically controlled by large-scale circulation.Besides， the influence of non-local soil moisture on extended precipitation was evaluated， the results of which showed that the surface soil moisture in Indo-China Peninsula mainly contributed to the extended precipitation in the Yangtze River Basin from the 15th day to the 30th day.By adding the surface soil moisture of Indo-China Peninsula to the extended precipitation model in Northeast China， it was found that surface the soil moisture failed to improve the extended forecast accuracy of precipitation in this area， which verified the availability of the machine learning model.This study provides a certain reference for forecasting precipitation in the extended period and exploring the contribution rate of forecasting factors.…”
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Exploring Visceral Fat as a Screening Marker for Cardiometabolic Risk in Children and Adolescents by Xia Wang, Hong Cheng, Jingfan Xiong, Junting Liu, Hongbo Dong, Liwan Fu, Xiangjun Xie, Xinying Shan, Xiaoyuan Zhao, Yinkun Yan, Pei Xiao, Jie Mi

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Lyophilized hydroalcoholic extract of Passiflora edulis and Zea mays L, as potential arterial hypotension and hypocholesterolemia in hypertensive Mus musculus induced hypertension by Víctor Carhuapoma-Delacruz, Mery L. Capcha Huamani, Nicasio Valencia Mamani, Mario Esparza

“…Forty-eight 8-week-old Swiss albino mice were used by dividing into 4 groups: G1- passion fruit (50 mg [n= 4], 100 mg [n= 4], and 200 mg [n= 4]), G2-purple corn (50 mg [n= 4], 100 mg [n= 4], and 200 mg [n= 4]), and G3-controls: negative control (distilled water [n= 12]), G4-positive control (N-nitro-L-arginine methyl ether (L-NAME) [n= 12]). …”
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Application of the Random Forest Algorithm for Accurate Bipolar Disorder Classification by Miguel Suárez, Ana M. Torres, Pilar Blasco-Segura, Jorge Mateo

“…The RF model demonstrated robust performance, achieving an average accuracy of 93.41%, with recall and specificity exceeding 93%. …”
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Herbal Remedies: A Complementary Approach to Diabetes Mellitus Management by Anupa Sivakumar, Prarthana Kalerammana Gopalakrishna, Sunil Pazhayanur Venkateswaran, Amardev Singh Thanu, Saravanan Jagadeesan, Radhakrishna S. Kommanda, Vishnumukkala Thirupathirao

“…Herbal remedies have been tested on animal models to assess their efficacy in diabetes prevention and optimize glucose metabolism. …”
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High Burden and Trend in Nonadherence to Blood Pressure‐Lowering Medications: Meta‐Analysis of Data From Over 34 000 Adults With Hypertension in Sub‐Saharan Africa by Leopold N. Aminde, Valirie N. Agbor, Noah T. Fongwen, Calypse A. Ngwasiri, Clovis Nkoke, Miriam A. Nji, Anastase Dzudie, Aletta E. Schutte

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Regulation of land use conflicts at indigenous peoples lands based on blockchain platform, russian arctic case study by A. V. Evseev, T. M. Krasovskaya, V. S. Tikunov, I. N. Tikunova

“…Blockchain transaction model for nature management at TTNU was elaborated. …”
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Study on artificial reinforced concrete roof’s thickness for subsequent backfilling method in fragmented rock mass deposits by Jiaxiang Zhou, Nan Yao, Yicheng Ye, Jian Du, Mingwei Sun

“…Additionally, FLAC3D numerical simulations are adopted to investigate the stope stability under different thicknesses of ARCRs and various RCF conditions at the optimal ARCR’s thickness. The combined theoretical analysis and numerical simulation results indicate that: (1) The safe thickness of the ARCR is 4–5 m, which ensures good stability of the artificial roof. (2) The RCF by expansive backfill (EB) can significantly improve the stability and stress distribution of the stope, reduce stress concentration, and minimize roof settlement and floor heaving. (3) The EB provides reverse support force through expansive stress, effectively controlling the compressive stress on the artificial roof and enhancing overall support performance. …”
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Surface Ice Detection Using Hyperspectral Imaging and Machine Learning by Steve Vanlanduit, Arnaud De Vooght, Thomas De Kerf

“…SWIR), revealing that model performance is sensitive to wavelength range, with SVM performing optimally in a reduced band set and RF benefiting from the full spectral range. …”
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Drosophila Topoisomerase 3β binds to mRNAs in vivo, contributes to their localization and stability, and counteracts premature aging. by Shohreh Teimuri, Beat Suter

“…The homologs of genes and (pre)mRNAs mis-expressed in these conditions show the same characteristics identified in the Drosophila Top3β targets, suggesting that Drosophila could model human Top3β. An in vivo test of this model showed that the enzymatic activity of Top3β reduces the neurodegeneration caused by the cytotoxic human (G4C2)49 RNA. …”
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