RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity by Lin Li, Hui Guo, Jie Hu, Lei Cui, Zining Wang, Feifei Xu, Xiaojuan Wang, Huanling Zhang, Chunyuan Xie, Yongxiang Liu, Xiaojun Xia, Zixuan Guo, Heping Li, Tiantian Wang, Ruhui Yao, Huan Jin, Yanxun Lin

“…Furthermore, knockout of RAC2 in human colorectal cancer cells leads to increased tumor susceptibility to NK cell-mediated cytotoxicity in a xenograft tumor model. Mechanistically, the absence of RAC2 enhances tumor cell sensitivity to NK cell-mediated killing by facilitating cell–cell contact.Conclusions These findings indicate that the inhibition of RAC2 in tumor cells substantially enhances their susceptibility to NK cell-mediated cytotoxicity, thereby providing a potential therapeutic target for optimizing NK cell therapy.…”
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A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…We used trastuzumab as a model for the incorporation of Neu5NAz in the novel Fab glycans that we designed. …”
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Use of Biowaste for Sodium Removal in Mediterranean Irrigation Water: A Sustainable Approach by Dámaris Núñez-Gómez, Alejandro Andy Maciá-Vázquez, Carlos Giménez-Valero, Juan José Martínez-Nicolás, Pilar Legua, Pablo Melgarejo

“…Kinetic studies indicated that sodium adsorption adhered to a pseudo-second order model, suggesting a chemically controlled process. …”
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Predictors of adherence to insulin therapy in type 2 diabetes mellitus: an application of the theory of planned behavior by Mariane Karin de Moraes Oliveira, Uiara Aline de Oliveira Kaizer, Fernanda Freire Jannuzzi, Henrique Ceretta Oliveira, Neusa Maria Costa Alexandre, Maria-Cecília Gallani, Thaís Moreira São-João, Marilia Estevam Cornélio, Roberta Cunha Matheus Rodrigues

“…Attitude was predictor of Intention and Perceived Behavioral Control moderated the effect of Attitude and Subjective Norm on Intention. …”
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Design and Characterization of a Low-Cost Capacitive Soil Moisture Sensor System for IoT based Agriculture Applications by Siddhanta Borah, R. Kumar, Subhradip Mukherjee

“…It has been observed from the response data that model B's performance is better than the other two presented models in terms of soil moisture. …”
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Co-design of a routine clinical review to improve the safety of high dose radical cure treatment for Plasmodium vivax malaria: findings from Cambodia and Ethiopia by Sarah A. Cassidy-Seyoum, Muthoni Mwaura, Keoratha Chheng, Muhaba Kejela, Kansite Gellebo Korra, Tsegaberhan Wodaj, Tamiru Shibiru Degaga, Michelle S. Hsiang, Lorenz von Seidlein, Rupam Tripura, Bipin Adhikari, Benedikt Ley, Dysoley Lek, Ric N. Price, Nora Engel, Kamala Thriemer

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Is postoperative radiotherapy effective in patients with completely resected pathologic stage IIIA(N2) non-small cell lung cancer? High-risk populations should consider it by Shu-Xian Zhang, Chen-Chen Zhang, Run-Ping Hou, Xu-Wei Cai, Jun Liu, Wen Yu, Qin Zhang, Jin-Dong Guo, Chang-Lu Wang, Hong-Xuan Li, Zheng-Fei Zhu, Xiao-Long Fu, Wen Feng

“…Patients were identified as high-LRR-risk patients via the prognostic index (PI) model and were randomly assigned to PORT-first or PORT-last treatment. …”
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The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review by Yan Chen, Yan Chen, Jiaojiao Zhao, Jiaojiao Zhao, Yifei Wang, Yifei Wang, Long Ge, Long Ge, Joey Sum-wing Kwong, Junjie Lan, Rui Zhang, Huaye Zhao, Linfang Hu, Jiaxue Wang, Shuimei Sun, Songsong Tan, Xiaoqing Lin, Rui He, Wenyi Zheng, Xiaosi Li, Jiaxing Zhang

“…We performed NMA with a frequentist random effects model and assessed the certainty of evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. …”
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Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications by Shiwei Yang, Xingming Hu, Jinmiao Zhu, Bin Zheng, Wenjie Bi, Xiaohong Wang, Jialing Wu, Zimeng Mi, Yifei Wu

“…<b>Results:</b> QbD implementation reduces batch failures by 40%, optimizes dissolution profiles, and enhances process robustness through real-time monitoring (PAT) and adaptive control. …”
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Predictability of Air Pollutants Based on Detrended Fluctuation Analysis: Ekibastuz Сoal-Mining Center in Northeastern Kazakhstan by Oleksandr Kuchanskyi, Andrii Biloshchytskyi, Yurii Andrashko, Alexandr Neftissov, Svitlana Biloshchytska, Sergiy Bronin

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A new method for determining factors Influencing productivity of deep coalbed methane vertical cluster wells by HUANG Li, XIONG Xianyue, WANG Feng, SUN Xiongwei, ZHANG Yixin, ZHAO Longmei, SHI Shi, ZHANG Wen, ZHAO Haoyang, JI Liang, DENG Lin

“…The results showed that: 1） The Beggs &amp; Bill model and Gray model exhibited poor applicability for predicting the bottom-hole flowing pressure of deep CBM wells, while the single-phase gas model demonstrated reduced overall error as water production declined. …”
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A methodology for evaluating the fracture width of a notched RC multiple-layer flat slab under cyclic loading by Nawir Rasidi, Taufiq Rochman

“…This model not only bridges the gap between theory and practical application in crack width prediction but also contributes to optimizing durability in RC structures exposed to cyclic stresses. …”
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Evolutionary game analysis of multi-agent behaviour decisions about sustainable agriculture by Xinlin Chen, Yun Teng, Guoming Du

“…Design/methodology/approach – In response to the characteristics of incomplete information and limited rationality among the government, farmers and consumers, an evolutionary game model was constructed among the three stakeholders to determine the conditions for stakeholders to obtain the optimal strategic combination to promote farmers’ green production behaviour (GB). …”
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Seismic Response Analysis of Double-Layer Isolation Structures in High-Rise Buildings by Guangxing Zhao, Lanfang Zhang, Dewen Liu, Kaoshan Shen

“…Three seismic waves were inputted into the model, and numerical simulations were carried out using the finite element calculation software ABAQUS (2022). …”
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Across Economics and Psychology: Development and Validation of the In-Game Purchase Motivation Scale by Mirko Duradoni, Nicolò Della Maggiora, Giacomo Barbagallo, Mustafa Can Gursesli, Ginevra Niccolai, Andrea Guazzini

“…In the second study, conducted with 284 gamers, the self-realization factor was added, increasing the scale’s explanatory power to 8% for the amount of money spent on in-game purchases. When controlling for variability attributed to the game type (i.e., analyzing just participants who spent money over a specific game), we observed an increase in the explanatory power of the scale from 5.4% to 12% for the initial four-factor model in Study 1 and from 8% to 27.5% for the evolved five-factor model in Study 2. …”
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Study on Purge Strategy of Hydrogen Supply System with Dual Ejectors for Fuel Cells by Yueming Liang, Changqing Du

“…This model effectively captures the accumulation and exhaust of hydrogen, nitrogen, and vapor within the anode. …”
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Whether exercises and testosterone replacement therapy support a treatment for cardiovascular and atherosclerotic patients with iliac artery stenosis and low total testosterone and... by Sid Solaković, Nina Solaković, Anes Jogunčić, Hajrudin Spahović, Fedja Hajrulahović, Mensur Vrcić, Emir Solaković, Amina Godinjak, Iryna Skrypchenko, Olena Dorofieieva, Kseniia Yarymbash

“…It also attempts to remodel a patient behavioral pattern, optimize ST levels and link them to outcomes and patency of vascular procedures on the iliac segment. …”
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The triglyceride glucose-body mass index predicts adverse reproductive outcomes in women with polycystic ovary syndrome undergoing frozen embryo transfer by Ziyin Ding, Ziyin Ding, Ziyin Ding, Kai Liao, Kun Liang, Shuo Zhang, Zhenle Pei, Feifei Zhang, Feifei Zhang, Liming Zhou, Congjian Xu, Congjian Xu, Congjian Xu

“…Combined with other identified risk factors, including basal luteinizing hormone, basal follicle stimulating hormone, total cholesterol, testosterone, infertility type and controlled ovarian stimulation protocols, the AUC value increased (AUC = 0.667, P &lt; 0.001) and this model showed good miscarriage prediction performance in most subgroups (AUC &gt; 0.650, P &lt; 0.05), especially in patients with normal or low weight (BMI &lt; 24 kg/m2, AUC = 0.743, P &lt; 0.001).ConclusionHigher TyG-BMI levels are independently associated with an increased risk of adverse reproductive outcomes in women with PCOS undergoing FET. …”
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Estimating Sediment Trap Efficiency of Flood Events During Flood Season in the Three Gorges Reservoir by Shi Ren, Yu Gao, Wei‐Jie Wang, Yinjun Zhou, Hanqing Zhao

“…The results provide a reference for sedimentation management and optimal operation in the TGR.…”
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Does Syndesmotic Fixation Technique Impact Complication Rates and Functional Outcomes Measured by PROMIS Scores Following Operative Repair of Ankle Fractures? by Steven Hadley BA, Rachel Bergman MD, John Peabody MD, Sarah Westvold MPH, Ryan Filler MD, Milap Patel DO, Anish Kadakia MD

“…Submission Type: Ankle Fractures Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Various techniques are used to repair the distal tibiofibular syndesmosis. …”
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