Correlation of safety and efficacy of atezolizumab therapy across indications by Jarushka Naidoo, Guru Sonpavde, Mark A Socinski, Rajat Mohindra, Corey Carter, Laurent Essioux, Gonzalo Durán-Pacheco, G Scott Chandler, Vidya Maiya, Javier Puente, Jose Vicente Cardona

“…We used a mixed-effect Cox proportional hazard model for time-varying covariates to address immortal-time bias; adjusted for baseline factors associated with irAEs and OS to control for confounding bias; and focused on five common irAEs (dermatologic, thyroid dysfunction, hepatitis, pneumonitis, and colitis) to avoid low statistical power for rare events.Results For patients treated with IO or C-IO, G1-2 irAEs were associated with improved OS (HR=0.65, p<0.01) and G3-4 irAEs showed a slight increased risk of death (HR=1.18, p=0.10) versus patients without irAEs. …”
Get full text

Newly designed curcumin-loaded hybrid nanoparticles: a multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue... by Heidi M. Abdel-Mageed, Nermeen Z. AbuelEzz, Ahmed A. Ali, Amira Emad Abdelaziz, Dina Nada, Sahar M. Abdelraouf, Shahinaze A. Fouad, Abeer Bishr, Rasha A. Radwan

“…For in vivo evaluation, the nanoparticles were incorporated into a hydrogel base and applied topically in a rat burn wound model, resulting in significantly accelerated wound closure (P < 0.05). …”
Get full text

Butterfly Pea and Roselle Combination Extracts Reduce V-CAM, ICAM, and IL-6 Levels in High Fat Atherogenic Diet Rats by Karnirius Harefa, Ahmad Hafizullah Ritonga, Riri Safitri, Barita Aritonang, Rahmad Gurusinga, Irmayani Irmayani, Sri Wulan

“…METHODS: A study with a post-test control group design using 36 male white rats was performed. …”
Get full text

Additive manufacturing of graphene oxide-doped SiOC/Si3N4 photothermal functional bioceramic scaffolds through stereolithography technology by Yange Li, Hongyu Xing, Lei Lai, Hui Li, Hongyu Zhao, Qingguo Lai, Bin Zou

“…To address GO-induced light scattering defects, a GO content-photosensitive parameter predictive model was established, which improved the dimensional accuracy of printed green bodies by 12.5% compared with that of their nonoptimized counterparts. …”
Get full text

Genome-Wide Association Study for Belly Traits in Canadian Commercial Crossbred Pigs by Zohre Mozduri, Graham Plastow, Jack Dekkers, Kerry Houlahan, Robert Kemp, Manuel Juárez

“…Phenotypes were measured using image analysis, DEXA, and fatty acid profiling, and genotyping was performed using low-pass sequencing (SkimSeq). After quality control, 18,911,793 single nucleotide polymorphisms (SNPs) were retained for further analysis. …”
Get full text

TAXI TRANSPORT SAFETY REQUIRES SYSTEM SOLUTIONS by N. O. Bludyan

“…The analysis of the reasons for the fundamental changes in the business model of taxi transport in the conditions of operation of aggregators has been carried out. …”
Get full text

Glucocorticoids induce femoral head necrosis in rats through the HIF-1α/VEGF signaling pathway by HaoXu Tang, Lingli Yuan, ZhiYuan Xu, GuiFen Jiang, YingJie Liang, Ce Li, PengLin Ding, MinLong Qian

“…Furthermore, Western blotting was carried out to investigate the expression of HIF-1α, runt-related transcription factor 2 (RUNX2), VEGF, osteopontin (OPN), and alkaline phosphatase (ALP) proteins to identify the optimal DEX concentration for simulating steroid-induced osteonecrosis cell models. …”
Get full text

Effects of cervical transcutaneous Vagus Nerve Stimulation (ctVNS) on military cognitive performance during sleep deprivation by C. Bottenheft, Y. M. Fonken, L. F. Hendrikse, M. Koedijk, A. Landman, O. Binsch

“…Further research is recommended to optimize stimulation protocols and investigate robustness of effects.…”
Get full text

Reducing personal protective equipment waste in the emergency department of a large regional hospital: codesign informed by system science by Mike Forrester, Rebecca Patrick, Steven Allender, Jaithri Ananthapavan, Urvi Thanekar, Hasini Gunasiri, Minoo Naebe, Maryam Naebe

“…Participants identified five key drivers of single-use PPE waste: (1) centralised state-level procurement processes limited hospital control over reusable or single-use PPE purchasing decisions; (2) lack of clarity of minimum PPE requirements for different clinical scenarios; (3) clinical capacity for cohorting infectious patients in ED; (4) waste management processes not capitalising on recyclable material; and (5) barriers to staff using optimal waste handling processes creating excessive ‘contaminated clinical waste.’ …”
Get full text

Protection of housing rights of Ukrainian citizens in conditions of armed aggression of the Russian Federation against Ukraine by Samoylenko G., Kosyrev D.

“…Purpose: the purpose of the article is to determine and justify the choice of the optimal model of civil-legal protection of housing rights in the event of their violation, which is caused or is a direct consequence of the armed aggression of the Russian Federation against Ukraine. …”
Get full text

Family adaptation as a predictor of family self-determination of digital generation students by S. V. Merzlyakova, E. P. Kayumova

“…A flexible level of family adaptation is optimal and contributes to the development of the importance of filial or affiliated roles, purposefulness, meaningfulness of life, an emotionally positive attitude to the headship and responsibility in the family, self-confidence, internal locus of control.Scientific novelty of the research lies in the establishment of the connection between family adaptation and the content characteristics of students’ family self-determination under the conditions of interaction of traditional and digital socialisation.Practical significance. …”
Get full text

Theoretical basis and field experiment of low-temperature gathering and transportation for high water-cut crude trunk pipeline by Yang LYU, Hanwen ZHANG, Luoqian LIU, Fuqiang ZHANG

Get full text

Direct numerical simulation study of multi-dispersed particle-bubble turbulent collision frequency based on the lattice boltzmann method by Xuesong YANG, Dongqin CHEN, Yunlin WANG, Zhe LI, Yaowen XING, Xiahui GUI

“…This indicates that controlling the particle/bubble size distribution during the flotation process is crucial for improving separation efficiency. …”
Get full text

SSMR-Net and Across Feature Mapping Attention are jointly applied to the UAV imagery semantic segmentation task of weeds in early-stage wheat fields by Xinyu Mei, Changchun Li, Yinghua Jiao, Guangsheng Zhang, Longfei Zhou, Xifang Wu, Taiyi Cai

“…This study presents a promising approach to precise weed identification and control in agriculture.…”
Get full text

Performance Evaluation of YOLOv11 and YOLOv12 Deep Learning Architectures for Automated Detection and Classification of Immature Macauba (<i>Acrocomia aculeata</i>) Fruits by David Ribeiro, Dennis Tavares, Eduardo Tiradentes, Fabio Santos, Demostenes Rodriguez

“…Inference throughput averaged 3.9 ms per image for YOLOv11x and 6.7 ms for YOLOv12x, highlighting a trade-off between speed and architectural complexity. Fused model representations revealed optimized layer fusion and reduced computational overhead (GFLOPs), facilitating efficient deployment. …”
Get full text

Development and validation of a nomogram for predicting the risk of obstructive coronary artery disease in rheumatoid arthritis patients based on LDL-C, Th17 cells, and IL-17 by Xiaoyang Wang, Baochen Li, Ruipeng Wei, Bin Hu, Yuming Feng, Bin Yang, Shuling Rong, Bao Li

“…The proposed model seeks to enable personalized cardiovascular risk assessment for RA patients, thereby optimizing clinical management strategies.MethodsA total of 120 patients with rheumatoid arthritis (RA) who were treated at the Second Hospital of Shanxi Medical University between January 2019 and September 2023 were enrolled in this study. …”
Get full text

Effect of tool angle in nanocutting of single crystal GaN using diamond cutter by Yongqiang WANG, Hao XIA, Zhihang HU, Shuaiyang ZHANG, Shaohui YIN

“…Large-scale MD simulations are meticulously performed to model the nanoscale cutting process of single-crystal GaN using a diamond tool. …”
Get full text

Prevalence and prediction of hepatocellular carcinoma in alcohol-associated liver disease: a retrospective study of 136 571 patients with chronic liver diseases by Li Gao, Lin Han, Qiaoling Wang, Yinying Lu, Binxia Chang, Hui Tian, Ang Huang, Xingran Zhai, Xueyuan Jin, Qingsheng Liang, Baosen Li, Huan Xie, Dong Ji, Zhengsheng Zou

Get full text

Design and In Vitro Validation of an Orthopaedic Drill Guide for Femoral Stem Revision in Total Hip Arthroplasty by Jan-Willem Klok, Jessica Groenewegen, Olivier Temmerman, Niels Van Straten, Bart Van Straten, Jenny Dankelman, Tim Horeman

“…The compliant drill guide centralizer significantly lowered the risk of cortical bone perforation during intramedullary canal drilling in the bone models due to better control of the cement drill position. …”
Get full text

Reduction of Ascites Susceptibility in Broiler Chickens under Cold Stress by Guanidinoacetic Acid Supplementation by Mousa Ezatikia, parviz Farhoomand, Sina Payvastegan, Bahram Pirooz, Negin Delfani

“…Supplementing with 0.18% guanidinoacetic acid also led to reductions in relative heart weight and the ratio of right ventricle weight to total ventricles compared to the control group. Nitric oxide concentration also significantly increased with supplementation of 0.18% guanidinoacetic acid and 0.5% arginine compared to the control group. …”
Get full text