Transcriptional regulation of ETV5 by mitogen-activated protein kinase via ETS-1 in human pancreatic cancer cells by Aya Noguchi, Masanobu Kimura, Yuriko Saiki, Tomohiko Ishikawa, Takashi Kokumai, Yuko Omori, Yusuke Ono, Yusuke Miszukami, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Michiaki Unno, Toru Furukawa

“…Abstract Pancreatic cancer is characterized by constitutive activation of mitogen-activated protein kinase /extracellular signal-regulated kinase 1/2 (ERK1/2) driven by gain-of-function mutations of KRAS. …”
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Natural Products as Novel Therapeutic Agents for Triple-Negative Breast Cancer: Current Evidence, Mechanisms, Challenges, and Opportunities by Qingzhou Li, Zhen Ye, Guilin Wang, Yuhui Chen, Jinghong Deng, Dong Wang, Yumei Wang

“…An in-depth exploration has unveiled their involvement in key signaling pathways, including the transforming growth factor-beta (TGF-β), vascular endothelial growth factor A (VEGFA), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), Wingless/Int-1 (Wnt) /β-catenin, and mitogen-activated protein kinase (MAPK) pathways. …”
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基于多尺度晶体塑性有限元的GCr15轴承钢拉-压不对称性研究 by 樊冬, 余丰, 李淑欣

“…In this paper,stress triaxiality is added to the classical crystal plasticity constitutive model to investigate the experimental phenomenon of tension-compression asymmetry for the GCr15 bearing steel.Firstly, the crystal plasticity constitutive model is extended by considering the effect of stress triaxiality on yield criterion and flow rule in each slip system.Secondly,representative volume element（ RVE） was simulated to regenerate the quasi-static uniaxial tensile and compression engineering stress-strain curve of GCr15 bearing steel by using crystal plasticity finite element method.The results show that stress concentration occurs at the grain boundary due to the crystal orientation difference among polycrystalline grains,and under the influence of triaxial stress state,the RVE simulation results show that the stress concentration has a significant effect on tensioncompression asymmetry.Therefore,it is concluded that the effect of stress triaxiality on the texture of mesoscopic crystal is an important factor that causes the phenomenon of tension-compression asymmetry.…”
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Abortion reforms in South Africa: An overview of the Choice on Termination of Pregnancy Act by Ramprakash Kaswa, Parimalaranie Yogeswaran

“…Access to sexual and reproductive healthcare is a constitutional right and on a broader perspective is part of the universal right to health. …”
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Assessment of Concentrations of Heavy Metals in Postmyocardial Infarction Patients and Patients Free from Cardiovascular Event by Grzegorz Józef Nowicki, Barbara Ślusarska, Andrzej Prystupa, Eliza Blicharska, Agnieszka Adamczuk, Tomasz Czernecki, Krzysztof Jacek Jankowski

“…Cardiovascular diseases (CVDs) constitute the first cause of death among the population of developing and developed countries. …”
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Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene‐ and protein expression profiles by Klaus H. Dittmann, Claus Mayer, Heribert Stephan, Christin Mieth, Michael Bonin, Beat Lechmann, H. Peter Rodemann

“…The initial proliferative phase was characterized by a constitutively high mRNA expression of extracellular matrix proteins. …”
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Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. by Yukio Yamamoto, Rick Moore, Richard A Flavell, Binfeng Lu, Masahiko Negishi

“…Given the known function of GADD45B as a factor that represses Mitogen-activated protein Kinase Kinase 7 - c-Jun N-terminal Kinase (MKK7-JNK) pathway-mediated apoptosis, we have now demonstrated that CAR interacts with GADD45B to repress Tumor Necrosis Factor alpha ( TNFalpha)-induced JNK1 phosphorylation as well as cell death. …”
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Exosomal encapsulation of a steviol derivative SD9 to overcome TRAIL resistance as a highly effective therapy against lung cancer by Quanjiang Li, Yufeng Xie, Wanting Zhang, Jun Peng, Zhujie Deng, Rui Tian, Xiubin Kuang, Bin Xie, Chen Huang, Yu Zhao, Zhengqiang Yuan

“…Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising pro-apoptotic factor. …”
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Engineering a controlled cardiac multilineage co-differentiation process using statistical design of experiments by Hirokazu Akiyama, Yosuke Katayama, Kazunori Shimizu, Hiroyuki Honda

“…In the trilineage co-differentiation stage, we developed unique multi-response models to delineate trilineage co-differentiation ratios within a defined parameter space of WNT signal inhibitor and vascular endothelial growth factor. This enabled the identification of potential conditions that steer co-differentiation toward desired cellular constitutions, a critical factor of effective cellular interplays. …”
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Global trends and sociodemographic inequalities in smoking and high-salt diet attributable to gastric cancer: a secondary analysis based on the global burden of disease 2021 study by Chao Rui Lin, Ming Xu Wang, Xiu Ying Guo, Yu Xin Huang, Bin Bin Yang, Yang Yang Duan, Fan Lin, Yong Wan

“…Smoking and a high-salt diet are behavioural risk factors for gastric cancer that can be easily controlled; however, comprehensive and systematic studies are lacking. …”
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SUMO2/3 modification of transcription-associated proteins controls cell viability in response to oxygen and glucose deprivation-mediated stress by Francisco Gallardo-Chamizo, Román González-Prieto, Vahid Jafari, Noelia Luna-Peláez, Alfred C. O. Vertegaal, Mario García-Domínguez

“…Thus, better outcomes in cell protection would rely on the appropriate combination of sumoylated and non-sumoylated forms of selected factors.…”
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Indicators for the Compression and Stretching Characteristics of the HTF-Coordinate of WRF by Hailiang Zhang, Huoqing Li, Shuiyong Fan

“…Such indicators, including the maximum factor of compression (MFC), eta corresponding to the MFC, and the critical point of compression (CPC), were defined and calculated in this study. …”
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Towards a Common Energy Policy in the European Union? by Andras Inotai

“…Steadily high energy (oil and gas) prices in the last years constitute one factor. However, global political and security issues of growing degree of uncertainty, the level of dependence on imported energy and, not less importantly, the forecasts of growing external dependence of the EU in this field have substantially contributed to the upgrading of the energy question. …”
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The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease by T. S. Krolevets, M. A. Livzan, S. I. Mozgovoy

“…Liver fibrosis constitutes the leading factor determining the prognosis of patients in NAFLD, including cases associated with cardiovascular complications. …”
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Numerical Simulation Study on the Strengthening Mechanism of Rock Materials under Impact Loads by Xin Liu, Kai Wang, Chunan Tang, Xikun Qian

“…A dynamic enhancement factor is introduced on the basis of static mesodamage constitutive theory, and a rate-dependent three-dimensional rock dynamic constitutive model is established. …”
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Przemiany w świadomości religijnej młodzieży polskiej by Michał Jóźwik

“…They affect the condition and functioning of the Polish family and thus they may influence the processes of intergenerational transfer of cultural tradition which constitute an essential factor in maintaining the society’s cultural identity. …”
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Metafizyczna «natura» bytu matematycznego. Uwagi wstępne by Jerzy Tupikowski

“…That interpretation is the important dimension specification of reality, which realizes varied types of features, elements, categories, where the quantitative structure constitutes the fundamental factor, which enables it’s realistic understanding.…”
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A High-reliability Energy Router Suitable for Multiple Types of New Energy Access in Intelligent Communities by GUO Xuan, ZHENG Zedong, LI Yongdong

“…The simulation results show that the proposed topology can achieve bidirectional flow of energy and arbitrary adjustment of power factor. Based on this topology, it presented an energy router and intelligent community power supply system architecture suitable for intelligent cells, which provides multiple types of new energy access interface, has multi-directional energy flow and fault handling functions, and can constitute the basic autonomous unit of the energy Internet.…”
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Do ambiguous images provide psychological insights? Testing a popular claim by Richard Wiseman, Caroline Watt

“…To explore this notion, participants indicated the first image that they perceived in four ambiguous pictures (Duck-Rabbit, Younger-Older Woman, Rubin’s Vase and Horse-Seal), and completed a Five Factor personality measure along with scales relating to optimism, procrastination, holistic thinking, and decision-making style. …”
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Time-history simulation of civil architecture earthquake disaster relief- based on the three-dimensional dynamic finite element method by Liu Bing, Qi Yaoguang, Du Jiyun

“…Earthquake action is the main external factor which influences long-term safe operation of civil construction, especially of the high-rise building. …”
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