A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma by Peng V. Wu, Matt Fish, Florette K. Hazard, Chunfang Zhu, Sujay Vennam, Hannah Walton, Dhananjay Wagh, John Coller, Joanna Przybyl, Maurizio Morri, Norma Neff, Robert B. West, Roel Nusse

“…Highly proliferative regions with embryonal histology show high expression of Wnt target genes, the embryonic biliary transcription factor SOX4, and striking focal expression of the growth factor FGF19. …”
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Neighbourhood immigrant density and COVID-19 infection and hospitalisation among healthcare workers in Sweden: a register-based observational study by Fredrik Nyberg, Huiqi Li, Jesper Löve, Carl Bonander, Ailiana Santosa, Chioma Nwaru

“…Introduction We investigated whether living in immigrant-dominated neighbourhoods constituted a risk factor for COVID-19 infection and hospitalisation among healthcare workers (HCWs) in Sweden, and if so, whether such exposure exacerbated the risk of COVID-19 among immigrant HCWs.Methods We used population-based register data from HCWs aged 20–62 years (N=86 187) resident in 14 Swedish municipalities (3 of which are Sweden’s largest metropolitan cities) on 1 January 2020. …”
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MiR-204-5p mediates PERK inhibition to suppress growth and induce apoptosis in ovarian cancer through the eIF2α/ATF-4/CHOP pathway by Faranak Fallahian, Seyedeh Sara Ghorbanhosseini, Shekufe Rezghi Barez, Mahmoud Aghaei

“…We ascertained that the inhibition of PERK by miR-204-5p decreased eukaryotic initiation factor 2alpha (eIF2α) phosphorylation. Moreover, activating transcription factor 4 (ATF4) and CCAAT-enhancer-binding homologous protein (CHOP) expression levels were notably elevated in response to miR-204-5p. …”
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Bioinformatics reveal macrophages marker genes signature in breast cancer to predict prognosis by Ying Li, Xin Zhao, Qiang Liu, Yujie Liu

“…And MMGS risk score remained independent prognostic factor in multivariate analysis after adjusting for classical clinical factors in both training and validation cohorts. …”
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Poder, clientelismo e violência política no Zimbabwe: a Terceira Chimurenga by Victor Hugo Nicolau

“…The vast majority of internal and external observers have put aside the notion that the racial dimension constitutes an autonomous factor in the conflict. It is at this stage generally accepted that the main conflicts present in contemporary Zimbabzean society can be included in three clearly identified areas: 1) an area of economic and social conflicts, 2) an area of fundamentally political conflicts, 3) an area of regional and ethnic conflicts.…”
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A Peptide Antagonist of the ErbB1 Receptor Inhibits Receptor Activation, Tumor Cell Growth and Migration In Vitro and Xenograft Tumor Growth In Vivo by Ruodan Xu, Gro Klitgaard Povlsen, Vladislav Soroka, Elisabeth Bock, Vladimir Berezin

“…The epidermal growth factor family of receptor tyrosine kinases (ErbBs) plays essential roles in tumorigenesis and cancer disease progression, and therefore has become an attractive target for structure-based drug design. …”
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Analysis of HPV and NKG2D rs1049174 Polymorphism in Vietnamese Patients With Oropharyngeal Squamous Cell Carcinoma by Nguyen Van Hung MD, Nguyen Hoang Viet PhD, Do Trung Duc MD, Tran The Dieu MD, Nguyen Thanh Binh MD, Le Huy Hoang PhD, Nguyen Quang Trung MD, PhD

“…Introduction Oropharyngeal Squamous Cell Carcinoma (OPSCC) etiology involves environmental and genetic factors, with Human Papillomavirus (HPV) being a key ecological driver. …”
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Expert-innovator behaviour questionnaire as a new tool for selecting potential experts by Deptuła Anna M., Nosal Czesław S.

“…The article presents the factor structure of a potential expert’s competencies measured using a questionnaire. …”
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A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. by Christina Spilker, Sven Nullmeier, Katarzyna M Grochowska, Anne Schumacher, Ioana Butnaru, Tamar Macharadze, Guilherme M Gomes, PingAn Yuanxiang, Gonca Bayraktar, Carolin Rodenstein, Carolin Geiseler, Angela Kolodziej, Jeffrey Lopez-Rojas, Dirk Montag, Frank Angenstein, Julia Bär, Wolfgang D'Hanis, Thomas Roskoden, Marina Mikhaylova, Eike Budinger, Frank W Ohl, Oliver Stork, Ana C Zenclussen, Anna Karpova, Herbert Schwegler, Michael R Kreutz

“…Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (CREB). …”
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Intrapore Geometry and Flow Rate Controls on the Transition of Non‐Fickian to Fickian Dispersion by Jacob Bradley, Kuldeep Singh, Lichun Wang

“…A set of intrapore geometries is designed and quantified by a dimensionless pore geometry factor (β), which accounts for a broad range of pore shapes likely found in nature. …”
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Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. by Elias Epp, Ghyslaine Vanier, Doreen Harcus, Anna Y Lee, Gregor Jansen, Michael Hallett, Don C Sheppard, David Y Thomas, Carol A Munro, Alaka Mullick, Malcolm Whiteway

“…We confirmed chemically the AGE3-dependent drug sensitivity by showing a potent fungicidal synergy between fluconazole and brefeldin A (an inhibitor of the guanine nucleotide exchange factor for ADP ribosylation factors) in wild type C. albicans as well as in drug resistant clinical isolates. …”
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Translation and psychometric validation of the Chinese version of the Nurses’ Work Value Scale: a cross-sectional study by Yuecong Wang, Xin Wang, Yaling Ji, Tianxiang Jiang, Meigui Bao

“…Abstract Background Nurses’ work values constitute the core driving force of their professional careers. …”
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Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis by Bethany Y. A. Hollingworth, Patrick N. Pallier, Stuart I. Jenkins, Ruoli Chen

“…When oxygen levels are reduced in the brain, constitutively expressed hypoxia-inducible factors (HIF) are stabilised, upregulating hundreds of genes, including neuroprotective factors. …”
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TWO CASES OF PRIMARY AMYLOIDOSIS PRESENTING WITH VERTEBRAL AMYLOIDOMA by Ebru Kavak Yavuz, Vehbi Demircan, Abdullah Karakus, Orhan Ayyildiz

“…The patient developed a hematoma in the surgical area, factor levels were studied, factor 10 level was found to be 10% low. …”
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The use of disinfectants in medical and health related Institutions: An Overview by J. O. Taiwo, C. O. Onyeaso, A. O. Okesola

“… The effective use of disinfectants in health institutions constitute a significant factor in the prevention of health care associated infections. …”
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NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation by Elisabeth Hessmann, Jin-San Zhang, Nai-Ming Chen, Marie Hasselluhn, Geou-Yarh Liou, Peter Storz, Volker Ellenrieder, Daniel D. Billadeau, Alexander Koenig

“…Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of acinar cells to external stress signals and is considered to be the initial step in pancreatic carcinogenesis. …”
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Reputation shortcoming in academic publishing. by Rémi Neveu, André Neveu

“…The establishment of a non-financial conflict of interest policy and the journals' impact factor were associated with changes in the number of publications of editors' former co-authors and authors with a publishing record in Nature journals. …”
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Investigating biomarkers for personality alterations in temporal lobe epilepsy patients: based on peripheral inflammatory indices, electroencephalography, and neuroimaging by Jia Wang, Fuchi Zhang, Yunshan Zhou, Xiulin Zhang, Jianyang Xu, Shouyong Wang, Chengbing Huang, Taipeng Sun, Hugen Xu, Xiangsong Shi

“…Hippocampal sclerosis or atrophy constituted an independent risk factor for personality alterations in TLE, although monotherapy seemed to serve as a protective factor.…”
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Production and Characterization of Semi-Solid Formulations for the Delivery of the Cosmetic Peptide Palmitoyl-GHK by Valentyn Dzyhovskyi, Federico Santamaria, Erika Marzola, Leda Montesi, Irene Donelli, Stefano Manfredini, Remo Guerrini, Elisabetta Esposito

“…The so-called “ethosomes” were evaluated as nanovesicular systems constituted of phosphatidylcholine, organized in vesicles, ethanol, and water. …”
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Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1, SMARCA4, and PTEN mutations by Alessandro Russo, Christian Rolfo, Francesco Drago, Giovanni Nigita, Roberto Borea, Rodrigo Paredes

“…KEAP1 mutations, through constitutive nuclear factor erythroid 2-related factor 2 activation, promote oxidative stress adaptation and metabolic reprogramming, creating an immune-excluded TME that reduces T-cell infiltration. …”
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