Frequency and factors associated with loss to follow-up in newly diagnosed rheumatoid arthritis patient: a single-centre study by Sumariyono Sumariyono, Rudy Hidayat, Faisal Parlindungan, Suryo Anggoro Kusumo Wibowo, Anna Ariane, Johanda Damanik, Abirianty Priandani Araminta, Ryzkianty Annis Nurdin

“…Introduction Lost to follow-up (LTFU) rheumatoid arthritis (RA) patients constitute a population that potentially experiences worsening of their disease. …”
Get full text

A key role of the PGC-1α/ERR-α pathway in regulation of angiogenic factors in proliferative diabetic retinopathy by Ahmed M. Abu El-Asrar, Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj M. Siddiquei, Eef Allegaert, Eef Allegaert, Priscilla W. Gikandi, Gert De Hertogh, Gert De Hertogh, Ghislain Opdenakker, Ghislain Opdenakker, Ghislain Opdenakker

“…BackgroundPGC-1α is induced by hypoxia and interacts with the receptor ERR-α to stimulate angiogenic factors expression and promote angiogenesis. We investigated the possible role of the PGC-1α/ERR-α pathway in regulating angiogenic factors expression in proliferative diabetic retinopathy (PDR).MethodsWe analysed vitreous fluid samples from PDR and non-diabetic patients and epiretinal fibrovascular membranes from PDR patients. …”
Get full text

Prevalence and associated factors of malaria among the displaced population in refugee camps in Africa: a systematic review and meta-analysis by Habtu Debash, Ermiyas Alemayehu, Melaku Ashagrie Belete, Hussen Ebrahim, Ousman Mohammed, Daniel Gebretsadik, Mihret Tilahun, Alemu Gedefie

“…A random-effects model was used to estimate the pooled prevalence and associated factors of malaria. Meta-regression and subgroup analysis were used to identify heterogeneity, while funnel plots and Egger’s statistical tests assessed the publication bias. …”
Get full text

Trends and Disparities in Liver Transplantation in the United States: A Nationwide Analysis of Demographic, Clinical, and Socioeconomic Factors (2016–2021) by Vignesh Krishnan Nagesh, Vivek Joseph Varughese, Marina Basta, Emelyn Martinez, Shruthi Badam, Lokaesh Subramani Shobana, Abdifitah Mohamed, Alin J, Simcha Weissman, Adam Atoot

“…The mean recipient age remained stable (51–52 years), with males comprising ~62% of transplants. White patients constituted the largest group of recipients (~66–68%), followed by Hispanic (~14–17%) and Black patients (~7–10%). …”
Get full text

Risk factors for mortality among kidney transplant recipients with COVID-19 in Saudi Arabia: a case-control study by Dema A. Alissa, Rawan Almasuood, Baraa Alghalyini, Hala Tamim, Mohammed Alaa Raslan, Abdul Rehman Zia Zaidi, Bader Abou Shaar, Mhd Malek Al Masri, Adnan Abdul Karim, Wejdan Aburas, Waled Aburas, Ahmed H. Al-jedai, Reem S. Almaghrabi

“…The primary objective is to identify mortality risk factors among COVID-19-infected kidney transplant patients. …”
Get full text

Potentially Inappropriate Medication and Associated Factors Among Older Patients with HIV/AIDS: A Multicenter Cross-Sectional Study by Li J, Hong D, Dong J, Zhao Q, Wang H

“…The analytical framework incorporated descriptive statistics, negative binomial regression for trend analysis, and multivariable logistic regression to evaluate PIM prevalence and identify associated risk factors.Results: The analysis included 2,642 patients (80.28% male; median age 71 years, IQR: 67~75). …”
Get full text

Genome-wide identification, characterization and expression analysis of WRKY transcription factors under abiotic stresses in Carthamus tinctorius L by Zhengwei Tan, Dandan Lu, Yongliang Yu, Lei Li, Lanjie Xu, Wei Dong, Qing Yang, Chunming Li, Xiufu Wan, Huizhen Liang

“…Abstract Background WRKY transcription factors constitute one of the largest families of plant transcriptional regulators, playing pivotal roles in plant responses to biotic and abiotic stresses, as well as in hormonal signaling and secondary metabolism regulation. …”
Get full text

Exploring the Effects of Internal and External Factors on the Early Growth of Anchovy (Engraulis japonicus) in the Yellow Sea Based on Otolith Microstructure by Wenwen WANG, Yongjun TIAN, Lijun LIU, Zhuo YIN, Bingqing CHEN, Wenchao ZHANG, Zhenjiang YE

“…The abundant and widely distributed resources of small pelagic fish in marine ecosystems constitute significant targets for commercial fisheries. …”
Get full text

Separatism in the Philippines: Islamist Terrorism, National Liberation or the Struggle for Resources? by A. D. Dikarev

“…In conclusion the article briefly describes the aggravation of situation in the South of Philippines due to the growing importance of “Islamic factor” and activities of international terrorism in the modern world.…”
Get full text

THE ROLE OF AP-1 TRANSCRIPTION FACTOR ACTIVATION IN THE CHANGES OF PRODUCTION AND UTILIZATION OF NITRIC OXIDE IN THE GASTRIC MUCOSA OF RATS UNDER CONDITIONS OF CHRONIC FLUORIDE INT... by O. Ye. Akimov

“…The effect of fluorides on the activation or inhibition of redox-sensitive transcription factors remains poorly understood. The aim of this research is to examine the effect of activation of the transcription factor AP-1 on changes in the activity of inducible NO synthase and constitutive isoforms of NO synthase, concentrations of peroxynitrites of alkali and alkaline earth metals, concentrations of nitrites and nitrosothiols in the gastric mucosa of rats under conditions of chronic fluoride intoxication. …”
Get full text

Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells. by Lin Sun, Anthony J St Leger, Cheng-Rong Yu, Chang He, Rashid M Mahdi, Chi-Chao Chan, Hongsheng Wang, Herbert C Morse, Charles E Egwuagu

“…Interferon Regulatory Factor-8 (IRF8) is constitutively expressed in monocytes and B cell lineages and plays important roles in immunity to pathogens and cancer. …”
Get full text

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. by Leonie Unterholzner, Rebecca P Sumner, Marcin Baran, Hongwei Ren, Daniel S Mansur, Nollaig M Bourke, Felix Randow, Geoffrey L Smith, Andrew G Bowie

“…PRRs activate both NF-κB and IFN regulatory factors (IRFs) to activate the IFN-β promoter induction. …”
Get full text

The Comparative Study of Platelet Rich Plasma (PRP) and Plasma Rich in Growth factor (PRGF) in Endometrial Thickness, Implantation Rate and Pregnancy Outcomes in IVF Patients by Mariyam Khan, Akash More, Namrata Anjankar

“…Background: Platelet-rich plasma (PRP) and Plasma Rich in Growth Factors (PRGF) are promising regenerative therapies aimed at enhancing endometrial thickness and improving in vitro fertilization (IVF) outcomes. …”
Get full text

Fatty liver index as a predictor of increased risk of cardiometabolic disease: finding from the Kuopio Ischaemic Heart Disease Risk Factor Study Cohort by Tomi-Pekka Tuomainen, Jussi Pihlajamäki, Olubunmi O. Olubamwo, Jyrki K. Virtanen, Pekka Mantyselka

“…The association of 4-year FLI increase with incident CMD was analysed in multivariable-adjusted Cox regression models, adjusting for baseline constitutional and lifestyle factors (model 1) and, in addition, metabolic and inflammation biomarker factors (model 2).Results During a mean follow-up of 15 years, 301 new CMD cases occurred. …”
Get full text

The Transcription Factor <i>ZmMYBR24</i> Gene Is Involved in a Variety of Abiotic Stresses in Maize (<i>Zea mays</i> L.) by Liangliang Bao, Wen Sun, Jiaxin Wang, Yuyang Zhou, Jiahao Wang, Qi Wang, Dequan Sun, Hong Lin, Jinsheng Fan, Yu Zhou, Lin Zhang, Zhenhua Wang, Chunxiang Li, Hong Di

“…MYB transcription factors constitute a diverse and functionally versatile family, playing central roles in regulating plant responses to a range of abiotic stressors. …”
Get full text

Risk factors and subtypes of ischemic strokes in young adults: A tertiary care hospital study from southern part of India by Konda M, Varalakshmi EA, Patil A, Kaul S, Yada PK, Jayasree M, Sitajayalakshmi S, Surath M

“…Males constituted 71.3% of cohort. Risk factors were alcohol abuse (39.63%), dyslipidemia (39.02%), hypertension (32.32%), smoking (27.44%), diabetes (25.61%), family history of stroke (23.78%) and past history of stroke (12.20%). …”
Get full text

Willingness and driving factors of rural homestead withdrawal in china’s major grain producing areas from the new quality productivity perspective by Huimin Zhou, Xuning Qiao, Yongju Yang, Jinyuan Zhang, Qianxi Zheng, Hongfei Gao, Yanwei Yan

“…Material needs and attachment to the countryside constitute two pivotal factors influencing farmers’ decisions to withdraw homesteads. …”
Get full text

Extraction and Association Analysis of Risk Factors in Gas Pipeline Network Emergencies Through Fusing Expert Knowledge and Pre-Trained Model by Xinghao Zhao, Yanzhu Hu, Xiaoyu Liu, Yingjian Wang

“…The gas pipeline network constitutes a critical component of urban infrastructure. …”
Get full text

S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease by Alexandru Schiopu, Ovidiu S. Cotoi

“…S100A8 and S100A9 (also termed MRP8 and MRP14) preferentially form the S100A8/A9 heterodimer (MRP8/14 or calprotectin) and are constitutively expressed in myeloid cells. The levels of circulating S100A8/A9 in humans strongly correlate to blood neutrophil counts and are increased by traditional cardiovascular risk factors such as smoking, obesity, hyperglycemia, and dyslipidemia. …”
Get full text

Exploring the Influencing Factors of Surface Ozone Variability by Explainable Machine Learning: A Case Study in the Basilicata Region (Southern Italy) by Roberta Valentina Gagliardi, Claudio Andenna

“…In this study, a methodological approach combining both supervised and unsupervised machine learning algorithms (MLAs) with the Shapley additive explanations (SHAP) method was used to understand the key factors behind O₃ variability and to explore the nonlinear relationships linking O₃ to these factors. …”
Get full text