Age-Related Changes in Gut Health and Behavioral Biomarkers in a Beagle Dog Population by Anna Fernández-Pinteño, Rachel Pilla, Jan Suchodolski, Emmanuelle Apper, Celina Torre, Anna Salas-Mani, Xavier Manteca

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Evaluating ginkgetin from Ginkgo biloba as a novel agent for sleep promotion through molecular docking and in vivostudies by Mir Behrad Aghazadeh Ghadim, Ebrahim Salimi-Sabour, Alireza Shahriari, Mahdi Niazi, Farideh Bahrami

“…Ultimately, the extracted compound (ginkgetin, a bioactive flavonoid from Ginkgo biloba) through molecular docking by considering the GABA A receptors will be evaluated through the in vivo method in an animal model to serve as proof for the findings from the molecular docking process.Materials and Methods: Utilizing a comprehensive approach, this research employed molecular docking to screen 2299 phytochemicals for their affinity towards the GABAA receptor, focusing on the GABA, benzodiazepine, and steroid-binding sites. …”
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Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling by Bulat Kenessov, Aset Muratuly

“…According to the two-layer model of evaporation, substantial positive effect of the vacuum can be expected for analytes with HLC lower than 1.6·10−4 atm m3 mol−1 (0.0065 at 25 °C), but the model does not consider possible effects of other important extraction parameters. …”
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Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation. by David J Huggins, Grahame J McKenzie, Daniel D Robinson, Ana J Narváez, Bryn Hardwick, Meredith Roberts-Thomson, Ashok R Venkitaraman, Guy H Grant, Mike C Payne

“…We employed inhomogeneous fluid solvation theory to consider the free energy of water molecules on the protein surface with respect to bulk water molecules. …”
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Interplay of polymorphisms in sex hormone receptors and facial sexual differentiation in shaping prosocial behavior by Claudia Rodriguez-Ruiz, Denisa Cristina Lupu, Ana Belen Fernandez-Martinez, Miguel Pita, Enrique Turiegano

“…However, these studies have never simultaneously considered the affinity of sex hormone receptors alongside variables such as sex-related facial morphology. …”
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Isolation, purification and molecular weight determination of serum immunoglobulin from silver carp Hypophthalmichthys molitrix by SUN Jun, GAO Qian, NIE Pin

“…Simultaneously, mannan-binding protein (MBP) affinity chromatography, saturated ammonium sulfate (SAS) sedimentation and TG affinity chromatography methods were also used to purify the serum IgM. …”
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Interaction profiling of cow milk metabolites against human Renin-Angiotensin System (RAS) proteins by Neelam Krishna, Shraddha Vishwakarma, Pramod Katara

“…The study attempts to find milk metabolites with high affinity towards RAS-proteins, and results from circumstances of interaction between them. …”
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PXR-dependant dysregulation of glucose metabolism induced by chronic exposure to NOAEL-level pesticide cocktail in mice by Yannick Dauwe, Lucile Marie, Marina Grimaldi, Patrick Balaguer, Yannick Lippi, Veronique Gayrard, Laila Mselli-Lakhal

“…Overall, the study underscores the need to consider cocktail effects in risk assessment.…”
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Characterization of Streptomyces Cell Surface by the Microbial Adhesion to Solvents Method by C. Zanane, S. Mitro, D. Mazigh, S. Lekchiri, T. Hakim, M. El Louali, H. Latrache, H. Zahir

“…This work has shown that these properties vary greatly depending on the Streptomyces strain. It is important to consider the change in physicochemical properties of surface cells with ionic strength when using Streptomyces in different bioprocesses.…”
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« Mon parent, ce nouvel ennemi ». Relations matrimoniales et intériorisation de l’Autre chez les Jebero d’Amazonie péruvienne by Ronan Julou

“…Nevertheless, the author shows that actual tensions aren’t linked to the identity of those outsiders but to the evolution of the relations between affines inside the village him-self. Those mutual accusations and conflicts reveal an underlying transformation of their way to conceive affinity : the affines, usually progressively absorbed by consanguinity, conserve their distances and reveal their otherness. …”
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Potential targets for the new anti-tuberculosis drug of the diarylquinoline group thiozonide by А. Yu. Savchenko, B. V. Shilov

“…Although some human proteins were also identified as potential targets for thiozonide, the affinity of thiozonide to these human targets is considered rather low.Conclusion. …”
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A 50-year-old woman with severe resting hypoxia not amendable to high-flow oxygen supplementation by Razi Even-dar, Reem Mhamid, Karwan Badarni, Evelyne Shabad, Yaron Bar-lavie, Yaniv Dotan

“…Conclusion: Haemoglobinopathies should be considered in the differential diagnosis of unexplained hypoxia. …”
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Interactive effects of microplastics and typical pollutants on the soil-plant system: a mini-review by Shahid Iqbal, Jianchu Xu, Heng Gui, Dengpan Bu, Sulaiman Almwarai Alharbi, Sehroon Khan, Sadia Nadir

“…At low concentrations, polyethylene, polypropylene, and polystyrene have low affinity to diazepam. In conclusion, serious ecological risks are associated with MPs and other pollutants' interactions to soil-plant system.…”
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Molecular docking and pharmacokinetic evaluations of curcumin-based scaffolds as MDM2-p53 inhibitors by Santosh Prasad Chaudhary Kurmi, Shankar Thapa, Dipanjan Karati

“…The stability of the protein–ligand complex was investigated using the imods server, which considers the higher flexibility of the complexes. …”
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Unveiling the Solvent Effect: DMSO Interaction with Human Nerve Growth Factor and Its Implications for Drug Discovery by Francesca Paoletti, Tjaša Goričan, Alberto Cassetta, Jože Grdadolnik, Mykola Toporash, Doriano Lamba, Simona Golič Grdadolnik, Sonia Covaceuszach

“…<b>Conclusions:</b> These results highlight the importance of considering solvent–protein interactions in drug discovery, as these low-affinity yet specific interactions can affect experimental outcomes and potentially alter the small molecules binding to the target proteins. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Since regulatory T (Treg) cells primarily express the high-affinity IL-2 receptor whereas naïve effector T and natural killer cells mainly express the low-affinity IL-2 receptor, CD25-blocking IL-2cx have traditionally been considered as potential cancer therapeutics, particularly in combination with immune checkpoint inhibitors (ICIs).Methods Stimulation of antigen-primed T cells by IL-2cx in the absence or presence of ICIs was evaluated through adoptive transfer of primed ovalbumin-specific T cells and analysis of expansion. …”
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The Use Of Mirtazapine As A Hypnotic by Francisca Magalhães Scoralick, Einstein Francisco Camargos, Otávio Toledo Nóbrega

“…Mirtazapine is a noradrenergic and specific serotonergic antidepressive agent that acts by antagonizing alpha-2 adrenergic receptors and blocking 5-HT2 and 5-HT3 receptors. It has high affinity for histamine H1 receptors, low affinity for dopaminergic receptors, and lacks anticholinergic activity. …”
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Evaluation of inhibitory efficacy of plantaricin JK against NSP1 from SARS-CoV-2 by in silico methods by Manisha Mandal, Shyamapada Mandal

“…Pln-JK had excellent interaction with NSP1 displaying binding affinity of 9.1 kcal/mol and KD value of 2.1 × 10−7. …”
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Aversion against machines with complex mental abilities: The role of individual differences by Andrea Grundke, Markus Appel, Jan-Philipp Stein

“…Overall, we conclude that certain individual differences play an important role in perceptions of machines with complex minds and should be considered in future research.…”
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Characterization of the Differences in Dissolved Organic Matter (DOM) Adsorbed on Five Kinds of Microplastics Using Multiple Methods by Xianshu Fu, Xiangliang Pan, Jun Chen, Mingzhou Zhang, Zihong Ye, Xiaoping Yu

“…Excitation-emission matrix-parallel factor analysis (EEM-PARAFAC) identified that tyrosine-like substances with high excitation in region IV and low excitation in region I were predominantly adsorbed on MPs, followed by tryptophan-like substances with low excitation in region II and protein-like substances in region IV, while humic- and fulvic-like substances in regions V and III, respectively, exhibited the least adsorption affinity. The findings underscored the critical need to comprehensively consider the interactions between MPs and DOM and their environmental impacts in pollution control strategies.…”
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