Development and biological characterization of the cyclic peptide cRGDTFI with potent binding affinity for integrins αvβ3 and αvβ5 by Yuji Yamada, Seiya Ohki, Masumi Matsunuma, Masaki Mishima, Mitsuhiro Takeda, Teppei Ikeya, Tomomi Furihata, Keisuke Hamada, Yamato Kikkawa, Motoyoshi Nomizu

“…Therefore, αvβ5 represents a promising target for therapeutic and diagnostic applications. Considering that the previously identified RGDTF motif has a high affinity for αvβ5, this study aimed to enhance αvβ5 affinity of RGDTF by designing cyclic RGDTF-containing peptides. …”
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A Special Role of Boolean Quadratic Polytopes among Other Combinatorial Polytopes by A. N. Maksimenko

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Soluble SARS-CoV-2 Spike glycoprotein: considering some potential pathogenic effects by Bruno Azzarone, Nadine Landolina, Francesca Romana Mariotti, Lorenzo Moretta, Enrico Maggi

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A novel mechanism and model of hydrogen isotope exchange in vacancy considering nuclear quantum effects by Qihang Liu, Fei Sun, Jipeng Zhu, Hai-Shan Zhou, Hongxiang Zong, Zhangcan Yang, Hong-Bo Zhou, Yasuhisa Oya, Yucheng Wu

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Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the <i>BCR-ABL</i> Gene: An Hierarchical Biochemoinformatics Analysis by Vitor H. da S. Sanches, Cleison C. Lobato, Luciane B. Silva, Igor V. F. dos Santos, Elcimar de S. Barros, Alexandre de A. Maciel, Elenilze F. B. Ferreira, Kauê S. da Costa, José M. Espejo-Román, Joaquín M. C. Rosa, Njogu M. Kimani, Cleydson B. R. Santos

“…LMQC04 presented better binding affinity (∆G = −12.2 kcal mol⁻¹ with a variation of ±3.6 kcal mol⁻¹) in relation to LMQC01. …”
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Region-based segmental swapping of homologous enzymes for higher cadaverine production by Seungjin Kim, Dae-yeol Ye, Hyun Gyu Lim, Myung Hyun Noh, Jae-Seong Yang, Gyoo Yeol Jung

“…Compared to the wild type CadA, structural modifications enhanced pH stability and improved the affinity of CadA toward pyridoxal 5-phosphate (PLP), its cofactor. …”
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…To fully utilize the potential of bpAbs for anti-HER2 drug development, it is crucial to consider formats that offer stability and high-yield production, along with a functional balance between the two epitopes. …”
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A Beautiful Bind: Phage Display and the Search for Cell-Selective Peptides by Babak Bakhshinejad, Saeedeh Ghiasvand

“…Furthermore, due to the often suboptimal binding affinity of peptides identified in phage display selections, this article discusses affinity maturation techniques, including random mutagenesis and rational design through structure–activity relationship (SAR) studies to optimize initial peptide candidates. …”
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Interval Economic Dispatch for Commercial Campus Integrated Energy System with Demand Response Considering Multiple Uncertainties by Xuan Sheng, Shunjiang Lin, Weikun Liang, Yue Pan, Mingbo Liu

“…Demand response (DR) is considered to be an effective way to bring significant economic benefit to the commercial campus integrated energy system (CCIES) due to the large amount of flexible cooling and electric vehicle (EV) charging loads. …”
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Evaluation of two Taenia solium cysticercal antigenic preparations (vesicular fluid and a glycoprotein fraction with affinity for lentil lectin) for the immunodiagnosis of neurocys... by Lisandra Akemi Suzuki, Cláudio Lúcio Rossi

“…OBJECTIVE: To evaluate the performance of two antigenic preparations (vesicular fluid - VF and a glycoprotein fraction, LLa-Gp fraction, purified from a whole parasite extract by lentil lectin affinity chromatography) from Taenia solium cysticerci for the immunodiagnosis of neurocysticercosis. …”
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Detection of the GH analogue somatrogon in doping control urine samples by means of LC-HRMS/MS by Katja Walpurgis, Andreas Thomas, Alexandra Rauer, Bettina Majer, Mitsuhiko Sato, Masato Okano, Maneera Al-Jaber, Wadha Abushareeda, Cristian-Gabriel Arsene, Hans Geyer, Mario Thevis

“…Within this follow-up project, this approach based on affinity purification, tryptic digestion, and LC-HRMS/MS was modified by implementing an additional ultrafiltration step to allow for the extraction of the intact drug and/or its metabolites from urine. …”
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Quantification of signal amplification for receptors: the Kd/EC50 ratio of full agonists as a gain parameter by Peter Buchwald, Peter Buchwald

“…., Kd &gt; EC50) is generally considered as evidence for the existence of “receptor reserve” or “spare receptors”. …”
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Calculated solvation and ionization energies for thousands of organic molecules relevant to battery design by Jan Weinreich, Konstantin Karandashev, Daniel Jose Arismendi Arrieta, Kersti Hermansson, O Anatole von Lilienfeld

“…For these calculations we used the COnductor-like Screening MOdel for Real Solvents (COSMO-RS) method; we additionally provide estimates of gas-phase atomization energies, as well as information about conformers considered during the COSMO-RS calculations, namely coordinates, energies, and dipole moments.…”
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Avaliação dos diferentes métodos de transformação para georreferenciar documentos cartográficos de 1812 e 1906 do Rio de Janeiro by Cláudio Chagas Figueiredo, Renato Fontes Guimarães, Paulo Márcio Leal de Menezes, Osmar Abilio de Carvalho Junior, Luiz Felipe Coutinho Ferreira da Silva

“…Thus, the development of an accurate georeferencing of ancient cartographic documents retrieved, became essential for urban development monitoring, considering the action of various actors involved, as the public policies adopted by governments, real estate speculation, the church's influence , among others, led to the current format of the Rio de Janeiro city. …”
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Resilient unit commitment against extreme cold events considering decision-dependent uncertainty-featured EV demand response by Wenqian Yin, Kun Zhuang, Pengcheng Fan, Zhengyang Sun, Jing Zhu, Jilei Ye

“…Specifically, first, we model how the temperature-sensitive EV charging loads change under extreme cold events considering the actual driving range and air conditioning load in EVs. …”
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Volt-ampere Characteristics of Metal-semiconductor Rectifier Diodes. Part 1: Formation of Conduction Currents and Displacement Currents at the <i>p–n</i> Junction by L. I. Gretchikhin

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A Multi-stage Scenario Tree Generation Method for Wind-Solar Load Based on Complex Feature Extraction and Sinkhorn Distance by Rui WANG, Zhixin FU, Jian WANG, Haoming LIU

“…The feature set of wind-solar load scenarios was clustered by using an improved affinity propagation algorithm based on density peak, and typical curves of wind-solar load were obtained as the root nodes of the scenario tree. …”
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Inversor of digits $Q^∗_2$-representative of numbers by M. V. Pratsiovytyi, Ya. V. Goncharenko, N. V. Dyvliash, S. P. Ratushniak

“…We consider structural, integral, differential properties of function defined by equality $$I(\Delta^{Q_2^*}_{\alpha_1\alpha_2...…”
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Robust Stochastic Dynamic Optimal Power Flow Model of Electricity-Gas Integrated Energy System considering Wind Power Uncertainty by Zhengfeng Qin, Xiaoqing Bai, Xiangyang Su

“…Then, the Wasserstein ambiguity set is affined to the eventwise ambiguity set, and the proposed RSO model is transformed into a mixed-integer programming model, which can be solved rapidly and accurately using commercial solvers. …”
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Motor Vehicle Brake Pad Wear—A Review by Ştefan Voloacă, Alexandro Badea-Romero, Francisco Badea-Romero, Marius Florin Toma

“…The paper offers an overview of the motor vehicle brake pad wear process. Considering the types of wear that occur between the pads and the disc, the study begins by presenting Archard’s fundamental wear law. …”
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