NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression and resistance to immunotherapy by modulating macrophages in urothelial bladder cancer by Jian Huang, Bo Wang, Dong Yan, Tianxin Lin, Lu Pei, Hao Yu, Wang He, Kaiwen Li, Meihua Yang, Weibin Hou, Honghui Zeng, Xin-Ke Zhang, Long Huang, Haide Qin

“…Elevated NNMT, specifically in CAFs, upregulates SAA expression and enhances the recruitment and differentiation of macrophages in the tumor microenvironment, thereby directly or indirectly promoting tumor progression and conferring resistance to immunotherapies in bladder cancer.…”
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Proton motive force and antibiotic tolerance in bacteria by Yingkun Wan, Jiaqi Zheng, Edward Wai‐Chi Chan, Sheng Chen

“…Previous works showed that bacterial antibiotic tolerance was attributed to the reduction in metabolic activities and activation of the stringent response, SOS response and the toxin–antitoxin system which down‐regulates transcription functions. The latest research findings, however, showed that decreased metabolic activities alone do not confer a long‐lasting tolerance phenotype in persisters, and that active defence mechanisms such as efflux and DNA repair are required for the long‐term maintenance of phenotypic tolerance. …”
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Identification and characterization of GLDC as host susceptibility gene to severe influenza by Jie Zhou, Dong Wang, Bosco Ho‐Yin Wong, Cun Li, Vincent Kwok‐Man Poon, Lei Wen, Xiaoyu Zhao, Man Chun Chiu, Xiaojuan Liu, Ziwei Ye, Shuofeng Yuan, Kong‐Hung Sze, Jasper Fuk‐Woo Chan, Hin Chu, Kelvin Kai‐Wang To, Kwok Yung Yuen

“…The higher expression of GLDC derived from genetic variations may confer a higher risk to H7N9 and severe H1N1 infection. …”
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The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study by Hiroyuki Tominaga, Ichiro Kawamura, Hirofumi Shimada, Hiromi Sasaki, Noboru Taniguchi, Yuki Shiratani, Akinobu Suzuki, Hidetomi Terai, Takaki Shimizu, Kenichiro Kakutani, Yutaro Kanda, Masayuki Ishihara, Masaaki Paku, Yohei Takahashi, Toru Funayama, Kousei Miura, Eiki Shirasawa, Hirokazu Inoue, Atsushi Kimura, Takuya Iimura, Hiroshi Moridaira, Hideaki Nakajima, Shuji Watanabe, Koji Akeda, Norihiko Takegami, Kazuo Nakanishi, Hirokatsu Sawada, Koji Matsumoto, Masahiro Funaba, Hidenori Suzuki, Haruki Funao, Tsutomu Oshigiri, Takashi Hirai, Bungo Otsuki, Kazu Kobayakawa, Koji Uotani, Hiroaki Manabe, Shinji Tanishima, Ko Hashimoto, Chizuo Iwai, Daisuke Yamabe, Akihiko Hiyama, Shoji Seki, Yuta Goto, Masashi Miyazaki, Kazuyuki Watanabe, Toshio Nakamae, Takashi Kaito, Hiroaki Nakashima, Narihito Nagoshi, Satoshi Kato, Shiro Imagama, Kota Watanabe, Gen Inoue, Takeo Furuya

“…In matched patients presenting primarily with spinal instability and pain, the addition of decompression did not appear to confer a significant functional benefit within 6 months postoperatively.…”
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Enzyme‐Responsive Nanoparachute for Targeted miRNA Delivery: A Protective Strategy Against Acute Liver and Kidney Injury by Songhang Li, Yuxuan Zhao, Xiaoying Lyu, Ye Chen, Tao Zhang, Shiyu Lin, Zhiqiang Liu, Xiaoxiao Cai, Taoran Tian, Yunfeng Lin

“…Abstract MicroRNA (miRNA)‐based therapy holds significant potential; however, its structural limitations pose a challenge to the full exploitation of its biomedical functionality. Framework nucleic acids are promising owing to their transportability, biocompatibility, and functional editability. …”
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Les enjeux du végétal dans une ville du « Sud »  by Mustapha El Hannani, Aude Nuscia Taïbi, Naïma Brabra, Sigrid Giffon

“…Gentrification has led to food production being abandoned to the benefit of recreational and aesthetic landscape functions.…”
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Influence of printing configuration on the resulting topology and antibacterial effectiveness of PVDF-graphene composites by Antrea Spanou, Karin Hjort, Ken Welch, Dan I. Andersson, Cecilia Persson

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ORGANIZATIONAL DESIGN AND CHANGE. THE EVOLUTION OF TRADE UNIONS ORGANIZATION FORMS IN ROMANIA AFTER 1989 by LUMINIŢA CRISTINA CIOCAN

“…Evolution of union organization forms in Romania after 1989” propose as subject of analyze a type of organization which, through its affiliation to the civil society and through its role conferred by low, becomes the key for the proper functioning of the labor market. …”
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FORMATION OF THE PERSONNEL DISTRIBUTION SYSTEM DURING THE FORMATION OF THE PARTY-STATE NOMENCLATURE IN THE 1920S-1930s: ON THE MATERIALS OF THE NORTH CAUCASUS by E. Tufanov

“…The Central government, through the system of personnel distribution, placed its personnel potential in leading positions in the party and Soviet institutions in the center and in the regions, ensured the implementation of the party's policy in Soviet society. The functions of the party apparatus in the ield of personnel distribution were the backbone element of the party-state model of the Soviet state.…”
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Dietary peptides in aging: Evidence and prospects by Khushwant S. Bhullar, Jianping Wu

“…With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. …”
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Sleeping sound with autism spectrum disorder (ASD): study protocol for an efficacy randomised controlled trial of a tailored brief behavioural sleep intervention for ASD by Harriet Hiscock, Cathrine Mihalopoulos, Nicole Papadopoulos, Emma Sciberras, Jane McGillivray, Lidia Engel, Matthew Fuller-Tyszkiewicz, Susannah T Bellows, Deborah Marks, Patricia Howlin, Nicole Rinehart

“…Sleep problems have been found to have a pervasive impact on a child’s socio-emotional functioning, as well as on parents’ psychological functioning. …”
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Safety and feasibility evaluation of planning and execution of surgical revascularisation solely based on coronary CTA and FFRCT in patients with complex coronary artery disease: s... by Daniele Andreini, Kaoru Tanaka, Hideyuki Kawashima, Ronny R Buechel, William Wijns, Torsten Doenst, Jonathon Leipsic, Gregg W Stone, Giulio Pompilio, Antonio L Bartorelli, Saima Mushtaq, Enrico Ferrari, Francesco Maisano, Mark La Meir, Johan De Mey, Ulrich Schneider, Ulf Teichgräber, Faisal Sharif, Robbert de Winter, Brian Thomsen, Charles Taylor, Campbell Rogers, Yoshinobu Onuma, Patrick W Serruys

“…Automatic non-invasive assessment of functional coronary anatomy complexity is also evaluated with FFRCT for functional Synergy Between percutaneous coronary intervention With Taxus and Cardiac Surgery Score assessment on CCTA. …”
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Spermatogenic Waves and Expression of AR and ERs in Germ Cells of Podarcis sicula by Mariailaria Verderame, Francesco Angelini, Ermelinda Limatola

“…The expression of the investigated receptors is peculiar in these cells that are positive in the middle-late pachytene stage of the meiotic prophase and negative in preleptotene. A possible functional role of the observed differences during spermatogenesis and in the spermatozoa is also discussed.…”
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Extracellular Vesicles in the Crosstalk of Autophagy and Apoptosis: A Role for Lipid Rafts by Agostina Longo, Valeria Manganelli, Roberta Misasi, Gloria Riitano, Tuba Rana Caglar, Elena Fasciolo, Serena Recalchi, Maurizio Sorice, Tina Garofalo

“…Lipid rafts are described to act as both physical and functional platforms during the early stages of autophagic and apoptotic processes. …”
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Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience by Mathilde S. Henry, Louis Gendron, Marie-Eve Tremblay, Guy Drolet

“…The roles of enkephalin transmission in the control of pain, physiological functions, like respiration, and affective disorders have been studied for more than 30 years. …”
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Yanomami skin microbiome complexity challenges prevailing concepts of healthy skin by Juliana Durack, Yvette Piceno, Hoang Vuong, Brian Fanelli, David A. Good, Nur A. Hasan, Manoj Dadlani, Larry Weiss, Julia Oh, Aleksandar D. Kostic, Thomas L. Dawson, Hortensia Caballero-Arias, Rita R. Colwell

“…These findings reveal that diverse, environmentally enriched microbiota may confer skin benefits that are overlooked in current models of healthy skin.…”
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A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment by Rui Liao, Yuequan Wang, Ziqi Lin, Yuting Wang, Hongyuan Zhang, Qin Chen, Shenwu Zhang, Jin Sun, Zhonggui He, Cong Luo

“…GSP not only readily forms nanoassembly with CTX, but also functions as a chemotherapeutic enhancer that unlocks an ultra-low-dose chemotherapeutic window. …”
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Oxygen vacancy-driven spin-transfer torque across MgO magnetic tunnel junctions by L. M. Kandpal, B. Taudul, E. Monteblanco, A. Kumar, K. Katcko, F. Schleicher, P. Gupta, S. Boukari, W. Weber, V. Da Costa, J. D. Costa, T. Bӧhnert, R. Ferreira, P. Freitas, M. Hehn, M. Alouani, P. K. Muduli, D. Lacour, M. Bowen

“…This should disrupt the status-quo on STT-MRAM R&D, by generating defect-specific research and new ideas to confer additional functionality to these next-generation electronic devices, as a nanoelectronics platform to industrialize quantum physics.…”
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Investigating the impact of electroconvulsive therapy on brain networks and sleep: an observational study protocol by Tamara Hershey, Masud Husain, Michael Green, Alyssa K Labonte, MohammadMehdi Kafashan, Orlandrea Hyche, R Edward Hogan, Tae Kim, Nuri B Farber, Ben Julian Agustin Palanca, Elliott Kraenzle, Aris Perez, Robby Greenspan, Allyson Quigley, Lucas Lebovitz, Sijia Zhao, Pilar Cristancho, Subha Subramanian, Logan Griffin, Paul Kang, Aditya Sehgal, Julie Schweiger

“…Graph-based network analyses of high-density EEG signals allow characterisation of functional networks locally in specific subnetworks and globally over large-scale functional networks. …”
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Rheumatoid Arthritis Real-world Cohort Study in China (ReALSA): protocol for a multicentre prospective, longitudinal cohort study by Long Zhang, Ying Yang, Lie Dai, Yingying Zhu, Jian-Zi Lin, Ze-Hong Yang, Qian-Hua Li, Zhi-Ming Ouyang, Hai-Jun Liu, Yao-Wei Zou, Kui-Min Yang, Li-Juan Yang, Ying-Qian Mo, Jian-Da Ma

“…Dissemination of results will occur via national and international conferences, in peer-reviewed journals, public conferences and social media.Trial registration number NCT06233929.…”
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