Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a m... by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

“…Findings will be disseminated through peer-reviewed journals and presented at scientific conferences.Trial registration number ISRCTN53507177.…”
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LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer by Wei Liu, Dong Wang, Qing Miao, Peilin Chen, Hongbing Liu, Jiawen Lv, Jie Yin, Jian Feng, Yong Song, Tangfeng Lv, Mingxiang Ye, Wenjie Yan, Liting Lv, Sutong Zhan

“…Background Loss-of-function mutations of liver kinase B (LKB1, also termed as STK11 (serine/threonine kinase 11)) are frequently detected in patients with non-small cell lung cancer (NSCLC). …”
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The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southea... by Eugene Messou, Marcel Yotebieng, Lukas Fenner, Helen Byakwaga, Stephany N Duda, Kara Wools-Kaloustian, Marie Ballif, Timothy R Sterling, Denise Evans, Annette H Sohn, Carolyn Bolton-Moore, Armel Poda, Olivier Marcy, Neelima Navuluri, Nathalie De Castro, Leslie A Enane, Thida Chanyachukul, Nana Mbonze, LaQuita R McDade, Marina Cruvinel Figueiredo, Jeremy Ross, Lameck Diero, Robert Akpata, Natalia Zotova, Aimee Freeman, Marie Flore Pierre, Dhanushi Rupasinghe, Martine Tabala, Robin Huebner

“…Findings from TB-SRN analyses will be shared with national TB programmes to inform TB programming and policy, and disseminated at regional and global conferences and other venues.…”
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Genetic Variation and Assessment of Seven Salt-Tolerance Genes in an <i>Indica</i>/<i>Xian</i> Rice Population by Yuanhang Cheng, Tao Wang, Yeying Wen, Xingfei Zheng, Haifeng Liu, Xiangsong Chen, Ying Diao, Zhongli Hu, Wenjie Feng, Zhaohui Chu

“…Natural variations conferring salt tolerance (ST) are of great value for breeding salt-tolerant rice varieties. …”
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Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines by Sujeethkumar Prithiviraj, Alejandro Garcia Garcia, Karin Linderfalk, Bai Yiguang, Sonia Ferveur, Ludvig Nilsén Falck, Agatheeswaran Subramaniam, Sofie Mohlin, David Hidalgo Gil, Steven J Dupard, Dimitra Zacharaki, Deepak Bushan Raina, Paul E Bourgine

“…We recently described the possibility to exploit custom human stem cell lines for eECM manufacturing. In addition to the conferred standardization, the availability of such cell lines opened avenues for the design of tailored eECMs by applying dedicated genetic tools. …”
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Study protocol: the ear–nose–throat (ENT) prospective international cohort of patients with primary ciliary dyskinesia (EPIC-PCD) by Andreas Anagiotos, Myrofora Goutaki, André Coste, Nagehan Emiralioglu, Amanda Harris, Andrea Burgess, Mieke Boon, Philipp Latzin, Jean François Papon, Eric G Haarman, Natalie Lorent, Yin Ting Lam, Mihaela Alexandru, Miguel Armengot, Emilie Bequignon, Ela Erdem, Sara-Lynn Hool, Bulent Karadag, Sookyung Kim, Ugur Ozcelik, Ana Reula, Jobst Roehmel, Christine van Gogh, Panayiotis Yiallouros, Soeren Marian Zappe

“…Collected data include diagnostic test results, results of ENT examinations, lung function measurements, information on management of ENT disease and patient-reported data on clinical symptoms and health-related quality of life (QoL). …”
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Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction by Xuhong Wang, Xuhong Wang, Xuhong Wang, Qi Zheng, Qi Zheng, Qi Zheng, Lingfeng Zha, Lingfeng Zha, Lingfeng Zha, Lingxue Zhang, Lingxue Zhang, Lingxue Zhang, Mingkai Huang, Mingkai Huang, Mingkai Huang, Si Zhang, Si Zhang, Si Zhang, Xuzhe Zhang, Xuzhe Zhang, Xuzhe Zhang, Qinlin Li, Qinlin Li, Qinlin Li, Xinglin Chen, Xinglin Chen, Xinglin Chen, Ni Xia, Ni Xia, Ni Xia, Min Zhang, Min Zhang, Min Zhang, Bingjie Lv, Bingjie Lv, Bingjie Lv, Jiao Jiao, Jiao Jiao, Jiao Jiao, Yuzhi Lu, Yuzhi Lu, Yuzhi Lu, Muyang Gu, Muyang Gu, Muyang Gu, Fen Yang, Fen Yang, Fen Yang, Jingyong Li, Jingyong Li, Jingyong Li, Nana Li, Nana Li, Nana Li, Xiang Cheng, Xiang Cheng, Xiang Cheng, Zihua Zhou, Zihua Zhou, Zihua Zhou, Tingting Tang, Tingting Tang, Tingting Tang

“…Crlf2-/- mice exhibited reduced survival and worsened cardiac function, increased interstitial fibrosis and cardiomyocyte cross-sectional area, and reduced CD31+ staining, with no change in the proportion of apoptotic cardiomyocytes within the border zone. …”
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A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes by Manyun Chen, Yilei Peng, Yuhui Hu, Zhiqiang Kang, Ting Chen, Yulong Zhang, Xiaoping Chen, Qing Li, Zuyi Yuan, Yue Wu, Heng Xu, Gan Zhou, Tao Liu, Honghao Zhou, Chunsu Yuan, Weihua Huang, Wei Zhang

“…Suppressing P. vulgatus growth with cefaclor or improving mitochondrial function using adenosylcobalamin may represent simple, safe, effective therapeutic strategies for addressing MMF.…”
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Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait a... by Teresa Liu-Ambrose, Eric Smith, Karen Messer, Pam Jarrett, Jennifer Walker, Louis Bherer, Andrew Lim, Nicole Anderson, Quincy J Almeida, Howard Feldman, Howard Chertkow, Nellie Kamkar, Manuel Montero-Odasso, Mark Speechley, Chris McGibbon, Grant Handrigan, Danielle Bouchard, Andrew M Sexton, Linda Yetman, Bryn Robinson, Stephanie Crapoulet, Ludivine Chamard-Witkowski, Laura Elizabeth Middleton, Manuel Montero Odasso, Sylvie Belleville, Haakon Nygaard, Danielle Alcock, Sarah Banks, Paul Brewster, Senny Chan, Marc Cuesta, Samir Das, Carol Evans, Guylaine Ferland, Tati Herold, Scott Hofer, Inbal Itzhak, Diane Jacobs, Jody-Lynn Lupo, Lisa Madlensky, Zia Mohades, Carolyn Revta, Julie Robillard, Penny Slack, Jingjing Zou, Carole C Tranchant

“…Introduction Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer’s disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. …”
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Peripheral blood immune cells from individuals with Parkinson's disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroid... by MacKenzie L. Bolen, Beatriz Nuñes Gomes, Blake Gill, Kelly B. Menees, Hannah Staley, Janna Jernigan, Nikolaus R. McFarland, Ellen M. Zimmermann, Christopher E. Forsmark, Malú Gámez Tansey

“…A mechanism linking chronic gut inflammation to iron dysregulation and mitochondrial function within peripheral immune cells has yet to be identified in conferring risk for PD. …”
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Impact of Acute Kidney Injury, Co-Existing with and without Chronic Kidney Disease on the Short&#x2010;Term Adverse Outcomes Following Atherosclerotic Cardiovascular Disease Events... by Chou CL, Zheng CM, Chiu HW, Tsou LLC, Kao PF, Hsu YH, Lin CL, Sung LC

“…Patients with DM who experienced the first ASCVD event were categorized by kidney function: no known kidney disease (NKD), AKI, CKD, and acute-on-CKD (AoCKD). …”
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Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression by Rui Cheng, Rui Cheng, Yuanjun Tang, Yuanjun Tang, Xuedi Cao, Xuedi Cao, Zhanya Huang, Zhanya Huang, Yunyun Guo, Yunyun Guo, Renjing Jin, Renjing Jin, Renjing Jin, Yan Wang, Yan Wang, Yang Liu, Yang Liu, Yang Liu, Lixiang Xue, Lixiang Xue, Lixiang Xue, Lixiang Xue, Yuqing Wang, Yuqing Wang

“…TRIM21 knockdown restored ID1 levels and promoted tumor cell function, whereas TRIM21 overexpression suppressed these malignant phenotypes and mitigated hypoxia-induced aggressiveness. …”
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Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice by Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier

“…The SYNT formulation reduced cell death, neuronal damage, and induced protective gene expression changes associated with neuronal protection and microglia modulation toward beneficial phenotype after TBI in vitro. In vivo, SYNT conferred similar long‐term functional benefits as CM, improving sensorimotor function up to 6 months and memory preservation at 4 months compared to saline‐treated animals, though only CM reduced contusion volume at 5 months. …”
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Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains by Diana Esparza, Carinna Lima, Sarah Abuelreich, Ima Ghaeli, Jinhee Hwang, Eunjin Oh, Ayelet Lenz, Angel Gu, Nan Jiang, Fouad Kandeel, Debbie C. Thurmond, Tijana Jovanovic-Talisman

“…Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and platelets, a phenotype also observed in a mouse model of T1D. …”
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A rare germline mutation reverses the suppressive effect of GPC5 thereby promoting lung adenocarcinoma development and tumorigenesis by Zhifa Zheng, Zhifa Zheng, Zhifa Zheng, Zhifa Zheng, Lina Zhao, Lina Zhao, Lina Zhao, Lina Zhao, Sen Zhao, Zhihong Wu, Zhihong Wu, Zhihong Wu, Nan Wu, Nan Wu, Nan Wu

“…Functional characterization demonstrated that compared to wild-type, the mutant variant conferred aggressive oncogenic properties: significantly enhanced proliferative capacity, impaired apoptosis induction, and markedly increased migratory potential. …”
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Prognostic and predictive importance of body mass index and type 2 diabetes in the European Organisation for Research and Treatment of Cancer 1325/KEYNOTE-054 phase III trial of pe... by Oliver John Kennedy, Nina Glassee, Michal Kicinski, Emanuel Bührer, Sara Valpione, Sara Gandini, Stefan Suciu, Christian U. Blank, Georgina V. Long, Victoria G. Atkinson, Stéphane Dalle, Andrew M. Haydon, Andrey Meshcheryakov, Adnan Khattak, Matteo S. Carlino, Shahneen Sandhu, James Larkin, Susana Puig, Paolo A. Ascierto, Piotr Rutkowski, Dirk Schadendorf, Marye Boers-Sonderen, Anna Maria Di Giacomo, Alfonsus J.M. van den Eertwegh, Jean-Jacques Grob, Ralf Gutzmer, Rahima Jamal, Alexander C.J. van Akkooi, Caroline Robert, Alexander M.M. Eggermont, Paul Lorigan, Mario Mandala

“…Background: Metabolic conditions, such as obesity and type 2 diabetes mellitus (T2DM), cause changes in immune function that may influence immunotherapy effectiveness and immune-related adverse events (irAEs). …”
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Aerosol inhalation of dimeric artesunate phospholipid-conjugated liposomes ameliorates inflammation, fibrosis, and ferroptosis in neonatal mice with hyperoxia-induced lung injury by Rong Guan, Rong Guan, Yu Chen, Qianqian Yu, Qianqian Yu, Bingrui Yu, Shuyu Chen, Siyuan Jia, Huifang Wang, Huaiping Cheng, Zhaofang Tian

“…This research examines the function and fundamental processes of dimeric artesunate phospholipid-conjugated liposomes (Di-ART-GPC) in BPD. …”
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Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…Although the N-terminal kinase domain of JSS1_004 is known to inhibit DndFGH through phosphorylation-dependent inactivation, the functional role of its C-terminal shutoff domain remained enigmatic. …”
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Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways by Mingyu Zhang, Xiaoxiang Guan, Zheng Dong, Chenxu Yang, Chao Xiong, Wenzheng Cheng, Aijing Shang, Yaru Liu, Xiaofei Guo, Bowen Zhang, Bo Zhang, Saidi Jin, Wenyi Qi, Berezhnova Tatjana Alexandrovna, Yuan Jiang, Zhimin Du, Chaoqian Xu

“…This study aims to investigate the regulatory function of Zfp36 in ferroptosis within the context of cardiac hypertrophy. …”
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The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study by Michael K Stickland, Stephen Lam, Hasina Samji, Sarah Svenningsen, Rachel L Eddy, Don D Sin, Rafael Meza, Xuan Li, Jonathon Leipsic, Ana I Hernandez Cordero, Julia Yang, Theo J Moraes, Joanna MacLean, Shawn Aaron, Jonathan H Rayment, Simon Couillard, Terence Ho, Clarus Leung, Laura L Struik, Heather Drew, Paloma Burns, Satvir S Dhillon, Jordan Guenette, Trisha Tulloch, Tina Afshar, Brandon Zanette, Giles Santyr, François-Pierre Counil, Sheila Matano, Giulia de Arruda Maluf, Carmen Feng, Lydia Bal, Harnoor Dhaliwal, Adeola Mumuni, Caitlyn Lui, Janice M Leung

“…Participants will undergo respiratory questionnaires, pulmonary function tests, oscillometry, cardiopulmonary exercise testing, hyperpolarised 129-xenon gas MRI and blood collection. …”
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