Oltre il topos letterario: il locus amoenus come spazio vissuto nei dialoghi ciceroniani - Beyond the Literary Topos: the Locus Amoenus as Inhabited Space in Cicero's Dialogues by Valentina Calcò

“…Descriptions of the locations in which philosophical dialogues are set serve more than an ornamental function, adding an essential element to the discourse. …”
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Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…The durable antitumor function was attributed to the optimal CAR tonic signaling that conferred CAR-T cells with autonomous activation, proliferation, survival and cytokine release in the absence of antigen stimulation. …”
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Identification of a novel aminoglycoside nucleotidyltransferase gene in Morganella morganii from farm sewage by Junwan Lu, Jing Wang, Mengdi Gao, Kexin Zhou, Jialei Liang, Chunhan Song, Xuying He, Chaoqun Liu, Huiyue Feng, Wei Pan, Qiyu Bao, Chunxia Yan, Dawei Huang

“…The protein AadA37 exhibited the highest amino acid identity (57.14%) with the functionally characterized aminoglycoside adenylyltransferase AadA33. aadA37 confers resistance to spectinomycin, streptomycin and ribostamycin, and enzyme kinetic analysis also demonstrated that it had adenosine transfer activities against spectinomycin and streptomycin, with k cat/K m values of 0.66 × 103 M− 1 s− 1 and 1.63 × 103 M− 1 s− 1, respectively. …”
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Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurodegeneration in glaucoma through ahr/rage pathway by Ning Wang, Chengyang Sun, Yijie Yang, Dandan Zhang, Lulu Huang, Chenrui Xu, Minghan Wang, Mengmeng Xu, Tongtong Yan, Yue Wu, Li Xu, Yahan Ju, Hao Sun, Wenyi Guo

“…In in vivo and in vitro models, B. fragilis or IAA restored AhR activation, suppressed inflammation by inhibiting microglial activation and the release of pro-inflammatory mediators throughout the retina, reduced retinal ganglion cells (RGCs) loss and preserved visual function. Mechanistically, IAA attenuated RAGE/NF-κB pathway activation via AhR-dependent signaling, conferring neuroprotection. …”
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Contribution of Fc-dependent cell-mediated activity of a vestigial esterase-targeting antibody against H5N6 virus infection by Zhiqiang Zheng, Su Hui Catherine Teo, Suganya Cheyyatraivendran Arularasu, Zhehao Liu, Nur Khairiah Mohd-Ismail, Chee Keng Mok, Chee Bing Ong, Justin Jang-hann Chu, Yee-Joo Tan

“…Collectively, these findings reveal the importance of ADCC/ADCP function for 9F4-WT protection against HPAIV H5N6 and demonstrate the potential of 9F4 to confer protection against the reassortant H5-subtype HPAIVs.…”
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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational... by Yi Guo, Dongyu Zhang, Rafael Meza, Jihyoun Jeon, Dejana Braithwaite, Gerard A Silvestri, Michael K Gould, Jiang Bian, Bruno Hochhegger, Shama D Karanth, Christopher G Slatore, Martin Tammemagi, Mattthew Schabath, Meghann Wheeler, Frederic J Kaye

“…We will fit a multivariable logistic regression model to estimate the adjusted ORs of comorbidity, functional limitations and impaired pulmonary function adjusted for relevant covariates. …”
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Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment by Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic, Andrew Gumbert, Jack Bergman, Preston Ge, Myriam Heiman, Marie-Eve Di Raddo, Sarah L. Withey, Bertha K. Madras, Susan R. George

“…Background: Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. …”
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Helicobacter pylori γ-glutamyltransferase is linked to proteomic adaptions important for colonization by Sonja Fuchs, Michaela K. Fiedler, Nicole Heiduk, Andreas Wanisch, Cora Mibus, Dharmesh Singh, Aleksandra W. Debowski, Barry J. Marshall, Michael Vieth, Christine Josenhans, Sebastian Suerbaum, Stephan A. Sieber, Markus Gerhard, Raquel Mejías-Luque

“…Although some studies addressed potential functional mechanisms, the supportive role of gGT for in vivo colonization remains unclear. …”
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Systematic literature review and trial-level meta-analysis of aromatase inhibitors vs tamoxifen in patients with HR+/HER2− early breast cancer by Wolfgang Janni, Michael Untch, Nadia Harbeck, Joseph Gligorov, William Jacot, Stephen Chia, Jean-François Boileau, Subhajit Gupta, Namita Mishra, Murat Akdere, Andriy Danyliv, Giuseppe Curigliano

“…Methods: A systematic literature review was conducted using key medical literature databases (eg, PubMed; inception to October 2023) and data from conferences (to December 2023). Phase 3 randomized controlled trials (RCTs) that had ≥80 % of patients with HR+/HER2− EBC (or available subgroup data) and reported a disease-free survival (DFS) hazard ratio for AI vs TAM were included in the meta-analysis, regardless of menopausal status and ovarian function suppression (OFS) use. …”
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Safety and tolerability of a single infusion of autologous ex vivo expanded regulatory T cells in adults with ulcerative colitis (ER-TREG 01): protocol of a phase 1, open-label, fa... by Carola Berking, Raja Atreya, Markus F Neurath, Sebastian Zundler, Britta Siegmund, Gerold Schuler, Francesco Vitali, Caroline J Voskens, Diane Stoica, Susanne Roessner, Marita Rosenberg, Manuel Wiesinger, Jutta Wunder, Beatrice Schuler-Thurner

“…The results will be published in peer-reviewed scientific journals and disseminated in scientific conferences and media.Trial registration number NCT04691232.…”
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DL-Tryptophan Alleviates Sepsis-Related Acute Liver Injury via AhR Activation by Li B, Wang Q, Hu L, Duan W, Chen Y, Wang Z, Liu C, Liao L

“…Western blotting was utilized to verify AhR expression, and its function was subsequently investigated using the AhR inhibitor CH223191.Results: DL-tryptophan markedly reduced the expression of pro-inflammatory cytokines (IL-6, TNF-α, IL-1β) and liver damage markers (AST, ALT) in CLP-induced sepsis. …”
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αAsarone alleviates neuronal injury by facilitating autophagy via miR-499-5p/PDCD4/ATG5 signaling pathway in ischemia stroke by Yonghuan Yan, Linfang Wu, Lu Wang, Dandan Wang, Mengting Huang, Jinyong Peng, Jinyong Peng, Yingying Huang, Yingying Huang, Yingying Huang

“…To further clarify the protective effect of αAsarone in vivo, TTC staining, neurological function score, H&E staining, Nissl staining, Laser speckle contrast imaging, transmission electron microscopy, immunofluorescence colocalization, WB and RT-qPCR were performed in the MCAO mice.ResultsαAsarone was observed to inhibit the apoptosis of neuronal cells, and enhance autophagy. …”
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Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis by Weiping Xiao, Yibing Yang, Lu Bai, Peixuan Yang, Runze Li, Daizhi Yang, Fanying Li, Lingzhi Quan, Qiupeng Liang, Yan Yan, Tiewei Qi, Feng Liang

“…These changes led to improvements in memory, motor function, and anxiety- and depression-like behaviors. …”
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A novel mechanism for A-to-I RNA-edited CYP1A1 in promoting cancer progression in NSCLC by Zhipeng Wang, Yan Wu, Ziqi Ding, Xinru Xiao, Yanhua Huang, Zhiguang Liu, Qian Zhang

“…This specific RNA editing, regulated by ADAR1, resulted in gain-of-function phenotypes characterized by enhanced tumor progression and more aggressive behavior. …”
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Towards Prepared mums (TOP-mums) for a healthy start, a lifestyle intervention for women with overweight and a child wish: study protocol for a randomised controlled trial in the N... by Luc J I Zimmermann, Régine P M Steegers-Theunissen, Yvon E G Timmermans, Kim D G van de Kant, Dorien Reijnders, Lina M P Kleijkers, Edward Dompeling, Boris W Kramer, Marc E A Spaanderman, Anita C E Vreugdenhil

“…Furthermore, exploratory outcomes include body composition, cardiometabolic alterations, time to pregnancy, need for assisted reproductive technologies, perinatal complications of mother and child, and lung function of the child. Vaginal and oral swabs, samples of faeces, breast milk, placenta and cord blood will be stored for evaluation of microbial flora, epigenetic markers and breast milk composition. …”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II): protocol of a feasibility randomised controlled trial by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…Outcomes assessed at baseline and 7 weeks include gross level of disability, arm function, spasticity, pain, fatigue and quality of life (QoL). …”
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Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…TXNIP inhibits the disulfide reductase enzymatic activity of thioredoxin (Trx), impairing its antioxidant function and, ultimately, leading to the disruption of cellular redox homeostasis. …”
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Protocol for an observational study to identify potential predictors of an acute exacerbation in patients with chronic obstructive pulmonary disease (the PACE Study) by Klaus Kenn, Paul W Jones, Carmen Schade-Brittinger, Rainer Gloeckl, Daniela Leitl, Tessa Schneeberger, Inga Jarosch, Wolfgang Hitzl, Peter Alter, Bernd Sczepanski, Sandra Winterkamp, Martina Boensch, Chrysanthi Skevaki, Olaf Holz, Claus F Vogelmeier, Andreas R Koczulla

“…The results will be presented in conferences and published in a peer-reviewed journal.Trial registration number NCT04140097.…”
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In Silico Design and Characterization of a Multiepitope Vaccine Candidate Against Brucella canis Using a Reverse Vaccinology Approach by Vicente Arriagada, Alberto Osorio, Crisleri Carrera-Naipil, Carlos A. Villacis-Aguirre, Cristian Escobar, Nicolás Morales, Danthe Villa, Lien Mardones, Dafne Pérez, Macarena Jara, Raúl E. Molina, Ítalo Ferrari, Sebastián Azocar, Leonardo A. Gómez, Ángel A. Oñate

“…Selection criteria emphasized their essential roles in bacterial function, lack of homology with proteins from dogs or mice, and presence of fewer than two transmembrane domains. …”
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Immune cell phenotypes as causal factors in liver disease progression revealed by Mendelian randomization by Jingtao Huang, Wenlu Zou, Zhihua Lv, Huan Han, Jiapeng Huang, Hanwen Su

“…Similarly, higher levels of HLA DR on CD14− CD16+ monocyte (OR 0.84, 95% CI 0.78–0.91; P  =  2.07 × 10− 5, P FDR = 1.32 × 10− 3) conferred lower risk for cirrhosis of liver. In hepatic failure, CD39+ resting CD4 regulatory T cell count (OR 0.85, 95% CI 0.79–0.92; P  =  1.70 × 10− 5, P FDR = 5.25 × 10− 3) played a protective role and CD28+ CD45RA− CD8dim T cell/CD8dim T cell (OR 1.14, 95% CI 1.06–1.22; P  =  2.63 × 10− 4, P FDR = 0.0406) exhibited a risk function. …”
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