Clinical effect of ePRO-based symptom monitoring and management on improving survival outcomes in patients with advanced cancer: a single-centre, prospective, randomised controlled... by Yan Wang, Yi He, Zimeng Li, Lili Song, Lili Tang, Ying Pang, Yening Zhang, Zhongge Su

“…There is some evidence that electronic symptom monitoring and management can improve patients’ physical function, symptom control, quality of life and survival outcomes. …”
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Effectiveness of resistance training of masticatory muscles for patients with temporomandibular disorders: protocol for a systematic review by Deborah Falla, Filippo Maselli, Giacomo Asquini, Andrea Giusti, Giulia Pisacane, Giovanni Galeoto, Firas Mourad, Paolo Bizzarri, Edoardo Balli, Cecilia Bagnoli, Anna Manzari, Marco Pernici

“…Resistance training (RT) has been shown to be effective at reducing pain and improving function for different musculoskeletal conditions (eg, neck pain, low back pain); however, the effectiveness of RT for patients with TMDs remains unclear. …”
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Integrative multi-omics analysis of radionuclide-induced intestinal injury reveals the radioprotective role of L-citrulline through histone H3-mediated Cxcl3 by Ping Yang, Hao Bai, Tao Yan, Xiaopeng Xu, Xiaoyou Tang, Bin Song, Yulan Liu, Yunyun Lu, Pengfei Liu, Wenling Tu, Yuhong Shi, Shuyu Zhang

“…A multi-omics analysis was employed to access alterations in gut microbiota, fecal and colonic metabolites profiles, and intestinal mRNA expression post-irradiation. The function of significant metabolite was validated at both cellular levels and organismal levels. …”
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Effectiveness and safety of nintedanib in prevention of pulmonary fibrosis induced by bleomycin in malignant ovarian germ cell tumour: study protocol for a randomised, double-blind... by Jie Yang, Tianyu Zhang, Xinyue Zhang, Jiaxin Yang, Sijian Li, Min Yin, Rundong Zhang

“…The secondary outcomes are the decline of other pulmonary function indices (forced expiratory volume in 1 s; FVC pred%, carbon monoxide diffusion capacity) and the patients’ QoL, oncological and fertility outcomes. …”
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Counselling for physical activity, life-space mobility and falls prevention in old age (COSMOS): protocol of a randomised controlled trial by Pekka Kannus, Ari Heinonen, Harri Sievänen, Lasse Kannas, Timo Rantalainen, Johanna Edgren, Saija Karinkanta, Taina Rantanen, Robin Daly, Timo Törmäkangas, Sarianna Sipilä, Outi Teittinen, R Nikander

“…Maintaining lower extremity muscle function with good balance has been associated with fewer falls and the need of help from others. …”
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Optical correction of hyperopia in school-aged children: a scoping review protocol by Su-Hsun Liu, Tawna L Roberts, Gayathri Srinivasan, Kristen L Kerber, Vivian M Manh, Kristine Huang, Alexandra Williamson, Soumen Sadhu, Morgan C Ollinger, Zahra Tajbakhsh, Jennifer H Fisher, Nathan L Cheung, Jasmine Junge, Kevin C H Chan, Jameel Rizwana Hussaindeen, Patrick Simard, Kelsey R Trast, Christina E Morettin, Samantha Krueger, Augustine N Nti, Debora M Lee Chen

“…We will exclude studies associated with myopia control treatments, ocular and visual pathway pathologies affecting vision or visual function. We will search Cochrane CENTRAL, Embase.com and PubMed. …”
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Near-infrared spectroscopy to monitor cerebral and renal oxygen saturation during cardiopulmonary bypass surgery for paediatric congenital heart disease: study protocol for a prosp... by Fang Wang, Jianmin Zhang, Lei Hua, Xiaoxue Wang, Zhengzheng Gao, Lijing Li, Zhangke Guo

“…Background Current indicators for monitoring intraoperative organ function remain predominantly indirect, delayed and non-specific, particularly in paediatric populations undergoing congenital heart surgery, where multifactorial influences further complicate functional assessments. …”
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Protocol of a randomised controlled trial to assess medical staff’s inhalation exposure to infectious particles exhaled by patients during oesophagogastroduodenoscopy and the effic... by Li Liu, Aiming Yang, Xi Wu, Shengyu Zhang, Zhiyu Yan, Yuheng Zhang, Mengjie Duan

“…The results will be disseminated through presentations at national and international conferences and publications in peer-reviewed journals.Trial registration number NCT05321056.…”
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Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised... by Job F. M. van Boven, Boudewijn H.J. Dierick, Maria Achterbosch, Sandra Been-Buck, Titia Klemmeier, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks

“…Study findings will be disseminated through conferences and peer-reviewed scientific and professional journals.Trial registration number NL9637.…”
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UPDATE trial: investigating the effects of ultra-processed versus minimally processed diets following UK dietary guidance on health outcomes: a protocol for an 8-week community-bas... by Rachel Batterham, Chris van Tulleken, Abigail Fisher, Friedrich C Jassil, Janine Makaronidis, Samuel Dicken, Kevin Hall, Adrian Carl Brown, Claudia A.M Gandini Wheeler-Kingshott

“…Peer-reviewed journals, conferences, PhD thesis and lay media will report results.Trial registration number NCT05627570…”
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Differential resilience of chickpea’s reproductive organs to cold stress across developmental stages: insights into antioxidant strategies for enhanced fertility by Deeksha Padhiar, Sarbjeet Kaur, Uday Chand Jha, P. V. Vara Prasad, Kamal Dev Sharma, Sanjeev Kumar, Swarup Kumar Parida, Kadambot H. M. Siddique, Harsh Nayyar

“…This study aimed to investigate the specific responses of anthers and ovules to cold stress, explore the role of oxidative stress and antioxidant mechanisms, and understand the relationship between oxidative stress and reproductive function to enhance our understanding of chickpea responses to cold stress. …”
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Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization by Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo

“…Fusion to the N-terminus of an RTX908 antigen derived from CyaA enabled an accelerated folding of the pertactin passenger domain (rPrn) in function of calcium loading of the RTX908 moiety and conferred on the rPrn-RTX908 fusion antigen a superior capacity to induce functional anti-Prn IgG antibodies. …”
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Insulin‐Like Growth Factor 2 mRNA‐Binding Protein 2 (IGF2BP2) Promotes Castration‐Resistant Prostate Cancer Progression by Regulating AR‐V7 mRNA Stability by Taruna Saini, Devesh Srivastava, Rajnikant Raut, Parul Mishra, Ashish Misra

“…AR‐V7 is critical for castration‐resistant prostate cancer (CRPC) development and progression; however, the molecular mechanisms regulating its expression and biological function remain poorly understood. Here, we investigate the role of IGF2BP2 in regulating AR‐V7 expression and CRPC progression. …”
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Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis by Abdullah Q. Alsaedi, Abdullah Q. Alsaedi, Manar A. Nader, Manar A. Nader, Dalia H. El-Kashef, Marwa E. Abdelmageed, Marwa E. Abdelmageed

“…Additionally, Mang attenuated DEX-induced alterations in liver function parameters and improved serum lipid profiles, oxidative stress, and antioxidant biomarkers. …”
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MAPK, PI3K/Akt Pathways, and GSK-3β Activity in Severe Acute Heart Failure in Intensive Care Patients: An Updated Review by Massimo Meco, Enrico Giustiniano, Fulvio Nisi, Pierluigi Zulli, Emiliano Agosteo

“…In the context of AHF, understanding the dual role of this pathway is crucial, as it functions both as a marker of compensatory adaptation and as a potential therapeutic target. …”
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Synthesizing the Academic Administrators’ Competencies: Developing of a Model by Homa Rahmani, Asadollah Khadivi

“…</p> <ol style="text-align: left;" start="3"> <li><strong>Methodology</strong></li> </ol> <p style="text-align: left;">The current research serves a functional purpose, employing a qualitative approach. …”
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Prevalence and Correlates of Neurocognitive Disorders among HIV Patients on Antiretroviral Therapy at a Kenyan Hospital by A. G. Mugendi, M. N. Kubo, D. G. Nyamu, L. M. Mwaniki, S. K. Wahome, J. E. Haberer

“…HIV-associated neurocognitive disorders (HAND) represent a spectrum of cognitive abnormalities affecting attention, concentration, learning, memory, executive function, psychomotor speed, and/or dexterity. Our objectives in this analysis are to determine the prevalence of HAND and the covariates in a Kenyan population. …”
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Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the... by Jing Cheng, Qi Cheng, Yingting Wu, Jiashun Yin, Fei He

“…Subgroup analyses demonstrated a consistent inverse TyG-BMI-mortality association across all strata (age, cardiac function, comorbidities), with pronounced risk reduction in HFrEF (LVEF ≤40%; all-timepoint HR >1, p<0.05) and patients without prior myocardial infarction (365-day aHR 0.69 vs. 0.81 with infarction). …”
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MOTIVATIONAL COMPONENT AS A SUCCESS TO ORGANIZE AN INDEPENDENT WORK OF STUDENTS AT THE DEPATMENT OF THERAPEUTIC DENTISTRY by Yu. V. Sidash

“…The above-mentioned conditions for the development of independence in the conditions of a credit-module system together with pedagogical means, forms and methods of teaching provide a developing personality function during educational activities. …”
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Comparison of robotic-assisted and laparoscopic-assisted surgery in the treatment of children with Hirschsprung's disease: a systematic review and meta-analysis by Zikang Li, Wanfu Li, Haojun Wang, Mengxue Xu

“…Egger's test and funnel plot analysis indicated no significant publication bias (P = 0.987).ConclusionsRAS confers advantages in reducing intraoperative blood loss and shortening hospital stay, although it is associated with a longer operative duration. …”
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