Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice by Lia J. Zallar, Jean K. Rivera-Irizarry, Peter U. Hamor, Irena Pigulevskiy, Ana-Sofia Rico Rozo, Hajar Mehanna, Dezhi Liu, Jacqueline P. Welday, Rebecca Bender, Joseph J. Asfouri, Olivia B. Levine, Mary Jane Skelly, Colleen K. Hadley, Kristopher M. Fecteau, Scottie Nelson, John Miller, Pasha Ghazal, Peter Bellotti, Ashna Singh, Lauren V. Hollmer, David W. Erikson, Jacob Geri, Kristen E. Pleil

“…Abstract Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for alcohol use disorder in women than men, and binge alcohol drinking is correlated with high estrogen levels, but a causal role for estrogen in driving alcohol drinking has not been established. …”
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CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer by Dorian V. Ziegler, Kanishka Parashar, Lucia Leal-Esteban, Jaime López-Alcalá, Wilson Castro, Nadège Zanou, Laia Martinez-Carreres, Katharina Huber, Xavier Pascal Berney, María M. Malagón, Catherine Roger, Marie-Agnès Berger, Yves Gouriou, Giulia Paone, Hector Gallart-Ayala, George Sflomos, Carlos Ronchi, Julijana Ivanisevic, Cathrin Brisken, Jennifer Rieusset, Melita Irving, Lluis Fajas

“…While CDK4 is known for its role in cell proliferation, its metabolic function in cancer, particularly in triple-negative breast cancer (TNBC), remains unclear. …”
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ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy by Caitlin M. Miller, James H. Morrison, Laura Bankers, Rachael Dran, Julia M. Kendrick, Emma Briggs, Virginia L. Ferguson, Eric M. Poeschla

“…Picornavirus RdRptg mice have an unusual constitutive MDA5 activation state, with very high lifelong MDA5-mediated ISG expression that confers robust protection from diverse lethal viruses. …”
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Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies by Wei Yan, Wei Yan, Yang Chen, Yang Chen, Dong Yan, Dong Yan, Jie Zhang, Jie Zhang, Ming Xian Chang, Ming Xian Chang

“…Functional assays demonstrated that gcTrim47 overexpression in CIK cells reduced viral titers and suppressed VIB formation, with SPRY domain deletion ablating these effects. …”
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Crohn’s disease therapeutic dietary intervention (CD-TDI): study protocol for a randomised controlled trial by Subrata Ghosh, Levinus A Dieleman, Christopher Ma, Ian Lewis, Herman W Barkema, Humberto Jijon, Kathy D McCoy, Georgios V Gkoutos, Maitreyi Raman, Lorian M Taylor, Jeff K Vallance, Derek M McKay, David M Mutch, Deanna Gibson, Marcus Rauch

“…Study findings will be presented at national and international conferences, submitted for publication in abstracts and manuscripts, shared on social media and disseminated through patient-education materials.Trial registration number NCT04596566.…”
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The effect of home-based behavioural weight loss combined with pelvic floor muscle training in women seeking weight loss combined with stress urinary incontinence: protocol for a r... by Wei Chen, ZhiJing Sun, Zhao Tian, Xiuqi Wang, Linru Fu, Zhe Du, Tangdi Lin

“…All results from the study will be submitted to international journals and international conferences.Trial registration number This trial has been registered with the Chinese Clinical Trial Registry (ChiCTR2400084015).…”
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A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants by Celio Cabral Oliveira, Eduardo Bassi Simoni, Mariana Abrahão Bueno Morais, Elizabeth Pacheco Batista Fontes, Pedro A. Braga dos Reis, Daisuke Urano, Alan M. Jones

“…This study presents the novel function of a highly conserved, known phosphorylation site, Ser278, within this linker region utilizing molecular dynamics (MD) simulations with in vivo experimental validation. …”
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Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes by Madison C. B. Paton, Alexandra R. Griffin, Remy Blatch-Williams, Annabel Webb, Frances Verter, Pedro S. Couto, Alexey Bersenev, Russell C. Dale, Himanshu Popat, Iona Novak, Megan Finch-Edmondson

“…We conducted a scoping review of published and registered reports of MSC treatment for CP, with meta-analysis of Gross Motor Function Measure (GMFM) outcomes to summarize research and provide future recommendations. …”
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miRNA Expression: I/R Cardiomyocyte and Sevoflurane by José Luis Guerrero-Orriach, Maria Dolores Carmona-Luque, Guillermo Quesada Muñoz, Maria Jose Rodriguez Capitán

“…Conclusions: Sevoflurane-induced miRNAs overexpression confers cardioprotection through various mechanisms at the DNA level and the different signaling pathways levels, such as Akt/ERK.…”
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A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1 by Trina Saha, Dipanjan Karati

“…Such isoform imbalance can interfere with neuronal function and play a role in AD pathogenesis, making it essential to target BIN1 splicing regulation as a therapeutic modality. …”
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Efficacy of DaXianXiong Decoction in Preventing the Progression of Acute Pancreatitis Severity: Protocol for a Randomized Controlled Trial by Dongsheng Ren, Judan Tan, Yuling Zhou, Zhenchun Luo

“…The study results will be presented at both national and international conferences and published in peer-reviewed journals. …”
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Application of T1 MRI in takotsubo cardiomyopathy by Liene Balode, Robert Kelly, David Gamble, Dana Dawson, James Ross

“…The regions of interest were selected manually by defining the endocardial and epicardial borders of the myocardium and using the American Heart Association 17-segment model.3 Cardiac function and T1ρ maps of basal, mid and apical segments were analysed. …”
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Assay of Serum Iron and TIBC: A Preliminary Study for Survey Shortlisting Suspected Tuberculosis Patients by Dipak Kumar Chattopadhyay

“…All the subjects in this study had normal liver function tests and they did not suffer from iron overload diseases or any malabsorption of iron syndrome. …”
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HIP fracture Supplemental Therapy to Enhance Recovery (HIPSTER): a protocol for a randomised controlled trial by Belinda J Gabbe, Ian A Harris, Graham Hepworth, Richard Page, Ilana N Ackerman, Anthony Harris, Anne E Holland, Justine M Naylor, Christina L Ekegren, Angela T Burge, Maame Esi Woode, Eleanor Raper, Lara A Kimmel

“…Physical rehabilitation plays a key role in regaining physical function and independence; however, there are no recommendations regarding the optimal intensity. …”
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Efficacy and safety of once-daily single-inhaler triple therapy for mild-to-moderate chronic obstructive pulmonary disease: a study protocol for a randomised and interventional stu... by Hiromasa Inoue, Ayako Takamori, Atsushi Kawaguchi, Takashi Kinoshita, Kazuhiro Yatera, Koichiro Takahashi, Tomotaka Kawayama, Hiroki Tashiro, Koichi Takagi, Kei Yamasaki, Kentaro Machida

“…The results will be disseminated through scientific peer-reviewed publications and domestic and international medical conferences.Trial registration numbers UMIN000046812 and jRCTs031190008.…”
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Seasonal and Species‐Level Water‐Use Strategies and Groundwater Dependence in Dryland Riparian Woodlands During Extreme Drought by Jared Williams, John C. Stella, Michael Bliss Singer, Adam M. Lambert, Steven L. Voelker, John E. Drake, Jonathan M. Friedman, Lissa Pelletier, Li Kui, Dar A. Roberts

“…Our results suggest that both species functioned as facultative phreatophytes that used shallow soil moisture when available but ultimately relied on groundwater to maintain physiological function during drought. …”
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Protocol for the RETHINK study: a randomised, double-blind, parallel-group, non-inferiority clinical trial comparing acetaminophen and NSAIDs for treatment of chronic pain in elder... by Tempei Miyaji, Mototsugu Shimokawa, Hiroyuki Aono, Sadamoto Zenda, Makoto Endo, Yasuharu Nakashima, TOSHIHIKO HARA, Shinya Kawahara, Taishi Sato, Masami Tokunaga, Taro Mawatari, Tsutomu Kawano, Sanae Sakamoto, Toshio Takano, Masumi Miyake

“…The results of the study will be submitted to international peer-reviewed journals, and the main findings will be presented at international scientific conferences.Trial registration number jRCTs071200112.…”
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Impact of suspected preterm labour in foetal cardiovascular and metabolic programming: a prospective cohort study protocol by Daniel Oros, Jon Schoorlemmer, Cristina Paules, Jesús Gonzalez, Marta Fabre, Sara Ruiz-Martínez, Lina Youssef, Natalia Abadía-Cuchí, Marcos Clavero-Adell, Ana Medel-Martinez, Ariadna Ayerza-Casas, Juan Lerma-Irureta, Pilar Maestro-Quibus, Jesús Rodriguez-Calvo, Diego Lerma

“…Study outcomes will be disseminated at international conferences and published in peer-reviewed scientific journals.Trial registration number NCT05670665.…”
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Influence of a structured, 1-year-long dietary intervention regarding body composition and cardiovascular risk (ARCTIC) in coeliac disease: a protocol of a multicentre randomised c... by Zsolt Szakács, Nelli Farkas, Judit Bajor, Nándor Faluhelyi, Krisztina Hagymási, Zsófia Vereczkei, Míra Zsófia Peresztegi, Klára Lemes, Sarolta Dakó, Eszter Dakó, Szilvia Lada, Gábor Szekeres, Gyula Pásztor, Gabriella Pár, Emese Mezősi

“…Findings will be disseminated at research conferences and in peer-reviewed journals.Trial registration number NCT05530070…”
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Effects of azithromycin in young adults with cystic fibrosis: a protocol for emulating a published randomised controlled trial using registry data by Bin Huang, Rhonda Szczesniak, Lutz Naehrlich, Freddy Frost, Gwyneth Davies, Sanja Stanojevic, Susan Charman, Nicole Mayer-Hamblett, Emily Granger, Alex Gifford, Josh Ostrenga, Jonathan Todd, Susan Christine Charman, Elizabeth Cromwell, Nicole Mayer Hamblett, Ruth Keogh, Josh Osttrenga

“…The results of this study will be published in a peer-reviewed journal and presented at relevant scientific conferences.…”
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