Genomic insights into the plasmidome of non-tuberculous mycobacteria by Margo Diricks, Florian P. Maurer, Viola Dreyer, Ivan Barilar, Christian Utpatel, Matthias Merker, Nils Wetzstein, Stefan Niemann

“…The annotated plasmids varied widely in length (most between 10 and 400 kbp) and gene content, with many genes having an unknown function. Predicted gene functions primarily involved plasmid replication, segregation, maintenance, and mobility. …”
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Effectiveness of a virtual reality-based sensory stimulation intervention in preventing delirium in intensive care units: a randomised-controlled trial protocol by Yong Liu, Dan Luo, Taoxue Wen, Surui Liang, Mingxin He, Jinfei Tian

“…Results will be disseminated through scientific publications, and presentations at local and international conferences.Trial registration number ClinicalTrials.gov NCT06153472. …”
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Tumor Initiation and Progression in People Living on Antiretroviral Therapies by Seun E. Olufemi, Daniel A. Adediran, Temitope Sobodu, Isaac O. Adejumo, Olumide F. Ajani, Elijah K. Oladipo

“…Firstly, while ART restores immune function, it does not fully normalize it. Chronic immune activation and persistent inflammation continue to be prevalent, creating a conducive environment for oncogenesis. …”
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How and why do participatory women’s groups (PWGs) improve the quality of maternal and child health (MCH) care? A systematic review protocol by Rebecca Evans, Sarah Larkins, Karen Carlisle, Judy Taylor, Robyn Preston, Sam Rannard, Catrina Felton-Busch, Karla Canuto, Michelle Redman-MacLaren, Nalita Nungarrayi Turner, Lee Yeomans, Emma Sanguineti, Megan Passey, Jane Farmer

“…We aim to demonstrate how PWGs function and why PWG interventions contribute to social and health outcomes.Methods and analysis The protocol will follow Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. …”
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How to measure the effectiveness of recovery community centers: insights gained from a nationwide survey of directors of RCCs by Bettina B. Hoeppner, Bettina B. Hoeppner, Alivia C. Williamson, Hazel Simpson, Diadora DeCristofaro, Catherine Weerts, Marion J. Riggs, Allison Futter, Amy A. Mericle, Philip X. Rutherford, Lauren A. Hoffman, Vinod Rao, Patty McCarthy, Julia Ojeda, Susanne S. Hoeppner, Susanne S. Hoeppner

“…Close collaboration with RCCs is needed to ensure that research on the effectiveness of RCCs is congruent with how RCCs function and seek to confer benefit.…”
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A digital programme to prevent falls and improve well-being in people living with dementia in the community: the KOKU-LITE feasibility randomised controlled trial protocol by Emma Stanmore, Jaheeda Gangannagaripalli, Emma Vardy

“…‘Keep On Keep Up’ (KOKU) is a National Health Service-approved gamified, digital health programme designed to maintain function and reduce falls through strength and balance exercises (Fitness and Mobility Exercise/OTAGO Exercise Programme (OTAGO)), and health literacy games. …”
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(Cost-)effectiveness of lower extremity nerve decompression surgery in subjects with diabetes: the DeCompression (DECO) trial—study protocol for a randomised controlled trial by Manuel Castro Cabezas, Erwin Birnie, Willem D Rinkel, Tirzah M Fakkel, J Henk Coert

“…Dissemination of results will be via journal articles and presentations at national and international conferences.Trial registration number NetherlandsTrial Registry NL7664.…”
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Variations in flanking or less conserved positions of Reb1 and Abf1 consensus binding sites lead to major changes in their ability to modulate nucleosome sliding activity by Fernanda Raiqueo, Roberto Amigo, José L. Gutiérrez

“…To determine the molecular functions that require long dwell times and the transcription factors responsible for these tasks will significantly contribute to untangle the grammar of cis-regulatory elements.…”
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The partial clinical remission phase of type 1 diabetes: early-onset dyslipidemia, long-term complications, and disease-modifying therapies by Benjamin Udoka Nwosu, Benjamin Udoka Nwosu

“…No therapy confers complete β-cell protection at any of the 3 stages of type 1 diabetes (T1D). …”
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Systematic Review and Meta-Analysis of Chicory Inulin-Type Fructans Supplementation on Weight Management Aspects by Yoghatama Cindya Zanzer, Stephan Theis

“…Increasing evidence from in vivo mechanistic and clinical studies has shown that the gut microbiota is interacting with the host's physiological function in regulating energy intake and body weight. …”
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Adaptive Sliding Mode Control of a Boost Converter With Unknown Constant Power Load by David A. Zambrano-Prada, Abdelali El Aroudi, Oswaldo Lopez-Santos, Luis Vazquez-Seisdedos, Luis Marti-Nez-Salamero

“…The estimation procedure is based on the integral of an odd-symmetric function of the output voltage error, which confers an adaptive nature to the switching regulator. …”
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Efficacy of biofeedback, repetitive transcranial magnetic stimulation and pelvic floor muscle training for female neurogenic bladder dysfunction after spinal cord injury: a study p... by Qing Zhang, Li Chen, Chengqi He, Feng Xiong, Lin Xu, Chenying Fu, Lihong Peng, Zejun Liang, Quan Wei

“…The results of this study will be accessible in peer-reviewed publications and be presented at academic conferences.Trial registration number Chinese Clinical Trial Registry (ChiCTR1900026126).…”
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Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice by Shi-Long Zhang, Bing Han, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, You Wu, Guo-Qiang Chen, Li-Shun Wang

“…Here, we show that the gut microbiota from healthy individuals conferred considerable sensitivity to anti-PD-1 in the colorectal cancer (CRC) tumor-bearing mice, whereas gut microbiota from CRC patients failed to do so. …”
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RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure by Konstantinos Ioannidis, Paul Wilkinson, Paul Fletcher, Samantha N Sallie, Laura Moreno-López, Muzaffer Kaser, Katja Schueler, Adrian Dahl Askelund, Lorinda Turner, Anne-Laura van Harmelen, Alicia J Smith, Camilla Nord, Eugenia M Davidson, Nadia González-García, Oksana Berhe, Rosalie Shrofer, Sofia Orellana, Sophie L Bellow, Suzanne Schweizer

“…We will use dimension reduction techniques (principal component analysis) on standard-normally transformed individual parameters of mental health, social functioning and CA to calculate a composite measure of adaptive (ie, ‘resilient’) psychosocial functioning. …”
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Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics by Jiachen Liu, Zihan Li, Zebin Deng, Yinhuai Wang, Fei Deng

“…Among these, loss-of-function mutations in AT targets SLC6A2 and SLC6A4 showed significant associations after multiple-testing correction with pancreatic cancer and erythematous conditions, respectively. …”
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Efficacy and safety of left bundle branch area pacing versus right ventricular apex pacing in patients with atrioventricular block: study protocol for a randomised controlled trial by Junjun Chen, Liting Cheng, Junmeng Zhang, Zefeng Wang, Zhuo Liang, Jieruo Chen, Yongquan Wu, Xiao Du, Ruiqing Dong, Fei Hang, Xinlu Wang, Ziyu Wang

“…The results of the trial will be presented at national and international conferences. We hypothesise that compared with RVAP, LBBaP will be superior for treating patients with AVB. …”
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PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications by Man Zheng, Yeting Li, Lei Gu, Chunyan Xiang, Xiaoning Li, Shanshan Li, Nannan Li, Hongtao Lan, Fenglei Zhang

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Effectiveness of a school-based high-intensity interval training intervention in adolescents: study protocol of the PRO-HIIT cluster randomised controlled trial by Yong Liu, Alan R. Barker, Anna-Lynne R. Adlam, Minghui Li, Stephanie L. Duncombe, Andrew O. Agbaje, Yaodong Gu, Huiyu Zhou, Craig A. Williams

“…Results from PRO-HIIT study will be disseminated via peer-reviewed journals, scientific conferences as well as local education system. The study protocol has been retrospectively registered on ClinicalTrials.gov Protocol Registration and Results System (NCT06374732), https://clinicaltrials.gov/study/NCT06374732.…”
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Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway by Xiaoyan Bi, Xinhui Huang, Chunmei Zhang, Xin Zhao, Junyu Ma, Mengyao Li, Xuexun Li, Bangzhao Zeng, Rong Li, Xian Zhang, Fuli Ya

“…Pharmacological inhibition revealed that the beneficial effects of SFN on platelet function were mediated mechanistically through AR downregulation, which attenuated p53 phosphorylation via Src-dependent ROS generation.ConclusionThese findings suggest that by inhibiting the Src/ROS/p53 signaling pathway and mitigating AR-mediated platelet dysfunction, SFN may confer significant protection against atherothrombosis during hyperglycemia.…”
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Identification of Candidate Genes for Cold Tolerance at Seedling Stage by GWAS in Rice (<i>Oryza sativa</i> L.) by Huimin Shi, Wenyu Zhang, Huimin Cao, Laiyuan Zhai, Qingxin Song, Jianlong Xu

“…The findings from this study provide valuable resources for enhancing rice’s ability for CT while laying a foundation for the future cloning of novel genes involved in conferring CT.…”
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