Antifatigue effect of okara protein hydrolysate supplementation during cycling exercise in men: a pre-post uncontrolled pilot study by Yu-Jou Chien, Jung-Piao Tsao, Chun-Tse Tsai, I-Shiung Cheng, Chin-Lin Hsu

“…Additionally, postexercise insulin sensitivity was increased after treatment.Conclusions This study showed that OPH supplementation can promote endurance in exercise by decreasing the accumulation of fatigue-related metabolites during exercise and can promote energy recovery by increasing insulin function. These findings suggest that OPH has an antifatigue property.…”
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Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats by Azza A. K. El-Sheikh, Mohamed A. Morsy, Ahlam M. Abdalla, Azza H. Hamouda, Ibrahim A. Alhaider

“…MTX caused deterioration in kidney and liver function, namely, blood urea nitrogen, creatinine, alanine aminotransferase, and aspartate aminotransferase. …”
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Myokines and Their Potential Protective Role Against Oxidative Stress in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by José Luis Bucarey, Isis Trujillo-González, Evan M. Paules, Alejandra Espinosa

“…This review focuses on discussing the roles of specific myokines in activating intracellular signaling pathways within the liver, which confer protection against steatosis and lipid peroxidation. …”
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Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms. by Isao Miyairi, Jesse Ziebarth, Jonathan D Laxton, Xiaofei Wang, Nico van Rooijen, Robert W Williams, Lu Lu, Gerald I Byrne, Yan Cui

“…We have previously demonstrated that polymorphisms in immunity-related GTPases (IRG) confer a significant difference in susceptibility to Chlamydia psittaci infection in BXD recombinant mice. …”
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Rotator cuff unloading versus loading exercise program in the conservative treatment of patients with rotator cuff tear: protocol of a randomised controlled trial by Ann Cools, Larissa Pechincha Ribeiro, Paula Rezende Camargo

“…The findings of the trial will be disseminated through peer-reviewed journals and scientific conferences.Trial registration number NCT03962231.…”
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Surgical Stress Abrogates Pre-Existing Protective T Cell Mediated Anti-Tumor Immunity Leading to Postoperative Cancer Recurrence. by Abhirami A Ananth, Lee-Hwa Tai, Casey Lansdell, Almohanad A Alkayyal, Katherine E Baxter, Leonard Angka, Jiqing Zhang, Christiano Tanese de Souza, Kyle B Stephenson, Kelley Parato, Jonathan L Bramson, John C Bell, Brian D Lichty, Rebecca C Auer

“…This effect is secondary to both reduced proliferation and impaired T cell function following antigen binding. In a prophylactic model, surgical stress completely abrogates tumor protection conferred by vaccination in the immediate postoperative period. …”
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Versatility of vimentin assemblies: From filaments to biomolecular condensates and back by Dolores Pérez-Sala, Silvia Zorrilla

“…Cytoskeletal structures shape and confer resistance to cells. The intermediate filament protein vimentin forms versatile structures that play key roles in cytoskeletal crosstalk, in the integration of cellular responses to a variety of external and internal cues, and in the defense against stress. …”
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Strategies occupational therapists employ to facilitate work-related transitions for persons with hand injuries: a study protocol for a scoping review by Michelle Elizabeth Uys, Helen Buchanan, Lana Van Niekerk

“…The findings will be presented at conferences to ensure the optimal dissemination of the scoping review’s conclusions.…”
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Light directs zebrafish period2 expression via conserved D and E boxes. by Gad Vatine, Daniela Vallone, Lior Appelbaum, Philipp Mracek, Zohar Ben-Moshe, Kajori Lahiri, Yoav Gothilf, Nicholas S Foulkes

“…The LRM contains E- and D-box elements that are critical for its function. While the E-box directs circadian clock regulation by mediating BMAL/CLOCK activity, the D-box confers light-driven expression. …”
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Unveiling the biological effects of radio-frequency and extremely-low frequency electromagnetic fields on the central nervous system performance by Ramin Eskandani, Mohammad Ismail Zibaii

“…Moreover, ELF-EMR exposure alters hippocampal function, notch signaling pathways, the antioxidant defense system, and synaptic activities. …”
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Efficient physical embedding of topologically complex information processing networks in brains and computer circuits. by Danielle S Bassett, Daniel L Greenfield, Andreas Meyer-Lindenberg, Daniel R Weinberger, Simon W Moore, Edward T Bullmore

“…Here we follow historic intuition that all physical information processing systems will share key organizational properties, such as modularity, that generally confer adaptivity of function. It has long been observed that modular VLSI circuits demonstrate an isometric scaling relationship between the number of processing elements and the number of connections, known as Rent's rule, which is related to the dimensionality of the circuit's interconnect topology and its logical capacity. …”
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Two receptor-targeting mechanisms of lambda-like siphophage Gifsy-1 of Salmonella Typhimurium. by Xiaoli Zeng, Wenyu Wang, Dekang Zhu, Mafeng Liu, Mingshu Wang, Renyong Jia, Shun Chen, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Bin Tian, Xumin Ou, Di Sun, Yu He, Zhen Wu, Anchun Cheng, Xinxin Zhao

“…This study intriguingly identified a shift in the receptor role of the core oligosaccharide in Gifsy-1 infection, which confers Gifsy-1 adaptation to OPS switching. The adaptability of the two targeting-mechanisms contributes to the understanding of the biological functions of Gifsy-1 and provides a blueprint for engineering phage therapy against multidrug-resistant Salmonella enterica.…”
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Gene drives for schistosomiasis transmission control. by Theresa Maier, Nicolas James Wheeler, Erica K O Namigai, Josh Tycko, Richard Ernest Grewelle, Yimtubezinash Woldeamanuel, Katharina Klohe, Javier Perez-Saez, Susanne H Sokolow, Giulio A De Leo, Timothy P Yoshino, Mostafa Zamanian, Jutta Reinhard-Rupp

“…Success in this arena is a function of many factors, including gene-editing specificity and efficiency, the level of resistance conferred by the gene drive, how fast gene drives may spread in a metapopulation over a complex landscape, ecological sustainability, social equity, and, ultimately, the reduction of infection prevalence in humans. …”
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Hearing loss in newborn infants with hypoxic ischaemic encephalopathy: protocol for a case–control study by Narendra Aladangady, Sujith Pereira, Milton D'costa

“…Systemic circulation may be affected due to poor myocardial function. The cochlear hair cells are vulnerable to changes in microcirculation, which may occur in HIE predisposing to hearing loss. …”
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Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. by Carsten Gründemann, Kathrin Thell, Karin Lengen, Manuel Garcia-Käufer, Yen-Hua Huang, Roman Huber, David J Craik, Gernot Schabbauer, Christian W Gruber

“…Furthermore, treatment with [T20K] kalata B1 led to an initial reduction of the effector function, as indicated by the reduced IFN-γ and TNF-α production, but the levels of both cytokines stabilized over time and returned to their normal levels. …”
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Depression of lncRNA NEAT1 Antagonizes LPS-Evoked Acute Injury and Inflammatory Response in Alveolar Epithelial Cells via HMGB1-RAGE Signaling by Hongchao Zhou, Xinhui Wang, Bin Zhang

“…High levels of the long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) have been positively correlated with increased severity and unfavorable prognoses in patients with sepsis. Nevertheless, the function and molecular mechanism of NEAT1 in ALI remain elusive. …”
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Migratory microbiomes: the role of the gut microbiome in bird migration eco‐physiology by Pablo Capilla‐Lasheras, Alice Risely

“…In this review, we synthesize current knowledge of gut microbiome composition and function during migration, outline possible mechanisms by which changes in the gut microbiome could benefit migrants, and identify future research priorities. …”
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Adipokines as Cardioprotective Factors: BAT Steps Up to the Plate by Keely McLeod, Victoria Datta, Scott Fuller

“…Given the overwhelming burden of cardiometabolic disease, further study of the functions of BAT and its secretome is warranted and will intensify in the future.…”
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Age-specific correlation between thyroid hormone concentrations and ultrasound thyroid volume for diagnosing thyroid dysfunction in preterm infants: a single-centre, prospective, o... by Renata Bokiniec, Aleksandra Mikołajczak, Katarzyna Kufel

“…Findings will be published in a peer-reviewed journal and disseminated at relevant national and international conferences.Trial registration number NCT04208503.…”
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Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome. by Tom Stiff, Meryem Alagoz, Diana Alcantara, Emily Outwin, Han G Brunner, Ernie M H F Bongers, Mark O'Driscoll, Penny A Jeggo

“…Mutations in ATR, which also functions during replication, can cause Seckel syndrome, a clinically related disorder. …”
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