IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection. by William G C Horsnell, Matthew G Darby, Jennifer C Hoving, Natalie Nieuwenhuizen, Henry J McSorley, Hlumani Ndlovu, Saeeda Bobat, Matti Kimberg, Frank Kirstein, Anthony J Cutler, Benjamin Dewals, Adam F Cunningham, Frank Brombacher

“…In this study, B cell function in protective T(H)2 immunity against N. brasiliensis infection was investigated. …”
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Acute Alcohol Tissue Damage: Protective Properties of Betaine by Lucy Petagine, Hannah Everitt, Victor Preedy, Roy Sherwood, Vinood Patel

“…Herein, we investigated how acute ethanol affects juvenile hepatic cells through changes in oxidative stress, apoptosis, and liver function, as well as the ability of betaine, which can replen-ish the antioxidant glutathione and mitigate oxidative injury. …”
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Analysis of Clade V MLO Gene Expressions in Hazelnut Leaves upon Exposure to Powdery Mildew by Ulku Baykal, Kadriye Özcan

“…This fungal disease causes significant economic losses by reducing the yield and quality of hazelnuts. Loss-of-function mutations in the mildew resistance locus o (MLO) gene family of many plants confer high levels of broad-spectrum resistance to powdery mildew. …”
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Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing's Sarcoma. by Sonja J Gill, Jon Travers, Irina Pshenichnaya, Fiona A Kogera, Syd Barthorpe, Tatiana Mironenko, Laura Richardson, Cyril H Benes, Michael R Stratton, Ultan McDermott, Stephen P Jackson, Mathew J Garnett

“…PARP inhibitors have efficacy in tumors with BRCA1/2 mutations, which confer deficiency in DNA double-strand break (DSB) repair by homologous recombination (HR). …”
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The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women by Duke Appiah, Richard N. Baumgartner

“…The apolipoprotein ε4 allele conferred almost a threefold elevated risk of mortality (HR = 2.76, CI: 1.42–5.37). …”
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TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3 by Haojie Qin, Yi Zhong, Jinhui Huang, Yanli Miao, Meng Du, Kai Huang

“…These findings unveil a novel function for TRIM56 in adipocyte browning, suggesting its potential as a therapeutic target for the treatment of metabolic disorders.…”
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Mechanism for microbial population collapse in a fluctuating resource environment by Serdar Turkarslan, Arjun V Raman, Anne W Thompson, Christina E Arens, Mark A Gillespie, Frederick von Netzer, Kristina L Hillesland, Sergey Stolyar, Adrian López García de Lomana, David J Reiss, Drew Gorman‐Lewis, Grant M Zane, Jeffrey A Ranish, Judy D Wall, David A Stahl, Nitin S Baliga

“…Abstract Managing trade‐offs through gene regulation is believed to confer resilience to a microbial community in a fluctuating resource environment. …”
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The histone core domain evolves at single-residue resolution to directly orchestrate transcription by Zachary H. Harvey, Kathryn M. Stevens, Jian Yi Kok, Akihisa Osakabe, Jiaying Liu, Tobias Warnecke, Frédéric Berger

“…We identified single-residue substitutions within the ultra-conserved core domain loop 2 (L2) of H2A.Z as sufficient to confer emergent properties and drive neofunctionalization. …”
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Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae. by Michelle Heacock, Vladimir Poltoratsky, Rajendra Prasad, Samuel H Wilson

“…In providing a 5'-dRP group removal function mediated by dRP lyase activity of Pol β, the effects of the 5'-dRP group were separated from those of the multinucleotide flap itself. …”
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Leishmania major Dihydrolipoyl dehydrogenase (DLD) is a key metabolic enzyme that drives parasite proliferation, pathology and host immune response. by Somtochukwu S Onwah, Zhirong Mou, Gaurav Gupta, Patience Obi, Nnamdi Ikeogu, Ping Jia, Wen-Wei Zhang, Saeid Ghavami, Ayesha Saleem, Jude Uzonna

“…Dihydrolipoyl dehydrogenase (DLD), a mitochondrial enzyme involved in oxidizing lipoamides to facilitate electron transfer for energy production and metabolism, plays a critical role in virulence of fungi and bacteria. However, its function in Leishmania virulence and pathogenesis remains unexplored. …”
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Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans. by Sarah K Torzone, Aaron Y Park, Peter C Breen, Natalie R Cohen, Robert H Dowen

“…Here, we demonstrate that DRL-1 and FLR-4, which share similarity with mammalian mitogen-activated protein kinases, maintain lipid homeostasis in the C. elegans intestine. DRL-1 and FLR-4 function in a protein complex at the plasma membrane to promote development, as mutations in drl-1 or flr-4 confer slow growth, small body size, and impaired lipid homeostasis. …”
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Conversion Rate of Abstracts Presented at the Société Internationale d’Urologie into Peer-Reviewed Journal Publications by Amandeep Virk, Scott Leslie, Nariman Ahmadi, Ruban Thanigasalam, Norbert Doeuk, Henry Woo

“…The abstract book assigned presentation topic groups to the moderated ePoster category; the most published abstract topic was sexual function (68.75%, 11 of 16). ConclusionsThe conversion rate of abstracts presented at the SIU to publications in peer-reviewed journals has shown improvement since previous reports; however, it remains lower than the rates associated with other major urological conferences. …”
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Plant-specific cochaperone SSR1 affects root elongation by modulating the mitochondrial iron-sulfur cluster assembly machinery. by Xuanjun Feng, Yue Hu, Tao Xie, Huiling Han, Diana Bonea, Lijuan Zeng, Jie Liu, Wenhan Ying, Bona Mu, Yuanyuan Cai, Min Zhang, Yanli Lu, Rongmin Zhao, Xuejun Hua

“…To elucidate the molecular function of SHORT AND SWOLLEN ROOT1 (SSR1), we screened for suppressors of the ssr1-2 (sus) was performed and identified over a dozen candidates with varying degrees of root growth restoration. …”
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Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…Most people with CF experience progressive lung function loss over their lifetime, and lung disease is the primary cause of death for people with CF. …”
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Convergent evolution of a mobile bony tongue in flighted dinosaurs and pterosaurs. by Zhiheng Li, Zhonghe Zhou, Julia A Clarke

“…Furthermore, only in the latter two taxa does the bony tongue structure include elongation of paired hyobranchial elements that have been associated in functional studies with hyolingual mobility. Pterosaurs and enantiornithine birds achieve similar elongation and inferred mobility via elongation of ceratobranchial elements while within ornithurine birds, including living Aves, ossified and separate paired epibranchial elements (caudal to the ceratobranchials) confer an increase in hyobranchial length. …”
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The Human Exersome Initiative (HEI): Rationale, study design, and protocol. by Daria Neyroud, Julia Primavesi, Guia Tagliapietra, Chantal Daucourt, Hector Gallart-Ayala, Raphael Gottardo, Julijana Ivanisevic, Aaron L Baggish

“…Habitual physical activity and exercise training (PA/EX) confers numerous health-benefits. Phenotypic adaptations and clinical health outcomes attributable to PA/EX are well-established, and molecular markers and mediators of the PA/EX response have been described. …”
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LSP1 promotes the progression of acute myelogenous leukemia by regulating KSR/ERK signaling pathway and cell migration by Tan Li, Xiaochen Gui, Bin Li, Xueying Hu, Yuanyin Wang

“…In this study, we established shLSP1 cell line to analyze the function of LSP1 in AML. We observed high expression of LSP1 in AML patients, whereas it showed no expression in normal adults. …”
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Loss of correlated proteasomal subunit expression selectively promotes the 20SHigh state which underlies luminal breast tumorigenicity by Rangapriya Sundararajan, Shubhada R. Hegde, Ashish Kumar Panda, Joel Christie, Nikhil Gadewal, Prasanna Venkatraman

“…As seen in luminal BrCa cell lines, this imbalance limits the number of double-capped 19S-20S-19S holocomplexes (30S) formed and promotes free 20S catalytic core accumulation that is widely-believed to confer survival advantage to tumors. By retaining connectivity with key tumor 19S:20S interface nodes, the PSMD9 19S subunit chaperone emerges as a crucial regulator of 26S/30S:20S ratios sustaining tumor cell proteasome function. …”
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Restoration of TP53 strategy via specific nanoparticles for ovarian cancer therapy by Menglei Zhang, Yuanyuan Gu, Fang Shen, Yingxin Gong, Zheng Gu, Keqin Hua, Guannan Zhou, Jingxin Ding

“…Abstract The p53 tumor suppressor gene, a master regulator of diverse cellular pathways, is frequently altered in various cancers. Loss of function in tumor suppressor genes is commonly associated with the onset/progression of cancer and treatment resistance. …”
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Morphological and Proteomic Analyses to Reveal Salt-Tolerant Mechanisms in Soybean Seedlings Treated with Titanium-Oxide Nanoparticles by Pwint Phoo Wai, Hisateru Yamaguchi, Keisuke Hitachi, Kunihiro Tsuchida, Setsuko Komatsu

“…These results suggest that TiO₂ NPs confer salt tolerance in soybean plants at the early growth stage by regulating vacuole transport and reactive oxygen scavenging systems.…”
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