Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver by Azza A. K. El-Sheikh, Rehab A. Rifaai

“…Preadministration of PIO, but not FEN, prior to CP challenge improved hepatic function and histology, and significantly reversed oxidative and inflammatory parameters. …”
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YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity by Haiyan Zhang, Xiaojing Luo, Wei Yang, Zhiying Wu, Zhicong Zhao, Xin Pei, Xue Zhang, Chonghao Chen, Josh Haipeng Lei, Qingxia Shi, Qi Zhao, Yanxing Chen, Wenwei Wu, Zhaolei Zeng, Huai-Qiang Ju, Miaozhen Qiu, Jun Liu, Bin Shen, Minshan Chen, Jianjun Chen, Chu-Xia Deng, Rui-Hua Xu, Jiajie Hou

“…Abstract RNA methylation is an important regulatory process to determine immune cell function but how it affects the anti-tumor activity of CD8 T cells is not fully understood. …”
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Effectiveness of isoniazid preventive treatment among patients on antiretroviral treatment in Southeast Nigeria: A retrospective cohort study by Chukwuma David Umeokonkwo, Bello Segun, Patrick Nguku, Muhammad Shakir Balogun, Peter Nsubuga, Lilian Bulage, Adanna Anthonia Umeokonkwo, Olufunmilayo Ibitola Fawole

“…It is, however, not clear if receiving a 6-month course of isoniazid preventive treatment (IPT) confers additional protection among HIV patients already on ART. …”
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Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development by G. F. Korytina, L. Z. Akhmadishina, V. A. Markelov, Y. G. Aznabaeva, O. V. Kochetova, T. R. Nasibullin, A. P. Larkina, N. N. Khusnutdinova, N. Sh. Zagidullin, T. V. Victorova

“…A significant genotype-dependent variation of lung function parameters was observed for SIRT1 (rs3818292), SIRT3 (rs3782116), PIK3R1 (rs3730089), and MTOR (rs2536). …”
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A Mathematical Model that Simulates Control Options for African Swine Fever Virus (ASFV). by Mike B Barongo, Richard P Bishop, Eric M Fèvre, Darryn L Knobel, Amos Ssematimba

“…The implementation of biosecurity measures was simulated through incorporation of a decay function on the transmission rate. The model predicts that biosecurity measures implemented within 14 days of the onset of an epidemic can avert up to 74% of pig deaths due to ASF while hypothetical vaccines that confer 70% immunity when deployed prior to day 14 of the epidemic could avert 65% of pig deaths. …”
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Newly Characterized Region of CP190 Associates with Microtubules and Mediates Proper Spindle Morphology in Drosophila Stem Cells. by Karen M Plevock, Brian J Galletta, Kevin C Slep, Nasser M Rusan

“…Collectively, we highlight a multivalent MT-binding architecture in CP190, which confers distinct subcellular cytoskeletal localization and function during mitosis.…”
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Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma. by Illya Tietzel, Christelle El-Haibi, Rey A Carabeo

“…IFN-gamma-inducible murine p47 GTPases have been demonstrated to function in resistance to chlamydia infection in vivo and in vitro. …”
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Transcriptional profiles reveal physiological mechanisms for compensation during a simulated marine heatwave in Yellowtail Kingfish (Seriola lalandi) by Sharon E. Hook, Ryan J. Farr, Jenny Su, Alistair J. Hobday, Catherine Wingate, Lindsey Woolley, Luke Pilmer

“…In the muscle, numerous transcripts with mitochondrial function had altered abundance. There was a profound change to the regulation of transcription, as well as numerous transcripts with differential exon usage, suggesting that this may be a mechanism for conferring physiological resilience to heat stress. …”
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Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans. by Neda Masoudi, Pablo Ibanez-Cruceyra, Sarah-Lena Offenburger, Alexander Holmes, Anton Gartner

“…We show that TSP-17 is expressed in dopaminergic neurons and provide genetic, pharmacological and biochemical evidence that it inhibits DAT-1, thus leading to increased 6-OHDA uptake in tsp-17 loss-of-function mutants. TSP-17 also protects against toxicity conferred by excessive intracellular dopamine. …”
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Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter. by Sashika N Richards, Megan N Nash, Eileen S Baker, Michael W Webster, Adele M Lehane, Sarah H Shafik, Rowena E Martin

“…However, CQ resistance-conferring isoforms of PfCRT (PfCRTCQR) also render the parasite hypersensitive to a subset of structurally-diverse pharmacons. …”
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Toward understanding sexual immune dimorphism in humans by Tomasz J. Nowak, Michael P. Muehlenbein

“…Females generally exhibit stronger immune responses than males, which confer protection against infections but also lead to a higher prevalence of autoimmune diseases. …”
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Revolutionizing heat stress tolerance in Glycine max: Exploring the latest advances in microbial application by Shifa Shaffique, Md. Injamum-Ul-Hoque, Azamal Husen, Sang-Mo kang, In-Jung Lee

“…Heat stress (HS) has become ubiquitous hazardous environmental stress, eliciting concerns regarding its adverse impacts on terrestrial and agroecosystems. Plant hormones function as signaling molecules essential for stress tolerance, defense mechanisms, and facilitation of plants' overall physiological growth and development. …”
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Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization by Yuejie Xu, Ying Chen, Ningning Bai, Yingying Su, Yafen Ye, Rong Zhang, Ying Yang, Caizhi Liu, Cheng Hu, Jiemin Pan

“…Conversely, overexpression of Usp2 in BAT conferred protection against high-fat diet-induced obesity and associated metabolic disorders. …”
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Network spreading and local biological vulnerability in amyotrophic lateral sclerosis by Asa Farahani, Justine Y. Hansen, Vincent Bazinet, Golia Shafiei, D. Louis Collins, Mahsa Dadar, Sanjay Kalra, Alain Dagher, Bratislav Misic

“…Epicenter probability maps show transcriptomic enrichment for biological processes involved in mitochondrial function as well as support cells, including endothelial cells and pericytes. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…Our results indicate that regulation of the AMC leading to altered L-met availability is a conserved regulatory function of CjNC110 in C. jejuni and confirm that L-met generation via the AMC as activated by CjNC110 is critical for optimal host colonization.IMPORTANCEDuring this study, the regulatory action and conservation of function of CjNC110 between two different zoonotically important Campylobacter jejuni strains were examined. …”
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Bufei huoxue capsules in the management of convalescent COVID‐19 infection: study protocol for a multicenter, double‐blind, and randomized controlled trial by Yuqin Chen, Wenjun He, Wenju Lu, Yue Xing, Jianling Bai, Hao Yu, Jiawei Zhou, Jingyi Liang, Jiyuan Chen, Chi Hou, Bihua Zhong, Ting Wang, Huazhuo Feng, Xu Chen, Tao Wang, Kai Yang, Nuofu Zhang, Nanshan Zhong, Chunli Liu, Jian Wang

“…Some small‐scale clinical trials have found that BFHX can improve lung ventilation function, reduce blood viscosity, and improve cardiopulmonary function. …”
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Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude. by Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta

“…Although a number of cell types are able to produce TNF, the ability of CD8+ T cells to produce TNF following viral infection is a hallmark of their effector function. As such, the regulation and role of CD8+ T cell-derived TNF following viral infection is of great interest. …”
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Effects of Vaccinium-derived antioxidants on human health: the past, present and future by Amrita Ghosh, Samir C. Debnath, Abir U. Igamberdiev

“…Reports show that whole berry consumption usually confers positive effects on human health, and the health-promoting potentials are likely due to the presence of polyphenols with antioxidant activities. …”
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Recurrent Fibrillary Glomerulonephritis Secondary to Chronic Lymphocytic Leukemia: Remission of Kidney Disease with Ibrutinib by Rafeea Shah, Bindu Vydianath, Guy Pratt, Jennifer Pinney

“…Conclusion: This case highlights the success of treating a potentially identifiable cause of FGN and highlights that even at relapse, treatment can confer benefits and help prevent end-stage renal failure.…”
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Protein-protein interactions in the RPS4/RRS1 immune receptor complex. by Sung Un Huh, Volkan Cevik, Pingtao Ding, Zane Duxbury, Yan Ma, Laurence Tomlinson, Panagiotis F Sarris, Jonathan D G Jones

“…Some NLR proteins function in pairs, forming receptor complexes for the perception of specific effectors. …”
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