Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid by Josep Fita-Torró, José Luis Garrido-Huarte, Lucía López-Gil, Agnès H Michel, Benoit Kornmann, Amparo Pascual-Ahuir, Markus Proft

“…We find that loss of Hfd1 fatty aldehyde dehydrogenase function efficiently sensitizes cells for t-2-hex inhibition and apoptotic cell death. …”
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Effects of tai chi on postural control during dual-task stair negotiation in knee osteoarthritis: a randomised controlled trial protocol by Bo Chen, Feng Xiong, Xiangbin Wang, Meijin Hou, Shaoqing Chen, Jiao Yu, Dalu Qi, Yanxin Zhang, Shengxing Fu, Zhenhui Li, Fengjiao Yang, Alison Chang, Anmin Liu, Xuerong Xie

“…Secondary outcomes include balance and proprioception, foot clearances, self-reported symptoms and function. A telephone follow-up to assess symptoms and function will be conducted at 20 weeks. …”
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Restoration of herbivory on Caribbean coral reefs: are fishes, urchins, or crabs the solution? by Mark J. Butler, Alain Duran, Colette J. Feehan, Alastair R. Harborne, Alwin Hylkema, Alwin Hylkema, Joshua T. Patterson, William C. Sharp, Angelo Jason Spadaro, Tom Wijers, Tom Wijers, Stacey M. Williams

“…Numerous studies extol the benefits of functional redundancy and complementarity for coral reef ecosystem stability, but whether this principal applies to the restoration of grazing function is untested. …”
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Surgical treatments of metastatic bone disease of the hip joint: a scoping review protocol by Jiling Liu, Li Mao, Zhenxiao Yang, Chiheng Yan, Dagang Feng

“…Introduction Metastatic disease of the hip causes severe pain and is a serious threat to the patient’s motor function. Surgery is required, but the actual efficacy is unclear, and there are many concerns for both patients and doctors. …”
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Can smartphone technology be used to support an effective home exercise intervention to prevent falls amongst community dwelling older adults?: the TOGETHER feasibility RCT study p... by A Stefanie Mikolaizak, Lorenzo Chiari, Helen Hawley-Hague, Sabato Mellone, Chris Todd, Fan Bella Yang, Jorunn L Helbostad, Carlo Tacconi, Ellen Martinez, Angela Easdon, Ting-Li Su

“…The secondary outcome is to compare standard outcome measures for falls, function and adherence to instrumented versions collected using smartphone. …”
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Directed evolution of a model primordial enzyme provides insights into the development of the genetic code. by Manuel M Müller, Jane R Allison, Narupat Hongdilokkul, Laurent Gaillon, Peter Kast, Wilfred F van Gunsteren, Philippe Marlière, Donald Hilvert

“…The increase in fitness they confer indicates that building blocks with very similar side chain structures are highly beneficial for fine-tuning protein structure and function.…”
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How selection affects phenotypic fluctuation by Yoichiro Ito, Hitoshi Toyota, Kunihiko Kaneko, Tetsuya Yomo

“…Abstract The large degree of phenotypic fluctuation among isogenic cells highlighted by recent studies on stochastic gene expression confers fitness on some individuals through a ‘bet‐hedging’ strategy, when faced with different selective environments. …”
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Tensiones de la responsabilidad social universitaria: perspectivas de análisis y reflexión crítica. by Jairo Rodrigo Velásquez Moreno, Ruth Amanda Cortés Salcedo

“…The methodology used is based on an exploratory documentary review, which brings together documents including articles, books, papers, conferences, and doctoral theses from Latin and Ibero-American countries. …”
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Right-restricting measures implemented by Public Health Surveillance services during the COVID-19 pandemic: a systematic review protocol by Tiago Correia, Marcelo Dayrell Vivas, Larissa Bragagnolo, Igor Antônio Lourenço da Silva, Fernando Tureck, Reinaldo Santos, Samara Kielmann, Debora do Carmo, Camila Avarca, Franciele da Silva, Mariana Paes, Luis Fernando Nogueira Tofani, Arthur Chioro

“…It will include only peer-reviewed publications, discarding opinion articles, editorials, conference papers and non-peer-reviewed publications. …”
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Telomere length and brain imaging phenotypes in UK Biobank. by Anya Topiwala, Thomas E Nichols, Logan Z J Williams, Emma C Robinson, Fidel Alfaro-Almagro, Bernd Taschler, Chaoyue Wang, Christopher P Nelson, Karla L Miller, Veryan Codd, Nilesh J Samani, Stephen M Smith

“…The mechanism underlying this risk is unclear, and may involve brain structure and function. However, the relationship between telomere length and neuroimaging markers is poorly characterized. …”
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Machine learning-based diagnostic model for neonatal intestinal diseases in multiple centres: a cross-sectional study protocol by Xiang Guo, Jing Shi, Yue Han, Qi Zhao, Jun Tang, Tao Xiong, Yi Yang, Jin Zhang, Qian Gao, Ling He

“…Early assessment of abnormal bowel function is critical for timely intervention and improving prognosis, underscoring the clinical importance of reducing mortality related to these conditions through rapid diagnosis and treatment. …”
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Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum. by Marna S Costanzo, Kyle M Brown, Daniel L Hartl

“…In Plasmodium falciparum, the parasite that causes the most serious form of malaria, antifolate drugs inhibit the function of essential enzymes in the folate pathway. …”
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Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint. by Martha Klovstad, Uri Abdu, Trudi Schüpbach

“…Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and other cancers in humans. …”
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Prevalence of mild cognitive impairment among former elite athletes without a history of sport-related concussions compared to the general older population: a protocol for a cross-... by Jingjing Ren, Qing Zhao, Haojie Li, Shuo Luan, Jiahui Cong, Hanzhi He, Jiaying Xu, Jinghua Qian

“…While past research has established a connection between sport-related concussions (SRCs) and later cognitive decline, less attention has been given to the cognitive function of former athletes who have not experienced SRCs. …”
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Identification of RING E3 pseudoligases in the TRIM protein family by Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger

“…Abstract TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain. …”
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Multicentre online registration of bronchopulmonary dysplasia in very preterm infants in China: protocol for a prospective, open, observational cohort study by Ping Zhou, Cheng Chen, Xin Guo, Zhangbin Yu, Fei Hu, Jiebo Liu, Yanping Guo, Dan Dan Rao, Shengnan He, Haibo Peng, Xudong Yan, Qian Su, Boshi Yu, Yubai Li

“…Bayley-III Scale assessment, gross motor function and pulmonary function evaluation will be performed at the age of correction, that is, 18–24 months and 30–36 months. …”
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CHANGES IN QUANTITATIVE AND QUALITATIVE PROPERTIES OF ORAL LIQUID DURING REPLACEMENT OF DENTAL DEFECTS IN PATIENTS WITH ISCHEMIC HEART DISEASE by N.O. Riabushko

“…In recent years, the attention of scientists to the study of the unique properties of saliva and related diagnostic capabilities has increased significantly. Many data on the function and composition of oral fluid in healthy people and in various somatic pathologies. …”
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Development and Validation of Virtual Reality Cognitive Training for Older Adults with Mild Cognitive Impairment: Protocol for a Mixed-Methods Program Evaluation Study by Chen IC, Wu CY, Hu YL, Huang YM

“…Both groups will complete 16 sessions over eight weeks, with cognitive and functional performance assessed at various intervals. …”
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PIEZO1 variant implications for biological understanding and human health by Chew W. Cheng, Sophie L. Earle, Oleksandr V. Povstyan, Chloe Randall, Katie A. Smith, Marjolaine Debant, Fraser L. Macrae, Daniel G. Beech, Anna McGrane, Fiona Bartoli, Eulashini Chuntharpursat-Bon, Richard M. Cubbon, Kathryn J. Griffin, Marc A. Bailey, Antreas C. Kalli, Lara C. Morley, Klaus K. Witte, David J. Beech

“…PIEZO1 may be non-essential in red blood cells but the amplification of its function by gene variation quite selectively alters these cells, leading to haemolytic anaemia and other related disturbances that may be only mildly adverse and confer survival advantage. …”
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A perspective on the selection and design of nanozyme-based aptasensors for small molecules by Tanu Bhardwaj, Tarun Kumar Sharma

“…In these sensors, aptamers confer specificity to the target analyte, while nanozymes function as transducers, converting a binding event (the binding of the aptamer to its target) into a detectable signal. …”
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