Probiotic peptidoglycan skeleton enhances vaccine efficacy against MRSA by inducing trained immunity via the TLR2/JAK-STAT3 pathway by Lingdi Niu, Lingdi Niu, Haoyuan Duan, Jiaqing Wang, Zheng Jia, Hai Li, Junjie Guo, Shuhe Zhang, Ning Liu, Yaxin Miao, Junwei Ge, Fang Wang

“…In an in vivo model, BLP confers protection against S. aureus 26003 even without specific antigens. …”
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Sur quelques théories de la représentation visuelle avant Kepler by Dominique Demange

“…The question of vision as a mental representation dates as far back as Aristotle, conferring to the internal senses (phantasia, common sense) the major function in elaborating the content of perception. …”
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Role of riboflavin biosynthesis gene duplication and transporter in Aeromonas salmonicida virulence in marine teleost fish by Hajarooba Gnanagobal, Trung Cao, Ahmed Hossain, Ignacio Vasquez, Setu Chakraborty, Joy Chukwu-Osazuwa, Danny Boyce, María Jesus Espinoza, Víctor Antonio García-Angulo, Javier Santander

“…Monocistronic mRNA ribA, ribB and ribE2 encode for their corresponding functional riboflavin biosynthetic enzyme. While the product of ribBA conserved the RibB function, it lacked the RibA function. …”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…The nt5 gene of S. aureus, encoding 5’-nucleotidase (NT5), is nearly unknown for its function in drug resistance and bacterial infection. …”
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Acupuncture for poststroke hemiplegia focusing on cerebral bilateral connections: study protocol for a randomised controlled neuroimaging trial by Yue Wang, Hua Zhang, Xiao Han, Lan Jiang, Hualei Geng, Mengxin Lu, Zhongming Du, Pei Chen, Lixin Tang, Zhongjian Tan, Yihuai Zou

“…Introduction Acupuncture is safe and effective for improving the motor function of poststroke hemiplegic patients, but there still exists a certain gap between clinical practice and understanding its neural mechanisms. …”
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Early Supervised Incremental Resistance Training (ESpIRiT) following cardiac surgery via a median sternotomy: a study protocol of a multicentre randomised controlled trial by Doa El-Ansary, Md Ali Katijjahbe, Mohd Rizal Abdul Manaf, Colin Royse, Alistair Royse, Nur Ayub Md Ali, Mohd Ramzisham Abdul Rahman, Suriah Ahmad, Chong Tze Huat, Mohamad Arif Muhammad Nor, Jeswant Dillon, Hairulfaizi Haron, Muhamad Ishamudin Ismail

“…The primary outcomes are upper limb function and pain. The secondary outcomes will be functional capacity, multidomain recovery (physical and psychological), length of hospital stay, incidence of respiratory complications and quality of life. …”
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Anti-leishmanial activity of Carthamus tinctorius and Matricaria chamomilla extracts on the survival of promastigotes of Leishmania major by S Hamoonnavard, H Rezvan, M Maleki, H Heydarianpour, B Bazargani-Gilani, F Behdarvand

“…Safflower extracts functionally regulate monoamine transporters. Journal of Ethnopharmacology 2009; 124(1): 116-24. ## 8.Shirwaikar A, Khan S, Kamariya YH, Patel BD, Gajera FP. …”
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Lactobacillus lysates protect oral epithelial cells from pathogen-associated damage, increase secretion of pro-inflammatory cytokines and enhance barrier integrity by Steven D. Mercer, Christopher Doherty, Gurdeep Singh, Thomas Willmott, Tanaporn Cheesapcharoen, Rawee Teanpaisan, Catherine O’Neill, Ruth G. Ledder, Andrew J. McBain

“…All lysates significantly improved TEER in the presence of pathogenic material, demonstrating a protective effect on barrier function.…”
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Trial to assess the tolerability of using felodipine to upregulate autophagy as a treatment of Huntington’s disease (FELL-HD): a phase II, single-centre, open-label, dose-finding t... by Roger A Barker, Laura Oakley, Emma Cutting, David C Rubinsztein, Dimitrios Apostolopoulos, Nikolaos Demiris, Katie Andresen, Amy H Evans, Alimu Dayimu, Katherine Bongaerts, Robyn Staples, Wendy Gooding

“…Exploratory outcomes include additional measures of motor and cognitive function, non-motor symptoms and quality of life scales, as well as peripheral and central disease biomarkers assessed through brain MRI. …”
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Cell Transformation and the Evolution of a Field of Precancerization As It Relates to Oral Leukoplakia by L. Feller, J. Lemmer

“…The evolution of a clone of keratinocytes culminating in a precancerous phenotype is a function of the number of mutagenic events, rather than the sequential order in which they occur. …”
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A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges by Dino Osmanović, Yitzhak Rabin, Yoav Soen

“…Systematic analysis of outcomes as a function of population properties further identifies a non‐traditional regime of adaptation mediated by stochastic changes that are rapidly acquired within a lifetime. …”
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Efficacy and safety of butylphthalide in patients with mild cognitive impairment: a multicentre, randomised, double-blind, placebo-controlled trial (EBMCI study) by Pin Wang, Chang Xu, Yufei Chen, Yuting Yang, Jin Gong, Wenxian Sun, Xiaodong Han, Heya Luan, Shaoqi Li, Ruina Li, Boye Wen, Sirong Lv, Cuibai Wei

“…Introduction The efficacy of multitarget neuroprotective drug DL-3-n-butylphthalide (NBP) in improving cognitive function has been confirmed in patients with vascular cognitive impairment without dementia. …”
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Cognitive and behavioral benefits of 2′-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota by Liuying Zhu, Zhiyi Zhang, Ting Luo, Hongyan Li, Zeyuan Deng, Jing Li, Liufeng Zheng, Jinqiang Liao, Minghui Wang, Bing Zhang

“…This study aimed to assess the impact of 2′-FL on the gut-brain axis microbiota and cognitive function in growing mice, along with its potential mechanisms of action. …”
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Contemporary Patient Satisfaction Rates for Three-Piece Inflatable Penile Prostheses by Raymond M. Bernal, Gerard D. Henry

“…Nevertheless, we found that patients in general were quite satisfied with their three-piece IPPs and restoration of sexual function. We also identified reasons for patient dissatisfaction and reviewed the literature to find ways by which satisfaction could be improved. …”
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Signal sequences target enzymes and structural proteins to bacterial microcompartments and are critical for microcompartment formation by Elizabeth R. Johnson, Nolan W. Kennedy, Carolyn E. Mills, Shiqi Liang, Swetha Chandrasekar, Taylor M. Nichols, Grant A. Rybnicky, Danielle Tullman-Ercek

“…Encapsulating heterologous pathways of interest in MCPs could confer these benefits to industrially relevant pathways. …”
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Differentiating Probiotics and Prebiotics in Terms of Mechanism of Action and Clinical Application by Marlena Jankowska, Karolina Baran, Natalia Jańczyk, Katarzyna Bartnik, Jakub Pokrzepa, Michał Presak, Adrianna Pacołta, Marcelina Nalepka, Mikołaj Pograniczny, Adrianna Mielżyńska

“…A detailed examination of their impact on gastrointestinal health, metabolic disorders, immune function, neurological health, and more is provided. …”
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The early-life gut microbiome in common pediatric diseases: roles and therapeutic implications by Taiwo Bankole, Yuanyuan Li

“…During this critical window, the gut microbiome is vulnerably subjected to environmental factors, leading to transient microbial reprogramming and functional changes. The dynamic early-life intestinal microbiota is frequently manipulated by environmental factors, which impact the composition and function of the gut microflora, hence confer to short-and/or long-term health outcomes extending to adulthood. …”
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CHI study: protocol for an observational cohort study on ageing and mental health in community-dwelling older adults by Lei Feng, Lieng Hsi Ling, Qiushi Feng, Rachael Zhi Yi Lee, Junhong Yu, Iris Rawtaer, Patrick Finbarr Allen, Zhiming Bao, Jeong Kyu Lee, Chin Tat Lim, Leng Leng Thang, Thet Naing, D Y Wang, Kai Zhen Yap, EH Kua, Rathi Mahendran

“…Assessments include basic sociodemographic, physical health and function (cardiac, oral and blood profiles and visual function), cognitive functioning, daily functioning, physical fitness, emotional state, free-flowing speech, sleep quality, social connectedness, caregiver burden, intergenerational communication, quality of life, life satisfaction, attitudes to ageing and gratitude and compassion. …”
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Peroxiredoxin alleviates the fitness costs of imidacloprid resistance in an insect pest of rice. by Rui Pang, Ke Xing, Longyu Yuan, Zhikun Liang, Meng Chen, Xiangzhao Yue, Yi Dong, Yan Ling, Xionglei He, Xianchun Li, Wenqing Zhang

“…However, how modifier mutations evolve and function to overcome the fitness cost of resistance still remains unknown. …”
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Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosisResearch in context by Zeyu Liu, Qi Zheng, Zhoubin Li, Moli Huang, Cheng Zhong, Ruize Yu, Rong Jiang, Haotian Dai, Jingyuan Zhang, Xiaohua Gu, Yongle Xu, Chunwei Li, Shan Shan, Feng Xu, Yue Hong, Tao Ren

“…Post-transplantation assessments included lung function, exercise capacity and high resolution computed tomography (HRCT) scans were analyzed to quantify the clinical benefits conferred by the BCs transplantation. …”
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