Conjugated bile acids promote metabolic dysfunction-associated steatotic liver disease through inducing nuclear translocation of sphingosine-1-phosphate receptor 2 to disrupt perox... by Rong-Rong Miao, Ming-Yong Tan, Han-Bing Shao, Zhi-Meng Sun, Sheng Zhan, Wei-Shi Liang, Xiao-Hui Liu, Ke-Qin Li, Yu-Yao Cheng, Xin-Feng Wu, Rui Xu, Shu-Xiang Cui, Yong Hai, Xian-Jun Qu

“…Cleaved S1PR2 (S1PR2’) was thus translocated into the nucleus to bind with PPARα, thereby interdicting the function of PPARα in regulating the genes involved in lipid catabolism. …”
Get full text

Air Pollution and Its Impact on Health and Performance in Football Players by George John, Ekaterina A. Semenova, Dana Amr Mohamed, Tiffany Georges Abi Antoun, Rinat A. Yusupov, Ildus I. Ahmetov

“…Long-term exposure exacerbates respiratory conditions, suppresses immune function, and heightens the risk of illness and injury. …”
Get full text

Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels by Shuhui Zhou, Liping Zheng, Tingxuan Zheng, Haiyan Zhan, Qiuyuan Lin, Jiaoao Wei, Yong Huang

“…This facilitated the upregulation of the target genes CD2AP and nephrin, which are critical for maintaining glomerular integrity and improving renal function in PAN nephropathy models.ConclusionShensu IV and NaHS confer renal protection primarily by modulating oxidative stress and restoring the integrity of the glomerular filtration barrier through mechanisms involving the enhancement of the PI3K/AKT pathway and modulation of H2S levels. …”
Get full text

CALL FOR PAPERSFOR THE SPECIAL ISSUE OF Zeszyty Teoretyczne Rachunkowości (ZTR – The Theoretical Journal of Accounting) in 2026

“…We want to underline that the articles (ca. 32,000–50,000 characters) should pertain to the theme of the special issue of ZTR and should not have been published earlier in hard copy or an electronic version, whether in magazines, journals, books, or conference materials.The deadline for submitting papers is 30th June 2026. …”
Get full text

Bibliometric analysis of laryngeal cancer treatment literature (2003–2023) by Yan Zhao, Jiancheng Xue

“…To ensure data quality, conference papers, letters, and editorial materials were excluded, focusing only on original research papers and review articles. …”
Get full text

Effects of intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation on post-stroke dysphagia in hospitalised patients: study protocol for a prospect... by Min Yang, Xi Chen, Xueling Li, Jiayi Zhu, Wenjing Bai, Jianxiong Wang, Jihua Yu, Rui Jian

“…The findings will be published in peer-reviewed journals and presented at academic conferences.Trial registration number ChiCTR2400079679.…”
Get full text

Ameliorative Effect of <i>Artemisia absinthium</i> Ethanolic Extract Against Sodium Fluoride Toxicity in Rat Testes: Histological and Physiological Study by Sawsan A. Ali, Zainab A. H. AL-Mousawi, Ahlam A. AL-Rikaby, Sameh Mohamed Farouk, Shaaban S. Elnesr

“…The results allow us to conclude that the administration of <i>Artemisia absinthium</i> confers positive effects on male reproductive function by inhibiting fluoride, maybe via ameliorative testicular function.…”
Get full text

Pancreatic, nutritional and clinical outcomes in children 0–5 years with cystic fibrosis during the first 2 years of CFTR modulator therapy (PaNC): a multicentre prospective observ... by Tamarah Katz, Sophie King, Gillian M Nixon, Caitlin Miles, Jodi Grunert, Kristyn Ford, Carla Hall, Charlotte Hawthorn, Denise Wong See, Mylie McMahon, Hannah Vass, Sarah Watkins, Gemma Zanardo, Isabella Brookes, Siobhan Handley, Talia Woodward, Jasmin Wademan, Bella Cameron, Zoe Davidson

“…Background Cystic fibrosis (CF) is a genetic condition of impaired membrane electrolyte transport and is characterised by defects in the production and function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. …”
Get full text

A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors by Paolo Romania, Loredana Cifaldi, Loredana Cifaldi, Paula Gragera, Valerio D’Alicandro, Matteo Caforio, Valentina Folgiero, Valeria Lucarini, Ombretta Melaiu, Ombretta Melaiu, Roberto Bei, Franco Locatelli, Franco Locatelli, Doriana Fruci

“…The most promising candidates were functionally validated through single-target gene silencing and overexpression. …”
Get full text

Physical activity interventions in adult kidney transplant recipients: an updated systematic review and meta-analysis of randomized controlled trials by Roseanne E. Billany, Nicolette C. Bishop, Ellen M. Castle, Matthew P. M. Graham-Brown, Sharlene A. Greenwood, Courtney J. Lightfoot, Thomas J. Wilkinson

“…Significant improvements were observed in CRF (V̇O2peak; +3.87 mL/kg/min, p = .0004), physical function (sit-to-stand-60; +7.72 repetitions, p = .0001), and high-density lipoprotein (HDL; +0.13 mmol/L, p = .02). …”
Get full text

Effect of vestibular rehabilitation treatment (VRT) on patients with unsteadiness after intratympanic gentamicin in Menière’s disease: protocol for a randomised controlled trial by Peixia Wu, Yue Zhou, Qiling Tong, Huiqian Yu

“…The primary outcome will be the improvements in vestibular function quantified through the Functional Gait Assessment. …”
Get full text

Que cachent les « termes barbares » de la crise financière internationale ? by Pascale Janot

“…The present article examines the use of 'barbaric' as conferring a specific alterity to the terminology in question. …”
Get full text

Bilingualism Does Not Hinder Grammatical Development in Down Syndrome: Evidence from a Sentence Repetition Task by Alexandra Perovic, Katie Levy, Inès Aertsen, Andrea Baldacchino

“…Further research is needed to determine whether bilingualism confers specific benefits in grammatical morpheme use and complex syntactic constructions.…”
Get full text

Rhein alleviates hepatic steatosis in NAFLD mice by activating the AMPK/ACC/SREBP1 pathway to enhance lipid metabolism by Weiwei Dai, Qishu Hou, Jifeng Ye

“…Serum lipid profiles, liver function biomarkers, and inflammatory cytokine levels were measured. …”
Get full text

Study protocol for VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a UK multicentre randomised controlled trial with an internal pilot (t... by Tim Batchelor, Babu Naidu, Chris A Rogers, Jane Blazeby, Alan Kirk, Paula Rogers, Stacey Stewart, Syed Qadri, Fiona Strachan, Sarah Wordsworth, Susan J Dutton, Arjun Nair, Amy Kerr, Rajesh Shah, Lisa Jones, Elizabeth A Stokes, Mark Ainsworth, Kathryn Saunders, Daisy Elliott, Rosie Harris, Sangeetha Paramasivan, Tom Treasure, Martyn Cain, Eric Lim, Michael Shackcloth, Joel Dunning, Niall McGonigle, Tim Brush, Lucy Dabner, Holly E Mckeon, Dawn Phillips, Holly Mckeon, Chloe Beard, Alba Realpe Rojas, Elizabeth Stokes, Andrew G Nicholson, Sofina Begum, Simon Jordan, Paulo De Sousa, Monica Tavares Barbosa, Eveline Internullo, Rakesh Krishnadas, Gianluca Casali, Doug West, Karen Bobruk, Catherine O’Donovan, Louise Flintoff, Amelia Lowe, Joanna Nicklin, Emma Heron, Jo Chambers, Becky Houlihan, Laura Beacham, Heather Hudson, Katy Tucker, Toni Farmery, Danielle Davis, Mike Shackcloth, Julius Asante-Siaw, Susannah Love, Sarah Feeney, Lindsey Murphy, Almudena Duran Rosas, Andrea Young, Ian Paul, Hyder Latif, Charlotte Jacobs, Alison Chilvers, Edward Stephenson, Nazalie Iqbal, Vladimir Anikin, Claire Prendergast, Hazem Fallouh, Maninder Kalkat, Richard Steyn, Nicola Oswald, Charlotte Ferris, Jo Webb, Joanne Taylor, Hollie Bancroft, Salma Kadiri, Zara Jalal Senior, Elizabeth Belcher, Dionisios Stavroulias, Francesco Di Chiara, May Havinden-Williams, Mahmoud Loubani, Karen Dobbs, Paul Atkin, Dominic Fellowes, Leanne Cox, Vipin Zamvar, Ruth Langley, Joy Adamson, Ian Hunt, Peter B Licht, Chris Hall, Mike Cowen, Keith Kerr, Nagmi Qureshi

“…We will test the hypothesis that VATS lobectomy is superior to open lobectomy with respect to self-reported physical function 5 weeks after randomisation (approximately 1 month after surgery). …”
Get full text

Swapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationship. by Mark T Lek, Siobanth Cruz, Nnejiuwa U Ibe, Wendy H J Beck, John K Bielicki, Paul M M Weers, Vasanthy Narayanaswami

“…However, apoAI-NT/apoE-CT displayed an enhanced ability to promote cholesterol efflux compared to apoAI, indicative of a significant role for apoE CT domain in mediating this function. Together, these results indicate that the functional attributes of apoAI and apoE3 can be conferred on each other and that NT-CT domain interactions significantly modulate their structure and function.…”
Get full text

An observational cohort study comparing ibuprofen and oxycodone in children with fractures. by Samina Ali, Robin Manaloor, David W Johnson, Rhonda J Rosychuk, Sylvie LeMay, Bruce Carleton, Patrick J McGrath, Amy L Drendel, Pediatric Emergency Research Canada

“…Oxycodone prescribing was associated with more adverse events and negatively impacted function. Oxycodone use does not appear to confer any benefit over ibuprofen for pain relief and has a negative adverse effect profile. …”
Get full text

Two-year follow-up of gait and postural control following initiation of recombinant human tripeptidyl intracerebroventricular enzyme replacement therapy in two atypical CLN2 patien... by Rahul Soangra, Marybeth Grant-Beuttler, Harriet Chang, Raymond Y. Wang

“…However, declines in more complex motor functions, including sit-to-stand performance and postural complexity, persist, underscoring the progressive nature of the disease despite ongoing therapeutic intervention.…”
Get full text

Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties by Vincenzo Giancotti, Natascha Bergamin, Palmina Cataldi, Claudio Rizzi

“…The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. …”
Get full text

Effect of aerobic exercise combined with meditation on cognitive frailty: study protocol for a parallel group randomised controlled trial by Wenju Wang, Lei Yang, Feng Chen, Weilin Liu, Tao Jiang, Sijia Xia, Jingfang Zhu, Minguang Yang, Qing Xiang

“…The primary outcomes will include the Edmonton Frailty Scale, while secondary outcomes will encompass evaluations of cognitive functions (including global cognitive function, memory, attention, executive function and visuospatial abilities), physical performance (measured by gait speed and lower extremity strength), subjective experiences (such as fatigue, quality of life, mindfulness, mood and sleep quality), as well as structural and functional MRI assessments and serum biomarkers. …”
Get full text