Digital cognitive training in children with attention-deficit/hyperactivity disorder: a study protocol of a randomised controlled trial by Sally Richmond, Hannah Kirk, Kim Cornish, Mark A Bellgrove, Tori Gaunson, Meg Bennett

“…Assessments of the primary outcome (ie, attention and inhibitory control) and secondary outcomes (ie, selective attention, interference control, sustained attention, inhibition, behavioural attention, impairment in everyday functioning, working memory and executive functioning) will occur at preintervention, immediately postintervention and at 3-month follow-up. …”
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Azithromycin to prevent acute lower respiratory infections among Australian and New Zealand First Nations and Timorese children (PETAL trial): study protocol for a multicentre, int... by Anne B Chang, Keith Grimwood, Yuejen Zhao, Gabrielle B McCallum, Catherine A Byrnes, Heidi Smith-Vaughan, Peter S Morris, Christine Connors, Adrian Trenholme, Shirley Lawrence, Joshua Francis, Kobi L Schutz, Mark D Chatfield, Nevio Sarmento, Robyn L. Marsh, Emily R Bowden, Nicholas Fancourt, Adriano Vieira, Kim M Hare, Dennis Bonney, Felicity Marwick, Bronwyn Karvonen, Carolyn Maclennan, Milena Santos Lay, Endang Soares da Silva

“…Severe (hospitalised) and recurrent ALRIs in the first years of life are associated with future chronic lung diseases (eg, bronchiectasis) and impaired lung function. Despite the high burden and long-term consequences of severe ALRIs, clinical, evidence-based and feasible interventions (other than vaccine programmes) that reduce ALRI hospitalisations in children are limited. …”
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Exploring the ripple effects of an Australian hospital redevelopment: a protocol for a longitudinal, mixed-methods study by Jeffrey Braithwaite, Kate Churruca, Louise A Ellis, Chiara Pomare, Janet C Long, Brett Gardiner

“…Introduction Hospital redevelopment projects typically intend to improve hospital functioning and modernise the delivery of care. There is research support for the proposition that redevelopment along evidence-based design principles can lead to improved quality and safety. …”
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Morphological Research Directions at Neuroscience-Related Institutes of the German Max Planck Society, 1948–2002 by Frank W. Stahnisch

“…It covers the research tradition in the brain sciences, which can be described by an emphasis on gross anatomy, the functional implications of morphological substrates, and the analysis of neurohistological research paths of the human brain in comparative contexts. …”
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Reduced expression of IFIH1 is protective for type 1 diabetes. by Kate Downes, Marcin Pekalski, Karen L Angus, Matthew Hardy, Sarah Nutland, Deborah J Smyth, Neil M Walker, Chris Wallace, John A Todd

“…This common amino acid substitution does not cause a loss of function and evidence suggests the protective allele, Ala(946), may mark a haplotype with reduced expression of IFIH1 in line with the protection conferred by the four rare loss of function alleles. …”
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A Service-Learning proposal for Architecture, Building and Urbanism Students: getting involved in Education Tours in Madrid by Gabriel Pinto, Victoria Alcázar, María M. Conde, Ángel Aguero, Marina P. Arrieta, Freddys R. Beltrán, Patricia García-Muñoz, Javiera A. Sepulveda

“…Tailored for diverse audiences including international participants, scientific conference attendees, and students from specific areas, these tours also involve students and faculty from architecture, building, and urban planning backgrounds. …”
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The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. by Yi Zhang, Zhiyong Shao, Zhiwei Zhai, Chuan Shen, Jo Anne Powell-Coffman

“…We isolated and characterized additional hif-1 mutations, and we found that each of 3 loss-of-function mutations conferred increased longevity in normal lab culture conditions, but, unlike HIF-1 over-expression, a hif-1 deletion mutation did not extend the lifespan of daf-16 or skn-1 mutants. …”
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Influence of combined vitamin D3 supplementation and resistance exercise training on musculoskeletal health in older men and women (EXVITD): protocol for a randomised controlled tr... by Carolyn A Greig, Neil Gittoes, Janet Lord, Susan Lanham-New, Alison Doyle, Anneka Elizabeth Welford, Julie Robinson

“…Introduction Sarcopenia is a progressive loss in muscle mass, strength and function, the adverse consequences of which are severe, affecting quality of life and placing an increasing burden on social and healthcare systems. …”
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Computational modelling of immunological mechanisms: From statistical approaches to interpretable machine learning by María Rodríguez Martínez, Matteo Barberis, Anna Niarakis

“…To conclude the workshop, a round table was organized to foster discussions on the existing challenges and chart a roadmap for the development of the next generation of computational models dedicated to investigating the cellular and molecular functions that underlie the immune system.…”
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Assessment of the use of Unna boot in the treatment of chronic venous leg ulcers in adults: systematic review protocol by Thalita Paranhos, Caroline S B Paiva, Fernanda C I Cardoso, Priscila P Apolinário, Flavia Figueiredo Azevedo, Maria G B Saidel, Henrique C Oliveira, Ariane P Dini, Ana R S O Kumakura, Maria H Melo Lima

“…Introduction Chronic venous insufficiency (CVI) is an anomaly of the normal functioning of the venous system caused by valvular incompetence with or without the obstruction of venous flow. …”
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CLINICAL CASE OF REPLACEMENT OF ENDOTHELIN RECEPTOR ANTAGONIST (BOSENTAN) BY SOLUBLE GUANYLATE CYCLASE STIMULATOR (RIOCIGUAT) IN THE PATIENT WITH PULMONARY ARTERIAL HYPERTENSION by E. A. Devetyarova, A. A. Dyuzhikov, A. A. Dyuzhikova, S. V. Sobin, A. V. Sumin, E. V. Pashchenko

“…Due to condition deterioration on the background of bosentan dose increase, medical conference decided to switch this patient to another class of PAH-specific therapy (sGC stimulator riociguat) with consequent follow-up. …”
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Cuticular collagens mediate cross-kingdom predator-prey interactions between trapping fungi and nematodes. by Han-Wen Chang, Hung-Che Lin, Ching-Ting Yang, Rebecca J Tay, Dao-Ming Chang, Yi-Chung Tung, Yen-Ping Hsueh

“…Using forward genetic screens, we identified C. elegans mutants that escape fungal traps and revealed the nuclear hormone receptor NHR-66 as a key regulator of fungal-nematode adhesion. Loss-of-function mutations in nhr-66 conferred resistance to fungal trapping through the downregulation of a large subset of cuticular collagen genes. …”
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Quality Improvement in Critical Care: Selection and Development of Quality Indicators by Carla A. Chrusch, Claudio M. Martin, The Quality Improvement in Critical Care Project

“…An approach to monitor and compare the function of different intensive care units (ICUs) is needed to optimize outcomes for patients and the health system as a whole. …”
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Human life history evolution explains dissociation between the timing of tooth eruption and peak rates of root growth. by M Christopher Dean, Tim J Cole

“…With more time to grow longer roots prior to eruption and smaller teeth that now require less support at the time they come into function, the root growth spurt no longer confers any advantage in modern humans. …”
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Non-absorbable surgical sutures versus autologous tendons in the reconstruction of medial patellofemoral ligaments: a randomised controlled trial protocol by Xu Liu, Gaoming Liu, Yusheng Li, Wenhao Lu, Linyuan Pan, Hongfu Jin, Wenfeng Xiao

“…Pain assessment is performed using the Visual Analogue Scale (VAS). Knee function will be assessed using the Kujala score, Lysholm score and International Knee Documentation Committee (IKDC) knee function score. …”
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Outcome measures used and psychometrically tested in children with upper limb loss or difference: a scoping review protocol by Sara Morgan, Abigail Stepnitz, Caroline Gormley, Jessica Schiller, Meghan Munger, Jennifer Laine, Michelle J Hall

“…To guide this specialised care, outcome measures can be used to assess important constructs, such as physical function, health-related quality of life (HRQoL) and satisfaction with medical treatments and services. …”
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TRANSCENDENT (Transforming Research by Assessing Neuroinformatics across the Spectrum of Concussion by Embedding iNterdisciplinary Data-collection to Enable Novel Treatments): prot... by Charlotte Anderson, Nick Reed, Andrée-Anne Ledoux, Roger Zemek, Keith Yeates, Carolyn Emery, Pamela Fuselli, Isabelle J Gagnon, Kathryn J Schneider, Sharon Johnston, David R Howell, Richard Webster, Peter Tanuseputro, Andrew R Mayer, Miriam H Beauchamp, Rebecca Robillard, Christina L Master, Kristine Dalton, Khaled El Emam, John Leddy, Noah Silverberg, Jennifer Dawson, Martin H Osmond, Stephanie Cowle, Christopher Giza, Monica Lamoureux, Nicholas Barrowman, Kitty Chen, Daniel J Corwin, Erin Fox, Lisa M Albrecht, Araba Chintoh, Achelle Cortel-LeBlanc, Miguel Cortel-LeBlanc, Andrew Dodd, Steven Hicks, Stephen Alexander Kutcher, Carlos Lalonde, Rebekah C Mannix, Ivan Terekhov, Cheryl Lea Wellington

“…Dissemination of findings will be multifaceted, including conference presentations, peer-reviewed publications and sharing of adapted materials (eg, videos, infographics, plain language summaries) with community groups and key knowledge users.…”
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Time Matters: Methane Inhalation Mitigates Mitochondrial and Organ Dysfunction in Advanced Experimental Sepsis by Levente Frigyes Gulácsi, Attila Rutai, László Juhász, Bálint László Czakó, Andrea Szabó, Mihály Boros, József Kaszaki, Marietta Zita Poles, Szabolcs Péter Tallósy

“…All CH₄-treated groups demonstrated improved renal function and enhanced tissue oxygenation. Targeted CH₄ inhalation during sepsis confers protective effects by preserving mitochondrial function, reducing inflammation, and improving oxygen dynamics, suggesting promising therapeutic potential.…”
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Current status and prognostic factors of paediatric arterial ischaemic stroke in China: a study protocol for Chinese Paediatric Ischaemic Stroke Registry (CPISR) by Wei Li, Bin Zhu, Wen Sun, Fan Wu, Pan Zhang, Lulu Xiao, Huiping Wang, Gang Cai, Yingjie Xu, Wanqiu Zhang, Cuirong Duan, Mingyang Niu, Qiankun Li, Zhiwen Su

“…The findings of this study will be disseminated through peer-reviewed journals, national and international conference presentations and reports to participating institutions and relevant stakeholders.Trial registration number ChiCTR2200059915.…”
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Validation of an integrated service model, Health-RESPECT, for older patients in long-term care institution using information and communication technologies: protocol of a cluster... by In-Hwan Oh, Jae-Young Lim, Jung-Yeon Choi, Kwang-il Kim, Hongsoo Kim, Young-il Jung, Seungyeon Chun, Gi-Soo Kim, Jin Young Ko

“…Primary outcomes are control levels of the three chronic diseases, adequacy of drug management and overall functional status. Patients will be assessed at before and after study period and 3 months after study ended. …”
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