Randomised controlled trial with parallel process evaluation and health economic analysis to evaluate a nutritional management intervention, OptiCALS, for patients with amyotrophic... by Simon Waterhouse, Chin Maguire, Vanessa Halliday, Cindy Cooper, Elizabeth Coates, Mike Bradburn, Pamela J Shaw, Ammar Al-Chalabi, Tracey Anne Young, Christopher J McDermott, Wendy Baird, Paul Norman, Janet Cade, Sean White, Daniel Beever, Gemma Hackney, Elaine Scott, David Alexander White, Arron Peace, Shamila Ditta, Jonathan Woodward, Naseeb Ezaydi, Haris Stavroulakis

“…Primary outcome is functional change measured over 12 months, using the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale. …”
Get full text

Syndecan-1 is required to maintain intradermal fat and prevent cold stress. by Ildiko Kasza, Yewseok Suh, Damian Wollny, Rod J Clark, Avtar Roopra, Ricki J Colman, Ormond A MacDougald, Timothy A Shedd, David W Nelson, Mei-I Yen, Chi-Liang Eric Yen, Caroline M Alexander

“…This physiology probably confers a unique role for Sdc1 in this adipocyte sub-type. …”
Get full text

NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model. by Caroline Dillard, José Teles-Reis, Ashish Jain, Marina Gonçalves Antunes, Paula Ruiz-Duran, Yanyan Qi, Roland Le Borgne, Heinrich Jasper, Tor Erik Rusten

“…Using a well-studied cooperative RasV12-driven epithelial-derived tumor model, we here describe functions of Toll-NF-κB signaling in malignant RasV12, scrib- tumors. …”
Get full text

Study protocol for a multi-center stepped-wedge cluster randomized trial to explore the usability and outcomes among young people living with HIV in Kiambu and Kirinyaga counties o... by Eric Nturibi, Jared Mecha, Elizabeth Kubo, Albert Orwa, Florence Kaara, Faith Musau, Christine Wamuyu, Justus Kilonzi, Randeep Gill, Sanne Roels

“…Results will be disseminated through stakeholder forums, scientific conferences, peer-reviewed publications, and the media.…”
Get full text

Real-time capture of σN transcription initiation intermediates reveals mechanism of ATPase-driven activation by limited unfolding by Andreas U. Mueller, Nina Molina, B. Tracy Nixon, Seth A. Darst

“…Abstract Bacterial σ factors bind RNA polymerase (E) to form holoenzyme (Eσ), conferring promoter specificity to E and playing a key role in transcription bubble formation. σN is unique among σ factors in its structure and functional mechanism, requiring activation by specialized AAA+ ATPases. …”
Get full text

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. by Yiannis N Kallis, Christopher J Scotton, Alison C Mackinnon, Robert D Goldin, Nicholas A Wright, John P Iredale, Rachel C Chambers, Stuart J Forbes

“…Liver fibrosis results from the co-ordinated actions of myofibroblasts and macrophages, a proportion of which are of bone marrow origin. The functional effect of such bone marrow-derived cells on liver fibrosis is unclear. …”
Get full text

Models, systems, networks in economics, engineering, nature and society by M.I. Krevskiy, A.S. Bozhday

“…The application of the ideas and methods discussed in this review in practice will significantly expand the functionality of process analytics systems using only classical Process Mining methods, predict the progress of the process with high accuracy, avoid information loss, ensure transparency and validity of the proposed changes. …”

BMSC-Derived Exosomes Alleviate Intervertebral Disc Degeneration by Modulating AKT/mTOR-Mediated Autophagy of Nucleus Pulposus Cells by Quan Xiao, Zhe Zhao, Yun Teng, Lungang Wu, Jinlong Wang, Hongjun Xu, Sumei Chen, Quan Zhou

“…Exosomes are the main paracrine mediators and are microvesicles with biological functions similar to those of the cells from which they are derived. …”
Get full text

Conceptual and theoretical foundations of personalised learning by E. F. Zeer, O. V. Krezhevskikh

“…The aim of the article is to describe the development and testing of a structural and functional model of personalised learning in education of future teachers.Methodology and research methods. …”
Get full text

Exploration of the Mechanisms of <i>Acorus</i><i> tatarinowii</i> in the Treatment of Major Depressive Disorder Based on Network Pharmacology and Molecular Docking Techniques by Li Han, Siwen Wei, Rong Wang, Yiran Liu, Yi Zhong, Huaiqing Luo

Get full text

Gut microbiome reveals the trophic variation and significant adaption of three sympatric forest-dwelling ungulates on the eastern Qinghai-Xizang Plateau by Haonan Zhang, Yichen Wang, Zhengwei Luo, Baofeng Zhang, Xianna Lan, Liancheng Xu, Xuxin Li, Zhixin Huang, Jin Bai, Defu Hu

“…The complex stomach architecture of ruminants, in conjunction with the metabolic capabilities of their microbiota, confers a considerable adaptive advantage to these animals. …”
Get full text

NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis by Wenle Ye, Yanchun Zhao, Yutong Zhou, Jiansong Huang, Xiao He, Zhixin Ma, Xin Huang, Chao Hu, Fenglin Li, Qing Ling, Huafeng Wang, Hongyan Tong, Jie Sun, Jie Jin

“…NSUN2 was aberrantly upregulated in AML patient samples and correlated with poor prognosis. Functional studies demonstrated that NSUN2 promoted leukemic cell proliferation, enhanced tumor growth in xenograft models, and conferred resistance to ferroptosis—a regulated cell death process driven by lipid peroxidation. …”
Get full text

Optimization of phenolic extraction method and in vitro bioaccessibility of microencapsulated pigmented rice bran extracts and their antioxidant and anticancer properties by Rhowell Navarro Tiozon, Jr., Glenn Vincent P. Ong, Kristel June D. Sartagoda, Sheba Mae M. Duque, Saleh Alseekh, Aldrin P. Bonto, Shem Gempesaw, Jr., Vipin Pratap, Florencio C. Reginio, Jr., Jonina Marie J. Tengco, Christian Seagan, Joel H G Tolentino, Dennis Marvin O. Santiago, Alisdair R. Fernie, Nese Sreenivasulu

“…Pigmented paddy rice is rich in a diverse array of phytochemicals that confer notable antioxidant and anticancer properties. …”
Get full text

Hearing problems in humans and mouse models with rare copy number variants associated with schizophrenia: a scoping review protocol [version 2; peer review: 2 approved, 1 approved... by Noushin Saadullah Khani, Maria Richards-Brown, Jennifer F Linden, Lauren Varney, Elvira Bramon, Stephen Murtough, Chen Lu, Daniele Panconesi, Marius Cotic, Rosemary Abidoph, Alvin Richards-Belle, Daisy Mills

“…Conclusions To our knowledge, this will be the first scoping review to explore auditory functioning across all CNVs that confer high schizophrenia risk. …”
Get full text

Report of the First Completed On-site Vascular Neurosurgery Fellowship Program in Cameroon by Vincent Djientcheu, Haman Nassourou Oumarou, Potho Thazo, Carole Djientcheu, Francis Fezeu, Alexandros Doukas, Leonidas Trakolis, Athanasios K. Petridis

“…The expert traveled to Cameroon four times. Online conferences andtheoretical courses were organized.Results: The overall morbidity rate was 10.5% with a long-term functional morbidity rate of5.2%. …”
Get full text

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine by Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang

“…Association mapping and haplotype analysis identified novel loci and candidate genes for berry shape (bHLH017), soluble sugars (ACT), and organic acids (ALMT1 and FUSC2), as well as vine cold tolerance (NAC08), and fine‐mapped the flower sex determination locus. Furthermore, the functional role of NAC08 is validated, demonstrating that it activates the expression of a raffinose synthase gene, thereby increasing raffinose levels and conferring cold tolerance. …”
Get full text

Bioinspired Co-Assembled Hydrogels Constructed from Marine Self-Assembling Peptides and Polyphenol Network: Antioxidant and Infected Wound Healing by Chuhan Wang, Dingyi Yu, Wen Liu, Xiang Zhu, Hanzhe Zhang, Shuang Zheng, Jingdi Chen

“…Integrated with AAPs’ pro-regenerative functions and PDA’s broad-spectrum antimicrobial efficacy, this system generates therapeutic synergy. …”
Get full text

A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease by Carmen Sevilla-Ortega, Alba Angelina, Leticia Martín-Cruz, Mario Pérez-Diego, Angel Maldonado, Begoña Lavín, Beatriz Marcos-Ramiro, Luis Pérez de Llano, Auba Gayá, Francisco X. Real, Laura Conejero, José Luis Subiza, Oscar Palomares

“…Here we show MV130 prevents house dust mite (HDM)-induced local type 2 immune responses and associated eosinophilic airway inflammation, conferring protection up to 9 weeks after vaccination. …”
Get full text

Berries anthocyanins as potential SARS-CoV–2 inhibitors targeting the viral attachment and replication; molecular docking simulation by Omar Messaoudi, Hicham Gouzi, Abdelaziz Nasr El-Hoshoudy, Farouk Benaceur, Chirag Patel, Dweipayan Goswami, Djoudi Boukerouis, Mourad Bendahou

“…All compounds mentioned above shown high drug-likeness and fulfils the Lipinski’s rule of five, as well as confer favorable toxicity parameters, in addition to ADME values. …”
Get full text

Identifying the Intergenic ALK Fusion LOC388942‐ALK as a Driver of Non–Small Cell Lung Cancer by Xiaoqian Zhai, Manli Wang, Qi Zhang, Donglin Li, Yanmou Wu, ZuoYu Liang, Jiewei Liu, Weiya Wang, Yu Liu, Guowei Che, Qinghua Zhou, Chong Chen

“…Using CRISPR/Cas9, we generated the LA fusion in A549 and H441 cells, confirming elevated ALK expression via qRT‐PCR and immunohistochemistry (IHC) staining. Functional analyses showed that LA significantly promoted tumor growth in vitro and in vivo while conferring increased resistance to alectinib. …”
Get full text