Mapping Current Studies of tRNA Fragments onto Disease Landscape by Sathyanarayanan Vaidhyanathan, MacKenna Durbin, Adesupo A. Adetowubo, Lisa H. Do, Sheida Kavehmoghaddam, Sai Anusha Jonnalagadda, Bryan Ramirez Aguilar, Tamin Ortiz-Gomez, Yan X. Lin, Asim Dave, Fatmanur Kiliç, Alexa R. Karp, Mohammed Imthiyas Rahmah, Noor F. Riaz, Nikhila Mandava, Aleece Siner, Andrey Grigoriev

“…Despite the growing recognition of tRFs as functional RNAs rather than sequencing noise, this field of study faces numerous challenges. …”
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Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction by Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Aditya Jhaveri, Ying Cao, Johannes Falter, Janek Frantzén, Fredrika Koskimäki, Seán B. Lyne, Tomi Rantamäki, Riikka Takala, Jussi P. Posti, Susanna Roine, Sulo Kolehmainen, Kenneth Nazir, Miro Jänkälä, Jukka Puolitaival, Melissa Rahi, Jaakko Rinne, Anni I. Nieminen, Eero Castrén, Janne Koskimäki

“…In this longitudinal prospective observational study, serum samples were collected early (46 ± 24 h) and late (142 ± 52 h) post-injury from 70 patients with ischemic stroke, aneurysmal subarachnoid hemorrhage, and traumatic brain injury that had outcomes dichotomized as favorable (modified Rankin Scores (mRS) 0–3) and unfavorable (mRS 4–6) three months post-injury. …”
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Effect of sarcopenia combined with Metabolic Syndrome (MS) on the prognosis of intertrochanteric fractures: a retrospective clinical study by Cheng Zhang, Ding Wang, Xitao Wu, Qinrui Zhang, Lei Chen, Junzhe Lang, Congcong Wu

“…Chronic inflammation, insulin resistance, and muscle-bone metabolic dysregulation drive adverse outcomes. Comprehensive preoperative screening for sarcopenia and MS, coupled with tailored nutritional support and early rehabilitation, is critical to mitigate complications and improve functional recovery. …”
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A Comparative Study on Physicochemical Properties and Biological Activities of Polysaccharides from <i>Coreopsis tinctoria</i> Buds Obtained by Different Methods by Shang Gao, Weipei Li, Moupan Yin, Rui-Bo Jia, Chunxia Zhou, Xinhui Pan, Bingwu Liao

“…Then, the Hw were degraded by ultrasound, an alkali solution, and an acid solution, and the three resultant kinds of polysaccharides were denoted Ultra-Post-proc, Al-Post-proc, and Ac-Post-proc. The study comprehensively compared and analyzed the physical and chemical characteristics, structural properties, and in vitro activities of each polysaccharide. …”
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Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury by Beibei Yu, Yongfeng Zhang, Yujie Yang, Shijie Yang, Haining Wu, Xue Gao, Yiming Hao, Shengyou Li, Bing Xia, Jintao Liu, Lingli Guo, Borui Xue, Mingze Qin, Huangtao Chen, Jianzhong Li, Shouping Gong, Teng Ma, Jinghui Huang

“…Here, we identified neonatal mice with balanced PCD post-SCI as an ideal model for adult SCI. Accordingly, we developed “Thanatoset”, an SCI-specific gene panel to map tissue and cellular pan-PCD dynamics across neonatal and adult mice. …”
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Insights into miRNAs of the Stingless Bee <i>Melipona quadrifasciata</i> by Dalliane Oliveira Soares, Lucas Yago Melo Ferreira, Gabriel Victor Pina Rodrigues, João Pedro Nunes Santos, Ícaro Santos Lopes, Lucas Barbosa de Amorim Conceição, Tatyana Chagas Moura, Isaque João da Silva de Faria, Roenick Proveti Olmo, Weyder Cristiano Santana, Marco Antônio Costa, Eric Roberto Guimarães Rocha Aguiar

“…MicroRNAs (miRNAs) are key post-transcriptional regulators involved in a wide range of biological processes in insects, yet little is known about their roles in stingless bees. …”
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Reduced Levels of miR-145-3p Drive Cell Cycle Progression in Advanced High-Grade Serous Ovarian Cancer by Eva González-Cantó, Mariana Monteiro, Cristina Aghababyan, Ana Ferrero-Micó, Sergio Navarro-Serna, Maravillas Mellado-López, Sarai Tomás-Pérez, Juan Sandoval, Antoni Llueca, Alejandro Herreros-Pomares, Juan Gilabert-Estellés, Vicente Pérez-García, Josep Marí-Alexandre

“…Among these, miR-145-3p was consistently downregulated post-neoadjuvant therapy and was able to distinguish tumoural from control tissues. …”
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Cooling devices used to avoid warm ischemia time injury during kidney transplantation. Systematic review and meta-analysis by Marco A. Arizmendi-Villarreal, Alejandro Diaz Gonzalez-Colmenero, Jorge A. Cantú-Hernández, Javier Sanchez-Maldonado, Gerardo E. Muñoz-Maldonado, Edelmiro Perez-Rodriguez, Homero A. Zapata-Chavira, Rene Rodriguez-Gutierrez, Rene Rodriguez-Gutierrez, Francisco J. Reyna-Sepulveda

“…Cooling devices effectively lower graft temperature and may improve early functional outcomes. However, evidence of histological benefit remains inconclusive. …”
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Assessment of Pain and Associated Factors in Female Patients Undergoing Surgical Treatment for Breast Cancer: Cross-Sectional Study by Leonardo Breno do Nascimento de Aviz, Laerte Jonatas Leray Guedes, Raphaely Cristiny Sanches Progênio, Carolina Lima da Fonte, Victória Tavares Brioso, Maikon da Silva e Silva, Laura Maria Tomazi Neves, Saul Rassy Carneiro

“…The functional impact of postoperative pain is considerable, as it can interfere with activities of daily living and compromise limb mobility. …”
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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…RNA-binding proteins (RBPs), which orchestrate post-transcriptional gene regulation through dynamic interactions with target transcripts, are increasingly implicated in autoimmune pathogenesis. …”
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Analytical model of Iran-Saudi Arabia relations from 1979 to 2024 by Sajad Mohseni

“…Over the years, both Iran and Saudi Arabia have adapted to a political existence that functions independently of the other, shaped by longstanding distrust and tension. …”
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Genetics of catatonia: a systematic review of case reports and a gene pathway analysis by Mylene Moyal, Anton Iftimovici, Wafa Ghoul, Marion Plaze, Boris Chaumette

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Comparison of Per-Operative Outcomes between Simultaneous and Staged Bilateral Total Hip Arthroplasties by S Hiranya Kumar, N Vamshikrishna Chand, B A Pradeep, Thippeswamy Darshan, R V Chandan Kumar, D V Harish

“…Patients who go through the surgery experience better functioning and overall satisfaction with their lives. …”
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Alternative splicing in ovarian cancer by Liwei Wei, Yisheng Li, Jiawang Chen, Yuanmei Wang, Jianmin Wu, Huanming Yang, Yi Zhang

“…These novel splicing variants warrant further functional characterization to unlock the underlying molecular mechanisms. …”
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Overcoming challenges of developing a live-attenuated dengue vaccine and the path forward by Dr Walid Kandeil, Dr Mayuri Sharma

“…Additional immunogenicity analysis across phase I/II/III trials revealed engagement of long-lasting tetravalent, functional antibody, and cell-mediated immune responses directed against the structural and nonstructural components of the vaccine, irrespective of baseline serostatus. …”
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GNNs and ensemble models enhance the prediction of new sRNA-mRNA interactions in unseen conditions by Shani Cohen, Lior Rokach, Isana Veksler-Lublinsky

“…Abstract Bacterial small RNAs (sRNAs) are pivotal in post-transcriptional regulation, affecting functions like virulence, metabolism, and gene expression by binding specific mRNA targets. …”
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社群媒體使用與憂鬱： 社會比較與社會排斥的中介效果 Social Media Use and Depression: The Mediating Effects of Social Comparison and Social Exclusion by 江文慈 Wen-Tzu Chiang

“…For example, receiving no likes or comments on posts or being unfollowed can result in negative emotions (Hayes et al., 2018). …”
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Effectiveness of Digital Behavioral Activation Interventions for Depression and Anxiety: Systematic Review and Meta-Analysis by Eric Jia, Jushawn Macon, Michelle Doering, Joanna Abraham

“…However, no significant changes were identified in anxiety and functioning and disability outcomes at either 3 months (anxiety: P=.08, I²=68%) or 6 months (anxiety: P=.24, I²=44%; functioning and disability: P=.88, I²=90%). …”
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Regeneration of Two-Walled Infrabony Periodontal Defects in Swine After Buccal Fat Pad-Derived Dedifferentiated Fat Cell Autologous Transplantation by Daisuke Akita, Naoki Tsukimura, Tomohiko Kazama, Rie Takahashi, Yoshiki Taniguchi, Jin Inoue, Ayana Suzuki, Nodoka Tanabe, Keisuke Seki, Yoshinori Arai, Masatake Asano, Shuichi Sato, Yoshiyuki Hagiwara, Koichiro Kano, Masaki Honda, Taro Matsumoto

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ORGANIZING THE WORK OF THE DONOR BREAST MILK BANK AT THE LVIV PERINATAL CENTER IS AN EXPERIENCE THAT MOTIVATES FURTHER DEVELOPMENT by М. Малачинська, М. Кісельова, О. Шлемкевич, Н. Вереснюк, Г. Коваленко

“…Errors in feeding breastfed infants negatively affect not only the child’s physical health but also their functional capacities. No substitute for human milk can compete with the presence of biologically active substances inherent to the mother-child symbiosis. …”
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