Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds by Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega

“…Collectively, these findings demonstrate that our protocol effectively preserves the structural and functional hallmarks of the testicular ECM, underscoring its potential as a biologically relevant scaffold for future applications in fish reproductive biology. …”
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Regreening Practices and Effectiveness Evaluation for Rocky Slope Drawdown Zones in Pumped Storage Power Station Reservoirs by YANG Zhi-chao, MA Xiao-xiao, CHANG Shi-ju, TANG Yu-shuang, ZHAO Rui-yi, WAN Dan, ZHANG Qian-zhu

“…Plants exhibited strong resilience in terms of post-submersion recovery, expansion, and colonization, achieving an overall survival rate of 83.2%. …”
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Identification and characterization of signature genes related to fetoplacental vascular endothelial cell programming in gestational diabetes mellitus using bioinformatics analysis by Chunhong Liu, Chunhong Liu, Chunhong Liu, Caicheng Wei, Caicheng Wei, Caicheng Wei, Yulan Lu, Fu Chai, Fu Chai, Fu Chai, Chunfang Wang, Chunfang Wang, Chunfang Wang, Yonglong Zeng, Yonglong Zeng, Yonglong Zeng, Huatuo Huang, Huatuo Huang, Huatuo Huang

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed significant enrichment in pathways related to ribosome function, neurodegenerative diseases, and oxidative phosphorylation. …”
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Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues by Basak Eraslan, Dongxue Wang, Mirjana Gusic, Holger Prokisch, Björn M Hallström, Mathias Uhlén, Anna Asplund, Frederik Pontén, Thomas Wieland, Thomas Hopf, Hannes Hahne, Bernhard Kuster, Julien Gagneur

“…Abstract Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a quantification of their effects are still lacking. …”
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Psychological intervention in severe asthma: from theory to practice by Cleofé Fernández Aracil, María José Zamora Muñoz, María del Mar García Ródenas, María Rodríguez Aguilar, Carlos J. van-der Hofstadt Román, Luis Hernández Blasco

“…Psychological and quality-of-life variables were assessed at baseline, post-intervention, and at 6 and 12 months of follow-up.Results A total of 41 patients completed the program. …”
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Selumetinib in Adult Neurofibromatosis 1 with Plexiform Neurofibroma by Carlen A. Yuen, Eleanor Chu, Ryan O’Connell, Bryan K. Sun, Raj Vyas, Michelle Zheng, Emma Elliott, Changrui Xiao

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Temporal profiling of host transcriptome highlights time- and tissue-dependent Interferon pathway activation in NNV-infected European sea bass by Luca Peruzza, Giulia Dalla Rovere, Serena Ferraresso, Rafaella Franch, Daniela Bertotto, Francesco Pascoli, Gaia Bacchin, Anna Toffan, Luca Bargelloni

“…Here, we report on a time-course transcriptome analysis of brain and head kidney in NNV-infected bass that integrated the statistical evidence of differential expression with the information on temporal profiles (i.e. 6, 12, 24, 48, and 72 h post-infection (hpi)) compared to mock-infected controls. …”
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Comparative Forced Degradation Study of Anticomplement C5 Biosimilar and Originator Monoclonal Antibodies by Merve Celik Yamaci, Ceren Pamukcu, Yigit Erdemgil, Ahmet Emin Atik, Zeynep Zulfiye Yildirim Keles, Ozge Can

“…In this study, biosimilar products were comprehensively characterized and compared with originator products under forced degradation. …”
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Hypoperfusion regions linked to National Institutes of Health Stroke Scale scores in acute stroke by Hana Kim, Alex Teghipco, Chris Rorden, Julius Fridriksson, Mathew Chaves, Argye E. Hillis

“…Understanding the potential for neurological recovery post-reperfusion is essential for guiding treatment decisions. …”
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Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma. by Yulou Luo, Yinghui Ye, Yilina Saibaidoula, Yuting Zhang, Yan Chen

“…A constructed predicted competing endogenous RNA (ceRNA) network implicated PSMB8 in complex post-transcriptional regulation. Finally, in vitro assays confirmed the upregulation of PSMB8, underscoring its relevance in THCA and as a target for future research. …”
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Problems of assessing socio-economic damage due to epidemics by G. D. Bryukhanova, V. N. Gorodin, S. M. Romanov, A. N. Redko, D. V. Nosikov, S. V. Grinenko

“…The sudden epidemiological complications that have emerged in the current century have highlighted the serious difficulties on the part of medical services and States in general in responding to epidemiological emergencies of international significance, which required a comprehensive study of the scale of the problem of the negative socio-economic consequences of epidemics for the modern state. …”
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Mentorship to strengthen health system leadership: A case study of the Walungu rural health zone in the eastern Democratic Republic of Congo. by Rosine Bigirinama, Ghislain Bisimwa, Samuel Makali, Aimé Cikomola, Janvier Barhobagayana, Jean-Corneille Lembebu, Christian Chiribagula, Pacifique Mwene-Batu, Abdon Mukalay, Denis Porignon, Albert Tambwe

“…Simple linear regression (p<0.05) measured the influence of IHFs on service use. The LRZ's functionality and performance were assessed using an internal benchmarking approach, with results presented as trend curves. …”
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Research on a PTSD Risk Assessment Model Using Multi-Modal Data Fusion by Youxi Luo, Yucui Shang, Dongfeng Zhu, Tian Zhang, Chaozhu Hu

“…The importance of multi-modal data fusion lies in its ability to integrate data from different dimensions and provide a more comprehensive PTSD risk assessment. For multi-modal data fusion, two sets of solutions are proposed: the first is to extract EEG features using B-spline basis functions, combined with questionnaire data, to construct a multi-modal Zero-Inflated Poisson regression model; the second is to build a multi-modal deep neural network fusion prediction model to automatically extract and fuse multi-modal data features. …”
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Serum fibrinogen level and fibrinogen administration in patients with traumatic brain injury: A systematic review and meta-analysis protocol. by Joanne Igoli, Jeremiah Oluwatomi Itodo Daniel, Halleluyah Oludele, Adedoyin Esther Alao, Idemudia Stephen Ogedegbe, Adewale Olaniyan, Michael Adeshola Adebayo, Damilola Matthew, Temidayo Elizabeth Oyepitan, Daniel Brabi, Olatomiwa Olukoya, Temidayo Osunronbi

“…Primary outcomes include functional outcome and mortality assessments such as the Glasgow Outcome Score and modified Rankin Score. …”
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A Qualitative Study Examining the Unintended Consequences from Implementing a Case Management Team to Reduce Avoidable Hospital Readmission in Singapore by Shilpa Surendran, Stephen So, Toon Wei Lim, David Bruce Matchar

“…Results: Data analysis generated seven subthemes: ineffective targeting of patient population, fund constraints, lack of patient ownership, limited post discharge follow up, comprehensive care approaches, role overlap and patient confusion. …”
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Study protocol for a randomized controlled trial of Regulating Together (RT), a group therapy for emotion dysregulation in school-age autistic youth and their caregivers by Walker S. McKinney, Lauren J. Tadevich, Lauren M. Schmitt, Paul S. Horn, Jennnifer R. Ruberg, Susan W. White, Debra L. Reisinger, Karen W. Burkett, Shivali Sarawgi, Sungeun Kang, Rebecca C. Shaffer

“…Participants will be 144 autistic youth (8–12 years; IQ ≥ 65) randomized to either 5-week treatment condition. A comprehensive assessment battery integrating self-, caregiver-, and clinician-report information, functional outcomes (i.e., number of psychiatric hospitalizations), objective outcomes (probabilistic reversal learning task), and biobehavioral measures (heart rate variability) will be collected and compared between baseline (Week 0), post-treatment (Week 7), post-generalization (Week 16), and at long-term follow-up (Week 29). …”
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Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies by Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu, Yong Zeng, Xiulin Jiang

“…This review systematically explores the enzymatic and nonenzymatic mechanisms underlying protein lactylation, shedding light on the interplay between cellular metabolism and epigenetic control. We comprehensively analyze its biological functions in normal physiology, such as immune homeostasis and tissue repair, and its dysregulation in pathological contexts, including cancer, inflammation, and metabolic disorders. …”
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The effects of annual cycle stages and life-history traits on feather abrasion by Yosef Kiat, Quentin Dupriez, Gina Pyo, Oliver J. L. Fox, Rafi Paz, Hans-Jürgen Eilts, Carlos Talabante, Nir Sapir

“…The application of the proposed abrasion measurement method is expected to facilitate better understanding of plumage function and properties, as well as bird moult strategies, thereby enhancing our comprehension of avian ecology, biomechanics, life-history traits and sexual selection, as well as their evolution.…”
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Effect of treatment modality on long-term outcomes in attention-deficit/hyperactivity disorder: a systematic review. by L Eugene Arnold, Paul Hodgkins, Hervé Caci, Jennifer Kahle, Susan Young

“…<h4>Background</h4>Evaluation of treatments for attention-deficit/hyperactivity disorder (ADHD) previously focused on symptom control, but attention has shifted to functional outcomes. The effect of different ADHD treatment periods and modalities (pharmacological, non-pharmacological, and combination) on long-term outcomes needs to be more comprehensively understood.…”
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Deciphering the mechanistic roles of ADARs in cancer pathogenesis, tumor immune evasion, and drug resistance by Xiaoke Wang, Fei Yin, Yangfang He, Yue Qiao, Yan Yan, Jingru Ma

“…RNA is a fundamental biological macromolecule that undergoes several post-transcriptional modifications, including adenosine to inosine (A-to-I) editing by adenosine deaminases acting on RNA (ADARs). …”
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