Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning by Chenghao Zhou, Lifeng Ding, Huailan Wang, Gonghui Li, Lei Gao

“…IntroductionLactylation, a post-translational modification characterized by the attachment of lactate to protein lysine residues on proteins, plays a pivotal role in cancer progression and immune evasion. …”
Get full text

Porcine decellularized nerve matrix hydrogel attenuates neuroinflammation after peripheral nerve injury by inhibiting the TLR4/MyD88/NF-κB axis by Rui Li, Jianquan Liu, Liuxun Li, Guotian Luo, Xinrong Yuan, Shichao Shen, Yongpeng Shi, Jianlong Wu, Bin Yan, Lei Yang

“…Using peripheral nerve injury model rats treated with porcine decellularized nerve matrix hydrogel, we evaluated structural and functional recovery, macrophage phenotype alteration, specific cytokine expression, and changes in related signaling molecules in vivo. …”
Get full text

Dynamic innate immune responses of human bronchial epithelial cells to severe acute respiratory syndrome-associated coronavirus infection. by Tomoki Yoshikawa, Terence E Hill, Naoko Yoshikawa, Vsevolod L Popov, Cristi L Galindo, Harold R Garner, C J Peters, Chien-Te Kent Tseng

“…Based on microarray-based functional genomics, we report here the global gene response of 2B4 cells, a cloned bronchial epithelial cell line derived from Calu-3 cells. …”
Get full text

Lessons learned from an fMRI-guided rTMS study on performance in a numerical Stroop task. by Lysianne Beynel, Hannah Gura, Zeynab Rezaee, Ekaete C Ekpo, Zhi-De Deng, Janet O Joseph, Paul Taylor, Bruce Luber, Sarah H Lisanby

“…To do so we used a traditional reaction time analysis and we performed, post-hoc, a more advanced comprehensive drift diffusion modeling approach. …”
Get full text

A bibliometric analysis of artificial intelligence and machine learning applications for human resource management by Güler Koştı, İsmail Kayadibi

“…Compared to the previous studies, this research provides a more comprehensive bibliometric analysis of AI and ML applications in HRM. …”
Get full text

New mutation of the TP53 gene associated with the hereditary breast cancer in a young Tuvinian woman by P. A. Gervas, A. Yu. Molokov, A. A. Zarubin, A. A. Ponomareva, N. N. Babyshkina, V. A. Belyavskaya, L. F. Pisareva, E. L. Choynzonov, N. V. Cherdyntseva

“…We reclassified the mutation of the unknown significance using the activedrivedb database that assessed the effect of mutations on sites of post-translational modifications, and the proteinpaint tool that complemented the existing cancer genome portals and provided a comprehensive and intuitive view of cancer genomic data. …”
Get full text

Integrating Interpretability in Machine Learning and Deep Neural Networks: A Novel Approach to Feature Importance and Outlier Detection in COVID-19 Symptomatology and Vaccine Effic... by Shadi Jacob Khoury, Yazeed Zoabi, Mickey Scheinowitz, Noam Shomron

“…This finding underscores the importance of monitoring patients post-recovery for potential complications and tailoring medical interventions accordingly. …”
Get full text

Scenario-based assessment design: an implementation and analysis of Iranian EFL learners’ writing performance by Masumeh Rahimivand, Saeideh Ahangari, Nasrin Hadidi Tamjid

“…Abstract Writing comprehensibly, dynamically, and persuasively in a foreign language is a significant challenge for learners. …”
Get full text

Genomic and molecular characterization of a ceftazidime-avibactam resistant Klebsiella pneumoniae strain isolated from a Chinese tertiary hospital by Yanye Tu, Hui Gao, Feng Wang, Rongqing Zhao, Shiyong Chen, Yanzi Chang, Hong Li

“…Plasmid analysis identified three distinct plasmids, among which an IncX3-type plasmid carrying bla NDM−5 was confirmed, while the functional characteristics of the remaining two plasmids require further investigation. …”
Get full text

The influence of a conservation‐based grazing program on greater sage‐grouse habitat selection by Jennifer E. Helm, Elizabeth G. Simpson, Lorelle I. Berkeley, Mark Szczypinski, Shea P. Coons, Victoria J. Dreitz

“…We used resource selection functions to assess sage‐grouse selection for pastures enrolled in a CGP as well as plant functional type and topography. …”
Get full text

The Notable Role of Telomere Length Maintenance in Complex Diseases by Jiahui Lv, Xinmiao Zhao, Linjie Zhao, Chengjun Gong, Wanjie Zheng, Li Guo, Jun Wang, Tingming Liang

Get full text

Different roles of astrocytes in the blood–brain barrier during the acute and recovery phases of stroke by Jialin Cheng, Yuxiao Zheng, Fafeng Cheng, Chunyu Wang, Jinhua Han, Haojia Zhang, Xin Lan, Chuxin Zhang, Xueqian Wang, Qingguo Wang, Changxiang Li

“…This comprehensive review explores the physiological and pathological morphological and functional changes in astrocytes and the blood–brain barrier in ischemic stroke. …”
Get full text

Evaluating Effectiveness, Safety, and Patient Outcomes of 3D Printing in Orthopedic Implant Design and Customization: A PRISMA-Complaint Systematic Review by Mainak Roy, Madhan Jeyaraman, Naveen Jeyaraman, Arpit Sahu, Sanjeevi Bharadwaj, Abhijith K Jayan

“…Results: The analysis included data from numerous studies, highlighting several key findings, such as (a) customization: 3D-printed implants provide a highly personalized fit that conforms precisely to individual anatomies, enhancing biomechanical performance and reducing complications, (b) surgical outcomes: The use of 3D-printed implants significantly reduces surgery time and intraoperative errors due to advanced imaging and meticulous pre-operative planning, (c) patient satisfaction: Patients reported higher satisfaction rates due to improved implant stability and functionality, leading to quicker recovery and a better quality of life post-surgery, and (d) challenges: The high costs of 3D printing technology and concerns about the long-term durability and performance of 3D-printed implants remain significant barriers to widespread adoption. …”
Get full text

Tribological Performance Enhancement in FDM and SLA Additive Manufacturing: Materials, Mechanisms, Surface Engineering, and Hybrid Strategies—A Holistic Review by Raja Subramani, Ronit Rosario Leon, Rajeswari Nageswaren, Maher Ali Rusho, Karthik Venkitaraman Shankar

“…However, the tribological performance and surface integrity of parts manufactured by AM are the biggest functional deployment challenges, especially in wear susceptibility or load-carrying applications. …”
Get full text

Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry. by Edward C Hutchinson, Eleanor M Denham, Benjamin Thomas, David C Trudgian, Svenja S Hester, Gabriela Ridlova, Ashley York, Lauren Turrell, Ervin Fodor

“…Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. …”
Get full text

Advances in Cerebellar TMS Therapy: An Updated Systematic Review on Multi-Session Interventions by Andrea Ciricugno, Sonia Paternò, Nicole Barbati, Renato Borgatti, Zaira Cattaneo, Chiara Ferrari

“…<b>Results:</b> The results show that repeated sessions of cerebellar TMS are safe, well-tolerated, and associated with functional improvements primarily in motor disorders—such as spinocerebellar ataxia, Parkinson’s disease, multiple system atrophy, essential tremor, and post-stroke deficits—as well as in psychiatric populations, particularly patients with schizophrenia. …”
Get full text

Deep learning vulnerability detection method based on optimized inter-procedural semantics of programs by Yan LI, Weizhong QIANG, Zhen LI, Deqing ZOU, Hai JIN

Get full text

Facial recognition targeted attack algorithm based on multiscale frequency decomposition and meta-learning by CAI Jun, HUANG Tianqiang, ZHENG Aokun, YE Feng, XU Chao

Get full text

Class-consistent technology-based outlier detection for incomplete real-valued data based on rough set theory and granular computing by Li Zhaowen, He Hongxuan, Wang Pei

Get full text

Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…At this intersection, lactylation-a recently discovered lactate-derived post-translational modification (PTM)-acts as a molecular bridge linking metabolic rewiring to transcriptional and post-transcriptional control. …”
Get full text