Analysis of Cascading Failure in Urban Metro Networks: A Dynamic Perspective Incorporating Changes in Travel Decisions by Huiying Lei, Xuedong Hua, Weijie Yu, Yongtao Zheng, Wei Wang

“…Notably, stations with integrated functionalities may hold more significant roles than those with singular functions. …”
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Teclistamab for patients with heavily pretreated relapsed/refractory multiple myeloma and renal impairment by Danai Dima, Aimaz Afrough, Utkarsh Goel, Ariel F. Grajales-Cruz, Jack Khouri, Kelley Julian, Oren Pasvolsky, Rahul Banerjee, Beatrice Razzo, Christopher J. Ferreri, Mariola A. Vazquez-Martinez, James A. Davis, Aishwarya Sannareddy, Omar Castaneda, Shahzad Raza, Andrew J. Portuguese, Mahmoud R. Gaballa, Masooma S. Rana, Alex Lieberman-Cribbin, Shaun DeJarnette, Rebecca Gonzalez, Anna Chen, Megan M. Herr, Lekha Mikkilineni, Hitomi Hosoya, Evguenia Ouchveridze, Gurbakhash Kaur, Adriana Rossi, Leyla Shune, Faiz Anwer, Yi Lin, Shambavi Richard, Douglas W. Sborov, Rachid C. Baz, Alfred L. Garfall, Hans C. Lee, Larry D. Anderson, Jr., Andrew J. Cowan, Krina K. Patel, Peter M. Voorhees, Surbhi Sidana, Doris K. Hansen, Shebli Atrash, Sandra P. Susanibar-Adaniya

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Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination by Kristina V. Korochina, Tatyana V. Chernysheva, Irina E. Korochina

“…Combined OA phenotype was characterized by variable clinical and histopathological features. Conclusion — Comprehensive comparative clinical and morphological analysis of late-stage knee OA of various origin was completed, and age-related, post-traumatic, metabolic and combined OA phenotypes were studied. …”
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A single-cell RNA-seq dataset of synovial fluid from rheumatoid arthritis treated with TNF-α/JAK inhibitor by Chenjia He, Zhixiang Ren, Xuyang Xia, Zhinan Xue, Feng Zhang, Maoxiang Qian, Yang Shu, Geng Yin, Qibing Xie, Heng Xu

“…Here, we present a comprehensive scRNA-seq analysis of synovial fluid samples of RA patients treated with tofacitinib or adalimumab, both pre- and post-treatment. …”
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Genome-wide identification and characterisation of Toll-like receptors in Chinese spiny frog (Quasipaa spinosa) by Zehong Li, Zihan Gao, Dexin Mo, Zifeng Zhu, Jingqi Zhang, Mujin Liu, Han Xiao, Meng Zhou, Teng Gao, Rishen Liang

“…Protein structure prediction and motif analysis demonstrated that all QsTLRs are relatively conserved in both structure and function. mRNA expression levels of QsTLRs in spleen tissues were measured following stimulation with Elizabethkingia miricola, which revealing that 15 QsTLR genes exhibited up-regulation at various time points post-stimulation.DiscussionThese findings provide a comprehensive understanding of the QsTLR gene family and lay the groundwork for future studies exploring the functional evolution of the amphibian TLR gene family.…”
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Cardiac Remodeling and Arrhythmic Burden in Pre-Transplant Cirrhotic Patients: Pathophysiological Mechanisms and Management Strategies by Charilila-Loukia Ververeli, Yannis Dimitroglou, Stergios Soulaidopoulos, Evangelos Cholongitas, Constantina Aggeli, Konstantinos Tsioufis, Dimitris Tousoulis

“…<b>Methods</b>: A comprehensive literature review was conducted to evaluate the hemodynamic and structural cardiac alterations in cirrhosis. …”
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Durability of Supplemental Nucleus Pulposus Allograft in Patients with Lumbar Discogenic Pain by Costandi S, Beall DP, Davis TT, Amirdelfan K, Naidu RK, DePalma MJ, Yoon ES, Fleming JW, Block JE, Mekhail N

“…This report includes the final participant follow up at 24 months post procedure. Back pain severity was evaluated using an 11-point numeric rating scale (NRS) and back function using the Oswestry Disability Index (ODI). …”
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Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link by Alanoud Abdulla, Hana Q. Sadida, Jayakumar Jerobin, Imadeldin Elfaki, Rashid Mir, Sameer Mirza, Mayank Singh, Muzafar A. Macha, Shahab Uddin, Khalid Fakhro, Ajaz A. Bhat, Ammira S. Al-Shabeeb Akil

“…It also increases the risk of various cancers, including melanoma, endometrial, prostate, pancreatic, esophageal adenocarcinoma, colorectal carcinoma, renal adenocarcinoma, and pre-and post-menopausal breast cancer. Obesity-induced cellular changes, such as impaired CD8+ T cell function, dyslipidemia, hypercholesterolemia, insulin resistance, mild hyperglycemia, and fluctuating levels of leptin, resistin, adiponectin, and IL-6, contribute to cancer development by promoting inflammation and creating a tumor-promoting microenvironment rich in adipocytes. …”
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Comparative efficacy of conservative interventions for adolescent idiopathic scoliosis: a systematic review and network meta-analysis of randomized controlled trials by Jun Ren, Shoujian Wang, Miaoxiu Li, Xin Zhou, Ya Wen, Zonglin Wen, Jiannan Lin, Lingjun Kong, Min Fang

“…Brace plus physiotherapeutic scoliosis-specific exercises (PSSE, mean difference (MD): 4.80, 95% confidence interval (CI): 0.56 to 9.04, moderate certainty), manual therapy plus PSSE (MD: 5.26, 95% CI: 1.09 to 9.43, moderate certainty), and manual therapy plus mind–body exercise (MD: 5.14, 95% CI: 1.25 to 9.04, moderate certainty) could be intermediately effective in improving Cobb angle of patients with AIS at post-interventions. Although brace alone (MD: 1.53, 95% CI: 1.09 to 2.14, high certainty) could be the intermediate effective intervention in preventing scoliosis progression, moderate to high certainty evidence showed that brace alone and PSSE alone probably have little or no difference in improving Cobb angle, function, mental health, self-image, angle of trunk rotation (ATR), or satisfaction of patients with AIS compared to minimal interventions. …”
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Clinical and Immunological Analysis of Retinal Pigment Epithelium Transplantation Derived from Induced Pluripotent Stem Cells under Pharmacological Immunosuppression in Rabbits by N. V. Neroeva, N. V. Balatskaya, A. G. Brilliantova, L. A. Katargina, A. E. Kharitonov, M. A. Lagarkova, A. N. Bogomazova

“…The observation period was 14, 28 and 60 days. Post-transplant evaluation was carried out using standard and specialized ophthalmological examination methods. …”
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Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib by Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta

“…Linear models were used to determine differentially expressed genes (DEGs) (1) at baseline according to clinical responses and (2) in the pre‐post comparison after tofacitinib treatment and in relation to EULAR responses. …”
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Testosterone Deficiency and Lipid Dysregulation in Individuals with Coexisting Hypothyroidism and Type 2 Diabetes: Clinical and Metabolic Implications by Mandayal Jamatia, Mohammad N Khan, Ashok Kumar

“…Statistical analysis was performed using analysis of variance and Tukey's <i>post-hoc</i> test to compare group differences, while Pearson's correlation analysis assessed associations between biochemical markers. …”
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Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development by Zhangmin Ke, Zhangmin Ke, Kaikai Shen, Li Wang, Hao Xu, Xia Pan, Zhenjue Qian, Yuting Wen, Tangfeng Lv, Xiuwei Zhang, Yong Song

“…Succinylation represents an emerging class of post-translational modifications (PTMs), characterized by the enzymatic or non-enzymatic transfer of a negatively charged four-carbon succinyl group to the ϵ-amino group of lysine residues, mediated by succinyl-coenzyme A. …”
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Effectiveness of using autologous platelet cryolysate after knee arthroscopy by S.I. Gerasymenko, M.V. Poluliah, A.M. Babko, A.S. Gerasymenko, D.M. Poluliah, R.M. Ostpchuk, D.S. Yarosh, O.M. Lushchii, N.Y. Marchenko

“…Depending on the treatment method, the patients were divided into three groups: the first group received autologous platelet cryolysate (APC), the second group received stem cell therapy, and the third group received conventional ОА treatment. A comprehensive, multifactorial analysis assessed clinical indicators, including pain level on the visual analogue scale (VAS), joint functionality on the Lysholm scale, quality of life on the EQ-5D scale, recovery duration, and complication rates across different treatment groups. …”
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Effects of a virtual simulative diabetes care program on learning ability and clinical thinking skills in nursing interns by Tianhui Xu, Qin Wang, Fang Liu, Li Yang, Rong Wang, Huiting Weng

“…Traditional teaching methods are limited by clinical settings, hindering the development of comprehensive theoretical and clinical competencies. …”
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MC21 v.10 – coupled-radiation Monte Carlo transport solver with support for multiphysics simulations by Griesheimer David P., Gill Daniel F., Nease Brian R., Pavlou Andrew, Stedry Mark H., Thompson Jason T., Burke Paul E., Dobreff Peter S.

“…Notable improvements include enhanced interaction physics models, efficient model representation and tracking algorithms, support for coupled physics calculations using both in-line and externally coupled feedback modules, and the development of native visualization and results post-processing tools. As a result of these improvements, MC21 v.10 provides a comprehensive analysis framework that allows complicated engineering problems to be solved with minimal reliance on external tools.…”
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Transcatheter aortic valve replacement in quadricuspid aortic valve: a systematic review and meta-analysis by Mostafa A. Khalifa, Hashim Talib Hashim, Aya Ahmed Shimal, Fathima Raahima Riyas Mohamed, Srinithi Ragunathan, Ahmed Sermed Al Sakini, Mohamed H. Elbadawi, Mohammed Rushdhi Irfan, Ibrahim Moqbel, Marwah Mohammed Almualed, Mohammedbaqer Al-Ghuraibawi, Batool S. Al-Aboudi

“…No patients experienced aortic post-dilation, and one (5.8%) had an atrioventricular block within 30 days post-procedure.ConclusionTAVR is an effective and growing treatment for high-risk patients with aortic valve disease, including those with QAV. …”
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Emergency Power Supply Management Strategy for Low-Performance Distribution Networks Based on Mobile Multi-Port Interconnection Equipment by Xin Ning, Tianhao Zhu, Tong Kang, Jiran Zhu, Keyan Liu, Lijing Sun, Jinliang You, Xin Wang, Qi Guo

“…However, due to limitations in configuration, the continuous power supply capacity of existing electrical vehicles (EVs) is insufficient, making it difficult to meet the needs of energy transfer and flow regulation in post-disaster distribution networks. Therefore, in this study, we comprehensively considered the energy time-shift characteristics of EVs and the flexible control function of soft open points (SOPs), integrated their advantages, and designed an emergency vehicle with SOP (EV-SOP) and its management strategy for distribution network line faults. …”
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Transcriptional Profiling of Caudal Fin Regeneration in Zebrafish by Michael Schebesta, Ching-Ling Lien, Felix B. Engel, Mark T. Keating

“…Of those, 563 were up-regulated and 266 were down-regulated. We constructed a comprehensive database containing expression data, functional assignment, and background information from the literature for each differentially expressed transcript. …”
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Advanced Digital System for International Collaboration on Biosample-Oriented Research: A Multicriteria Query Tool for Real-Time Biosample and Patient Cohort Searches by Alexandros Fridas, Anna Bourouliti, Loukia Touramanidou, Desislava Ivanova, Kostantinos Votis, Panagiotis Katsaounis

“…The platform employs a modular, distributed architecture that ensures high availability, redundancy, and interoperability among diverse stakeholders, as well as integrates advanced features, including secure access management, comprehensive query functionalities, real-time availability reporting, and robust data mining capabilities. …”
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