Further characterization and engineering of an 11-amino acid motif for enhancing recombinant soluble protein expression by Jiawu Bi, Elaine Tiong, Ying Sin Koo, Weibiao Zhou, Fong Tian Wong

“…Results A comprehensive analysis was performed to improve the characteristics of the 11-amino acid tag. …”
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Polyamine-Mediated Growth Regulation in Microalgae: Integrating Redox Balance and Amino Acids Pathway into Metabolic Engineering by Leandro Luis Lavandosque, Flavia Vischi Winck

“…Polyamines (putrescine, spermidine, and spermine) biology in microalgae, particularly <i>Chlamydomonas reinhardtii</i>, is reviewed, exploring their critical function in modulating cell cycle progression, enzymatic activity, and stress responses through nucleic acid stabilization, protein synthesis regulation, and post-translational modifications. …”
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Advancements and Challenges in Immune Protection Strategies for Islet Transplantation by Xue Wang, Ziyuan Zeng, Dayan Li, Kai Wang, Wei Zhang, Yang Yu, Xi Wang

“…However, the limited availability of human cadaveric islet donors and the need for ongoing administration of immunosuppressive agents post‐transplantation hinder the widespread use of this treatment. …”
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Features of women’s reproductive dysfunctions associated with prolonged stressful situations by O. H. Horbatiuk, A. S. Shatkovska, A. P. Hryhorenko, O. V. Vaskiv, I. O. Bets, I. M. Kustovska, A. I. Petrash

“…The aim of the work was a comprehensive study of the hormonal function of pituitary gland, ovaries, thyroid gland and adrenal glands in women of reproductive age with various types of menstrual cycle disorders caused by a prolonged stressful situation. …”
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Factors contributing to the delayed diagnosis of endometriosis—a systematic review and meta-analysis by Wenwei Li, Huiyan Feng, Qingjian Ye

“…Random-effects analysis was used to estimate the overall SMDs with 95% confidence intervals (CIs). For the primary post hoc analysis, subgroup analyses and evaluation of heterogeneity (I2 statistic) were conducted. …”
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Cardiac Rehabilitation After Mitral Valve Intervention: Tailored Assessment, Management, and Exercise Training by Francesco Perone, Monica Loguercio, Federica Sabato, Annalisa Pasquini, Marina Ostojic, Ashot Avagimyan, Vaida Sileikiene, Joanna Popiolek-Kalisz, Aneta Aleksova, Marco Ambrosetti

“…Specifically, we focus our review on the tailored assessment and management of these patients from post-operative to cardiac rehabilitation.…”
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Advances in the prerequisite and consequence of STING downstream signalosomes by Lu Xinliang, Li Xiaobing, Li Lili, Han Chuanhui, Li Sirui

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The Role of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Signaling in Cancer by Sourajeet Karfa, Shashank Saurav, Bryan Feng, Song Li, Brian K. Law, Pran K. Datta

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Exploring the role of neutrophils in inflammatory pain hypersensitivity via single-cell transcriptome profiling by Kai Ding, Xing Liu, Bin Zeng, Songyu Liu, Lu Zhang, Bo Li, Jinyi Zhou, Xiaosan Su, Jun Wang

“…This study employs single-cell RNA sequencing (scRNA-seq) to analyze CD11b+ cell composition in mice after surgery and CFA treatment and investigates the effects and mechanisms of Nicotinamide N-oxide (NAMO) on neutrophils and pain.MethodsscRNA-seq was used to analyze the transcriptomes of CD11b+ cells in murine models of post-operative and CFA-induced inflammation. Using comprehensive bioinformatics techniques, we identified distinct cell subpopulations and characterized their gene expression profiles and functional attributes. …”
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Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study by Amber Watts, Amber Watts, Shannon Donofry, Shannon Donofry, Hayley Ripperger, Nicole M. Eklund, Lu Wan, Chaeryon Kang, George Grove, Lauren E. Oberlin, Lauren E. Oberlin, Swathi Gujral, Eric D. Vidoni, Jeffrey M. Burns, Edward McAuley, Edward McAuley, Charles H. Hillman, Arthur F. Kramer, Arthur F. Kramer, M. Ilyas Kamboh, Kirk I. Erickson, Kirk I. Erickson

“…Hypothesis (3) We did not observe significant interactions between APOE4 status and oophorectomy or hormone therapy in their associations with cognitive performance.DiscussionOur results suggest exposure to estrogen during adulthood, specifically birth control and hormone therapy among women undergoing pre-menopausal oophorectomy, benefits cognitive function in older adulthood. Our comprehensive cognitive battery allowed us to examine cognitive function with a high degree of granularity. …”
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SIU-ICUD: Principles and Outcomes of Focal Therapy in Localized Prostate Cancer by Alessandro Marquis, Jonathan Olivier, Tavya G. R. Benjamin, Eric Barret, Giancarlo Marra, Claire Deleuze, Lucas Bento, Kae J. Tay, Hashim U. Ahmed, Mark Emberton, Arnauld Villers, Thomas J. Polascik, Ardeshir R. Rastinehad

“…The safety profile is excellent, with high rates of urinary continence and sexual function preservation. Post-treatment surveillance integrates PSA measurements, imaging, and histological assessment. …”
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Research progress in Pusher Syndrome after stroke by Huayong Wu, Haoyang Duan

“…Early rehabilitation intervention can significantly improve functional outcomes. This article comprehensively reviews the nomenclature, incidence, etiology, lesion sites, clinical manifestations, and prognosis of Pusher Syndrome, providing a research foundation for future studies on post-stroke Pusher Syndrome.…”
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Neuroleptics used in critical COVID associated with moderate-severe dyspnea after hospital discharge by Carlos Toufen, Gustavo Corrêa de Almeida, José Eduardo Pompeu, Celso Ricardo Fernandes de Carvalho, Carlos Roberto Ribeiro de Carvalho

“…Data were collected on clinical preconditions, hospital and ICU stays, and the use of corticosteroids, neuroleptics, neuromuscular blockers, midazolam, fentanyl, and noradrenaline. Post-discharge evaluations were conducted at 1 and 12 months, assessing dyspnea, frailty, quality of life, functional capacity, anxiety, and depression. …”
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RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium... by Gerard Badia-Bringué, Marta Alonso-Hearn

“…In this comprehensive review, we examine critical aspects of post-transcriptional regulation in the context of MAP infection. …”
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Fine-tuning immunity: ubiquitin-dependent regulation of interleukin-17A expression by Th17 cells by Desh Raj, Desh Raj, Desh Raj, Amit K. Verma, Amit K. Verma, Amit K. Verma, Risha Mathur, Risha Mathur, Risha Mathur, Jenna Woody, Jenna Woody, Jenna Woody, Mahesh Kathania, Mahesh Kathania, Mahesh Kathania, K. Venuprasad, K. Venuprasad, K. Venuprasad

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Design and Implementation of a Software System for Full-Process Animal Experiment Ethical Review by XU Xiao, WU Jiemin, LIANG Yi, YE Mingxia, ZHOU Shunchang

“…Additionally, this paper provides an in-depth exploration of the software, detailing its functional and non-functional requirements, as well as its security considerations. …”
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Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study by Vincent Dore, Christopher C Rowe, Meinir Krishnasamy, Haryana Dhillon, Adam K Walker, Karla Gough, Priscilla Gates, Carlene Wilson, Eliza Hawkes, Yuliya Perchyonok, Janette L Vardy, Michiel de Ruiter

“…Patients will complete comprehensive assessments at three time points: baseline (time 1, pre-treatment) and two post-baseline follow-up assessments (time 2, mid-treatment and time 3, 6–8 weeks post-treatment completion). …”
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Environmental Consequences Of the Capital Relocation In the Republic Of Kazakhstan by Natalia A. Koldobskaya

“…The subject of this article is the ecological transformation in former and modern capitals of the Republic of Kazakhstan, which was affected not only by post-Soviet changes but also by the transfer of capital functions from Almaty to Nur-Sultan. …”
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USP1 inhibits influenza A and B virus replication in MDCK cells by mediating RIG-I deubiquitination by Yuejiao Liao, Siya Wang, Tian Tang, Chengfang Li, Chenhao Yang, Liyuan Ma, Jin Ye, Jiamin Wang, Di Yang, Zilin Qiao, Zhongren Ma, Zhenbin Liu

“…The above results provide a more comprehensive understanding of the function of USP1 and the antiviral response mechanism, and provide a theoretical and methodological basis for the screening of target genes for the artificial establishment of high-yield MDCK cell lines for vaccine production.…”
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Current Review of Heart Failure-Related Risk and Prognostic Factors by Michał Maksymilian Wilk, Jakub Wilk, Szymon Urban, Piotr Gajewski

“…These findings underscore the importance of miRNAs in modulating the structural and functional changes seen in HF. Beyond the heart, HF affects multiple organ systems, including the kidneys and liver, with markers of dysfunction in these organs—such as worsening renal function and liver stiffness—being closely linked to increased morbidity and mortality. …”
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