Last Resort? Rationale for Comprehensive Molecular Analysis in Treatment-Refractory R/M HNSCC: A Case Report of Remarkable Response to Sacituzumab Govitecan Following Molecular and... by Henrike Barbara Zech, Philippe Schafhausen, Leonie Ramke, Janna-Lisa Velthaus, Simon Kreutzfeldt, Daniel Hübschmann, Kai Rothkamm, Carsten Bokemeyer, Anna Sophie Hoffmann, Stefan Fröhling, Hanno Glimm, Christian Stephan Betz, Malte Kriegs, Maximilian Christopeit

“…<b>Methods</b>: We report the case of a 43-year-old patient with recurrent oral cancer who was extensively pretreated and comprehensively characterized using both descriptive and functional testing. …”
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Digital Therapeutics in China: Comprehensive Review by Nan Jiang, Xiru Yu, Yuxi Yang, Guanqiao Li, Chanchan He, Man Ping Wang, Yih Chung Tham, Tien Yin Wong, Keqin Rao

“…Meta-analysis for cognitive disorder DTx showed significant improvement in global cognitive function in DTx-treated participants (SMD 0.65, 95% CI 0.37-0.94), despite notable heterogeneity (I²=71.7%). …”
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An in-depth exploration of four heterogeneity structure-based EGFR mutation subgroups in Chinese non-small cell lung cancer by Yongfeng Yu, Fei Yao, Jin Wang, Zhan Huang, Tao Hu, Changbin Zhu, Shun Lu

“…Conclusion In this study, we have employed a structure-based classification approach for EGFR mutants to comprehensively characterize the mutational landscape and heterogeneous biological traits at the transcriptional and functional levels in Chinese patients with NSCLC.…”
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Role of neurotransmitters in schizophrenia: a comprehensive study by Videsha Bansal, Indranath Chatterjee

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Anticancer Properties of Macroalgae: A Comprehensive Review by Sara Frazzini, Luciana Rossi

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Comprehensive Review: Mavacamten and Aficamten in Hypertrophic Cardiomyopathy by Helin Savsin, Tomasz Tokarek

“…Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease, with an estimated prevalence of 1:600 in the general population, and is associated with significant morbidity. …”
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Comprehensive evaluation of phosphoproteomic-based kinase activity inference by Sophia Müller-Dott, Eric J. Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M. Yaron-Barir, Sara R. Savage, Martin Garrido-Rodriguez, Jared L. Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T. Lei, Aurelien Dugourd, Karsten Krug, Lewis C. Cantley, D. R. Mani, Bing Zhang, Julio Saez-Rodriguez

“…Abstract Kinases regulate cellular processes and are essential for understanding cellular function and disease. To investigate the regulatory state of a kinase, numerous methods have been developed to infer kinase activities from phosphoproteomics data using kinase-substrate libraries. …”
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The Influence of Racket Sports on Longevity and Comprehensive Health Benefits by Adrianna Dylik, Łukasz Krawczak, Hanna Gulaczyk, Maria Spychalska, Jan Spychalski, Mikołaj Musiał, Mikołaj Kaczmarek, Wiktoria Grochowska, Weronika Gryczyńska

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Towards a comprehensive view of wetland benthic communities by Clélia Duran, Christine Dupuy, Hélène Agogué, Robert Duran, Cristiana Cravo-Laureau

“…Thus, a holistic view of the benthic community is necessary to fully understand their organization and functioning. This study assesses the implementation of a comprehensive view, using mock communities and environmental samples. …”
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A Comprehensive Study of Soft Palate Development in Mice. by Alexandre Grimaldi, Carolina Parada, Yang Chai

“…Cleft palate is one of the most common congenital birth defects. Tremendous efforts have been made over the last decades towards understanding hard palate development. …”
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The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review by Chunhao Gao, Nengyun Gong, Fangtian Chen, Shiran Hu, Qingxin Zhou, Xiang Gao

“…This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. …”
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A comprehensive perspective on electric vehicles as evolutionary robots by Haoyang Che, Haoyang Che, Shaolin Wang, Shaolin Wang, Lei Yao, Ying Gu

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A Comprehensive Study on the Development of an Isotonic Sports Drink Preserved by UV-C Light Assisted by Mild Heat and Loaded with Yerba Mate (<i>Ilex paraguariensis</i> St. Hill.)... by María Luz Kozono, Magdalena Durán Cassiet, Antonella Andreone, Marcela L. Schenk, Sandra N. Guerrero

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Subjective assessment of sensory function and oral function decline in older adults. by Tetsuo Ichikawa, Tomoya Koda, Mio Kitamura, Takahiro Kishimoto, Takashi Matsuda, Takaharu Goto, Masayuki Domichi, Akiko Suganuma, Shinji Fujiwara, Yasuhiko Shirayama, Kazuhiko Kotani, Naoki Sakane

“…Although several studies exist in this area, most were focused on individual senses, with few being conducted on comprehensive assessments of all five senses. …”
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Differential effects of GPT-based tools on comprehension of standardized passages by Hudson K. Etkin, Kai J. Etkin, Ryan J. Carter, Camarin E. Rolle

“…Consistent with our pre-registered hypotheses, we found a differential effect of AI tools as a function of baseline reading comprehension ability. …”
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Pregnancy after orthotopic liver transplantation: a comprehensive review by Daria A. Stelmach, Daria A. Stelmach, Kenneth J. Dery, Zoulikha Jabiry-Zieniewicz, Jerzy W. Kupiec-Weglinski

“…Procreation, one of the most powerful human instincts, drives the force behind the increasing popularity of pregnancies after OLT, with their numbers rising since the first documented case in 1976. …”
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Comprehensive evaluation of clinical, echocardiographic, and CMR findings in dilated cardiomyopathy by Prakash H Chaudhary, Chigullapalli Sridevi, Susheel K. Malani, Digvijay D Nalawade, Ankit Shokeen

“…Dyspnea (84%) was the predominant symptom, and systemic hypertension (61.3%) and diabetes mellitus (56%) were the most common comorbidities. Echocardiography revealed varying grades of LVDD, with Grade III present in 32%. …”
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Compilation, Analysis and Application of a Comprehensive Bangla Corpus KUMono by Aysha Akther, Md. Shymon Islam, Hafsa Sultana, A. K. Z. Rasel Rahman, Sujana Saha, Kazi Masudul Alam, Rameswar Debnath

“…Research in Natural Language Processing (NLP) and computational linguistics highly depends on a good quality representative corpus of any specific language. Bangla is one of the most spoken languages in the world but Bangla NLP research is in its early stage of development due to the lack of quality public corpus. …”
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A comprehensive overview of cyclodextrins in terms of production, properties, and applications by H. A. Abd Alhussein, A. J. Abd Al-Manhel

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Surgical Management of Lower Extremity Lymphedema: A Comprehensive Review by Pedro Ciudad, M. Diya Sabbagh, Mouchammed Agko, Tony C.T. Huang, Oscar J. Manrique, Carmen Román L., Cesar Reynaga, Ricardo Delgado, Michele Maruccia, Hung-Chi Chen

“…Such interventions slow down disease progression and reduce morbidity by allowing the surgeon to salvage the remaining functional lymphatic channels. When physiologic procedures fail or when faced with a delayed presentation, the addition of excisional procedures can provide a more comprehensive treatment of this debilitating disease. …”
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