Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes by Inger Johansson, Yuchen Lu, Yitian Zhou, Kristi Krebs, Martina Akcan, Lili Milani, Magnus Ingelman-Sundberg

“…This includes rare variants, which are estimated to account for 4–6% of drug response variability. Results To comprehensively elucidate the functional consequences and molecular mechanisms of rare variants, we conducted in vitro enzyme expression studies combined with in silico structure–function analyses. …”
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Patterns and risk factors of falls among older adults: a systematic review by Tetiana Yermakova

“…The findings highlight the diversity of approaches to risk assessment and prevention. A comprehensive strategy that integrates regular monitoring, individualized preventive measures, and modern technologies proves to be the most effective in reducing fall risk and maintaining the quality of life for older adults. …”
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The impact of physical activity on working memory in children with ADHD: a meta-analysis by Gong Cheng, Gong Cheng, Ce Song, XiaoQin Hong

“…BackgroundAttention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children, often associated with impairments in working memory and other cognitive functions. Physical activity interventions have gained attention as a promising non-pharmacological strategy to alleviate these deficits. …”
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Efficacy and safety of Danhong injection on inflammatory factors and vascular endothelial function in patients with unstable angina pectoris: a systematic review and meta-analysis... by Zunqi Kan, Wenli Yan, Cong Chen, Huanyu Gao, Yongmei Song

“…Several clinical studies have demonstrated DHI’s efficacy for treating UAP, with potential pharmacological effects on inflammatory factors and vascular endothelial function. However, to date, the current evidence has not been systematically summarized and analyzed.PurposeThis study provides a comprehensive overview of the most recent clinical findings and systematically analyzes the impact of DHI on inflammatory factors and vascular endothelial function among individuals diagnosed with UAP.MethodsWe searched for randomized controlled trials (RCTs) conducted until January 2023 from two clinical trial registries and eight literature databases. …”
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Using an Area-Weighted Loss Function to Address Class Imbalance in Deep Learning-Based Mapping of Small Water Bodies in a Low-Latitude Region by Pu Zhou, Giles Foody, Yihang Zhang, Yalan Wang, Xia Wang, Sisi Li, Laiyin Shen, Yun Du, Xiaodong Li

“…Quantitative and visual comparisons demonstrated AWBCE’s superiority over other imbalance-focused loss functions (weighted BCE, Dice, and Focal losses). These findings emphasize the importance of specialized approaches for comprehensive SWB mapping using high-resolution PlanetScope imagery in low-latitude regions.…”
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Noninvasive grading of renal interstitial fibrosis and prediction of annual renal function loss in chronic kidney disease: the optimal solution of seven MR diffusion models by Guanjie Yuan, Zhouyan Liao, Ping Liang, Lingli Cai, Kailun Zhou, Ting Yin, Wei Chen, Omar Darwish, Chuou Xu, Min Han, Zhen Li

“…Objectives To explore the optimal choice of seven diffusion models (DWI, IVIM, DKI, CTRW, FROC, SEM, and sADC) to assess renal interstitial fibrosis (IF) and annual renal function loss in chronic kidney disease (CKD).Methods One hundred thirty-three CKD patients and 30 controls underwent multi-b diffusion sequence scans. …”
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The effect of Vagus nerve stimulation (VNS) on seizure control, cognitive function, and quality of life in individuals with drug‐resistant epilepsy: A systematic review article by Daniel Molla Melese, Abebaye Aragaw, Wondyefraw Mekonen

“…We have established a uniform and comprehensive approach throughout the selected studies by mandating the inclusion of all three crucial parameters: vagus nerve stimulation, cognitive function, and quality of life. …”
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«Ten Questions a Hundred Famous Russian People» as Format Student Television Broadcasting by M. N. Kim, E. M. Pak, N. Ya. Evdokimova

“…The authors of the article comprehensively analyzed all technological and creative aspects of this project. …”
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Translation Technique Of The Book “Resep Masakan Indonesia Di 5 Benua†by Agus Darma Yoga Pratama, I Nyoman Kardana

“…Data collection involved reading and categorizing recipes, noting translation techniques, and analyzing CSIs and functional equivalence. Results show Transference as the most dominant technique (53.57%), preserving original Indonesian terms for cultural authenticity. …”
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Genome-wide identification and functional characterization of the LBD transcription factor gene family in Zanthoxylum armatum DC. reveal its potential role in leaf variation by Yifei Deng, Chong Sun, Xueqian Fu, Yuan Guo, Yongxing Zhu, Chongyu Liu, Ruxin Xu, Han Liu, Qiang Li, Ning Tang, Mi Kuang, Wenying Yang, Xia Liu, Zexiong Chen

“…Conclusions In this study, we comprehensively analyzed the functional characteristics and expression patterns of genes in the LBD family within the heterophyllous plant Z. armatum distributed at different latitudes. …”
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Efficacy of Spiritual-Religious Interventions on Clinical and Functional Outcomes in Iranian Adults with Mental Disorders/Negative Psychological Symptoms: A Systematic Review of Ra... by Hassan Farrahi, Fataneh Bakhshi, Hadi Basiri, Fatemeh Amini Khodashahri, Zeynab Haghdoost

“…Materials and Methods: A comprehensive search was conducted across Iranian and international scientific databases until 2022. …”
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BRCA loss of function including BRCA1 DNA-methylation, but not BRCA-unrelated homologous recombination deficiency, is associated with platinum hypersensitivity in high-grade ovaria... by Heidelinde Fiegl, Simon Schnaiter, Daniel U. Reimer, Katharina Leitner, Petra Nardelli, Irina Tsibulak, Verena Wieser, Katharina Wimmer, Esther Schamschula, Christian Marth, Alain G. Zeimet

“…Here we tested the hypothesis that BRCA loss of function (LOF) due to epigenetic or genetic aberrations is a better predictor for the clinical outcome than HRD. …”
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Learning a Foreign Language in Older Adults Shapes the Functional Connectivity of Distinct Cerebellar Sub‐Regions With Cortical Areas Rich in CB1 Receptor Expression by Giovanna Bubbico, Federica Tomaiuolo, Carlo Sestieri, Golnoush Akhlaghipour, Alberto Granzotto, Antonio Ferretti, Mauro Gianni Perrucci, Stefano L. Sensi, Stefano Delli Pizzi

“…We hypothesize that FLL primarily modulates the rs‐FC of the most “cognitive” cerebellar sub‐regions, such as the crus and the posterior lobules. …”
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Pre-design optimization of the manipulation system with hydraulic drive for mobile transport-technological machine by Lagerev I.A.

“…Also developed the original structure of a comprehensive objective function taking into account the additive effect of any number of important indicators of quality in the formation of the optimal variant of the de-signed construction. …”
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Extensive Numerical Analysis of PDF Parameters for Wind Energy in Brazil: A Study Across 27 Cities for 60 Years Wind Speed by Ahmed Badawi, Amaury Souza, I. M. Elzein, Hassan Ali, Alhareth Zyoud

“…This research conducts a comprehensive numerical assessment of wind energy potential across Brazil, utilizing six decades of wind speed data collected from 27 cities to analyze Probability Density Function (PDF) parameters and enhance wind resource mapping. …”
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Research progress of traditional Chinese medicine regulating intestinal flora in the treatment of hypertension by Wenjun Chen, Longfei Xiao, Wenlong Guo, Hailin Li, Rong Chen, Rong Chen, Zhongyu Duan, Qinghua Chen, Qinghua Chen, Qing Lei

“…Numerous studies have revealed that hypertension and the composition and functionality of the intestinal flora are closely correlated. …”
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Multi‐Objective Optimization of the Food‐Energy‐Water Nexus Problem: A Review of the Key Concepts and Emerging Opportunities in Objective Functions, Decision Variables, and Optimiz... by Isaac Okola, Elisha Opiyo Omulo, Daniel Orwa Ochieng, Gilbert Ouma

“…Abstract Food, energy, and water are basic needs that are quite important in livelihood sustainability. In most situations, their interactions make trade‐offs between these key areas of need challenging to attain. …”
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Evaluation and Influencing Factors of Coupling Coordination of “Production–Living–Ecological” Functions Based on Grid Scale: Empirical Experience of Karst Beibu Gulf in Southwest G... by Ting Feng, Dong Wu, Xiaodong Yu, Meilin Zhang, Renling Dong, Sihan Chen

“…Production space and ecological space has decreased, while living space has increased, with production and ecological spaces mostly flowing into living space. (2) The spatial distribution of production and ecological functions is relatively homogeneous, while the spatial differentiation of living functions is most significant. …”
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Efficacy and Autopoiesis of the System of Science, Education, Law and Politics by Ksenija Grubišić

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Double-helical macrostructure aids the passive movement of extinctive graptolites (Dicellograptus) revealed by CFD simulation by Shijia Gao, Jingqiang Tan, Wenhui Wang

“…This study highlights the close relationship between traditional paleontological analysis and modern computational methods and provides a more comprehensive understanding of the functional morphology of these ancient marine plankton.…”
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