Comprehensive approach to the choice of therapy in patients with osteoarthritis at the first visit to the doctor. Expert consensus (literature review and resolution) by A. M. Lila, O. N. Tkacheva, N. N. Yakhno, A. V. Naumov, L. I. Alekseeva, Yu. V. Kotovskaya, M. V. Putilina, M. L. Kukushkin, A. Yu. Kochish, E. A. Taskina, G. R. Abuzarova

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Dual Roles of microRNA-122 in Hepatocellular Carcinoma and Breast Cancer Progression and Metastasis: A Comprehensive Review by Essam Al Ageeli

“…In HCC, miR-122 is downregulated in most cases, suppressing oncogenic pathways and reducing tumor growth and metastasis. …”
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Copyright Research Protocol for Comprehensive Assessment of the Dento-Alveolar Complex in Patients with Temporomandibular Joint Disorders: Clinical Cases by S. V. Tekucheva, E. A. Bazikyan, Ya. I. Afanasyeva, M. A. Postnikov

“…The authors presented and proved clinically the algorithm of morphofunctional diagnostics for the dento-alveolar complex of patients with temporomandibular joint disorders, combining clinical, anthropometric, radiological and functional methods of examination, which allow the most dento-alveolar characteristics to be considered in order to make the main diagnosis and a personalized treatment protocol for such groups of patients…”
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UHPLC-MS/MS based comprehensive phenolic profiling, antimicrobial and antioxidant activities of Indian Rhodomyrtus tomentosa fruits by A Divya Priya, Asha Martin

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Case Report: A comprehensive digital workflow to enhance predictability and precision with fixed dental prostheses in the posterior region by Isabela Toser, Andrei-Bogdan Faur, Andrei-Bogdan Faur, Anca-Elena Anghel-Lorinți, Anca Jivănescu, Anca Jivănescu

“…While the design was sent to a dental laboratory for fabrication, the workflow demonstrated efficiency, minimal invasiveness, and a high degree of predictability in achieving both functional and aesthetic outcomes, mostly manageable in a chair-side manner. …”
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Optimizing Multiparametric MRI Protocols for Prostate Cancer Detection: A Comprehensive Assessment Aligned with PI‐RADS Guidelines by Mohammad Hossein Jamshidi, Ali Fatemi, Aida Karami, Sepehr Ghanavati, Durjoy D. Dhruba, Mohammad H. Negarestanian

“…ABSTRACT Background and Aim Multiparametric magnetic resonance imaging (mpMRI) is recognized as the most indicative method for diagnosing prostate cancer. …”
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Comprehensive analysis of the interaction microbiome and prostate cancer: an initial exploration from multi-cohort metagenome and GWAS studies by Gui-Chen Ye, Hao Peng, Jia-Cheng Xiang, Ling-Tao Miao, Cheng-Zhi Liu, Shao-Gang Wang, Qi-Dong Xia

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Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling by Jiaming Zhang, Wei Wang

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CFD modelling and simulation of anaerobic digestion reactors for energy generation from organic wastes: A comprehensive review by Muhammad Usman Farid, Indiana A. Olbert, Andreas Bück, Abdul Ghafoor, Guangxue Wu

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Sauerkraut juice fermented with different symbiotic starter cultures: comprehensive assessment of physicochemical, rheological, antioxidant, and microbiological characteristics by Richardos Nikolaos Salek, Pavel Pleva, Daniela Sumczynski, Štěpán Vinter, Jana Kopečková, Anita Rejdlová, Eva Lorencová

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Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat by Tushadri Singh, Tushadri Singh, H. M. Mamrutha, Rajender Singh, J. P. Jaiswal, Zeenat Wadhwa, Rakesh Kumar, Omvir Singh, O. P. Ahlawat, Ratan Tiwari

“…By virtue of wheat being a hexaploid crop and having a large genome size with repetitive DNA, a tailor-made strategy for designing the gRNA is crucial.ResultThe manuscript explains the comprehensive strategies and methods for efficient gRNA designing by considering the physical and structural expression of the target gene in the genome and explains the on-target and off-target effects of gRNA for its precise editing through the CRISPR/Cas9-mediated SDN1 method of genome editing in wheat.ConclusionThe present manuscript is first of its kind to address the holistic approach, starting from efficient gene selection, gRNA designing, and post-gRNA designing issues like gRNA stability, binding efficiency, and functionality for SDN1-CRISPR/Cas9 genome editing in wheat. …”
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The impacts of polystyrene microplastics on development, energy transfer and nutrient cycling of biofilms: A comprehensive chronic toxicity study by Shuangshuang Li, Duo Xu, Yu Zheng, Heng Liu, Yan Song, Mingcan Cai, Chun Wang

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A comprehensive risk model of disulfidoptosis-related lncRNAs predicts prognosis and therapeutic implications in bladder cancer by Zhixiong Zhang, Jinghua Zhong, Muhammad Sarfaraz Iqbal, Zhiwen Zeng, Xiaolu Duan

“…Background: Disulfidoptosis is an emerging form of regulated cell death; however, the roles of its associated long non-coding RNAs (dr-lncRNAs) in bladder cancer (BLCA) remain poorly characterized. By leveraging the most comprehensive curated dataset of disulfidoptosis-related genes to date, we systematically developed and validated a novel dr-lncRNA signature that elucidates the prognostic significance and immune microenvironmental dynamics in BLCA. …”
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Comprehensive analysis of prognosis and drug sensitivity of programmed cell death pattern-related genes in gastric cancer patients by Huiheng Qu, Peng Zhou, Zhihui Yang, Hao Wang, Kaiyuan Deng, Nan Wang, Yuyang Li, Yupeng Zhao, Yigang Chen, Qian Yang, Jiazeng Xia

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High Prevalence of Small-Fiber Neuropathy in Patients with Tarlov Cysts: Toward a More Comprehensive Clinical Understanding by Hulens M, Zajonc P, Bruyninckx F, Rasschaert R, De Mulder P, Bervoets C, Dankaerts W

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LEFT ATRIAL FUNCTION: MODERN ASSESSMENT METHODS AND CLINICAL SIGNIFICANCE by E. N. Pavlyukova, D. A. Kuzhel, G. V. Matyushin

“…Assessment of the left atrial (LA) function is important aspect of comprehensive cardiovascular system estimation. …”
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English Prepositions  Expressing Temporal Limits: Semantic Features and Functioning by A. A. Shirshikova

“…A review of various lexicographical sources, reference literature, and grammars is conducted, highlighting that not all sources provide comprehensive information on the meanings and functioning of prepositions, often offering only general information. …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…A molecular docking study revealed the significant impact of the H113P variant on the protein-ligand binding affinity, supported by MD simulation over 100 nanoseconds, which highlighted substantial stability differences between wild-type and H113P mutated proteins during ligand binding. This comprehensive analysis shed light on the potential functional consequences of genetic variation in the CXCR genes, offering valuable insights into the implications of disease susceptibility and may pave the way for future therapeutic interventions.…”
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DySCo: A general framework for dynamic functional connectivity. by Giuseppe de Alteriis, Oliver Sherwood, Alessandro Ciaramella, Robert Leech, Joana Cabral, Federico E Turkheimer, Paul Expert

“…DySCo is a framework that presents the most commonly used dFC measures in a common language and implements them in a computationally efficient way. …”
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Pattern, causes and functional outcome of peripheral neuropathies in the Amazon region. by Nathalie Deschamps, Mathieu Nacher, Pierre-Marie Preux, Valérie Takam, Romain Blaizot, Beatrice Cenciu, Nadia Sabbah, Bertrand De Toffol

“…Only GBS was significantly associated with functional severity but all patients with a deficiency had a severe score. …”
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