A dataset of estimated heterozygous individual and carrier couple frequencies for pan-ancestry carrier screeningMendeley Data by Mia J. Gruzin, Matthew Hobbs, Sarah Poll, Swaroop Aradhya, Leslie Burnett

“…The dataset enabled calculations of positive yield for individuals and couples across both ancestry-specific and pan-ancestry, optimised ''Goldilocks''-ranked gene panels, addressing population-specific variations in the frequencies of heterozygous individuals and carrier couples.The positive yield analysis offered a performance metric for carrier screening panels, facilitating the modeling of screening performance for panels of varying sizes and composition and providing resources for optimizing panel content to ensure equity across underrepresented genetic ancestriesThe dataset can support ongoing research into the equitable application of carrier screening and offers significant reuse potential for refining population genetic screening practices, validating computational models, and developing frameworks to update carrier screening panels in alignment with evolving genomic data, including in underrepresented and minority populations.…”
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Effect of forging sequence and heat treatment on microstructure of high-duty power-plant shaft made of Cr-Mo ultra-high strength steel by Skubisz P., Lisiecki Ł.

“…Using the Finite Element Modeling, the multi-stage sequence of upsetting and the cogging strain distribution were optimized to minimize the strain variation along the length to a range 2.2÷2.7, and correlated with the microstructure generated at each main stage on the large cross-sections of the shaft. …”
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Functional Asymmetries and Force Efficiency in Elite Junior Badminton: A Controlled Trial Using Hop Test Metrics and Neuromuscular Adaption Indices by Mariola Gepfert, Artur Gołaś, Adam Maszczyk, Kajetan Ornowski, Przemysław Pietraszewski

“…Contrary to initial hypotheses, traditional asymmetry metrics showed no significant correlations with performance variables (r < 0.1). Machine learning models (Random Forest) using FER and AII failed to classify responders reliably (AUC = 0.50). …”
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Sex disparities in hepatocellular carcinoma immunotherapy: hormonal and genetic influences on treatment efficacy by Lei Song, Liyan Sun, Yuning Ren, Yuning Ren, Xiaodan Wang, Xiaodan Wang, Lei Xian

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Ultra‐Long‐Term Anti‐Inflammatory Polyphenol Capsule to Remodel the Microenvironment for Accelerating Osteoarthritis Healing by Single Dosage by Shaoyin Wei, Zeyu Shou, Dong Yang, Linxiao Sun, Yan Guo, Yang Wang, Xingjie Zan, Lianxin Li, Chunwu Zhang

“…The capsule overcomes the limitations of short half‐life and low bioavailability of polyphenols and achieves single‐dose cure in mouse and dog OA models, providing an optimal therapeutic window for OA repair. …”
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Gut-brain-liver axis in growth hormone deficiency: role of microbiota-derived short-chain fatty acids in ethnic variability and therapeutic development by Dongming Meng, Wei Kong, Sai Cheng, Hua Liu, Congfu Huang

“…These approaches also aim to optimize precision therapies, such as nanoparticle-delivered SCFAs. …”
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A Memo on Factors Associated with Perception of Stigma Attached to PrEP: Evidence from the Keeping It LITE Study by Shahin Davoudpour, Gregory L. Phillips II, Pedro A. Serrano, Audrey L. French, Sybil G. Hosek

“…Although perception of stigma (PS) has been dubbed as a key barrier to the optimal uptake of PrEP, research on PS is sparse. …”
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EXPERIENCE IN DEVELOPMENT MEDICAL KITS FOR MEDICAL SERVICES OF THE RUSSIAN FEDERATION ARMED FORCES by E. O. Rodionov, Yu. V. Miroshnichenko, V. N. Kononov, A. V. Tikhonov, I. V. Klochkova

“…In accordance with the principles of the theory of constraints a strategy to optimize the composition of sets of medical equipment was developed. …”
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Exploring alternative solvents to n-hexane for green extraction of lipid from camellia oil cakes by Yingyi Lin, Yong Wang, Ying Li

“…Besides, Hansen solubility modeling could help better understand the dissolving mechanism. 2-MeOx was demonstrated as the optimal alternative bio-based solvent to n-hexane with comparable extractability and selectivity in the CO extraction.…”
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Identifying factors affecting the distribution strategy in the food industry with the attitude of marketing and online sales by solmaz seyedghafouri, Vahid nasehifar, Farid askari

“…To solve the problem, a Stackelberg game model with endogenous quality, optimal production and pricing decisions of companies and platforms under different sales models was used. …”
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Advancements in natural remediation management techniques for oil spills: Challenges, innovations, and future directions by Komal Sharma, Garishma Shah, Hanwant Singh, Upma Bhatt, Khushbu Singhal, Vineet Soni

“…However, several challenges must be overcome to optimize the effectiveness of natural remediation methods for oil spills. …”
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A Stability indicating TLC-Densitometric Method for the Determination of Remdesivir in presence of Its Degradation Products by Mai H. Abd El-Fattah, Yasmine Ahmed Sharaf, Heba M. El-Sayed, Said A. Hassan

“…Various method parameters—including mobile phase composition and detection wavelength—were systematically optimized to ensure high resolution, accuracy, and sensitivity. …”
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Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems by Viviana Aya, Daniel Pardo-Rodriguez, Laura Camila Vega, Mónica P. Cala, Juan David Ramírez

“…These findings underscore the complex relationship between the gut microbiota composition and metabolic responses tailored to athletic demands, laying the groundwork for personalized strategies to optimize performance. …”
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Medication management for older adults in interprofessional primary care teams: a qualitative interview study of family health teams in Ontario, Canada by Monika Roerig, Julie Vizza, David Rudoler, Sara Allin, Elisabeth Martin, Agnes Grudniewicz

“…To support older adults and others with complex health needs, opportunities to improve teamwork, strengthen collaboration, and optimize team composition should be identified and pursued.…”
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Equilibrium, kinetic and thermodynamic studies of the adsorption of Congo red on nZVI/Zn-Al layered double hydroxide intercalated with PO4 3− ion by Kofi Duodu, Gerheart Winfred Ashong, Francis Opoku, Nathaniel Owusu Boadi, Eric Selorm Agorku

“…Kinetic and isotherm studies also revealed that pseudo-second order kinetic and Langmuir isotherm models had the best fit compared to other kinetic and isotherm models employed in this study. …”
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A novel two-step framework for day-ahead wind power probabilistic forecasting considering uncertainties and ramp events by Yang Cui, Chi Cheng, Yan Zhu, Dan Meng, Zhenghong Chen

“…Third, we compared four deterministic wind power forecasting models and selected the optimal one, LSTM-WPRE, as the foundation of the proposed two-step model. …”
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High early strength concrete incorporating waste derived nanomaterials for sustainable construction by Nehal Hamed, M. I. Serag, M. M. El-Attar, M. S. El-Feky

“…Abstract This paper contributes to the expanding knowledge base on nanomaterial-enhanced cementitious composites, offering valuable insights for developing high-performance, sustainable concrete solutions. …”
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Combined Effects of Forest Conservation and Population Resettlement on the Ecological Restoration of Qilian Mountain National Park by Xi Wang, David Lopez-Carr, Liang Zhou

“…The distribution of high Composite Vegetation Index (CFI) values overlapped with concentrated forest restoration areas, revealing two main restoration models: forest conservation and population relocation. (3) RERI calculations divided the park into three ecological zones, Priority Conservation Area (PCA), Optimization and Enhancement Area (OEA), and Concerted Development Area (CDA), leading to the proposal of an ecological restoration and development framework for QMNP, characterized by “three zones, two horizontal axes, and one vertical axis”. …”
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Synthesis and Application of Natural Deep Eutectic Solvents (NADESs) for Upcycling Horticulture Residues by Udodinma Jude Okeke, Matteo Micucci, Dasha Mihaylova, Achille Cappiello

“…Using an initial many-factors-at-a-time (MFAT) screening followed by a rotatable central composite response surface methodology (RCCRSM) for optimization, quadratic models fitted the response data for all the synthesized NADESs given: TPC (R² = 0.984, <i>p</i> < 0.0001), TFC (R² = 0.9999, <i>p</i> < 0.0001), AA-CUPRAC (R² = 0.918, <i>p</i> < 0.0001), FRAP (R² = 1.000, <i>p</i> < 0001), and DPPH (R² = 0.9992, <i>p</i> < 0.0001). …”
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An active learning driven deep spatio-textural acoustic feature ensemble assisted learning environment for violence detection in surveillance videos by Duba Sriveni, Dr.Loganathan R

“…It applied the least confidence (LC), entropy margin (EM), and margin sampling (MS) criteria to retain the optimal frames for further feature extraction. The DestaVNet model executes pre-processing and feature extraction separately over the frames and corresponding acoustic signals. …”
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