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Therapeutic Mechanism of Zhuyang Tongbian Decoction in Treating Functional Constipation: Insights from a Pilot Study Utilizing 16S rRNA Sequencing, Metagenomics, and Metabolomics
Published 2025-02-01“…Xuan Zhang,1,* Hang Yin,2,* Xu Yang,3,* Jie Kang,1 Nan Sui1,4 1Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 2Scientific Education Section, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China; 3Department of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning Province, People’s Republic of China; 4Department of Anorectal Diseases, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nan Sui, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 35, Eleventh Wei Road, Shenyang, Liaoning, 110003, People’s Republic of China, Email suinan2226@163.comPurpose: To explore the mechanism of Zhuyang Tongbian Decoction (ZTD) in treating functional constipation (FC) by observing its effects on intestinal flora composition, the metabolic function of gut microbiota, fecal short-chain fatty acid (SCFA) levels, and serum concentrations of TLR4, NF-κB, TNF-α, and IL-6 in patients with FC.Patients and Methods: 40 patients with FC were randomly divided into the control group and the treatment group, 20 cases in each group. …”
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763
Reconstructing the Wave Function of Magnetic Topological Insulators MnBi_{2}Te_{4} and MnBi_{4}Te_{7} Using Spin-Resolved Photoemission
Published 2025-07-01“…Most importantly, our analysis reveals a new mechanism for reducing the magnetic gap of the topological surface states based on the orbital composition of the wave function.…”
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764
Idarubicin-loaded degradable hydrogel for TACE therapy enhances anti-tumor immunity in hepatocellular carcinoma
Published 2024-12-01“…Additionally, TACE can suppress the immune system by reducing immune cell numbers and function, contributing to poor treatment outcomes. …”
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765
Dietary Fish Meal Level and a Package of Choline, β-Glucan, and Nucleotides Modulate Gut Function, Microbiota, and Health in Atlantic Salmon (Salmo salar, L.)
Published 2023-01-01“…Salmon (186 g) were fed for 62 days in 16 saltwater tanks before samples were taken from 12 fish per tank for observation of biochemical, molecular, metabolome, and microbiome indicators of function and health. …”
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766
Antioxidant Peptides from Tiger Nut (<i>Cyperus esculentus</i> L.): Chemical Analysis and Cytoprotective Functions on HepG2 and Caco-2 Cells
Published 2025-01-01“…The tiger nut peptides (TNP) were found to perform excellent antioxidant activity supported by their chemical and cell antioxidant behaviors, amino acid composition, and morphological observation. Higher 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity (DPPH• RSA, 64.05–124.07%) and ferric ion-reducing antioxidant power (FRAP, 0.17–1.78 μmol/mL) were observed in the TNP with more hydrophobic amino acids (41.77 ± 1.36 g/100 g) compared with traditional soybean and peanut peptides. …”
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767
Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations
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768
Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer’s disease
Published 2025-08-01“…Conclusions This study identified distinct gut microbiota profiles associated with different stages of cognitive impairment in older Korean adults. The observed associations between gut bacterial composition and cognitive function, neurodegeneration biomarkers, and related clinical factors suggest potential relationships that warrant further investigation. …”
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769
Study of matrix micro-cracking in nano clay and acrylic tri-block-copolymer modified epoxy/basalt fiber-reinforced pressure-retaining structures
Published 2011-10-01“…Composite pipes modified with either the organic and inorganic nanoparticles exhibited moderate improvements in leakage failure strain (i.e. matrix cracking strain); however, reductions in functional and structural failure strength were observed.…”
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770
Chemical and physical modifications of the surface of sisal agave fibre used as a reinforcement in epoxy resin – A Review
Published 2024-12-01“…Thermal treatments affect the fiber’s morphology by increasing the crystallinity of the cellulose leading to stiffer composites. It was also observed that the improvement in fiber-matrix adhesion had an adverse effect on the impact strength of the composite.…”
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From Microbes to Metabolites: Advances in Gut Microbiome Research in Type 1 Diabetes
Published 2025-02-01“…In recent years, studies have revealed significant alterations in the taxonomic and functional composition of the gut microbiome associated with the development of islet autoimmunity and T1D. …”
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773
Bistable variable stiffness laminates - novel manufacturing and modeling strategies
Published 2025-07-01“…Bistable laminates offer a path to energy-efficient and multi-functional structures, with potential applications in various engineering domains. …”
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774
The Muscle Cells in Pelvic Floor Dysfunctions: Systematic Review
Published 2025-03-01“…These patients demonstrate a reduction in muscle tone, contraction strength, and resistance, a compromised neuromuscular activity, and an alteration of the normal composition and organization of the muscle cells. Conclusions: Women with pelvic floor dysfunction have anatomical muscle defects, disturbance of muscle function and cellular changes involving muscle cells and nerve fibers.…”
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775
Effect of alfalfa supplementary change dietary non-fibrous carbohydrate (NFC) to neutral detergent fiber (NDF) ratio on rumen fermentation and microbial function in Gansu alpine fi...
Published 2024-12-01“…Ruminococcus, Ruminococcaceae and Prevotella were observed as the predominant phyla in ruminal fluid microbiota. …”
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776
Macleaya cordata extract improves egg quality by altering gut health and microbiota in laying hens
Published 2024-12-01“…Dietary supplementation of 350 and 450 mg/kg MCE was observed to result in linear and quadratic increase in serum lysozyme levels (P < 0.05). …”
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777
RESULTS OF COMPREHENSIVE STUDIES OF THE UNDERGROUND HYDROSPHERE WITHIN THE WESTERN SHOULDER OF THE BAIKAL RIFT (AS EXEMPLIFIED BY THE BAYANDAI – KRESTOVSKY CAPE SITE)
Published 2015-09-01“…With the detail data on the Bayandai – Krestovsky Cape site, the above conclusions are more precisely determined, and it is generally concluded that the structural tectonic factor controls the hydrogeology of the region.The analysis of mineralization, composition, temperature and other characteristics of the underground waters (Fig. 3–6) show that at the low hierarchic level the NW boundary of the Obruchev interblock zone performs a function of a distinct hydrogeological barrier which represents the marginal suture of the Siberian platform. …”
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Depression and Associated Factors Among Diabetic Patients Undergoing Diabetic Retinopathy Assessments at a Tertiary Care Center: A Cross-Sectional Study
Published 2025-06-01“…Bilateral proliferative DR and bilateral center-involved DME were observed in 50.6% and 18.4% of participants, respectively. …”
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Effect of drought disturbance in a sclerophyll forest on the micromammal community in the Río Clarillo National Park, Metropolitan Region, Chile
Published 2025-01-01“…Results We observed differences in species composition and in richness, diversity, and cover variables between forest types. …”
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The effect of prolonged oxygen therapy on the clinical course of the disease and diaphragm function in patients with chronic obstructive pulmonary disease and hypoxemic respiratory...
Published 2019-10-01“…After the first year of using POT, an increase in the rates of contraction and relaxation of the diaphragm muscle under tidal respiration was observed. On the 2nd and 3rd year of using POT, it was noted that indicators of the functional state of the diaphragm stabilized. …”
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