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Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.
Published 2021-01-01“…Crystallographic analysis of the PBP3:vaborbactam complex reveals that vaborbactam forms a covalent bond with the catalytic S294. …”
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In-depth analysis of cystic fibrosis cases caused by CFTR gene variation and research on the prediction and simulation of the impact on protein function
Published 2025-05-01“…The results obtained by different prediction tools varied, and molecular dynamics simulations indicated that these mutations significantly affected the stability of the CFTR protein.ConclusionAnalysis of this new case using multiple tools and computational chemistry simulations helps to further understand the impacts of mutations on CFTR protein function and the disease, offering novel insights into the diagnosis, treatment, and genetic counseling of CF caused by the complex and diverse mutations of the CFTR gene.…”
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Formation of Bearings Parts Waviness in Centerless Mortise Grinding on Rigid Supports
Published 2023-06-01Get full text
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Numerical evaluation for SLAP type II tear in shoulder abduction applying the finite element method
Published 2025-04-01“…The shoulder joint in the human body is a complex anatomical structure composed of diverse biological tissues that connect and stabilize the joint. …”
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Comparative Study of Time Series Analysis Algorithms Suitable for Short-Term Forecasting in Implementing Demand Response Based on AMI
Published 2024-11-01“…LSTM showed potential in modeling complex temporal dependencies but was sensitive to hyperparameter settings and required a substantial amount of training data. …”
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Changes in network centrality of anxiety and depression symptoms associated with childhood trauma among Chinese college students
Published 2025-04-01“…This study employed network analysis to investigate the complex interplay of anxiety and depression symptoms among Chinese college students, focusing on identifying the core symptoms most directly affected by childhood trauma and those exerting the greatest influence on others. …”
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Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia
Published 2025-05-01“…Genkwanin, isorhamnetin, and quercetin were predicted to target SRC, with strong molecular docking affinities. ADME analysis suggested favorable pharmacokinetics, and molecular dynamics simulations confirmed structural stability. …”
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Silymarin as a potent polyphenol against metabolic disease pathways: A computational insight and ADMET/MM-PBSA analysis
Published 2025-07-01“…The observed changes in protein-ligand complex stability, particularly for FABP1 and FABP4, highlight their antimicrobial and anti-inflammatory properties. …”
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Brunauer-Emmett-Teller, Fourier-transform infrared, and scanning-electron-microscope analysis of biochar from marine organic waste
Published 2025-06-01“…FTIR tests reveal that the functional groups and chemical content of the biochar from marine organic waste include six types of vibrations with different wavenumbers and % transmittance values. SEM analysis at various magnifications shows that the biochar from marine organic waste (MOW) has a complex pore structure. …”
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Magnetic Nanomaterials in Chinese Medicine Chemical Composition Analysis and Drug Metabolism and Its Industry Prospect and Development Path Research
Published 2020-01-01“…Moreover, it showed effective results in repeatability, stability, and interference tests. Therefore, magnetic nanomaterials play an important role in the chemical composition analysis and drug metabolism of traditional Chinese medicine as well as its industrial prospect and development path.…”
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Morphological Analysis and Subtype Detection of Acute Myeloid Leukemia in High-Resolution Blood Smears Using ConvNeXT
Published 2025-02-01“…(1) Background: Acute Myeloid Leukemia (AML) is a complex hematologic malignancy where accurate subtype classification is crucial for targeted treatment and improved patient outcomes. …”
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Alignment-Based Pseudo-Label Generation With Collaborative Filtering Mechanism for Enhanced Cross-Domain Aspect-Based Sentiment Analysis
Published 2024-01-01“…Aspect-based sentiment analysis (ABSA) in areas such as online shopping and restaurants can effectively facilitate specific service improvements. …”
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Intelligent Computerized Video Analysis for Automated Data Extraction in Wave Structure Interaction; A Wave Basin Case Study
Published 2025-03-01“…Despite advancements in direct sensing technologies, accurately capturing complex wave–structure interactions remain a significant challenge in ship and ocean engineering. …”
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A Novel Surgical Treatment Strategy for Fixation of Intra-articular Distal Humerus Fractures: Prospective Analysis of Functional Outcomes
Published 2024-09-01“…Context: Fractures in the distal humerus are complex and challenging injuries for orthopedic surgeons that can be effectively treated with open reduction and internal fixation. …”
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Dynamic Analysis and Chaos Control for a NEV Enterprise and a Competitive TEV Enterprise under the CAFC-NEV Mandate
Published 2022-01-01“…This paper studies the complexity analysis in production between competition and R&D for a traditional energy vehicles enterprise and a new energy vehicles enterprise under the introduction of corporate average fuel consumption credits and new energy vehicle credits mandate. …”
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THE ROLE OF EXCHANGE PROPORTIONS IN THE INFLATION AND ECONOMIC CRISES
Published 2014-11-01Get full text
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