Valproate-induced hyperammonemic encephalopathy: the role of clinical pharmacists in medication safety—a case report by Wei Chen, Dong Wang, Wei Fu, Jinpeng Wang, Min Chen, Jun Li, Fei Li

“…Through a comprehensive analysis and discussion of appropriate interventions, we aim to offer valuable insights for optimizing antiepileptic drug therapy in clinical settings, thereby preventing adverse drug reactions and ensuring optimal treatment outcomes for patients. …”
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Three-Dimensional Distance Maps Demonstrate Intercuneiform and Naviculocuneiform Joint Involvement in Hallux Valgus Patients Compared with Matched Control Patients by Brian Closkey BS, Brett Steineman PhD, Scott Ellis MD, Matthew Conti MD

“…Submission Type: Hallux Valgus Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Hallux valgus (HV) is a complex three-dimensional (3D) deformity of the first ray. …”
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Constructive engagement in cognitive stimulation therapy groups among people with dementia: A mixed‐methods study by Anna Yan Zhang, Gloria Hoi Yan Wong, Terry Yat Sang Lum, Bob Woods, Aimee Spector

“…This study is the first to investigate constructive engagement (CE), which describes active involvement in meaningful activities or complex interventions, specifically CST, for persons with dementia. …”
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Dynamics of HBsAb persistence and associated BCR IgG-H CDR3 repertoire features in ultra-high versus extremely low responders to HBV vaccination by Ting-Wen Yang, Ting-Wen Yang, Li-Na Sun, Ting Zhang, Yu-Rong Pan, Jun Li, Yang-Yang Li, Zhi-Yong Han, Wan-Bang Sun, Xin-Sheng Yao, Xiao-Yan He

“…These findings could provide novel insights into the complex mechanisms of HBV vaccines and HBV infection.…”
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Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer by Jiawei Guan, Hongchuan Liu, Yan Chai, Jie Yu, Jian Yao, Jing Wang, Zhiwei Pan, Jing Zhang, Yuehua Zhou, Hui Liu, Sheng Yao, Jianxun Qi, Hui Feng, George F. Gao, Qihui Wang, Yi Shi, Shuguang Tan

“…Notably, two Tyr residues (VH-Y100 and VL-Y32) from the complementarity-determining region loops insert into the two cavities formed by the residues from the loops of CTLA-4, which may contribute to the stabilization of the binding. Comparative analysis with other anti-CTLA-4 mAbs indicates that the double “wedge-into-hole” binding mode is unique for JS007 and may be responsible for the high-affinity binding to CTLA-4. …”
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Comprehensive approach to the problem of the effect of residual monomer on the immune-metabolic profile of patients with orthopedic treatment of non-removable temporary constructio... by O. V. Voznyi, N. L. Khlystun, A. V. Dolia, P. L. Yushchenko, A. V. Yarova

“…/min, and in ІІІ group it is completely stabilized, equaling (96 ± 4) c.u./min, P ˂ 0.01. …”
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Elucidating the effect of brewing temperature on the sensory quality of Longjing tea based on multi-scale molecular sensory science by Sihan Deng, Qing-Qing Cao, Ying Gao, Weiwei Wu, Jian-Xin Chen, Fang Wang, Qian Zou, Fangxiang Xu, Xuefeng Cao, Weijiang Sun, Jun-Feng Yin, Yong-Quan Xu

“…Taste-addition experiments and molecular docking identified L-aspartic acid, L-theanine and L-arginine as key umami contributors, which synergistically enhanced umami intensity (1.77 to 6.83, p < 0.05) through stabilizing the Glu-T1R1/T1R3 complex and lowered binding free energy (−5.084 to −10.618 kcal/mol). …”
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Chemical composition, antimicrobial, and antioxidant properties of essential oils from Artemisia herba-alba asso. and Artemisia huguetii caball. from Morocco: in vitro and in silic... by Mohamed El Ouardi, Mohamed El Ouardi, Aziz Drioiche, Aziz Drioiche, Fadoua El Makhoukhi, Fadoua El Makhoukhi, Jamal Mabrouki, Mohammed Hakmi, Omkulthom Al kamaly, Bshra A. Alsfouk, Brahim Eddamsyry, Hamid Khamar, Touriya Zair, Mohammed Alaoui El Belghiti

“…Molecular docking studies revealed strong interactions between these compounds and key target proteins, such as NADPH-dependent catalase and dihydrofolate reductase. The stability of the protein-ligand complexes was confirmed by molecular dynamics, with davanone showing a significant impact. …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…Our antibody also effectively binds and stabilizes MICA/B expression in additional tumor types and demonstrates broad specificity. …”
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從工具示能性與關係行動主體之觀點 探討偏鄉教育系統賦能策略之研究 Investigating the Construction of Empowerment Action Models in Remote Educational Systems Through the Lenses of Tool Affordance and Relational Age... by 陳佩英 Peiying Chen, 洪琴雯 Chin-Wen Hung

“…Conclusion In conclusion, the complex problems embedded in rural schools in terms of structure and system still require policy support. …”
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Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma by Cainan Li, Pujie Wu, Xiaoting Xie, Xinjie Chen, Liping Chen, Liang Zhu, Zhixuan Xuan, Tianyuan Liu, Wen Tan, Shaosen Zhang, Dongxin Lin, Chen Wu

“…Silencing Notch-signaling substantially suppressed the ability of ESCC cells to promote angiogenesis in vitro and in vivo. By integrating analysis of CUT&Tag and RNA sequencing data, we identified ubiquitin-specific protease 5 (USP5) as a Notch-signaling downstream effector that is transcriptionally upregulated by the NOTCH1 intracellular domain (NICD1)–RBPJ complex and mediates tumor angiogenesis. …”
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Progress and Challenges in Morphodynamics of Braided Rivers in Source Region of Yangtze River by LI Zhi-wei, OUYANG Wei-qi

“…An integrated research framework that combines process analysis, threshold identification, and evolutionary trend modeling should be established. …”
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snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation by Yusha Yang, Yusha Yang, Guanyu Zhang, Ting Yi, Ting Yi, Shuran Yang, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Xiuxuan Wu, Jun Li, Danfeng Yang

“…Given the limited understanding of the microscopic dynamic changes and underlying mechanisms during this process, we established a temporally dynamic mouse model spanning the entire period from cold stimulation to the return to thermoneutrality, with inguinal sWAT (iWAT) selected as the study subject.MethodsBased on preliminary data demonstrating stabilization in iWAT histology, expression levels of key thermogenic proteins, and the bulk transcriptome, we selected the two-week time point after the return to thermoneutrality for detailed analysis. …”
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M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…This interaction facilitated IGF2BP2-mediated stabilization of NUP160 mRNA, a nuclear pore complex component. …”
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Synergistic ROS/enzyme dual-responsive oral drug delivery system: A novel multi-mechanistic platform for spatiotemporal control and overcoming drug resistance in colorectal cancer... by Weitong Sun, Bingbing Fan, Xiaohan Qin, Xin Zhang, Pengxia Zhang, Yu Zhang

“…Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, driven by complex interactions between inflammatory pathways, gut microbiota dysbiosis, and tumor microenvironment remodeling. …”
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Orchestrators of innovation networks in the city level: the case of Pacto Alegre by Julhete Mignoni, Bruno Anicet Bittencourt, Silvio Bitencourt da Silva, Aurora Carneiro Zen

“…In this sense, the authors expected to contribute for research related to the roles and activities of the orchestrators of innovation networks constituted in the scope of cities given the large number and diversity of complex and multiple dimensions social actors (Castells & Borja, 1996; Reypens, Lievens & Blazevic, 2019). …”
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Concrete‐Inspired Bionic Bone Glue Repairs Osteoporotic Bone Defects by Gluing and Remodeling Aging Macrophages by Chong Li, Wei Xu, Lei Li, Yonghui Zhou, Gang Yao, Guang Chen, Lei Xu, Ning Yang, Zhanjun Yan, Chen Zhu, Shiyuan Fang, Yusen Qiao, Jiaxiang Bai, Meng Li

“…The current bottleneck in clinical treatment is to achieve strong fixation of the comminuted bone fragments and effective regulation of the complex microenvironment of aging macrophages. Inspired by cement and gravel in concrete infrastructure, a biomimetic bone glue with poly(lactic‐co‐glycolic acid) microspheres is developed and levodopa/oxidized chitosan hydrogel stabilized on an organic‐inorganic framework of nanohydroxyapatite, named DOPM. …”
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Influence of slaughter age on meat quality, metabolite and volatile organic compound changes in Lueyang black-bone chickens by Jie Gao, Ning Chen, Jia Cheng, Zhengnan Yuan, Wenxian Zeng, Hongzhao Lu, Tao Zhang, Ling Wang

“…Key findings revealed that the carcass yield of Lueyang black-bone chickens tended to stabilize at 6 months of age, while shear force as a key indicator of meat tenderness increased progressively with age. …”
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Regional Design by Verena Balz

“…The above research questions were therefore investigated by means of an exploratory case-study analysis, which is an appropriate research methodology to stabilize and detail propositions in a context of uncertainty. …”
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Altitudinal patterns of bacterial communities across soil layers in the alpine meadows of the Qinghai-Tibet Plateau by Zhiyuan Chen, Yeteng Xu, Xinyue Wang, Tong Ma, Yang Liu, Xiang Qin, Wei Zhang, Tuo Chen, Guangxiu Liu, Binglin Zhang

“…Community assembly in surface soils was predominantly governed by homogeneous selection (71.5 %), whereas in subsurface soils, it was co-dominated by heterogeneous selection (40 %) and homogeneous selection (39.5 %). Network analysis revealed that subsurface bacterial networks exhibited greater complexity and a higher prevalence of negative correlations compared to surface soil networks. …”
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