State policy of ensuring demographic security: characteristics of basic concepts by Z.O. Hrytsyshena

“…Scientific approaches to defining the concept of «demographic security» are systematized and generalized, among which the following are distinguished: security-protective, reproductive-dynamic and stabilization-development approaches. Based on a critical analysis of scientific sources, a comprehensive definition of demographic security has been formulated as a state of protection of the state, society and individual citizens from demographic threats, characterized by balanced quantitative and qualitative indicators population reproduction, optimal demographic structure and functioning of effective social institutions, which meets national interests and contributes to the sustainable development of the state at all levels. …”
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A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle. by Maren Mönnich, Zoë Kuriger, Cristin G Print, Julia A Horsfield

“…Cohesion is mediated by a multi-subunit complex called cohesin, which is loaded onto chromosomes by NIPBL. …”
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P09 | EFFECTS OF NUTLIN-3A ACTIVITY ON 2D AND 3D RETINOBLASTOMA MODELS

“…We observed significant cell viability reduction, cell cycle blockade in the G2/M phase, apoptosis increases and p53 pathway activation, by cytofluorometric and western blotting analysis. Next, we used the same cell lines to create and characterize innovative 3D bioprinted models, using 2% alginate and 5% gelatine bioink and printing 10x106/mL Y79 and 20x106/mL Weri Rb1 cells; crosslinking with 50 mM CaCl2 stabilized the model. …”
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Exploring ultrasound-induced free radical formation: A comparative study in water and sour cherry juice using glutathione and terephthalic acid indicators by Nursena Aktı, Semanur Yildiz

“…Following sonication of GSH- and TPA-added SCJ under the same conditions, analysis by LC-QTOF-MS and fluorescence spectrophotometry revealed no GSSG or fluorescence formation, confirming the absence of notable oxidation of both indicators, likely due to the juice’s complex composition (e.g., presence of antioxidant compounds). …”
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Deletion of Fgf14 confers resilience to basal and stress-induced depressive-like behavior and reduces anxiety in mice by Francesca Montarolo, Anita Maria Rominto, Luna Berrino, Antonio Bertolotto, Fernanda Laezza, Filippo Tempia, Eriola Hoxha

“…Fgf14-Nav channels complex is regulated by glycogen synthase kinase 3. …”
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Novel insights into electrical double layers in carbonate reservoirs under low-salinity water injection using molecular dynamics simulation by Saifali Al-Musawi, Fariborz Rashidi, Sepideh Amjad-Iranagh

“…Additionally, the observed differences in water–surface interactions between calcite and quartz were explained mechanistically: the highly charged calcite surface enabled strong inner-sphere coordination of water molecules at 2.37 Å, whereas the neutral quartz surface supported only weaker outer-sphere hydration at 3.1 Å. Ion mobility analysis further revealed enhanced dynamics of Na⁺ ions in SW system, facilitating disruption of oil–surface ionic bridges, while FW promoted ion clustering and reduced ionic mobility, stabilizing oil attachment. …”
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The legal conflictology in constitutional and municipal law by Irina A. Tretyak

“…It is necessary to take into account the following postulates of the General theory of conflictology in the study of legal conflicts in constitutional and municipal law:– the conflict is natural, objective and acts as an integral property of social life;–  the social conflict at the same time acts as a stabilizing factor of functioning of social system;– social conflict is a complex social phenomenon as well as a process having structural, spatial‐temporal and dynamic characteristics;– the organic connection of law conflict with the law. …”
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Insights into the binding selectivity of harzianoic acids A and B to tetraspanin CD81 by Gérard Vergoten, Christian Bailly

“…Key H-bonds between the acid groups of Hz-B and the CD81-LEL domain stabilize the ligand-protein complex. A comparison of the interaction with the homologous tetraspanin CD9, which also presents a dynamic open/closed equilibrium, underlined the marked selectivity of Hz-A/B for CD81 over CD9. …”
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Oxidative stress as a predictor of cataract surgery outcomes by M. A. Kovalevskaya, N. V. Vedrintseva

“…All patients have undergone detailed clinical and complex eye examination and were divided into 2 groups depending on cataract genesis. …”
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Modeling from the first principles of the electronic properties of compositions of REE as precursors of high-temperature superconductors by A. V. Gulay, A. V. Dubovik

“…Modeling of the first principles of the electronic properties of complex oxides of rare earth elements (BaY2O4, BaGd2O4, BaLu2O4) as precursors of high-temperature superconductors has been performed. …”
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Augmented Anterior Inferior Tibiofibular Ligament Repair in Ankle Fractures and the Postoperative Effect on 3D Syndesmotic Volumes by Blake Moore MD, Ashley Suttmiller

“…Submission Type: Ankle Fractures Research Type: Level 2 - Prospective comparative study, Meta-analysis of Level 2 studies or Level 1 studies with inconsistent results Introduction/Purpose: Dynamic fixation using the TightRope® (TR) system has led to improvements in outcomes after complex ankle syndesmotic injuries. …”
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Comparative study of surgical treatment of acromioclavicular luxation by Kezunović Miroslav, Bjelica Duško, Popović Stevo

“…Complications were more common and more complex in the Zugg-Bosw group, with 2 early and 8 late comlications. …”
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Heat-Mass Migration of Unsaturated Lead-contaminated Loess under Unidirectional Freezing Conditions by LUO Yang, ZHOU Feng-xi, LUO Chong-liang

“…Under negative temperature conditions, unsaturated soils exhibit complex water migration and phase transition processes. …”
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Exploring high entropy alloys: A review on thermodynamic design and computational modeling strategies for advanced materials applications by Peter Ifeolu Odetola, Bukola Joseph Babalola, Ayodeji Ebenezer Afolabi, Ufoma Silas Anamu, Emmanuel Olorundaisi, Mutombo Christian Umba, Thabang Phahlane, Olusoji Oluremi Ayodele, Peter Apata Olubambi

“…Through a novel case study of a septenary equiatomic Ni-Al-Co-Cr-Cu-Mn-Ti HEA, this analysis demonstrates the utility of these computational tools in unveiling the alloy's phase stability and microstructural evolution, reinforcing the synergy between theoretical predictions and experimental validation. …”
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SEC24D depletion induces osteogenic differentiation deficiency by inactivating the ATF6/TGF-β/Runx2 regulatory loop by Jing Zhang, Kai Yang, Wen-qi Chen, Dong-lan Sun, Hua-ying Hu, Qian Li, You-sheng Yan, Ya-zhou Li, Cheng-hong Yin, Qing Guo

“…R870fs*10) and c.938G>A (p. R313H). In silico analysis suggested that the missense R313H mutation most likely affects protein stability and secondary structure. …”
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Novel benzylidene derivatives: Synthesis and their antimicrobial and anticancer studies and in silico investigations by Sarkar M.A. Kawsar, Md. Ahad Hossain, Mohammad I. Hosen, Mehul P. Parmar, Subham G. Patel, Hitendra M. Patel, Imtiaj Hasan, Suvro Biswas, Md. Abu Saleh

“…The stability of the protein‒ligand complexes were ascertained via MMPBSA binding free energy calculations and molecular dynamics (MD) simulations. …”
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Use of Inulin and Pumpkin Oil in the Manufacture of High-Quality Mortadella-Style Sausage from Buffalo Meat by Silvia Jane Lombardi, Filomena Nazzaro, Luigi Grazia, Raffaele Coppola, Florinda Fratianni, Michela Pellegrini, Ilenia Iarusso, Patrizio Tremonte, Francesca Coppola

“…Reformulated products exhibited significantly reduced fat (<i>p</i> < 0.05), enhanced fiber, and a lipid profile rich in polyunsaturated fatty acids (>45%), qualifying for European Union health claims. Oxidative stability improved (<i>p</i> < 0.01), and sensory analysis revealed enhanced aroma complexity, with nutty and roasted notes. …”
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An immunoinformatics approach in designing high-coverage mRNA multi-epitope vaccine against multivariant SARS-CoV-2 by Ernawati Arifin Giri-Rachman, Al Mirahma Febri Kurnianti, Rizarullah, Aditya Hanung Setyadi, Anita Artarini, Marselina Irasonia Tan, Catur Riani, Dessy Natalia, Reza Aditama, Husna Nugrahapraja

“…Furthermore, molecular docking analysis revealed potent interactions between the validated 3D structure and the TLR4 and BCR receptors, while molecular dynamic simulations confirmed the stability of the VC-TLR4 and VC-BCR complexes. …”
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Assessing subtle changes in arid land river basin ecological quality: A study utilizing the PIE engine platform and RSEI by Aizemaitijiang Maimaitituersun, Han Yang, Nuerbiye Aobuliaisan, Kamuran Maimaitiaili, Ouyang Chenyu

“…Findings indicate: 1. The URB’s complexity resists representation by individual ecological indicators. …”
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Changes in the community composition and function of the rhizosphere microbiome in tobacco plants with Fusarium root rot by Min Yang, Yongzhan Cai, Tao Bai, Xiaonv Han, Rong Zeng, Dongmei Liu, Tao Liu, Rui Liu, Chan Ma, Lei Yu

“…To date, the community composition and functional shifts of the rhizosphere microbiome in tobacco plants infected with Fusarium root rot remain poorly understood.MethodsIn this study, we analyzed the differences in the compositions and functions of the bacterial and fungal communities in the rhizosphere and root endosphere of healthy tobacco plants and tobacco with Fusarium root rot using amplicon sequencing and metagenomic sequencing.Results and discussionOur results showed that Fusarium root rot disrupted the stability of bacteria–fungi interkingdom networks and reduced the network complexity. …”
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