Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach by Mohd Imran, Ahmed S. Alshrari, Mariah N. Hafiz, Mohammed M. Jawad, Abida Khan, Fadiyah Jadid Alanazi, Syed Mohammed Basheeruddin Asdaq

“…Molecular dynamics (MD) simulations assessed the stability of top ligand-protein complexes through RMSD RMSF and MM-GBSA free energy calculations. …”
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In-silico evaluation of putative maternal semiochemicals of pigs with receptor proteins by Devaraj Sankarganesh, Ambritha Balasundaram, Hayavadhan Sampath, Diya Manjunath, George Priya Doss C.

“…The RMSD data for these complexes also indicated stability over a 100-ns MDS period. …”
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Features оf the Development of Oil and Gas Condensate Field in the Tomsk Region by S. F. Mulyavin, A. V. Byakov, R. A. Neschadimov

“…The introduction of injection wells allowed stabilizing the reservoir pressure, but the main problems in the development of these complex objects remain unresolved. …”
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Financial Communication in Crisis Situations by Anatol Melega, Veronica Grosu, Corina Petrescu

“…The research findings underline the complexity and interdependence of the financial communication process in organizations, highlighting its evolution from transparency and reduction of information asymmetry in periods of stability, to the need for rapid adoption of digital technologies and integration of ESG dimensions during recent crises, all of which are essential to meet stakeholders' demands and maintain investors' trust. …”
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Multi-Strategy Fusion Path Planning Algorithm for Autonomous Surface Vessels with Dynamic Obstacles by Yongshun Xie, Chengyong Liu, Yixiong He, Yong Ma, Kang Liu

“…Through a comprehensive analysis of its control output, the proposed integrated algorithm accomplishes efficient obstacle avoidance via agile control of angular velocity while preserving navigational stability and achieves path optimization through consistent acceleration adjustments, thereby asserting its superiority and practical worth in challenging maritime environments.…”
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Coastal Urban Ecological Security Pattern Identification Integrating Land Subsidence Factors: A Deep Learning-Based Case Study of Zhuhai City by Yuan Shaoxiong, Gong Qinghua, Ye Yuyao, Wang Jun, Hao Yinlei, Zhang Yaze, Liu Bowen

“…Although Ecological Security Pattern (ESP) construction is important for ecosystem stability and sustainable development, traditional approaches rarely incorporate vertical geological factors, such as land subsidence. …”
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Exploring the mechanisms and targets of proton pump inhibitors-induced osteoporosis through network toxicology, molecular docking, and molecular dynamics simulations by Yaqi Mu, Yaqi Zhou, Xinan Zhang, Yiming Shao

“…Molecular dynamics simulations confirmed the structural stability of these complexes, characterized by low root mean square deviation and root mean square fluctuation values and consistent hydrogen bond formation.ConclusionThis study identified EGFR, ESR1, and SRC as key regulatory genes in PPIs-induced osteoporosis, highlighting their roles in bone metabolism. …”
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Protein kinase C epsilon activation improves early survival in an acute porcine model of controlled hemorrhage by Maya Simchoni, Linn Wagnert-Avraham, Estela Derazne, Dean Nachman, Yuval Gershon, Eliraz Cohen Levi, Adi Horesh, Yaron Cohen, Maya Nitecki, Yuval Glick, Arik Eisenkraft, Nir Suissa, Gilad Twig, S. David Gertz, Ann Saada, Ariel Furer

“…This benefit was associated with a more favorable hemodynamic profile, including more stable blood pressure, heart rate and cardiac output, and a better acid–base balance. Mitochondrial analysis identified a significant increase in electron transport chain complex-I activity in the myocardium of treated animals compared with the controls (p = 0.033). …”
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The Problem of Ensuring Maritime Security in the Asian Region by V. N. Koval, S. V. Ochkurenko, S. A. Vasiliev

“…This work is devoted to the analysis of relations in the field of merchant shipping from the point of view of ensuring security and stability in order to understand the possibility of improving international legal norms. …”
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Characterization of Arabidopsis thaliana thylakoid lumen 7.6 protein functions in photosystem II assembly by Pan Ren, Ruizi Li, Kai Chen, Chenchen Zheng, Zitian Li, Tao Wang, Cong Ma, Bingyao Li, Xu Wang, Fei Sun, Tengyue Zhang, Yike Xie, Xiaonuan Hao, Huiwen Li, Wenqiang Yang, Aigen Fu, Yaqi Hao

“…Blue native PAGE analysis demonstrated a substantial reduction in PSII supercomplexes and light-harvesting complex II (LHCII) in cyp38-2/tlp7.6-1, while PSII monomer (PSII-M) were significantly increased. …”
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Mineralization of Soil Organic Carbon and Its Control Mechanisms Under Different Tea Plantations in Southwest Yunnan, China by Dongyu Xiao, Batande Sinovuyo Ndzelu, Xi Chen, Shuihong Yao, Yueling Zhang

“…However, the mechanisms underlying the stability and mineralization of soil organic carbon (SOC) in different tea plantations remain unclear. …”
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Rapid Detection of Trace Toxicants in Blood Using Thermal Desorption Coupled to Continuous Atmospheric Pressure Interfaced Ion Trap Mass Spectrometry by Hui-wen RUAN, Gui-yun SONG, Zhi-gang FAN, Suo-suo YANG, Jian KANG, Lei HUA, Wei-guo WANG

“…The instrument exhibited good stability, with the relative standard deviation of 6.41% over 100 repeated tests. …”
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In-silico studies of glutathione peroxidase4 activators as candidate for multiple sclerosis management by Alaa Alnoor Alameen, Mohnad Abdalla, Hanan M. Alshibl, Monerah R. AlOthman, Manal M. Alkhulaifi, Tabyan O. Mirgany, Rasha Elsayim

“…Interestingly, the receptor–ligand complex showed deep continuous bands for Lapatinib with Lys127 and Gly128. …”
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Healthy dietary patterns, biological aging, and kidney stones: evidence from NHANES 2007–2018 by Chengcheng Wei, Qian Yang, Qian Yang, Jingke He, Yu Luo, Kun Han, Junkun Li, Shuai Su, Shuai Su, Jindong Zhang, Hongxing Wang, Hongxing Wang, Delin Wang

“…Machine learning with SHAP revealed the relative importance of dietary patterns and specific dietary components in this association. The sensitivity analysis was largely consistent with the primary analyses.ConclusionThese findings provide valuable insights into the complex interplay between dietary patterns, biological aging, and the risk of kidney stone. …”
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Investigating the Therapeutic Potential of Sericin Nanofibers and Rice-Encapsulated Nanosericin for Psoriasis: Mechanistic Insights from a 3D Skin Model by Sukphopetch P, Aramwit P, Reamtong O, Thiangtrongjit T, Kanjanapruthipong T, Muangkaew W, Kengkoom K, Fongsodsri K, Ampawong S

“…This study explores the therapeutic potential of sericin-based nanofibers and rice-encapsulated nanosericin (ReS) as innovative treatments, aiming to address current limitations by enhancing drug delivery, stability, and efficacy, and providing a targeted approach to managing this complex condition.Methods: This study investigates the efficacy of sericin nanofibers and derivatives, including ReS, for psoriasis treatment using a 3D artificial human skin model. …”
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DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS by A. O. Elagina, A. V. Belyatskaya, I. I. Krasnyuk (Jr.), I. I. Krasnyuk, O. I. Stepanova, T. V. Fateeva, E. A. Smolyarchuk, S. V. Kozin, O. N. Plakhotnaya, O. V. Rаstopchina, J. V. Rau

“…The method of quantitative determination of the furazolidone content in the effervescent tablets was validated. A complex of physicochemical methods for the analysis of tablets was carried out. …”
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An Electrochemical Sensor for the Simultaneous Detection of Pb²⁺ and Cd²⁺ in Contaminated Seawater Based on Intelligent Mobile Detection Devices by Zizi Zhao, Wei Qu, Chengjun Qiu, Yuan Zhuang, Kaixuan Chen, Yi Qu, Huili Hao, Wenhao Wang, Haozheng Liu, Jiahua Su

“…Traditional methods for detecting marine Pb²⁺ and Cd²⁺ rely on laboratory analyses, which are hindered by limitations such as sample degradation during transport and complex operational procedures. In this study, we present an electrochemical sensor based on intelligent mobile detection devices. …”
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Revolutionizing Clear-Sky Humidity Profile Retrieval with Multi-Angle-Aware Networks for Ground-Based Microwave Radiometers by Yinshan Yang, Zhanqing Li, Jianping Guo, Yuying Wang, Hao Wu, Yi Shang, Ye Wang, Langfeng Zhu, Xing Yan

“…AngleNet breakthrough performance is especially notable in consistently capturing complex RH profile features, which are critical for accurate numerical weather forecasting and climate monitoring.…”
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A participatory framework for identifying and ranking multidimensional solutions to nutritional behavior issues in female school students: a stakeholder-based mixed-methods study by Nasrin Mehrjoyan, Fatemeh Zarei, Fazlollah Ghofranipour, Fazlollah Ahmadi

“…Despite the increasing prevalence of poor dietary habits among adolescent girls, existing interventions often fail to address the complex social, cultural, and environmental determinants of nutritional behavior. …”
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Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study by Jian Wang, Feiyang Yuan, Mahadevi Kendre, Zhijin He, Shaowei Dong, Abhinandan Patil, Kausing Padvi

“…MD simulations over 100 ns confirmed the stability of the MK1-EGFR complex, with RMSD values stabilizing post-50 ns and RMSF values consistently below 3 Å. …”
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