Mechanistic insights curcumin’s anti-inflammatory in pancreatic cancer: experimental and computational evidence implicating IL1B interference via IL10RA upregulation and NLRP3/TLR3... by Jun-Feng Cao, Jun-Feng Cao, Kuan Hang, Hao Zhang, Qingjie Xia, Xiao Zhang, Jie Men, Jin Tian, Zengliang Xia, Dunshui Liao, Kezhou Li, Kezhou Li

“…PurposePancreatic cancer is a highly aggressive malignancy characterised by a complex tumour microenvironment and chronic inflammation. …”
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Barriers and facilitators to housing and healthcare services for people experiencing homelessness with concurrent brain injury, mental health and substance use disorders: a qualita... by Grace C. Warren, Cole J. Kennedy, Cole J. Kennedy, Cole J. Kennedy, Nicholas Gavas, Julia Schmidt, Julia Schmidt, Erica Woodin, Erica Woodin, Janelle Breese Biagioni, Mauricio A. Garcia-Barrera, Mauricio A. Garcia-Barrera

“…Manifest content analysis revealed five barriers and five facilitators: Barriers included (1) Stigma, (2) Insufficient Investment, (3) Siloed Systems, (4) Generalized Approaches to Housing, and (5) Policies that do not Support Complex Needs, while facilitators included (1) Increasing Discourse on the Intersections of ABI, MHSU, and Homelessness, (2) Government Commitment to Systemic Change, (3) Collaboration Across Organizations, (4) Community-Based Services, and (5) Supportive Housing Models.ConclusionsThese findings highlight gaps in existing policies and services while identifying effective approaches to supporting individuals experiencing these intersections. …”
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Single Nucleotide Polymorphism (SNP) Assays for Disaster Victim Identification (DVI) by Sahar M. Ibrahim, Arwa M. Salih, Dina Hameed Haider, sabaa Raad Jaafar, Marwa Adel Hussein, Nada Hassan Bedair, Ruaa Hussein Ali, Ruaa Maan Attallah, Omar A Mahmoud, Farah B. Abd, Shahrazad H. Muhi

“…Unlike traditional methods, SNP typing offers a more powerful set of genetic markers, enabling complex analysis and profiling techniques suitable for various genotyping scenarios, from specialized forensic markers to expanded tiling arrays. …”
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Enhancing uterine contraction detection through novel EHG signal processing: a pilot study leveraging the relationship between slow and fast wave components to improve signal quali... by Hansong Gao, Hansong Gao, Zichao Wen, Meng Jiang, Yuan Nan, Yuan Nan, Yong Wang, Yong Wang, Yong Wang, Yong Wang

“…Uterine contractions, driven by complex electrical activities within the uterine smooth muscle cells, play a critical role in labor and delivery. …”
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Predictive and Explainable Machine Learning Models for Endocrine, Nutritional, and Metabolic Mortality in Italy Using Geolocalized Pollution Data by Donato Romano, Michele Magarelli, Pierfrancesco Novielli, Domenico Diacono, Pierpaolo Di Bitonto, Nicola Amoroso, Alfonso Monaco, Roberto Bellotti, Sabina Tangaro

“…The analysis highlighted the critical roles of specific pollutants, including benzene and socio-economic factors such as life quality and instruction, in influencing mortality rates. …”
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Psychological well-being and value-semantic sphere of personality among psychology students by T. S. Pilishvili, A. I. Savushkina, A. L. Danilova, N. C. Soruko Torres

“…The results of factor analysis demonstrate the presence of five factors in the personality structure: the factor of safety and stability of life when it is meaningful and manageable; the factor of self-actualisation regardless of the environment; the factor of psychological well-being with the meaningfulness of personal development; the factor of manifesting concern for the well-being of loved ones with a decrease in exactingness and responsibility for them; the factor of achieving personal success with the ability to take risks.Scientific novelty. …”
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Expanding structural insights into DNA packaging apparatus and endolysin LysSA05 function of Epsilon15 bacteriophage by Muhammad Saleem Iqbal Khan, Ju Wu, Shenlin Ji, Demeng Tan, Bingrui Sui, Shanshan Peng, Jinbiao Zhan, Jiajun Yin

“…The DNA packaging machinery, comprising the core, portal, and hub, was resolved at high resolution, including a 42 nm-long and 18 nm-wide injection channel anchored by a dodecameric portal complex visualized at ~7 Å resolution. Concurrently, we characterized LysSA05, a dual-acting endolysin harboring a glycoside hydrolase 19 (GH19) catalytic domain accommodating peptidoglycan (PG) residues N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) through structural docking, indicating plausible binding interactions that promote hydrolysis support vector machine (SVM), random forest (RF), discriminant analysis (DA), artificial neural network (ANN) and physicochemical scanning identified an amphipathic helix (residues 59-112) with predicted antimicrobial peptide (AMP)-like properties. …”
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Discovering the therapeutic potential of Naringenin in diabetes related to GLUT-4 and its regulatory factors: A computational approach by Ali Khakpour, Shamim Ghiabi, Ali Kazemi Babaheydari, Seyedeh Atefeh Mirahmadi, Payam Baziyar, Ehsan Heidari-Soureshjani, Mohammad Karami Horestani

“…Molecular dynamics (MD) simulations conducted over 100 ns confirmed the stability of the GLUT4-Naringenin complex, showing a reduced RMSD of 1.25 nm and a more compact structure with a Radius of Gyration (Rg) value of 2.14 nm. …”
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Psychosocial considerations in pediatric heart transplantation: Initial validation of the Pediatric Psychosocial Assessment Tool at a single center by Michael O. Killian, PhD, MSW, Sonnie E. Mayewski, MSW, Schyler E. Brumm, MSW, Zhe He, PhD, Dipankar Gupta, MBBS, DCH, MD

“…Psychosocial factors such as family dynamics, health literacy, mental health, financial stability, and adherence potential are often multidimensional and interdependent, making their assessment both vital and complex. …”
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Education and Symptom Reporting in an mHealth App for Patients With Cancer: Mixed Methods Development and Validation Study by Carolina Muñoz Olivar, Miguel Pineiro, Juan Sebastián Gómez Quintero, Carlos Javier Avendaño-Vásquez, Pablo Ormeño-Arriagada, Silvia Palma Rivadeneira, Carla Taramasco Toro

“…The early detection and management of the side effects are vital but complex. This study introduces a mobile health app designed to bridge the communication gaps between patients with cancer and health care providers. …”
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Comparative investigation of PFS and PAC coagulants with activated carbon in cellulose microfiltration systems for treatment of real printing ink wastewater by Maryam Gull, Zoya Shahid, Ahmad Raza, Shanza Mazhar, Zafar Masood

“…Printing Ink wastewater (PIW) generated during printing machine cleaning, ink formulation, and paper processing is a significant environmental concern because of its hazardous chemical composition. A complex combination of pollutants is generated as a result of printing ink operations, including toxic chemicals such as heavy metals (lead, cadmium, and chromium), volatile organic compounds (VOCs), resins, solvents, and synthetic dyes. …”
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The sporophytic type of fertility restoration in the A3 CMS-inducing cytoplasm of sorghum and its modification by plant water availability conditions by L. A. Elkonin, V. V. Kozhemyakin, M. I. Tsvetova

“…The A3 type of CMS in sorghum is one of the most difficult to restore fertility because of the low frequency of fertilityrestoring genes among sorghum accessions, the complex mechanism of fertility restoration that occurs with the complementary interaction of two gametophytic genes Rf3 and Rf4, and the sensitivity of their expression to air and soil drought. …”
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Impact of twin shield tunnel construction on the deformation of bridge pile groups beneath multiple bridges: a case study by Lan Deng, Jizhixian Liu, Chenze Huang, Shan Yang, Junzhou Huang, Junzhou Huang, Cai Wu

“…However, tunnel excavation significantly affects the surrounding soil and elevated bridge pile foundations, potentially leading to complex mechanical responses and safety risks for structures. …”
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A Novel Hybrid Optimizer Based on Coati Optimization Algorithm and Differential Evolution for Global Optimization and Constrained Engineering Problems by Saptadeep Biswas, Binanda Maiti, Gyan Singh, Absalom E. Ezugwu, Kashif Saleem, Laith Abualigah, Aseel Smerat, Uttam Kumar Bera

“…Furthermore, convergence behaviour, measurement of exploration and exploitation, and sensitivity analysis highlight the algorithm’s adaptability and stability across varied problem domains. …”
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Multiple objectives escaping bird search optimization and its application in stock market prediction based on transformer model by Dedai Wei, Zimo Wang, Minyu Qiu, Juntao Yu, Jiaquan Yu, Yurun Jin, Xinye Sha, Kaichen Ouyang

“…By assessing the performance of these models using R2, RMSE, and RPD metrics on both training and testing sets, the results demonstrate that the Transformer model optimized by MOEBS significantly outperforms the other methods in terms of prediction accuracy and prediction stability. This research offers a new solution for complex optimization scenarios and lays a foundation for advancements in stock market prediction technologies.…”
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Exploring the therapeutic potential of Emblica officinalis natural compounds against hepatocellular carcinoma (HCC) by Sidra Ilyas, Abdul Manan, Yeojin Choi, Donghun Lee

“…Subsequently, MD simulation was conducted to assess the stability and dynamics of protein-ligand complexes. …”
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Enhancing corn industry sustainability through deep learning hybrid models for price volatility forecasting. by Chengjin Yang, Yanzhong Zhai, Zehua Liu

“…The fluctuations in corn prices not only increase uncertainty in the market but also affect farmers' planting decisions and income stability, while also impeding crucial investments in sustainable agricultural practices. …”
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A new hybrid distance and similarity based scenario reduction approach for stochastic economic operation of microgrid by Gaurav Gangil, Amit Saraswat, Sunil Kumar Goyal

“…This paper attempts to develop a multi-time period stochastic optimization model for economic operations of a typical microgrid by employing a scenario-based analysis approach to exploit various uncertainties associated with variable renewable energy (VRE) generations, electricity prices, and load demand. …”
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<i>Bacillus</i><i> thuringiensis</i> Exopolysaccharide BPS-2 Ameliorates Ulcerative Colitis in a Murine Model Through Modulation of Gut Microbiota and Suppression of the NF-κB Casc... by Zexin Gao, Huan Li, Jungang Wen, Wenping Ding, Jie Yu, Yue Zhang, Xiaojuan Song, Jianrong Wu

“…Complementary molecular dynamics simulations revealed exceptional conformational stability in the p65-BPS-2U complex. These findings establish BPS-2 as a natural food additive that modulates the microbiota-barrier–inflammation axis through dietary intervention, offering a novel strategy to alleviate UC.…”
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Structurally Ordered NIPUs via Catalyst-Free Synthesis with Hard Segments Based on Erythritol and a Long-Chain Diamine by Edyta Hebda, Karolina Wróbel, Aleksandra Cieślik, Kinga Szołdrowska, Jan Ozimek, Paulina Zając, Konstantinos N. Raftopoulos, Krzysztof Pielichowski

“…A detailed chemical structure analysis of the synthesized NIPU was performed using a combination of FTIR and ¹H NMR. …”
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