An In-Depth Study of Personalized Anesthesia Management Models in Gastrointestinal Endoscopy Based on Multimodal Deep Learning by Hanqi Shi, Hongyu Wang, Xibing Ding, Zheng Dang

“…This model significantly improves prediction accuracy and stability over traditional methods, thereby enhancing operational efficiency in complex surgical environments. …”
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Natural AI-based drug designing by modification of ascorbic acid and curcumin to combat buprofezin toxicity by using molecular dynamics study by Haleema Sadia, Irfan Zia Qureshi, Muhammad Naveed, Tariq Aziz, Metab Alharbi, Abdullah F. Alasmari, Thamer H. Albekairi

“…The ADME analysis revealed favorable gastrointestinal absorption and aqueous solubility for both compounds. …”
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Constitutive Study of Limestone Damage in Karst Areas under Acidic Dry-Wet Cycles by ZHANG Yan, YUAN Pu-long, HUANG Lan-tao

“…The research reveals the complex mechanisms of acid-induced damage in limestone, offering new theoretical insights and methods for geotechnical design and slope stability analysis in karst regions, and provides an important reference for evaluating and predicting the performance of limestone materials in practical engineering applications in karst regions.…”
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Neuropharmacological Assessment of Sulfonamide Derivatives of Para-Aminobenzoic Acid through In Vivo and In Silico Approaches by Ankit Ganeshpurkar, Ravi Singh, Pratigya Tripathi, Qadir Alam, Sairam Krishnamurthy, Ashok Kumar, Sushil Kumar Singh

“…Background/Objectives: Alzheimer’s disease (AD), a complex neurogenerative disorder, manifests as dementia and concomitant neuropsychiatric symptoms, including apathy, depression, and circadian disruption. …”
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Pore-scale flow mechanism of immiscible gas-assisted gravity drainage in strongly heterogeneous glutenite reservoirs by Liu Yang, Yan Liu, Wendong Wang, Mingjun Li, Suling Wang, Benchao Xu, Yongmin Shi, Hao Chen

“…Abstract Tight glutenite reservoirs are known for strong heterogeneity, complex wettability, and challenging development. …”
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Revising the Nottingham Inversion Instability as a bifurcation between two branches of steady states solutions of thermo-field emission from micro-protrusions by Darius Mofakhami, Benjamin Seznec, Philippe Teste, Romaric Landfried, Philippe Dessante, Tiberiu Minea

“…This bifurcation represents an intermediate possibility between the two usual scenarios envisaged to date - a stable transition with increasing electric field (applied voltage) from low to high-temperature steady states up to the melting temperature versus the occurrence of a resistive instability beforehand. A stability analysis of the microprotrusion self-heating during electron emission is proposed to formally compare this third path with the other two. …”
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Professional commitment and turnover intentions of elementary school teachers during educational crisis by Moran Amir, Orly Lipka, Orly Lipka, Miriam Sarid

“…The findings highlight the complex relationship between professional commitment and turnover intentions during systemic disruptions, particularly for vulnerable teacher subgroups with less seniority and advanced degrees. …”
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Repeated mechanical recycling of biodegradable polymers: PLA exhibits less deterioration than PBAT/PLA blend by Naiara C. Farias, Ludivine Coudert, Declan Devine, Golnoosh Abdeali, Romina Pezzoli

“…Despite higher crystallinity and a more moderate decline in complex viscosity and storage modulus than PLA, PBAT/PLA showed reduced mechanical properties, with a 90 % drop in elongation at break and nearly 50 % in stress at break, highlighting the need for interventions to control PBAT degradation. …”
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Pharmacophore-based virtual screening for identification of marine sponge bioactive compound inhibitors against Alzheimer's disease by Suruthi SS, Prashanth KK, Baskaran A

“…Further, the best interacting AchE-Xestosaprol J complex along with standard AchE Agonist Donepezil was subjected to Molecular dynamics simulation and analysis, which maintained its stability between 65 and 85 ns with RMSD value ranging between 0- 3.5 Å in the virtual biological environment. …”
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Effect of Carboxymethyl chitosan-sodium alginate hydrogel loaded with Astragalus membranaceus-Panax notoginseng on wound healing in rats by Jing Li, Jing Li, Linai Li, Yue Yu, Ruixin Qin, Chaoyan Yu, Chen Chen, Youming Dong, Yadong Tan, Yunen Liu, Xuanli Liu

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2D robust intrinsic ferromagnetic half-metals Cr2XP with high Curie temperature by Xiao-Ping Wei, Jiao-Yang Zhang, Hao-Kai Sun, Jiang-Liu Meng, Ya-Ling Zhang, Xiaoma Tao

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Adaptive constraint control based peak-attenuated disturbance observer for the electric vehicle used permanent magnet synchronous motor by Yao Wang, Yang Jiao, Hong Chen, Lunjun Yao

“…Following this, a rigorous stability analysis is performed. Finally, the effectiveness of the SSCC-based ADO (SSCC-ADO) is validated on a 200 W PMSM platform. …”
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Molecular dynamics simulations of primary damage formation and tensile properties of irradiated Cu–Ni binary alloys by Xiao-Ping Wei, Hairui Li, Yaling Zhang, Xue Li, Chen Li

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Computational discovery of plant-derived flavonoids as potential amyloid-β fibril disaggregating agents for alzheimer’s disease by Uthirapathi Logeswari Rakesh, Golla Anil Kumar, Theivendren Panneerselvam, Parasuraman Pavadai, Suganthan Veerachamy, Ponnusamy Palanisamy, SunilKumar Bandral, Selvaraj Kunjiappan

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Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine by Karishma Sahoo, Prakash Lingasamy, Masuma Khatun, Sajitha Lulu Sudhakaran, Andres Salumets, Vino Sundararajan, Vijayachitra Modhukur

“…Aberrant methylation patterns enable early cancer detection and therapeutic stratification; however, their complex patterns necessitates advanced analytical tools. …”
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A DFT investigation of the adsorption mechanism of paclitaxel on functionalized graphene oxide for enhanced drug delivery by Bader Huwaimel, Saad Alqarni

“…The presence of these functional groups also enhanced the binding affinity and stability of the drug-nanocarrier complex. Charge transfer analysis revealed that the rGO-COOH and rGO-SO systems exhibited significant changes in electronic properties, with charge transfers estimated at -0.16e and − 0.08e, respectively. …”
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A Novel Optimized Hybrid VMD-PCA-XGBoost Model for Forecasting Precipitation: Exemplified by the Beijing-Tianjin-Hebei Study Region in China by Qiaoli Kong, Qian Li, Qi Bai, Xiaolong Mi, Joseph Awange, Shi Wang, Yi Yang, Guoli Bo

“…Traditional forecasting methods, such as numerical weather prediction, radar nowcasting, downscaling techniques, etc., frequently fail to capture the complex nonlinear dynamics of such events. In this study, we propose a novel hybrid model, variational mode decomposition-principal component analysis-extreme gradient boosting (VMD-PCA-XGBoost), which integrates VMD for effective signal processing, PCA for dimensionality reduction, and XGBoost for enhancing predictive accuracy. …”
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Revealing inhibitory activity of luteolin from Vietnamese Jatropha Podagrica Hook against Staphylococcus aureus by integrating in vitro and in silico approaches by Manh Hung Tran, Phu Chi Hieu Truong, Thuy Tram Thi Le, Hong Khuyen Thi Pham, Van Ngo Thai Bich, Y Ngo Huynh Thien, Loi Huynh, Phu Tran Vinh Pham

“…Further molecular dynamics simulations over 100 ns confirmed the structural stability of the luteolin–SrtA complex, with minimal RMSD fluctuation and sustained hydrogen bonding throughout the simulation. …”
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Feedback between p21 and reactive oxygen production is necessary for cell senescence by João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki

“…The pathways leading to establishment of senescence are proving to be more complex than was previously envisaged. Combining in‐silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here that there exists a dynamic feedback loop that is triggered by a DNA damage response (DDR) and, which after a delay of several days, locks the cell into an actively maintained state of ‘deep’ cellular senescence. …”
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Enhancing Structured Pathology Report Generation With Foundation Model and Modular Design by Kyung A Kim, Sungman Hong, Sehwan Yoo, Yousun Kang, Hyo Sup Shim

“…Pathology report generation, which requires analyzing giga-pixel Whole Slide Images (WSIs), is a complex and labor-intensive task. Despite this, it is crucial for clinical decision-making. …”
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