Integrating analytical quality by design into bioanalytical method development: an HPLC-FLD method for quantification of alectinib in biological matrix by Eun Ji Lee, Nahyun Koo, Min Ju Kim, Kyeong-Ryoon Lee, Yoon-Jee Chae

“…Unlike conventional QbD applications, which primarily address synthetic formulations or instrumental settings, this study systematically applied AQbD principles to the complex environment of biological matrices. Critical method parameters, including the organic phase ratio, buffer concentration, and flow rate, were identified through Failure Mode and Effects Analysis, and optimized using a Box–Behnken design. …”
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Temporary Anchorage Devices in Clear Aligner Therapy: A Systematic Review by Grazia Marinelli, Angelo Michele Inchingolo, Alessio Danilo Inchingolo, Laura Ferrante, Pasquale Avantario, Merigrazia Campanelli, Andrea Palermo, Francesco Inchingolo, Gianna Dipalma

“…After eligibility, 14 records were selected for qualitative analysis. The findings suggest that the combination of aligners and miniscrews significantly enhances treatment precision and control, especially in cases requiring complex tooth movements, such as intrusion, extrusion, and distalization. …”
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Protease production by Serratia liquefaciens NRC1 using fish gut waste as a sustainable approach to antimicrobial peptide generation and combating Candida auris acquired resistance by Shaymaa A. Ismail, Heba M. Shalaby, Amira A. Hassan, Marwa Mahmoud, Bahgat Fayed

“…The protease demonstrated stability at neutral pH and moderate temperatures (40–50 °C), and efficiently hydrolyzed complex proteins such as collagen and keratin. …”
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Biodegradation of polycyclic aromatic hydrocarbons: The role of ligninolytic enzymes and advances of biosensors for in-situ monitoring by Eshet Lakew Tesfaye, Fekadu Mazengiaw Bogale, Tadele Assefa Aragaw

“…These enzymes, produced by different living organisms, have demonstrated significant potential in degrading complex PAH structures, contributing to cleaner and more sustainable remediation techniques. …”
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Role of identity in shaping the well-being of Kazakh youth by М. Ақмади, Д. Бурханова, Г. Кенжакимова, Я. Пак

“…The ISI-5 questionnaire evaluates three styles of processing identities: informational, related to active search and analysis of information; normative, based on following social norms and expectations; and diffuse-avoidant. …”
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Spatial association network structure of agricultural carbon emission efficiency in Chinese cities and its driving factors by Xu Wei, Bohong Chen

“…Central cities generally exhibit higher efficiency levels, while the surrounding cities tend to have lower efficiency. (2) The carbon emission efficiency of city agriculture in China displays multidimensional, complex, and organic characteristics, with potential for enhanced network stability. (3) Agricultural regions in central and southeastern China dominate the spatial network, while regions with weaker agricultural sectors, like Beijing, Shanghai, and Ningxia, occupy peripheral positions. (4) Within the spatial association network of city agricultural carbon emission efficiency in China, Intra block spatial correlations are low, while interblock spatial correlations are strong, exhibiting significant spillover effects. (5)Variations in agricultural development levels and mechanization significantly enhance the formation of networks related to city agricultural carbon emission efficiency in China. …”
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Designing and Cloning of the Gene Vaccine Carrying the Viral Haemorrhagic Septicaemia Multi‐Epitope Gene in the pNZ8121 Secretion Vector by Ramin Shukripour, Abbas Doosti, Mohsen Forouzanfar, Mojtaba Jafarinia

“…Subsequently, the optimum complex was identified as −19.38 (kcal/mol). On the basis of the acquired results, the proposed vaccine has promising efficacy in mitigating fish infection resulting from VHSV. …”
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Algorithm for Control of Unmanned Aerial Vehicles in the Process of Visual Tracking of Objects with a Variable Movement’s Trajectory by A. A. Adnastarontsau, D. A. Adnastarontsava, R. V. Fiodortsev, D. V. Katser, A. Y. Liavonau, D. V. Romanov, D. N. Tcherniakovski, A. О. Mikhailau

“…The purpose of the research was to create an algorithm for determining and correcting the output parameters of the navigation module and the flight-navigation complex of unmanned aerial vehicles which provides control of an aviation gyro-stabilized platform with a multispectral optoelectronic system during flight and tracking various objects of observation.Principles of control of an aviation technical vision system located on an unmanned aerial vehicle on a two-degree gyro-stabilized platform with the possibility of full turn around two perpendicular axes along the course and pitch are considered. …”
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Unraveling the economic and environmental impacts of emerging financial risks: A strategic perspective by Lingli Yang, Mammadova Simuzar Sultan, Mammadova Intizar Ibrahim, Ziyodulla Xakimov, Cong Zhang

“…Emerging financial risks—driven by global market volatility, climate change, technological disruption, and geopolitical instability—pose complex challenges to both economic stability and environmental sustainability. …”
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Comparing Zinc Oxide- and Zinc Silicate-Related Metal-Organic Networks via Connection-Based Zagreb Indices by Muhammad Tanveer Hussain, Muhammad Javaid, Usman Ali, Ali Raza, Md Nur Alam

“…Metal-organic networks (MONs) are among the unique complex and porous chemical compounds. So, these chemical compounds consist of metal ions (vertices) and organic ligands (edges between vertices). …”
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Exploration of the molecular mechanism of melatonin against polycystic ovary syndrome based on a network pharmacology approach and experimental validation by Ran Cheng, Ran Cheng, Ran Cheng, Ying Zhu, Sheng-kai Wang, Chun-Xiao Zong, Hong-Li Zhao, Hong-Li Zhao, Hong-Li Zhao, Qin Zhang, Qin Zhang, Qin Zhang

“…The stability of the AR/CYP19A1-melatonin complex was verified through computational simulations using molecular dynamics techniques. …”
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Runoff Generation Mechanisms of Flash Flood Forecasting in Guanshan River Basin by LI Miao, TANG Wen-jian, DONG Lin-yao, ZENG Yu-jie

“…By comparing the performance of saturation-excess, infiltration-excess, and hybrid runoff generation modes in simulating flash floods of different magnitudes, we also seek to overcome the limitations of single-mode simulation under complex terrain and different rainfall intensities. …”
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Exploring highly dispersive optical solitons and modulation instability in nonlinear Schrödinger equations with nonlocal self phase modulation and polarization dispersion by Wafy M. Hasan, Hamdy M. Ahmed, Ahmed M. Ahmed, Haytham M. Rezk, Wafaa B. Rabie

“…Additionally, we perform a modulation instability (MI) analysis to examine the stability of steady-state solutions. …”
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LEGAL BASIS FOR THE ACTIVITIES OF THE ECONOMIC SECURITY BUREAU AS AN AGENCY RESPONSIBLE FOR ENSURING THE FINANCIAL SECURITY OF THE STATE by Andrii Borovyk, Nataliia Derevianko, Oleksandr Shyra

“… At the present stage, it is extremely important to ensure the economic security of the country, and this is what prompted the creation of the Economic Security Bureau of Ukraine, which has undergone a complex development process over the years of its existence. …”
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Preparation of Nitrogen-Doped Carbon-Supported Co-V Catalyst for Catalystic Depolymerization of Lignin to Produce Monophenolic Compounds by Yuqiao MA, Xingwang LIU, Yong QIAN, Xinping OUYANG

“…Lignin, a renewable biomass component, holds promise as a fossil fuel alternative through its depolymerization into monophenolic compounds for liquid fuel production. However, its complex chemical structure presents significant challenges to efficient degradation. …”
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ENSURING STATE SOVEREIGNTY AS A GUARANTEE OF THE COUNTRY'S ECONOMIC DEVELOPMENT by Iryna Drobush, Liudmila Kornuta, Mykola Ukrainets

“…Ensuring Ukraine's state sovereignty as an independent, democratic, social and legal state is a complex, multifaceted and multi-level process that includes such key areas of activity as: guaranteeing the stability of the Ukrainian state; developing all elements of Ukraine's legal system; improving the efficiency of the organisation and functioning of the entire system of state power, not just individual branches and/or bodies of state power; strengthening the economic, cultural, social, political, environmental and security potential of the state; positioning Ukraine on the international and domestic arena as an active player capable of solving complex problems at the national and global levels and capable of predictable and reliable international co-operation; strengthening the democratic nature of the Ukrainian state and guaranteeing the foundations of Ukraine's constitutional order. …”
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Enhanced mitochondrial function and delivery from adipose-derived stem cell spheres via the EZH2-H3K27me3-PPARγ pathway for advanced therapy by Ming-Min Chang, Dinh Toi Chu, Sheng-Che Lin, Jung-Shun Lee, Thuy Duong Vu, Hue Thi Vu, Thamil Selvee Ramasamy, Shau-Ping Lin, Chia-Ching Wu

“…High expressions of mitochondrial complex I genes and elevated levels of mitochondrial complex proteins were observed without an increase in reactive oxygen species (ROS). …”
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EtHgSC: Eigen Trick-Based Hypergraph Stable Clustering Algorithm in VANET by Mays Kareem Jabbar, Hafedh Trabelsi

“…In addition to relative speed, neighboring degree, and eccentricity that are used to select the CH, the vehicle time to leave metric is introduced to increase the CH stability. The grey relational analysis model is used to find each vehicle’s score, and the CH is selected based on the maximum vehicle’s score. …”
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Uncertainty management in multiobjective electric vehicle integrated optimal power flow based hydrothermal scheduling of renewable power system for environmental sustainability by Susanta Dutta, Siddhartha Ghosh, Tushnik Sarkar, Provas Kumar Roy, Chandan Paul, Ruba Abu Khurma, Mohd Asif Shah, Saurav Mallik

“…Utilizing statistical analysis, the suggested technique’s robustness has been assessed. …”
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Effects of Inlet Tip Clearance on Internal Flow Characteristic and Aerodynamic Performance of Centrifugal Compressor by Y. Zhang, J. Chen, Y. Shu, Z. Wang, H. Yang, Y. Wei

“…The focus lies in investigating the impact of the inlet tip-clearance (ITC) on the characteristics of the internal complex flow and the aerodynamic performance of centrifugal compressors. …”
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