Optimization of Reverse Logistics Networks for Hazardous Waste Incorporating Health, Safety, and Environmental Management: Insights from Large Cruise Ship Construction by Huilin Li, Jiaqi Yang, Wei Zhang

“…The comparative analysis shows that DCSA performs as well as NSGA-II, while outperforming DGWO, demonstrating both stability and efficiency. …”
Get full text

Problems of socio-economic development of Kazakhstan’s regions in the context of adaptation to the sustainable development by G. Khajieva, A. Omir

“…Based on the analysis, there were identified certain imbalances in the regional development of Kazakhstan. …”
Get full text

A new approach for monitoring spatial and temporal changes in forest types in subtropical regions with sample migration and multi-source remote sensing data by Pengfei Zheng, Dongyang Han, Jiang Liu, Bin Xu, Panfei Fang, Shaodong Huang, Wendou Liu, Shaozhi Chen

“…Accurate and cost-effective monitoring of forest-type distribution and dynamics is crucial for managing the rich resources and complex ecosystems of subtropical regions. However, the region’s complex terrain and climate conditions pose significant challenges to precise forest classification and change detection. …”
Get full text

Repurposed drugs as histone deacetylase 8 inhibitors: Implications in cancer and neuropathological conditions by Mohammed Alrouji, Kumar Venkatesan, Mohammed S. Alshammari, Fahad A. Alhumaydhi, Sheeba Shafi, Sharaf E. Sharaf, Moyad Shahwan, Anas Shamsi

“…Structural deviation, compactness, folding behavior, hydrogen bonds analysis, and secondary structure content profiling revealed complex stability formed by HDAC8 and the selected compounds. …”
Get full text

Leveraging multi-source data and teleconnection indices for enhanced runoff prediction using coupled deep learning models by Jintao Li, Ping Ai, Chuansheng Xiong, Yanhong Song

“…The results show that: (1) Compared to baseline single models, the SRA-MLPR model reduced RMSE (from 798.47 to 594.45) by 26% and MAPE (from 34.79 to 22.90%) by 34%, while achieving an NSE (from 0.67 to 0.76) improvement of 13%, particularly excelling in extreme runoff scenarios. (2) The inclusion of teleconnection indices not only enriched the predictive feature set but also improved model stability, with the SRA-MLPR demonstrating enhanced capability in capturing latent nonlinear relationships. (3) A one-month lag in atmospheric circulation indices was identified as the optimal predictor for basin-scale runoff, providing actionable insights into temporal runoff dynamics. (4) To enhance model interpretability, SHAP (SHapley Additive exPlanations) analysis was employed to quantify the contribution of atmospheric circulation indices to runoff predictions, revealing the dominant climate drivers and their nonlinear interactions. …”
Get full text

Thiazolo-pyridopyrimidines: An in silico evaluation as a lead for CDK4/6 inhibition, synthesis and cytotoxicity screening against breast cancer cell lines by Chaithra R Shetty, C. S. Shastry, Parasuraman P, Srinivas Hebbar

“…Furthermore, molecular dynamics simulation studies uncovered an elevated level of stability within the 4c- 6OQO complex. Conclusion: By integrating insights from computational, in vitro, and molecular dynamics simulation findings, compound 4c emerges as a leading candidate for future investigations. …”
Get full text

Comparative tests on failure mechanisms of slopes with different geotechnical strengths in open-pit mines by Shuwei SUN, Yuan LI, Jiabing HU, Liu LIU

“…In open-pit mining projects, the geotechnical conditions of stope slopes are complex, and the stability and failure modes of slopes with different geotechnical strengths are different, making daily maintenance of open-pit mines more difficult. …”
Get full text

Mechanism of astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique by Jian Ding, Qian Xue, Weizhen Guo, Gang Cheng, Lu Zhang, Tantan Huang, Di Wu, Jiabing Tong, Cheng Yang, Yating Gao, Zegeng Li

“…Kinetic simulations indicated the stability of the protein–ligand complex, as evidenced by RMSD values ranging from 0.2 to 0.4 nm. …”
Get full text

Intra-Domain Routing Protection Scheme Based on the Minimum Cross-Degree Between the Shortest Path and Backup Path by Haijun Geng, Xuemiao Liu, Wei Hou, Lei Xu, Ling Wang

“…Especially in complex networks, this scheme has more performance and protection advantages than traditional routing protection methods. …”
Get full text

Efficient biodegradation and detoxification of reactive black 5 using a newly constructed bacterial consortium by Manar K. Abd Elnabi, Mohamed A. Ghazy, Sameh S. Ali, Marwa Eltarahony, Amr Nassrallah

“…Among these dyes, Reactive Black 5 (RB5) is one of the most widely used and environmentally persistent due to its complex aromatic structure, high stability, and extensive use in the textile sector. …”
Get full text

Molecular Docking and Pharmacological In Silico Evaluation of Camptothecin and Related Ligands as Promising HER2-Targeted Therapies for Breast Cancer by Elmer Joel Millan-Casarrubias, Yunia Verónica García-Tejeda, Claudia Haydée González-De la Rosa, Lucero Ruiz-Mazón, Yazmín Mariela Hernández-Rodríguez, Oscar Eduardo Cigarroa-Mayorga

“…Molecular dynamics (MD) simulations of the camptothecin-HER2 complex indicate stable binding, with minimal fluctuations observed over 100 nanoseconds, confirming the stability of the ligand–receptor interaction. …”
Get full text

Predicting pile bearing capacity using gene expression programming with SHapley Additive exPlanation interpretation by Adil Khan, Majid Khan, Waseem Akhtar Khan, Muhammad Ali Afridi, Khawaja Atif Naseem, Ayesha Noreen

“…Abstract The accurate determination of pile-bearing capacity is crucial in construction projects to ensure the stability and safety of structures built on foundation piles. …”
Get full text

Design of a multi-epitope vaccine candidate against Helicobacter pylori in gastric cancer: an immunoinformatic approach by Shojaeian, Ali, Sanami, Samira, Mahmoudvand, Shahab, Amini, Razieh, Alibakhshi, Abbas

“…The results of molecular docking analysis along with molecular dynamics (MD) simulation on the multi-epitope vaccine and immune receptors complex showed the structure has appropriate interaction energy between its two components and good stability. …”
Get full text

Combined Distal Femoral Osteotomy and Medial Patellofemoral Ligament Reconstruction for Patellar Instability and Genu Valgus: A Case Report and Literature Review by Bin Zhao, Zijian Lian, Xuan Jiang, Songqing Ye, Haohao Bai, Wei Luo, Xinlong Ma

“…In this article, we report a case of complex lower limb malformations, including genu valgus, lower limb shortening, and increased femoral anteversion angle. …”
Get full text

Sustainable thermal buffering of microencapsulated bio-phase change materials through an engineered biochar dopant by Dimberu G. Atinafu, Ji Yong Choi, Jihee Nam, Beom Yeol Yun, Sumin Kim

“…However, the low thermal transport and thermal stability of bulk PCMs, as well as the expensive and complex synthesis of additive materials, hinder their large-scale utilization. …”
Get full text

Automatic vibration fault detection of coal mine explosion-proof electrical equipment based on One-Class Support Vector Machine by ZHENG Tiehua, WANG Fei, ZHAO Gelan, DU Chunhui

“…Experimental results showed that: ① When the number of iterations is 20, the OCSVM algorithm can complete convergence and achieve stability. ② In the electrical equipment signal classification experiment based on OCSVM, the use of the polynomial kernel function accurately classified samples for detection. ③ In the performance analysis of automatic vibration fault detection, the proposed method showed significantly higher accuracy across different sample sizes than infrared thermography and detection methods based on grey wolf optimization and support vector machine. …”
Get full text

Design of a Novel Macro-Micro Integrated Brain Surgery Robot Based on Modular Parallel Mechanisms by Hao Zheng, Chenbo Liang, Feng Gao, Chenkun Qi, Bingze He, Renqiang Liu, Longhai Chen

“…Abstract The advancement and development of medical surgical robots have provided new technological support for brain surgery and neurosurgical procedures, improving the reliability of highly complex and precise surgeries. In turn, this urges the design and development of novel surgical robots to possess higher precision, stability, and enhanced motion capabilities. …”
Get full text

Carotenoid Interactions with PCSK9: Exploring Novel Cholesterol-Lowering Strategies by Alessandro Medoro, Giovanni Scapagnini, Simone Brogi, Tassadaq Hussain Jafar, Truong Tan Trung, Luciano Saso, Sergio Davinelli

“…Density functional theory analysis confirmed the stability of astaxanthin and its favorable electronic properties, suggesting its potential as an effective inhibitor. …”
Get full text

A novel one-pot microwave assisted green synthesis of pyridinyl-1,3,5-triazine-2,4-diamine hybrids as potent antimicrobial agents by Omniya Sayed Zaky, Mohamed Hisham, Mohamed Abd-Elmonem, Ramadan Yahia, Laila Abdulmohsen Jaragh-Alhadad, Ramadan Ahmed Mekheimer, Gamal El-Din A. Abuo-Rahma, Moustafa Sherief Moustafa, Manal Makboul Ebied, Kamal Usef Sadek

“…Molecular dynamics simulations of the 6 g-urease complex over 25 ns demonstrated stable ligand binding, minimal structural perturbations, and strong interactions with key active site residues, confirming the complex's stability and integrity. …”
Get full text

Discovery of novel and potent celastrol derivatives as PRDX1 inhibitors for cancer therapy through structure-based virtual screening by Lixia Guan, Yifei Geng, Yuting Wang, Miao-Miao Niu, Kun Shi

Get full text