Ub-POD: A Ubiquitin-Specific Proximity-Dependent Labeling Technique to Identify E3 Ubiquitin Ligase Substrates in Human Cells by Urbi Mukhopadhyay, Sophie Levantovsky, Christian Behrends, Sagar Bhogaraju

“…Here, we present an efficient protocol that enables the selective biotinylation of substrates of a given ubiquitin ligase. …”
Get full text

A novel acidic laminarinase derived from Jermuk hot spring metagenome by Ani Paloyan, Tigran Soghomonyan, Mariam Karapetyan, Hasmik Grigoryan, Anna Krüger, Fiona Cuskin, Jon Marles-Wright, Christin Burkhardt, Garabed Antranikian

“…Abstract Laminarinase, an enzyme with a specific affinity for laminarin—a complex polysaccharide found in the cell walls of brown algae and select marine organisms—was investigated in this study. …”
Get full text

Interpersonal and intrapersonal leadership competencies: an interpretative phenomenological analysis on effective leadership strategies by Marion Koreen Andrea Aquino, Alicia Mae Bumacod, Arizzandra Gerriz Calapine, Jan Marie Therese Yaco, Margarett Luz Dimailig, Avon Pearl Amores, Joseph Francisco

“…Effective leadership is critical to organizational success, requiring leaders who can efficiently manage both their tasks and employees. Thus, it is valuable to explore and identify competencies possessed by competent leaders.MethodsThe study utilized an Interpretative Phenomenological Analysis (IPA) approach to have a detailed exploration of the strategies and practices leaders find most effective in navigating complex organizational challenges, such as strategy adoption, teamwork improvement, client relationship management, ethical decision-making, and industry adaptation. …”
Get full text

Immunoinformatics-Based development of a Multi-Epitope vaccine candidate targeting coinfection by Klebsiella pneumoniae and Acinetobacter baumannii by Gul Afshan, Namrah Yaseen, Syed H Ali, Asad U. Khan

“…Molecular dynamics (MD) simulations of the vaccine-TLR4 complex predicted a net binding energy of -508.0 kJ/mol, indicating high stability. …”
Get full text

MRDDA: a multi-relational graph neural network for drug–disease association prediction by Congzhou Chen, Yaozheng Zhou, Yinghong Li, Jin Xu, Demin Li, Lingfeng Wang

“…Biological entities such as drugs, genes, proteins, RNA, and diseases interact within a complex network. How to adequately extract the intrinsic relationships among them and accurately predict the drug-disease associations remains a challenge. …”
Get full text

Spiking Neural Networks for Multimodal Neuroimaging: A Comprehensive Review of Current Trends and the NeuCube Brain-Inspired Architecture by Omar Garcia-Palencia, Justin Fernandez, Vickie Shim, Nicola Kirilov Kasabov, Alan Wang, the Alzheimer’s Disease Neuroimaging Initiative

“…SNNs use discrete spikes for event-driven communication, making them energy-efficient and well suited for the real-time processing of dynamic brain data. …”
Get full text

Convolutional neural network-based deep learning for landslide susceptibility mapping in the Bakhtegan watershed by Li Feng, Maosheng Zhang, Yimin Mao, Hao Liu, Chuanbo Yang, Ying Dong, Yaser A. Nanehkaran

“…Abstract Landslides pose a significant threat to infrastructure, ecosystems, and human safety, necessitating accurate and efficient susceptibility assessment methods. Traditional models often struggle to capture the complex spatial dependencies and interactions between geological and environmental factors. …”
Get full text

Integrated transmission expansion planning incorporating fault current limiting devices and thyristor-controlled series compensation using meta-heuristic optimization techniques by Abdulaziz Almalaq, Khalid Alqunun, Rabeh Abbassi, Ziad M. Ali, Mohamed M. Refaat, Shady H. E. Abdel Aleem

“…Abstract Transmission expansion planning (TEP) is a vital process of ensuring power systems' reliable and efficient operation. The optimization of TEP is a complex challenge, necessitating the application of mathematical programming techniques and meta-heuristics. …”
Get full text

68Ga-labeled fluorinated benzamide derivatives for positron emission tomography imaging of melanoma. by Chaewon Lee, Boreum Song, Eunsu Kim, Yejin Seo, Dagyeong Hong, Jiyu Kim, Wookyeong Jeong, Seong-Young Kwon, Dong-Yeon Kim, Ayoung Pyo

“…The radiochemical yield and radiochemical purity of the 68Ga chelation complex were confirmed by radio-thin layer chromatography (radio TLC). …”
Get full text

A Facile Method for Screening DPP IV Inhibitors in Living Cell System Based on Enzyme Activity Probe by Shu-Mei Pan, Chun-Yu Xing, Hong-Wei Li, Rui-Min Wang, Xin-Yue Pu, Tie-Gang Wang, Dan-Dan Wang, Li-Wei Zou

“…Deciphering the relevance of DPP IV to human diseases and screening the inhibitors of DPP IV requires reliable tools, which can sense the function of this key enzyme in complex biological samples. Therefore, we aimed to construct a simple and easy-to-use assay for human DPP IV activity in a living cell system to achieve highly sensitive and selective detection of DPP IV function and further screening for its inhibitors. …”
Get full text

Analysis of health information needs of elderly patients with chronic diseases based on Kano Model: a descriptive cross-sectional study by Ying Tang, Xintong Deng, Chan Chen, Linlin You, Jing Gong, Xing Liu, Jing Zhou

“…Methods  A total of 469 older inpatients was selected from a tertiary general hospital in Zunyi City through convenience sampling between January and July 2024. …”
Get full text

Research on the Instability Mechanism and Control Technology of Gob-Side Entry in Deep Mines with Soft Rock by Lu Ma, Luyi Xing, Chang Liu, Tongyuan Cui, Xi Qiao, Wang Miao, Peng Kong

“…The gob-side entry driving in deep mines with soft rock exhibits a complex deformation and instability mechanism. This complexity leads to challenges in roadway stability control which greatly affects the coal mine production succession and safe and efficient mining. …”
Get full text

Behçet's syndrome patients' perception of the health system's accountability to care needs: A content analysis study by Neda Sayadi, Simin Jahani, Elham Rajaei

“…Background: Behçet's syndrome (BS) is a chronic, multisystem inflammatory disorder characterized by diverse and complex clinical manifestations, resulting in varied patient care requirements. …”
Get full text

A novel interval valued bipolar fuzzy hypersoft topological structures for multi-attribute decision making in the renewable energy sector by Muhammad Imran Harl, Muhammad Saeed, Muhammad Haris Saeed, Muhammad Salman Habib, Seung-June Hwang

“…Also, a novel decision-making algorithm leveraging the presented structure for multi-criteria analysis and complex system modeling is designed. The algorithm is applied to select optimal renewable energy source based on their economic, environmental, and technical aspects. …”
Get full text

What can be lost? Genomic perspective on the lipid metabolism of Mucoromycota by Blanka Sokołowska, Małgorzata Orłowska, Alicja Okrasińska, Sebastian Piłsyk, Julia Pawłowska, Anna Muszewska

“…Some strains have been selected as promising biotechnological organisms due to their ability to produce polyunsaturated fatty acids and efficient conversion of nutrients into lipids. …”
Get full text

Combination of solid-liquid hollow fiber liquid phase microextraction method with electromembrane extraction for extraction of Tolmetin and its determination followed by high perfo... by Samaneh Niazipour, Jahan Bakhsh Raoof, Milad Ghani, Reza Ojani

“…Additionally, the method attained a Blue Applicability Grade Index (BAGI) score of 67.5, confirming its high applicability and resource-efficient design. Conclusion: This approach offers high sensitivity, short extraction time, and excellent selectivity and reproducibility, making it well suited for trace analysis of tolmetin in complex matrices.…”
Get full text

Pharmacists’ Experiences on Adverse Drug Reactions in Saudi Arabia: A Cross-Sectional Study by Dalal Salem Bakheit Aldossari, Naeema Taha Alshalaan, Khuloud Salem Alshammari, Fatima Ahmed Lubbad, Mudhi Ratyan Alanazi, Neamah Ahmed Lubbad, Nada Suliman Fahad Alessa, Sheraz Ali

“…Background and objectives: As part of Vision 2030, Saudi Arabia aims to strengthen its healthcare system by enhancing efficiency, reducing medical errors, and ensuring drug safety. …”
Get full text

Artificial intelligence methods used in various aquaculture applications: A systematic literature review by Thurein Aung, Rafiza Abdul Razak, Adibi Rahiman Bin Md Nor

“…However, the review also uncovered substantial challenges that will continue limiting widespread adoption, including restricted access to representative data, prohibitive expenses, technical complexities, lack of social acceptance, and data privacy and security concerns. …”
Get full text

Vowel classification with combining pitch detection and one‐dimensional convolutional neural network based classifier for gender identification by Chia‐Hung Lin, Hsiang‐Yueh Lai, Ping‐Tzan Huang, Pi‐Yun Chen, Chien‐Ming Li

“…The proposed PD‐based extractor and voice classifier could reduce complexity and improve classification efficiency. Acoustic datasets were selected from the Hillenbrand database for experimental tests on 12 vowels classifications, and K‐fold cross‐validations were performed. …”
Get full text

PATH PLANNING AND OBSTACLE AVOIDANCE METHODS FOR AUTONOMOUS MOBILE ROBOTS by Ihor Berizka

“…This leads to some complexity in the method but solves typical problems of the classical algorithm, such as local minima, and increases the optimality and smoothness of the path. …”
Get full text