ALK Family Inhibitor A83-01 Promotes the Proliferation of Mouse Male Germline Stem Cells (mGSCs) Under Serum- and Feeder-Free Conditions by Meng YU, Long WANG, Yue HU, Zhi-min LIAN, Jin-lian HUA

“…A83-01 is a selective inhibitor of the TGF-β type I receptor ALK, which inhibits the TGF-β-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation. …”
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CRISPR-Cas9-based electrochemical biosensor for the detection of katG gene mutations in isoniazid-resistant tuberculosis by Dika Apriliana Wulandari, Muhammad Ihda Hamlu Liwaissunati Zein, Salma Nur Zakiyyah, Safri Ishmayana, Mehmet Ozsoz, Yeni Wahyuni Hartati, Irkham

“…The selected gRNA achieved the highest on-target score of 61.2 and an off-target score of 49.0 at cut position 2928, with a PAM sequence of AGG. …”
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Remediation of Hg-Contaminated Groundwater via Adsorption on Supramolecular Polymers in Batch Process and Column Test by Zongwu Wang, Wei Liu, Xiaoyan Sun, Qing Zhang, Jiapu Ji, Yimeng Yan, Jianhui Sun

“…The batch test study demonstrated that the SP can efficiently adsorb Hg from groundwater with superior selectivity and a high uptake capacity (up to 926.1 ± 165.3 mg g⁻¹). …”
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Repurposing FDA-Approved Agents to Develop a Prototype <i>Helicobacter pylori</i> Shikimate Kinase (HPSK) Inhibitor: A Computational Approach Using Virtual Screening, MM-GBSA Calcu... by Abdulaziz H. Al Khzem, Tagyedeen H. Shoaib, Rua M. Mukhtar, Mansour S. Alturki, Mohamed S. Gomaa, Dania Hussein, Nada Tawfeeq, Mohsina Bano, Mohammad Sarafroz, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o

“…While current therapies face challenges from rising antibiotic resistance, particularly to clarithromycin, alongside treatment complexity and costs, the World Health Organization has prioritized the development of new antibiotics to combat this high-risk pathogen. …”
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The Effect of Gamified Physical Activities on the Quality of Students' Leisure Time (Case Study: Female Secondary School Students in Ardabil City) by aylar sefidgar, Hamed Kheirollahi Meidani, Mehrdad Moharramzadeh

“…The statistical population included female high school sophomores in Ardabil city, from which 30 were selected by convenience sampling and divided into two groups of 15, experimental and control. …”
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Integrated multi-omics reveals the impact of ruminal keystone bacteria and microbial metabolites on average daily gain in Xuzhou cattle by Yingying Jiang, Zhenjiang An, Wenjie Li, Shuwen Xia, Qiang Ding, Jifeng Zhong, Huili Wang, Yan Xu, Kunlin Chen, Yangyang Shen

“…ABSTRACT The rumen microbiome plays a crucial role in determining the metabolic and digestive efficiency of livestock. Despite its crucial role, the impact of the rumen microbiome on average daily gain (ADG) in Xuzhou cattle remains underexplored. …”
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Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Additionally, this compound is characterized by selectivity of action towards MCF-7 breast cancer and has low cytotoxicity towards normal cells. …”
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Transfer of Periodic Phenomena in Multiphase Capillary Flows to a Quasi-Stationary Observation Using U-Net by Bastian Oldach, Philipp Wintermeyer, Norbert Kockmann

“…Miniaturization promotes the efficiency and exploration domain in scientific fields such as computer science, engineering, medicine, and biotechnology. …”
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Deep Learning-Based Seedling Row Detection and Localization Using High-Resolution UAV Imagery for Rice Transplanter Operation Quality Evaluation by Yangfan Luo, Jiuxiang Dai, Shenye Shi, Yuanjun Xu, Wenqi Zou, Haojia Zhang, Xiaonan Yang, Zuoxi Zhao, Yuanhong Li

“…However, the working environment of rice transplanters in paddy fields is complex, and data obtained solely from GPS devices installed on agricultural machinery cannot directly reflect the specific information of seedlings, making it difficult to accurately evaluate the quality of rice transplanter operations. …”
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Results of Water Inflow Elimination in Wells Draining Gas Сondestate Deposits by E. Vaganov, S. Sokhoshko, A. Sarancha, E. Levitina, I. Krasnov, T. Kharitonova

“…At the initial stage of LPW implementation, a water-repellent agent is used, which has selective filterability in the most permeable and watered reservoir intervals. …”
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Аdsorption of Co²⁺ and radioactive ⁶⁰Со by mesoporous TiO₂ by H. V. Vasylyeva, I. F. Mironyuk, I. M. Mykytyn

“…The mesoporous TiO2 with the initial pore size ratio (Smeso/S = 58 %; Vmeso/V = 64 %) was selected as adsorbent. Synthesis of adsorbents was carried out by the method of liquid phase hydrolysis of aqua complex of TiCl4. …”
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Ozonation of 4-aminotoluene as a new method of synthesis of 4-aminobenzaldehyde – an intermediate for the production of anti-tuberculosis drugs by A. H. Halstian, A. S. Вushuiev, Ye. Yu. Vasylenko

“…Manganese (II) acetate in the presence of potassium bromide forms a manganese bromide complex with increased catalytic activity, which under the same conditions contributes to the predominant production of 4-aminobenzaldehyde.…”
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Technical note: Flow cytometry assays for the detection, counting and cell sorting of polyphosphate-accumulating bacteria by C. Bouquet, H. Billard, H. Billard, C. C. Bidaud, J. Colombet, J. Colombet, Y.-T. Chang, J. Artigas, I. Batisson, K. Benzerara, F. Skouri-Panet, E. Duprat, A.-C. Lehours

“…The potential of flow cytometry to quantify and sort polyphosphate-accumulating bacteria in complex environmental samples, including soil, freshwater and sediments, was also examined. …”
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Bioherbicides: revolutionizing weed management for sustainable agriculture in the era of One-health by Taqi Raza, Muhammad Farhan Qadir, Shakeel Imran, Zobia Khatoon, Muhammad Yahya Khan, Mouna Mechri, Waleed Asghar, Muhmmad Ishaq Asif Rehmani, Sergio de los Santos Villalobos, Tooba Mumtaz, Rashid Iqbal

“…To develop an effective bioherbicide, specific and complex types of interaction have been developed between targeted weeds and biological agents. …”
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Lipid Profile, PCSK9, ANGPTL3 and Lipoprotein (a) Levels in Men Diagnosed With Localized High‐Grade Prostate Cancer and Men At‐Risk of Prostate Cancer by Ann‐Charlotte Bergeron, Emilie Wong‐Chong, France‐Hélène Joncas, Chloé Castonguay, Frédéric Calon, Nabil G. Seidah, Jonatan Blais, Karine Robitaille, Alain Bergeron, Vincent Fradet, Anne Gangloff

“…The present data suggest a complex interplay between PCSK9, PSA, and the lipid profile in localized PCa.…”
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Laser-Induced Breakdown Spectroscopy Quantitative Analysis Using a Bayesian Optimization-Based Tunable Softplus Backpropagation Neural Network by Xuesen Xu, Shijia Luo, Xuchen Zhang, Weiming Xu, Rong Shu, Jianyu Wang, Xiangfeng Liu, Ping Li, Changheng Li, Luning Li

“…Laser-induced breakdown spectroscopy (LIBS) has played a critical role in Mars exploration missions, substantially contributing to the geochemical analysis of Martian surface substances. However, the complex nonlinearity of LIBS processes can considerably limit the quantification accuracy of conventional LIBS chemometric methods. …”
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Identification of novel antioxidant and anti-inflammatory peptides from bovine hemoglobin by computer simulation of enzymolysis, molecular docking and molecular dynamics by Xuan-Ying Xin, Chao-Hui Ruan, Yi-Hui Liu, Huai-Na Jin, Sung-Kwon Park, Sun-Jin Hur, Xiang-Zi Li, Seong-Ho Choi

“…Due to the structural diversity and complex mechanisms of action of bioactive peptides, screening for specific functional peptides is often challenging. …”
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Modeling the hillside movement in the area of Sattarkhan dam reservoir using by predictive models Logistic Regression and Neural Network by soghra andaryani, Nasrin Samandar, Ohammadreza Nikjoo

“…This method is quite small and the effect of each independent variable on the dependent variable to quantify and anti-log coefficients and coefficients are specified. Considering the background of selected models, the area of Sattar Ahar dam, having a lot of slope motion phenomena, is regarded as a prone area, therefore, applying this model, we can make sure about the validity of the findings. …”
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Evaluation criteria of centralization options in the architecture of multicomputer systems with traps and baits by Antonina Kashtalian, Sergii Lysenko, Anatoliy Sachenko, Bohdan Savenko, Oleg Savenko, Andrii Nicheporuk

“…New mathematical models were developed for the criteria for operational efficiency, stability, integrity and security in relation to the system center, which, unlike the known mathematical models for evaluating system centers for selecting the next options for centralization, are presented in analytical expressions that take into account the features of the types of centralization in the system architecture, indicators of operational efficiency, stability, integrity and security in relation to the system center and allow forming on their basis an objective function for evaluating options for centralization in systems, the feature of which is the hiding of components with the system center from detection by attackers. …”
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Sensitivity analysis of the INRA 2018 feeding system for ruminants by hybrid local and global approaches: Comparing the contribution of dietary input variables to multiple response... by Seoyoung Jeon, Tristan Senga Kiessé, Sophie Lemosquet, Pierre Nozière

“…The sensitivity of 5 selected animal responses (output variables) to input variables was analyzed: DMI, milk protein yield (MPY), energy in methane (ECH4), nitrogen utilization efficiency (NUE), and the ratio between urine and total N excretion (UN/TN). …”
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