Discovery of KRAS(G12D) selective degrader ASP3082 by Tomohiro Yoshinari, Takeyuki Nagashima, Hiroki Ishioka, Kohei Inamura, Yoshihiro Nishizono, Mamoru Tasaki, Kanako Iguchi, Atsushi Suzuki, Chikako Sato, Ayako Nakayama, Yasushi Amano, Yukihiro Tateishi, Yosuke Yamanaka, Fumio Osaki, Masayasu Yoshino, Kazuyuki Kuramoto, Tomoyoshi Imaizumi, Masahiko Hayakawa

“…Herein, we report the discovery and characterization of ASP3082, a KRAS(G12D)-selective degrader, and the crystal structure of the drug-induced ternary complex of KRAS(G12D)/ASP3082/VHL (von Hippel–Lindau). …”
Get full text

Image-based maturity detection for selective cauliflower harvesting in field condition by Ajay Kushwah, P.K. Sharma, H.L. Kushwaha, Brij Bihari Sharma, Naseeb Singh, Ramineni Harsha Nag, Manojit Chowdhury, Nrusingh Charan Pradhan, Gopal Carpenter, Silpa Mandal, Ali Salem

Get full text

A Multiagent Decision-Making Model for Martian Landing Site Selection by Rong Wang, Yongjiu Feng, Panli Tang, Pengshuo Li, Yiyan Dong, Yusheng Xu, Chao Wang, Sicong Liu, Yanmin Jin, Shijie Liu, Xiaohua Tong

“…Selecting suitable landing sites on Mars remains one of the key challenges due to the complex terrain of Mars and the diverse scientific objectives in Mars exploration missions. …”
Get full text

Income inequality and economic complexity in Africa: the moderating role of governance quality by Amsalu Bedemo Beyene

“…This study examines the relationship between economic complexity and income inequality in 24 selected African countries. …”
Get full text

Path Planning Algorithm for Manipulators in Complex Scenes Based on Improved RRT* by Xiqing Zhang, Pengyu Wang, Yongrui Guo, Qianqian Han, Kuoran Zhang

“…The algorithm generates multiple candidate points per iteration, selecting a sampling point probabilistically based on heuristic values, thereby optimizing sampling efficiency and reducing unnecessary nodes. …”
Get full text

LCD: IDENTIFYING INFLUENTIAL NODES IN COMPLEX NETWORKS WITH LAYERED CLUSTERING AND DEGREE by Abdulhakeem Othman Mohammed

“…While numerous algorithms have been proposed in the literature, many struggle with either limited spreading efficiency or high computational complexity. To address this challenge, we present Layered Clustering Degree (LCD), an effective method for identifying a set of well-distributed spreaders with high spreading ability, while maintaining a computational complexity of  making it highly suitable for large-scale networks where both efficiency and computational complexity are essential. …”
Get full text

An Innovative Priority Queueing Strategy for Mitigating Traffic Congestion in Complex Networks by Ganhua Wu

“…The GPQ strategy provides a practical and adaptable solution for improving transportation efficiency in complex networks, bridging the gap between conventional routing techniques and emerging demands for dynamic congestion management.…”
Get full text

Software complex for simulation modelling of single nucleotide genetic polymorphism sites by M. M. Yatskou, D. D. Sarnatski, V. V. Skakun, V. V. Grinev

“…A software complex has been developed for simulation modelling and identification of single nucleotide polymorphism sites using machine learning methods. …”
Get full text

LINKING MARKETING AND HUMAN RESOURCES RECRUITMENT TO OBTAIN ORGANIZATIONAL EFFICIENCY by Nicoleta Valentina FLOREA

Get full text

Proteomics approaches – their potential for answering complex questions in meat science research by Elisabeth Huff-Lonergan, Steven M. Lonergan

“…New information can be used to make precise changes in management or genetic selection to improve the ability to efficiently produce the high-quality meat that customers and consumers expect. …”
Get full text

Analysis of Methods for Training Robotic Manipulators to Perform Complex Motion Trajectories by Yurii Senchuk, Fedir Matiko

“…The article examines current approaches to training robotic manipulators for executing complex tasks in dynamic and changing environments. …”
Get full text

A Complexity Reduction Method for Intra Prediction Method in HEVC Standard by Zahra Mirian, Mohammadreza Ramezanpour

“…High Efficiency Video Coding (HEVC) is considered the last standard for video compression with about 50% additional compression compared to the previous standard i.e. …”
Get full text

Location-Based Relay Selection in Full-Duplex Random Relay Networks by Jonghyun Bang, Taehyoung Kim

“…Furthermore, we introduce a low-complexity relay selection algorithm that selects the relay node nearest to the potential relay location. …”
Get full text

The Complexity of Oxidative Stress in Human Age-Related Diseases—A Review by Alicja Płóciniczak, Ewelina Bukowska-Olech, Ewa Wysocka

“…One of the key contributors to aging and age-related diseases is oxidative stress, resulting from an imbalance between the generation of reactive oxygen species (ROS) and the efficiency of antioxidant defense systems. In this review, we introduce the concept of the oxidative stress complexity—a network encompassing ROS-generating systems, enzymatic and non-enzymatic antioxidants, and genetic determinants that collectively shape redox homeostasis. …”
Get full text

An Integrated Algorithm with Feature Selection, Data Augmentation, and XGBoost for Ovarian Cancer by Jingxun Cai, Zne-Jung Lee, Zhihxian Lin, Chih-Hung Hsu, Yun Lin

“…Once ovarian cancer reaches an advanced stage, the complexity and difficulty of treatment increase substantially, affecting patient survival rates. …”
Get full text

Efficient Differential Diagnosis using Cost-aware Active Testing by Emile van Gerwen, Leonardo Barbini, Michael Borth, Robert Passmann

Get full text

Learning Energy-Efficient Transmitter Configurations for Massive MIMO Beamforming by Hamed Hojatian, Zoubeir Mlika, Jeremy Nadal, Jean-Francois Frigon, Francois Leduc-Primeau

“…Hybrid beamforming (HBF) and antenna selection are promising techniques for improving the energy efficiency (EE) of massive multiple-input multiple-output (mMIMO) systems. …”
Get full text

An efficient hybrid framework with knowledge transfer for solving capacitated vehicle routing problems by Yanlin Wu, Yanguang Cai, Chuncheng Fang

Get full text

Efficient Onboard Multitask AI Architecture Based on Self-Supervised Learning by Gabriele Inzerillo, Diego Valsesia, Enrico Magli

Get full text

Efficient and provably-secure certificateless sequential aggregate signature scheme by Zhu WANG, Siqi YANG, Fenghua LI, Kui GENG, Tingting PENG, Mengyao SHI

“…Aiming at the problem that current schemes mostly let the latter signer to verify the multiple signatures of the previous signer, and the message is signed and then passed to the next signer, leading to the efficiency problem of long overall signature time.A sequential aggregate signature scheme based on bilinear pairs was proposed.The aggregate signatures of documents were generated by multiple users in a certain order, and only the final signature was needed to be verified to confirm the correct order of signatures and the legitimacy of multiple user signatures.The complexity of verifying the multi-user sequential signature was effectively reduced and the offline verification of the authenticity of signature was realized when the user was offline or in a delay-tolerant network with limited node caching capacity and network resources.It is shown that the proposed scheme is existential unforgeability against chosen-message attacks under adversary adaptive selection messages in the random oracle model.…”
Get full text